PROCR cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PROCR
Entrez Gene ID	10544
Full Name	protein C receptor
Synonyms	CCCA,CCD41,EPCR
General protein information	Preferred Names protein C receptor Names endothelial protein C receptor APC receptor CD201 antigen activated protein C receptor cell cycle, centrosome-associated protein centrocyclin protein C receptor, endothelial
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.22
Summary	The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013].
Disorder MIM:	600646

mRNA and Protein(s)

mRNA	Protein	Name
NM_006404.4	NP_006395.2	endothelial protein C receptor precursor
NM_006404.5	NP_006395.2	endothelial protein C receptor precursor
XM_011528496.1	XP_011526798.1	endothelial protein C receptor isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PROCR	XP_514602.3
Bos taurus (cattle)	PROCR	NP_776862.1
Homo sapiens (human)	PROCR	NP_006395.2
Mus musculus (house mouse)	Procr	NP_035301.2
	PROCR	XP_001100647.1
Canis lupus familiaris (dog)	PROCR	XP_005635023.1
Rattus norvegicus (Norway rat)	Procr	NP_001020904.1
Gallus gallus (chicken)	PROCR	NP_001029992.1

Gene Ontology
Bibliography

Related articles in PubMed

Carbon monoxide-releasing molecule-2 suppresses thrombomodulin and endothelial protein C receptor expression of human umbilical vein endothelial cells induced by lipopolysaccharide in vitro.
Meng X, Fei D, Liu M, Yang S, Song N, Jiang L, Kang K, Nan C, Luo Y, Pan S, Zhao M
Medicine96(21)e6978(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Elevated endothelium-related mediators (vWF, E-selectin and EPCR) appear to participate in the development of pancreatic necrosis and may be a potential indicator of overall prognosis.
Title: Endothelial markers are associated with pancreatic necrosis and overall prognosis in acute pancreatitis: A preliminary cohort study.

The results showed that AS-IV could significantly inhibit PMA-induced EPCR shedding.
Title: Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway.

CORM-2 protects human umbilical vein endothelial cells from lipopolysaccharide-induced injury, by way of suppressing NF-kappaB activity, which downregulates TM and EPCR mRNAs. It also decreases MMP-2 expression and prevents the shedding of TM and EPCR from the surface of endothelial cells, so as to preserve their protective effect.
Title: Carbon monoxide-releasing molecule-2 suppresses thrombomodulin and endothelial protein C receptor expression of human umbilical vein endothelial cells induced by lipopolysaccharide in vitro.

This study demonstrates that impaired EPCR function can be detected by thrombin generation and clot lysis assays on cells expressing thrombomodulin and EPCR. Deficiency in EPCR has procoagulant effects that lead to a delay in clot lysis.
Title: The impact of the endothelial protein C receptor on thrombin generation and clot lysis.

EPCR polymorphisms may be associated with increased risk of sepsis, but this has no effect on the release of soluble EPCR in patients with sepsis.
Title: Endothelial protein C receptor polymorphisms and risk of sepsis in a Chinese population.

The following PROCR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PROCR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23952	NM_006404.5 Latest version!	Homo sapiens protein C receptor (PROCR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu64113	XM_011528496.1 Latest version!	Homo sapiens protein C receptor (PROCR), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu23952	NM_006404.4	Homo sapiens protein C receptor (PROCR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PROCR ( NM_006404.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006395.2 Homo sapiens protein C receptor (PROCR), mRNA.

Price & Availability↑

CloneID	OHu23952
Clone ID Related Accession (Same CDS sequence)	NM_006404.4 , NM_006404.5
Accession Version	NM_006404.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-01
Organism	Homo sapiens(human)
Product	endothelial protein C receptor precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM808358.1, HY110044.1, AK314887.1 and BQ939781.1. This sequence is a reference standard in the RefSeqGene project. On Jul 25, 2013 this sequence version replaced NM_006404.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014451.1, SRR1163658.436485.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTTGACAA CATTGCTGCC GATACTGCTG CTGTCTGGCT GGGCCTTTTG TAGCCAAGAC 
GCCTCAGATG GCCTCCAAAG ACTTCATATG CTCCAGATCT CCTACTTCCG CGACCCCTAT 
CACGTGTGGT ACCAGGGCAA CGCGTCGCTG GGGGGACACC TAACGCACGT GCTGGAAGGC 
CCAGACACCA ACACCACGAT CATTCAGCTG CAGCCCTTGC AGGAGCCCGA GAGCTGGGCG 
CGCACGCAGA GTGGCCTGCA GTCCTACCTG CTCCAGTTCC ACGGCCTCGT GCGCCTGGTG 
CACCAGGAGC GGACCTTGGC CTTTCCTCTG ACCATCCGCT GCTTCCTGGG CTGTGAGCTG 
CCTCCCGAGG GCTCTAGAGC CCATGTCTTC TTCGAAGTGG CTGTGAATGG GAGCTCCTTT 
GTGAGTTTCC GGCCGGAGAG AGCCTTGTGG CAGGCAGACA CCCAGGTCAC CTCCGGAGTG 
GTCACCTTCA CCCTGCAGCA GCTCAATGCC TACAACCGCA CTCGGTATGA ACTGCGGGAA 
TTCCTGGAGG ACACCTGTGT GCAGTATGTG CAGAAACATA TTTCCGCGGA AAACACGAAA 
GGGAGCCAAA CAAGCCGCTC CTACACTTCG CTGGTCCTGG GCGTCCTGGT GGGCAGTTTC 
ATCATTGCTG GTGTGGCTGT AGGCATCTTC CTGTGCACAG GTGGACGGCG ATGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006395.2
CDS	219..935
Translation	MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC

Target ORF information:

RefSeq Version	NM_006404.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein C receptor (PROCR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006404.4

ORF Insert Sequence:

ATGTTGACAA CATTGCTGCC GATACTGCTG CTGTCTGGCT GGGCCTTTTG TAGCCAAGAC 
GCCTCAGATG GCCTCCAAAG ACTTCATATG CTCCAGATCT CCTACTTCCG CGACCCCTAT 
CACGTGTGGT ACCAGGGCAA CGCGTCGCTG GGGGGACACC TAACGCACGT GCTGGAAGGC 
CCAGACACCA ACACCACGAT CATTCAGCTG CAGCCCTTGC AGGAGCCCGA GAGCTGGGCG 
CGCACGCAGA GTGGCCTGCA GTCCTACCTG CTCCAGTTCC ACGGCCTCGT GCGCCTGGTG 
CACCAGGAGC GGACCTTGGC CTTTCCTCTG ACCATCCGCT GCTTCCTGGG CTGTGAGCTG 
CCTCCCGAGG GCTCTAGAGC CCATGTCTTC TTCGAAGTGG CTGTGAATGG GAGCTCCTTT 
GTGAGTTTCC GGCCGGAGAG AGCCTTGTGG CAGGCAGACA CCCAGGTCAC CTCCGGAGTG 
GTCACCTTCA CCCTGCAGCA GCTCAATGCC TACAACCGCA CTCGGTATGA ACTGCGGGAA 
TTCCTGGAGG ACACCTGTGT GCAGTATGTG CAGAAACATA TTTCCGCGGA AAACACGAAA 
GGGAGCCAAA CAAGCCGCTC CTACACTTCG CTGGTCCTGG GCGTCCTGGT GGGCAGTTTC 
ATCATTGCTG GTGTGGCTGT AGGCATCTTC CTGTGCACAG GTGGACGGCG ATGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PROCR ( NM_006404.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006395.2 Homo sapiens protein C receptor (PROCR), mRNA.

Price & Availability↑

CloneID	OHu23952
Clone ID Related Accession (Same CDS sequence)	NM_006404.4 , NM_006404.5
Accession Version	NM_006404.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	endothelial protein C receptor precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK314887.1 and BQ939781.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006404.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014451.1, SRR5189652.204729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216968.5/ ENSP00000216968.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGACAA CATTGCTGCC GATACTGCTG CTGTCTGGCT GGGCCTTTTG TAGCCAAGAC 
GCCTCAGATG GCCTCCAAAG ACTTCATATG CTCCAGATCT CCTACTTCCG CGACCCCTAT 
CACGTGTGGT ACCAGGGCAA CGCGTCGCTG GGGGGACACC TAACGCACGT GCTGGAAGGC 
CCAGACACCA ACACCACGAT CATTCAGCTG CAGCCCTTGC AGGAGCCCGA GAGCTGGGCG 
CGCACGCAGA GTGGCCTGCA GTCCTACCTG CTCCAGTTCC ACGGCCTCGT GCGCCTGGTG 
CACCAGGAGC GGACCTTGGC CTTTCCTCTG ACCATCCGCT GCTTCCTGGG CTGTGAGCTG 
CCTCCCGAGG GCTCTAGAGC CCATGTCTTC TTCGAAGTGG CTGTGAATGG GAGCTCCTTT 
GTGAGTTTCC GGCCGGAGAG AGCCTTGTGG CAGGCAGACA CCCAGGTCAC CTCCGGAGTG 
GTCACCTTCA CCCTGCAGCA GCTCAATGCC TACAACCGCA CTCGGTATGA ACTGCGGGAA 
TTCCTGGAGG ACACCTGTGT GCAGTATGTG CAGAAACATA TTTCCGCGGA AAACACGAAA 
GGGAGCCAAA CAAGCCGCTC CTACACTTCG CTGGTCCTGG GCGTCCTGGT GGGCAGTTTC 
ATCATTGCTG GTGTGGCTGT AGGCATCTTC CTGTGCACAG GTGGACGGCG ATGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006395.2
CDS	84..800
Translation	MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC

Target ORF information:

RefSeq Version	NM_006404.5
Organism	Homo sapiens(human)
Definition	Homo sapiens protein C receptor (PROCR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006404.5

ORF Insert Sequence:

ATGTTGACAA CATTGCTGCC GATACTGCTG CTGTCTGGCT GGGCCTTTTG TAGCCAAGAC 
GCCTCAGATG GCCTCCAAAG ACTTCATATG CTCCAGATCT CCTACTTCCG CGACCCCTAT 
CACGTGTGGT ACCAGGGCAA CGCGTCGCTG GGGGGACACC TAACGCACGT GCTGGAAGGC 
CCAGACACCA ACACCACGAT CATTCAGCTG CAGCCCTTGC AGGAGCCCGA GAGCTGGGCG 
CGCACGCAGA GTGGCCTGCA GTCCTACCTG CTCCAGTTCC ACGGCCTCGT GCGCCTGGTG 
CACCAGGAGC GGACCTTGGC CTTTCCTCTG ACCATCCGCT GCTTCCTGGG CTGTGAGCTG 
CCTCCCGAGG GCTCTAGAGC CCATGTCTTC TTCGAAGTGG CTGTGAATGG GAGCTCCTTT 
GTGAGTTTCC GGCCGGAGAG AGCCTTGTGG CAGGCAGACA CCCAGGTCAC CTCCGGAGTG 
GTCACCTTCA CCCTGCAGCA GCTCAATGCC TACAACCGCA CTCGGTATGA ACTGCGGGAA 
TTCCTGGAGG ACACCTGTGT GCAGTATGTG CAGAAACATA TTTCCGCGGA AAACACGAAA 
GGGAGCCAAA CAAGCCGCTC CTACACTTCG CTGGTCCTGG GCGTCCTGGT GGGCAGTTTC 
ATCATTGCTG GTGTGGCTGT AGGCATCTTC CTGTGCACAG GTGGACGGCG ATGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PROCR ( XM_011528496.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011526798.1 Homo sapiens protein C receptor (PROCR), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu64113
Clone ID Related Accession (Same CDS sequence)	XM_011528496.1
Accession Version	XM_011528496.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	endothelial protein C receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGACAA CATTGCTGCC GATACTGCTG CTGTCTGGCT GGGCCTTTTG TAGCCAAGAC 
GCCTCAGATG GCCTCCAAAG ACTTCATATG CTCCAGATCT CCTACTTCCG CGACCCCTAT 
CACGTGTGGT ACCAGGGCAA CGCGTCGCTG GGGGGACACC TAACGCACGT GCTGGAAGGC 
CCAGACACCA ACACCACGAT CATTCAGCTG CAGCCCTTGC AGGAGCCCGA GAGCTGGGCG 
CGCACGCAGA GTGGCCTGCA GTCCTACCTG CTCCAGTTCC ACGGCCTCGT GCGCCTGGTG 
CACCAGGAGC GGACCTTGGC CTTTCCTCTG ACCATCCGCT GCTTCCTGGG CTGTGAGCTG 
CCTCCCGAGG GCTCTAGAGC CCATGTCTTC TTCGAAGTGG CTGTGAATGG GAGCTCCTTT 
GTGAGTTTCC GGCCGGAGAG AGCCTTGTGG CAGGCAGACA CCCAGGTCAC CTCCGGAGTG 
GTCACCTTCA CCCTGCAGCA GCTCAATGCC TACAACCGCA CTCGGTATGA ACTGCGGGAA 
TTCCTGGAGG ACACCTGTGT GCAGTATGTG CAGAAACATA TTTCCGCGGA AAACACGAAA 
GATCTCTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011526798.1
CDS	62..673
Translation	MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKDLY

Target ORF information:

RefSeq Version	XM_011528496.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein C receptor (PROCR), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528496.1

ORF Insert Sequence:

ATGTTGACAA CATTGCTGCC GATACTGCTG CTGTCTGGCT GGGCCTTTTG TAGCCAAGAC 
GCCTCAGATG GCCTCCAAAG ACTTCATATG CTCCAGATCT CCTACTTCCG CGACCCCTAT 
CACGTGTGGT ACCAGGGCAA CGCGTCGCTG GGGGGACACC TAACGCACGT GCTGGAAGGC 
CCAGACACCA ACACCACGAT CATTCAGCTG CAGCCCTTGC AGGAGCCCGA GAGCTGGGCG 
CGCACGCAGA GTGGCCTGCA GTCCTACCTG CTCCAGTTCC ACGGCCTCGT GCGCCTGGTG 
CACCAGGAGC GGACCTTGGC CTTTCCTCTG ACCATCCGCT GCTTCCTGGG CTGTGAGCTG 
CCTCCCGAGG GCTCTAGAGC CCATGTCTTC TTCGAAGTGG CTGTGAATGG GAGCTCCTTT 
GTGAGTTTCC GGCCGGAGAG AGCCTTGTGG CAGGCAGACA CCCAGGTCAC CTCCGGAGTG 
GTCACCTTCA CCCTGCAGCA GCTCAATGCC TACAACCGCA CTCGGTATGA ACTGCGGGAA 
TTCCTGGAGG ACACCTGTGT GCAGTATGTG CAGAAACATA TTTCCGCGGA AAACACGAAA 
GATCTCTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Carbon monoxide-releasing molecule-2 suppresses thrombomodulin and endothelial protein C receptor expression of human umbilical vein endothelial cells induced by lipopolysaccharide in vitro.
Medicine96(21)e6978(2017 May)
Meng X,Fei D,Liu M,Yang S,Song N,Jiang L,Kang K,Nan C,Luo Y,Pan S,Zhao M

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PROCR cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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