P3H3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	P3H3
Entrez Gene ID	10536
Full Name	prolyl 3-hydroxylase 3
Synonyms	GRCB,HSU47926,LEPREL2
General protein information	Preferred Names prolyl 3-hydroxylase 3 Names prolyl 3-hydroxylase 3 gene rich cluster, B leprecan-like 2 procollagen-proline 3-dioxygenase protein B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013].
Disorder MIM:	610342

mRNA and Protein(s)

mRNA	Protein	Name
NM_014262.4	NP_055077.2	prolyl 3-hydroxylase 3 precursor
NM_014262.5	NP_055077.2	prolyl 3-hydroxylase 3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LEPREL2	XP_003313512.2
Canis lupus familiaris (dog)	LEPREL2	XP_003433588.2
Mus musculus (house mouse)	Leprel2	NP_038562.2
Gallus gallus (chicken)	LEPREL2	XP_416512.4
Bos taurus (cattle)	LEPREL2	XP_003586189.2
Homo sapiens (human)	LEPREL2	NP_055077.2
	LOC713865	XP_001110328.2
Rattus norvegicus (Norway rat)	Leprel2	NP_001100090.2
Danio rerio (zebrafish)	leprel2	XP_696266.3

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
Major JM, Yu K, Chung CC, Weinstein SJ, Yeager M, Wheeler W, Snyder K, Wright ME, Virtamo J, Chanock S, Albanes D
The Journal of nutrition142(5)866-71(2012 May)

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD 3rd, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occupational and environmental medicine66(12)848-53(2009 Dec)

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devri?ze F, Dartigues JF, Tzourio C, Bu?e L, Pasquier F, Berr C, Mann D, Lendon C, Alp?rovitch A, Kamboh MI, Amouyel P, Lambert JC
Molecular psychiatry14(11)1004-16(2009 Nov)

The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer.
Shah R, Smith P, Purdie C, Quinlan P, Baker L, Aman P, Thompson AM, Crook T
British journal of cancer100(10)1687-96(2009 May)

Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes.
Vranka JA, Sakai LY, B?chinger HP
The Journal of biological chemistry279(22)23615-21(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

Observational study of gene-disease association. (HuGE Navigator)
Title: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.

The following P3H3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the P3H3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20503	NM_014262.5 Latest version!	Homo sapiens prolyl 3-hydroxylase 3 (P3H3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$517.30 $739.00
View Old Accession Versions >>
OHu20503	NM_014262.4	Homo sapiens prolyl 3-hydroxylase 3 (P3H3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$517.30 $739.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

P3H3 ( NM_014262.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055077.2 Homo sapiens prolyl 3-hydroxylase 3 (P3H3), mRNA.

Price & Availability↑

CloneID	OHu20503
Clone ID Related Accession (Same CDS sequence)	NM_014262.4 , NM_014262.5
Accession Version	NM_014262.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2211bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	prolyl 3-hydroxylase 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ430349.1 and BQ009002.1. This sequence is a reference standard in the RefSeqGene project. On Aug 7, 2013 this sequence version replaced NM_014262.3. ##Evidence-Data-START## Transcript exon combination :: AK025976.1, BC080630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCCGGC TCCTCCGGCC GCTGCTGCTA CTGCTGCTGC TGCCTCCCCC GGGGTCCCCT 
GAGCCCCCCG GCCTGACCCA GCTGTCCCCG GGGGCGCCCC CGCAGGCCCC CGACTTGCTC 
TACGCTGACG GGCTGCGCGC CTACGCGGCC GGGGCTTGGG CGCCGGCCGT GGCGCTGCTG 
CGGGAGGCGC TGCGGAGCCA GGCGGCGCTG GGCCGGGTGC GGCTGGATTG CGGGGCGAGC 
TGCGCGGCCG ATCCGGGCGC CGCGCTCCCC GCCGTGCTTC TCGGGGCCCC GGAGCCCGAC 
TCCGGGCCGG GACCCACGCA GGGGTCCTGG GAGCGACAGC TTCTCCGTGC AGCGCTCCGC 
CGCGCAGACT GCCTGACCCA GTGCGCAGCA CGGAGGCTGG GCCCCGGGGG CGCGGCGCGG 
CTTCGCGTGG GGAGCGCGCT CCGGGACGCC TTCCGCCGTC GGGAGCCCTA CAACTACCTG 
CAGAGGGCCT ATTACCAGTT GAAGAAGCTG GATCTGGCAG CTGCGGCAGC ACACACCTTC 
TTTGTAGCAA ACCCCATGCA CCTGCAGATG CGGGAGGACA TGGCTAAGTA CAGACGAATG 
TCGGGAGTTC GGCCCCAGAG CTTCCGGGAC CTGGAGACGC CCCCACACTG GGCAGCCTAT 
GACACTGGCC TGGAGCTACT GGGGCGCCAG GAGGCAGGAC TGGCACTGCC CAGGCTAGAG 
GAGGCTCTTC AGGGGAGCCT GGCCCAGATG GAGAGCTGCC GTGCTGACTG TGAGGGGCCT 
GAGGAGCAGC AGGGGGCTGA AGAAGAGGAG GATGGGGCTG CGAGCCAGGG GGGCCTCTAT 
GAGGCCATTG CAGGACACTG GATTCAGGTC CTGCAGTGCC GGCAACGCTG TGTGGGGGAA 
ACAGCCACAC GCCCTGGTCG CAGCTTCCCT GTCCCAGACT TCCTTCCCAA CCAGCTGAGG 
CGGCTACATG AGGCCCATGC TCAGGTGGGC AATCTGTCCC AGGCTATAGA AAATGTCCTG 
AGTGTCCTGC TCTTCTACCC GGAGGATGAG GCTGCCAAGA GGGCTCTGAA CCAGTACCAG 
GCCCAGCTGG GAGAGCCGAG ACCTGGCCTC GGACCCAGAG AGGACATCCA GCGCTTCATC 
CTCCGATCCC TGGGGGAGAA GAGGCAGCTC TACTATGCCA TGGAGCACCT GGGGACCAGC 
TTCAAGGATC CTGACCCCTG GACCCCTGCA GCTCTCATCC CTGAGGCACT TAGAGAAAAG 
CTCAGAGAGG ATCAAGAGAA GAGGCCTTGG GACCATGAGC CCGTGAAGCC AAAGCCCTTG 
ACCTACTGGA AGGATGTCCT TCTCCTGGAG GGTGTGACCT TGACCCAGGA TTCCAGGCAG 
CTGAATGGGT CGGAGCGGGC GGTGTTGGAT GGGCTGCTCA CCCCAGCCGA GTGTGGGGTG 
CTGCTGCAGC TGGCTAAGGA TGCAGCTGGG GCTGGAGCCA GGTCTGGCTA TCGTGGTCGC 
CGCTCCCCTC ACACCCCCCA TGAACGCTTC GAGGGGCTCA CGGTGCTTAA GGCTGCGCAG 
CTGGCCCGGG CTGGGACAGT GGGCAGTCAG GGTGCTAAGC TGCTTCTGGA GGTGAGCGAG 
CGGGTGCGGA CCTTGACCCA GGCCTACTTC TCCCCGGAAC GGCCCCTGCA TCTGTCCTTC 
ACCCACCTGG TGTGCCGCAG CGCCATAGAA GGAGAGCAAG AGCAGCGCAT GGACCTGAGT 
CACCCAGTGC ACGCAGACAA CTGCGTCCTG GACCCTGACA CGGGAGAGTG CTGGCGGGAG 
CCCCCAGCCT ACACCTATCG GGACTACAGC GGACTCCTCT ACCTCAACGA TGACTTCCAG 
GGTGGGGACC TGTTCTTCAC GGAGCCCAAC GCCCTCACTG TCACGGCTCG GGTGCGTCCT 
CGCTGTGGGC GCCTTGTGGC CTTCAGCTCC GGTGTCGAGA ATCCCCATGG GGTGTGGGCC 
GTGACTCGGG GACGGCGCTG TGCCCTGGCA CTGTGGCACA CGTGGGCACC TGAGCACAGG 
GAGCAGGAGT GGATAGAAGC CAAAGAACTG CTGCAGGAGT CACAGGAGGA GGAGGAAGAG 
GAAGAGGAAG AAATGCCCAG CAAAGACCCT TCCCCAGAGC CCCCTAGCCG CAGGCACCAG 
AGGGTCCAAG ACAAGACTGG AAGGGCACCT CGGGTTCGGG AGGAGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055077.2
CDS	69..2279
Translation	MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREKLREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL

Target ORF information:

RefSeq Version	NM_014262.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prolyl 3-hydroxylase 3 (P3H3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014262.4

ORF Insert Sequence:

ATGCTCCGGC TCCTCCGGCC GCTGCTGCTA CTGCTGCTGC TGCCTCCCCC GGGGTCCCCT 
GAGCCCCCCG GCCTGACCCA GCTGTCCCCG GGGGCGCCCC CGCAGGCCCC CGACTTGCTC 
TACGCTGACG GGCTGCGCGC CTACGCGGCC GGGGCTTGGG CGCCGGCCGT GGCGCTGCTG 
CGGGAGGCGC TGCGGAGCCA GGCGGCGCTG GGCCGGGTGC GGCTGGATTG CGGGGCGAGC 
TGCGCGGCCG ATCCGGGCGC CGCGCTCCCC GCCGTGCTTC TCGGGGCCCC GGAGCCCGAC 
TCCGGGCCGG GACCCACGCA GGGGTCCTGG GAGCGACAGC TTCTCCGTGC AGCGCTCCGC 
CGCGCAGACT GCCTGACCCA GTGCGCAGCA CGGAGGCTGG GCCCCGGGGG CGCGGCGCGG 
CTTCGCGTGG GGAGCGCGCT CCGGGACGCC TTCCGCCGTC GGGAGCCCTA CAACTACCTG 
CAGAGGGCCT ATTACCAGTT GAAGAAGCTG GATCTGGCAG CTGCGGCAGC ACACACCTTC 
TTTGTAGCAA ACCCCATGCA CCTGCAGATG CGGGAGGACA TGGCTAAGTA CAGACGAATG 
TCGGGAGTTC GGCCCCAGAG CTTCCGGGAC CTGGAGACGC CCCCACACTG GGCAGCCTAT 
GACACTGGCC TGGAGCTACT GGGGCGCCAG GAGGCAGGAC TGGCACTGCC CAGGCTAGAG 
GAGGCTCTTC AGGGGAGCCT GGCCCAGATG GAGAGCTGCC GTGCTGACTG TGAGGGGCCT 
GAGGAGCAGC AGGGGGCTGA AGAAGAGGAG GATGGGGCTG CGAGCCAGGG GGGCCTCTAT 
GAGGCCATTG CAGGACACTG GATTCAGGTC CTGCAGTGCC GGCAACGCTG TGTGGGGGAA 
ACAGCCACAC GCCCTGGTCG CAGCTTCCCT GTCCCAGACT TCCTTCCCAA CCAGCTGAGG 
CGGCTACATG AGGCCCATGC TCAGGTGGGC AATCTGTCCC AGGCTATAGA AAATGTCCTG 
AGTGTCCTGC TCTTCTACCC GGAGGATGAG GCTGCCAAGA GGGCTCTGAA CCAGTACCAG 
GCCCAGCTGG GAGAGCCGAG ACCTGGCCTC GGACCCAGAG AGGACATCCA GCGCTTCATC 
CTCCGATCCC TGGGGGAGAA GAGGCAGCTC TACTATGCCA TGGAGCACCT GGGGACCAGC 
TTCAAGGATC CTGACCCCTG GACCCCTGCA GCTCTCATCC CTGAGGCACT TAGAGAAAAG 
CTCAGAGAGG ATCAAGAGAA GAGGCCTTGG GACCATGAGC CCGTGAAGCC AAAGCCCTTG 
ACCTACTGGA AGGATGTCCT TCTCCTGGAG GGTGTGACCT TGACCCAGGA TTCCAGGCAG 
CTGAATGGGT CGGAGCGGGC GGTGTTGGAT GGGCTGCTCA CCCCAGCCGA GTGTGGGGTG 
CTGCTGCAGC TGGCTAAGGA TGCAGCTGGG GCTGGAGCCA GGTCTGGCTA TCGTGGTCGC 
CGCTCCCCTC ACACCCCCCA TGAACGCTTC GAGGGGCTCA CGGTGCTTAA GGCTGCGCAG 
CTGGCCCGGG CTGGGACAGT GGGCAGTCAG GGTGCTAAGC TGCTTCTGGA GGTGAGCGAG 
CGGGTGCGGA CCTTGACCCA GGCCTACTTC TCCCCGGAAC GGCCCCTGCA TCTGTCCTTC 
ACCCACCTGG TGTGCCGCAG CGCCATAGAA GGAGAGCAAG AGCAGCGCAT GGACCTGAGT 
CACCCAGTGC ACGCAGACAA CTGCGTCCTG GACCCTGACA CGGGAGAGTG CTGGCGGGAG 
CCCCCAGCCT ACACCTATCG GGACTACAGC GGACTCCTCT ACCTCAACGA TGACTTCCAG 
GGTGGGGACC TGTTCTTCAC GGAGCCCAAC GCCCTCACTG TCACGGCTCG GGTGCGTCCT 
CGCTGTGGGC GCCTTGTGGC CTTCAGCTCC GGTGTCGAGA ATCCCCATGG GGTGTGGGCC 
GTGACTCGGG GACGGCGCTG TGCCCTGGCA CTGTGGCACA CGTGGGCACC TGAGCACAGG 
GAGCAGGAGT GGATAGAAGC CAAAGAACTG CTGCAGGAGT CACAGGAGGA GGAGGAAGAG 
GAAGAGGAAG AAATGCCCAG CAAAGACCCT TCCCCAGAGC CCCCTAGCCG CAGGCACCAG 
AGGGTCCAAG ACAAGACTGG AAGGGCACCT CGGGTTCGGG AGGAGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

P3H3 ( NM_014262.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055077.2 Homo sapiens prolyl 3-hydroxylase 3 (P3H3), mRNA.

Price & Availability↑

CloneID	OHu20503
Clone ID Related Accession (Same CDS sequence)	NM_014262.4 , NM_014262.5
Accession Version	NM_014262.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2211bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	prolyl 3-hydroxylase 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ430349.1 and BQ009002.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_014262.4. ##Evidence-Data-START## Transcript exon combination :: AK025976.1, BC017217.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000290510.10/ ENSP00000478600.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCCGGC TCCTCCGGCC GCTGCTGCTA CTGCTGCTGC TGCCTCCCCC GGGGTCCCCT 
GAGCCCCCCG GCCTGACCCA GCTGTCCCCG GGGGCGCCCC CGCAGGCCCC CGACTTGCTC 
TACGCTGACG GGCTGCGCGC CTACGCGGCC GGGGCTTGGG CGCCGGCCGT GGCGCTGCTG 
CGGGAGGCGC TGCGGAGCCA GGCGGCGCTG GGCCGGGTGC GGCTGGATTG CGGGGCGAGC 
TGCGCGGCCG ATCCGGGCGC CGCGCTCCCC GCCGTGCTTC TCGGGGCCCC GGAGCCCGAC 
TCCGGGCCGG GACCCACGCA GGGGTCCTGG GAGCGACAGC TTCTCCGTGC AGCGCTCCGC 
CGCGCAGACT GCCTGACCCA GTGCGCAGCA CGGAGGCTGG GCCCCGGGGG CGCGGCGCGG 
CTTCGCGTGG GGAGCGCGCT CCGGGACGCC TTCCGCCGTC GGGAGCCCTA CAACTACCTG 
CAGAGGGCCT ATTACCAGTT GAAGAAGCTG GATCTGGCAG CTGCGGCAGC ACACACCTTC 
TTTGTAGCAA ACCCCATGCA CCTGCAGATG CGGGAGGACA TGGCTAAGTA CAGACGAATG 
TCGGGAGTTC GGCCCCAGAG CTTCCGGGAC CTGGAGACGC CCCCACACTG GGCAGCCTAT 
GACACTGGCC TGGAGCTACT GGGGCGCCAG GAGGCAGGAC TGGCACTGCC CAGGCTAGAG 
GAGGCTCTTC AGGGGAGCCT GGCCCAGATG GAGAGCTGCC GTGCTGACTG TGAGGGGCCT 
GAGGAGCAGC AGGGGGCTGA AGAAGAGGAG GATGGGGCTG CGAGCCAGGG GGGCCTCTAT 
GAGGCCATTG CAGGACACTG GATTCAGGTC CTGCAGTGCC GGCAACGCTG TGTGGGGGAA 
ACAGCCACAC GCCCTGGTCG CAGCTTCCCT GTCCCAGACT TCCTTCCCAA CCAGCTGAGG 
CGGCTACATG AGGCCCATGC TCAGGTGGGC AATCTGTCCC AGGCTATAGA AAATGTCCTG 
AGTGTCCTGC TCTTCTACCC GGAGGATGAG GCTGCCAAGA GGGCTCTGAA CCAGTACCAG 
GCCCAGCTGG GAGAGCCGAG ACCTGGCCTC GGACCCAGAG AGGACATCCA GCGCTTCATC 
CTCCGATCCC TGGGGGAGAA GAGGCAGCTC TACTATGCCA TGGAGCACCT GGGGACCAGC 
TTCAAGGATC CTGACCCCTG GACCCCTGCA GCTCTCATCC CTGAGGCACT TAGAGAAAAG 
CTCAGAGAGG ATCAAGAGAA GAGGCCTTGG GACCATGAGC CCGTGAAGCC AAAGCCCTTG 
ACCTACTGGA AGGATGTCCT TCTCCTGGAG GGTGTGACCT TGACCCAGGA TTCCAGGCAG 
CTGAATGGGT CGGAGCGGGC GGTGTTGGAT GGGCTGCTCA CCCCAGCCGA GTGTGGGGTG 
CTGCTGCAGC TGGCTAAGGA TGCAGCTGGG GCTGGAGCCA GGTCTGGCTA TCGTGGTCGC 
CGCTCCCCTC ACACCCCCCA TGAACGCTTC GAGGGGCTCA CGGTGCTTAA GGCTGCGCAG 
CTGGCCCGGG CTGGGACAGT GGGCAGTCAG GGTGCTAAGC TGCTTCTGGA GGTGAGCGAG 
CGGGTGCGGA CCTTGACCCA GGCCTACTTC TCCCCGGAAC GGCCCCTGCA TCTGTCCTTC 
ACCCACCTGG TGTGCCGCAG CGCCATAGAA GGAGAGCAAG AGCAGCGCAT GGACCTGAGT 
CACCCAGTGC ACGCAGACAA CTGCGTCCTG GACCCTGACA CGGGAGAGTG CTGGCGGGAG 
CCCCCAGCCT ACACCTATCG GGACTACAGC GGACTCCTCT ACCTCAACGA TGACTTCCAG 
GGTGGGGACC TGTTCTTCAC GGAGCCCAAC GCCCTCACTG TCACGGCTCG GGTGCGTCCT 
CGCTGTGGGC GCCTTGTGGC CTTCAGCTCC GGTGTCGAGA ATCCCCATGG GGTGTGGGCC 
GTGACTCGGG GACGGCGCTG TGCCCTGGCA CTGTGGCACA CGTGGGCACC TGAGCACAGG 
GAGCAGGAGT GGATAGAAGC CAAAGAACTG CTGCAGGAGT CACAGGAGGA GGAGGAAGAG 
GAAGAGGAAG AAATGCCCAG CAAAGACCCT TCCCCAGAGC CCCCTAGCCG CAGGCACCAG 
AGGGTCCAAG ACAAGACTGG AAGGGCACCT CGGGTTCGGG AGGAGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055077.2
CDS	35..2245
Translation	MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREKLREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL

Target ORF information:

RefSeq Version	NM_014262.5
Organism	Homo sapiens(human)
Definition	Homo sapiens prolyl 3-hydroxylase 3 (P3H3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014262.5

ORF Insert Sequence:

ATGCTCCGGC TCCTCCGGCC GCTGCTGCTA CTGCTGCTGC TGCCTCCCCC GGGGTCCCCT 
GAGCCCCCCG GCCTGACCCA GCTGTCCCCG GGGGCGCCCC CGCAGGCCCC CGACTTGCTC 
TACGCTGACG GGCTGCGCGC CTACGCGGCC GGGGCTTGGG CGCCGGCCGT GGCGCTGCTG 
CGGGAGGCGC TGCGGAGCCA GGCGGCGCTG GGCCGGGTGC GGCTGGATTG CGGGGCGAGC 
TGCGCGGCCG ATCCGGGCGC CGCGCTCCCC GCCGTGCTTC TCGGGGCCCC GGAGCCCGAC 
TCCGGGCCGG GACCCACGCA GGGGTCCTGG GAGCGACAGC TTCTCCGTGC AGCGCTCCGC 
CGCGCAGACT GCCTGACCCA GTGCGCAGCA CGGAGGCTGG GCCCCGGGGG CGCGGCGCGG 
CTTCGCGTGG GGAGCGCGCT CCGGGACGCC TTCCGCCGTC GGGAGCCCTA CAACTACCTG 
CAGAGGGCCT ATTACCAGTT GAAGAAGCTG GATCTGGCAG CTGCGGCAGC ACACACCTTC 
TTTGTAGCAA ACCCCATGCA CCTGCAGATG CGGGAGGACA TGGCTAAGTA CAGACGAATG 
TCGGGAGTTC GGCCCCAGAG CTTCCGGGAC CTGGAGACGC CCCCACACTG GGCAGCCTAT 
GACACTGGCC TGGAGCTACT GGGGCGCCAG GAGGCAGGAC TGGCACTGCC CAGGCTAGAG 
GAGGCTCTTC AGGGGAGCCT GGCCCAGATG GAGAGCTGCC GTGCTGACTG TGAGGGGCCT 
GAGGAGCAGC AGGGGGCTGA AGAAGAGGAG GATGGGGCTG CGAGCCAGGG GGGCCTCTAT 
GAGGCCATTG CAGGACACTG GATTCAGGTC CTGCAGTGCC GGCAACGCTG TGTGGGGGAA 
ACAGCCACAC GCCCTGGTCG CAGCTTCCCT GTCCCAGACT TCCTTCCCAA CCAGCTGAGG 
CGGCTACATG AGGCCCATGC TCAGGTGGGC AATCTGTCCC AGGCTATAGA AAATGTCCTG 
AGTGTCCTGC TCTTCTACCC GGAGGATGAG GCTGCCAAGA GGGCTCTGAA CCAGTACCAG 
GCCCAGCTGG GAGAGCCGAG ACCTGGCCTC GGACCCAGAG AGGACATCCA GCGCTTCATC 
CTCCGATCCC TGGGGGAGAA GAGGCAGCTC TACTATGCCA TGGAGCACCT GGGGACCAGC 
TTCAAGGATC CTGACCCCTG GACCCCTGCA GCTCTCATCC CTGAGGCACT TAGAGAAAAG 
CTCAGAGAGG ATCAAGAGAA GAGGCCTTGG GACCATGAGC CCGTGAAGCC AAAGCCCTTG 
ACCTACTGGA AGGATGTCCT TCTCCTGGAG GGTGTGACCT TGACCCAGGA TTCCAGGCAG 
CTGAATGGGT CGGAGCGGGC GGTGTTGGAT GGGCTGCTCA CCCCAGCCGA GTGTGGGGTG 
CTGCTGCAGC TGGCTAAGGA TGCAGCTGGG GCTGGAGCCA GGTCTGGCTA TCGTGGTCGC 
CGCTCCCCTC ACACCCCCCA TGAACGCTTC GAGGGGCTCA CGGTGCTTAA GGCTGCGCAG 
CTGGCCCGGG CTGGGACAGT GGGCAGTCAG GGTGCTAAGC TGCTTCTGGA GGTGAGCGAG 
CGGGTGCGGA CCTTGACCCA GGCCTACTTC TCCCCGGAAC GGCCCCTGCA TCTGTCCTTC 
ACCCACCTGG TGTGCCGCAG CGCCATAGAA GGAGAGCAAG AGCAGCGCAT GGACCTGAGT 
CACCCAGTGC ACGCAGACAA CTGCGTCCTG GACCCTGACA CGGGAGAGTG CTGGCGGGAG 
CCCCCAGCCT ACACCTATCG GGACTACAGC GGACTCCTCT ACCTCAACGA TGACTTCCAG 
GGTGGGGACC TGTTCTTCAC GGAGCCCAAC GCCCTCACTG TCACGGCTCG GGTGCGTCCT 
CGCTGTGGGC GCCTTGTGGC CTTCAGCTCC GGTGTCGAGA ATCCCCATGG GGTGTGGGCC 
GTGACTCGGG GACGGCGCTG TGCCCTGGCA CTGTGGCACA CGTGGGCACC TGAGCACAGG 
GAGCAGGAGT GGATAGAAGC CAAAGAACTG CTGCAGGAGT CACAGGAGGA GGAGGAAGAG 
GAAGAGGAAG AAATGCCCAG CAAAGACCCT TCCCCAGAGC CCCCTAGCCG CAGGCACCAG 
AGGGTCCAAG ACAAGACTGG AAGGGCACCT CGGGTTCGGG AGGAGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
The Journal of nutrition142(5)866-71(2012 May)
Major JM,Yu K,Chung CC,Weinstein SJ,Yeager M,Wheeler W,Snyder K,Wright ME,Virtamo J,Chanock S,Albanes D

Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Occupational and environmental medicine66(12)848-53(2009 Dec)
Hosgood HD 3rd,Zhang L,Shen M,Berndt SI,Vermeulen R,Li G,Yin S,Yeager M,Yuenger J,Rothman N,Chanock S,Smith M,Lan Q

Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Molecular psychiatry14(11)1004-16(2009 Nov)
Chapuis J,Hot D,Hansmannel F,Kerdraon O,Ferreira S,Hubans C,Maurage CA,Huot L,Bensemain F,Laumet G,Ayral AM,Fievet N,Hauw JJ,DeKosky ST,Lemoine Y,Iwatsubo T,Wavrant-Devri?ze F,Dartigues JF,Tzourio C,Bu?e L,Pasquier F,Berr C,Mann D,Lendon C,Alp?rovitch A,Kamboh MI,Amouyel P,Lambert JC

The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer.
British journal of cancer100(10)1687-96(2009 May)
Shah R,Smith P,Purdie C,Quinlan P,Baker L,Aman P,Thompson AM,Crook T

Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes.
The Journal of biological chemistry279(22)23615-21(2004 May)
Vranka JA,Sakai LY,B?chinger HP

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P3H3 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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