RNASEH2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNASEH2A
Entrez Gene ID	10535
Full Name	ribonuclease H2 subunit A
Synonyms	AGS4,JUNB,RNASEHI,RNHIA,RNHL
General protein information	Preferred Names ribonuclease H2 subunit A Names ribonuclease H2 subunit A RNase H(35) RNase H2 subunit A RNase HI large subunit aicardi-Goutieres syndrome 4 protein ribonuclease H2, large subunit ribonuclease HI large subunit ribonuclease HI subunit A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.13
Summary	The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
Disorder MIM:	606034
Disorder Html:	Aicardi-Goutieres syndrome 4, 610333 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006397.3	NP_006388.2	ribonuclease H2 subunit A
NM_006397.2	NP_006388.2	ribonuclease H2 subunit A
XM_006722619.2	XP_006722682.1	ribonuclease H2 subunit A isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	rnaseh2a	NP_956520.2
Caenorhabditis elegans (roundworm)	rnh-2	NP_495796.1
Saccharomyces cerevisiae (baker's yeast)	RNH201	NP_014327.1
Eremothecium gossypii	AGOS_AER363W	NP_985219.2
Homo sapiens (human)	RNASEH2A	NP_006388.2
Canis lupus familiaris (dog)	RNASEH2A	XP_003639769.1
Drosophila melanogaster (fruit fly)	CG13690	NP_608521.1
Kluyveromyces lactis	KLLA0F04774g	XP_455296.1
Magnaporthe oryzae (rice blast fungus)	MGG_06959	XP_003709705.1
	RNASEH2A	XP_001109423.1
Bos taurus (cattle)	RNASEH2A	NP_001033623.1
Schizosaccharomyces pombe (fission yeast)	rnh201	NP_593684.1
Arabidopsis thaliana (thale cress)	AT2G25100	NP_565584.1
Pan troglodytes (chimpanzee)	RNASEH2A	XP_512415.1
Mus musculus (house mouse)	Rnaseh2a	NP_081463.1
Rattus norvegicus (Norway rat)	Rnaseh2a	NP_001013252.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007741	XP_317779.3
Neurospora crassa	NCU09608	XP_963372.2
Oryza sativa (rice)	Os11g0153900	NP_001065783.1
Xenopus tropicalis (tropical clawed frog)	rnaseh2a	NP_989146.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Gouti?res Syndrome and Beyond.
Livingston JH, Crow YJ
Neuropediatrics47(6)355-360(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2A in patients with Aicardi-Goutieres Syndrome.
Title: Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Gouti?res Syndrome and Beyond.

RNaseH2A may be involved in human gliomagenesis.
Title: RNaseH2A is involved in human gliomagenesis through the regulation of cell proliferation and apoptosis.

Studies indicate that most antiviral-defense systems involve RNase H-like enzymes destroying invading nucleic acids, RNA, or DNA.
Title: The reverse transcriptase-RNase H: from viruses to antiviral defense.

RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B-dependent manner.
Title: Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Gouti?res syndrome.

study identified two synonymous variants in RNASEH2A that result in loss of RNase H2 enzyme function and the consequent Aicardi-Goutieres syndrome phenotype
Title: Synonymous mutations in RNASEH2A create cryptic splice sites impairing RNase H2 enzyme function in Aicardi-Gouti?res syndrome.

The following RNASEH2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASEH2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25748	NM_006397.3 Latest version!	Homo sapiens ribonuclease H2 subunit A (RNASEH2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu51404	XM_006722619.2 Latest version!	Homo sapiens ribonuclease H2 subunit A (RNASEH2A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OHu25748	NM_006397.2	Homo sapiens ribonuclease H2 subunit A (RNASEH2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNASEH2A ( NM_006397.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006388.2 Homo sapiens ribonuclease H2 subunit A (RNASEH2A), mRNA.

Price & Availability↑

CloneID	OHu25748
Clone ID Related Accession (Same CDS sequence)	NM_006397.3 , NM_006397.2
Accession Version	NM_006397.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	ribonuclease H2 subunit A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK315327.1, AY363912.1 and BM664190.1. On Nov 22, 2019 this sequence version replaced NM_006397.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK315327.1, AY363912.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGATCTCA GCGAGCTGGA GAGAGACAAT ACAGGCCGCT GTCGCCTGAG TTCGCCTGTG 
CCCGCGGTGT GCCGCAAGGA GCCTTGCGTC CTGGGCGTCG ATGAGGCGGG CAGGGGCCCC 
GTGCTGGGCC CCATGGTCTA CGCCATCTGT TATTGTCCCC TGCCTCGCCT GGCAGATCTG 
GAGGCGCTGA AAGTGGCAGA CTCAAAGACC CTATTGGAGA GCGAGCGGGA AAGGCTGTTT 
GCGAAAATGG AGGACACGGA CTTTGTCGGC TGGGCGCTGG ATGTGCTGTC TCCAAACCTC 
ATCTCTACCA GCATGCTTGG GCGGGTCAAA TACAACCTGA ACTCCCTGTC ACATGATACA 
GCCACTGGGC TTATACAGTA TGCATTGGAC CAGGGCGTGA ACGTCACCCA GGTATTCGTG 
GACACCGTAG GGATGCCAGA GACATACCAG GCGCGGCTGC AGCAAAGTTT TCCCGGGATT 
GAGGTGACGG TCAAGGCCAA AGCAGATGCC CTCTACCCGG TGGTTAGTGC TGCCAGCATC 
TGTGCCAAGG TGGCCCGGGA CCAGGCCGTG AAGAAATGGC AGTTCGTGGA GAAACTGCAG 
GACTTGGATA CTGATTATGG CTCAGGCTAC CCCAATGATC CCAAGACAAA AGCGTGGTTG 
AAGGAGCACG TGGAGCCTGT GTTCGGCTTC CCCCAGTTTG TCCGGTTCAG CTGGCGCACG 
GCCCAGACCA TCCTGGAGAA AGAGGCGGAA GATGTTATAT GGGAGGACTC AGCATCCGAG 
AATCAGGAGG GACTCAGGAA GATCACATCC TACTTCCTCA ATGAAGGGTC CCAAGCCCGT 
CCCCGTTCTT CCCACCGATA TTTCCTGGAA CGCGGCCTGG AGTCAGCAAC CAGCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006388.2
CDS	91..990
Translation	MDLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVLGPMVYAICYCPLPRLADLEALKVADSKTLLESERERLFAKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKADALYPVVSAASICAKVARDQAVKKWQFVEKLQDLDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQTILEKEAEDVIWEDSASENQEGLRKITSYFLNEGSQARPRSSHRYFLERGLESATSL

Target ORF information:

RefSeq Version	NM_006397.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease H2 subunit A (RNASEH2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006397.3

ORF Insert Sequence:

ATGGATCTCA GCGAGCTGGA GAGAGACAAT ACAGGCCGCT GTCGCCTGAG TTCGCCTGTG 
CCCGCGGTGT GCCGCAAGGA GCCTTGCGTC CTGGGCGTCG ATGAGGCGGG CAGGGGCCCC 
GTGCTGGGCC CCATGGTCTA CGCCATCTGT TATTGTCCCC TGCCTCGCCT GGCAGATCTG 
GAGGCGCTGA AAGTGGCAGA CTCAAAGACC CTATTGGAGA GCGAGCGGGA AAGGCTGTTT 
GCGAAAATGG AGGACACGGA CTTTGTCGGC TGGGCGCTGG ATGTGCTGTC TCCAAACCTC 
ATCTCTACCA GCATGCTTGG GCGGGTCAAA TACAACCTGA ACTCCCTGTC ACATGATACA 
GCCACTGGGC TTATACAGTA TGCATTGGAC CAGGGCGTGA ACGTCACCCA GGTATTCGTG 
GACACCGTAG GGATGCCAGA GACATACCAG GCGCGGCTGC AGCAAAGTTT TCCCGGGATT 
GAGGTGACGG TCAAGGCCAA AGCAGATGCC CTCTACCCGG TGGTTAGTGC TGCCAGCATC 
TGTGCCAAGG TGGCCCGGGA CCAGGCCGTG AAGAAATGGC AGTTCGTGGA GAAACTGCAG 
GACTTGGATA CTGATTATGG CTCAGGCTAC CCCAATGATC CCAAGACAAA AGCGTGGTTG 
AAGGAGCACG TGGAGCCTGT GTTCGGCTTC CCCCAGTTTG TCCGGTTCAG CTGGCGCACG 
GCCCAGACCA TCCTGGAGAA AGAGGCGGAA GATGTTATAT GGGAGGACTC AGCATCCGAG 
AATCAGGAGG GACTCAGGAA GATCACATCC TACTTCCTCA ATGAAGGGTC CCAAGCCCGT 
CCCCGTTCTT CCCACCGATA TTTCCTGGAA CGCGGCCTGG AGTCAGCAAC CAGCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNASEH2A ( NM_006397.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006388.2 Homo sapiens ribonuclease H2 subunit A (RNASEH2A), mRNA.

Price & Availability↑

CloneID	OHu25748
Clone ID Related Accession (Same CDS sequence)	NM_006397.3 , NM_006397.2
Accession Version	NM_006397.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-06
Organism	Homo sapiens(human)
Product	ribonuclease H2 subunit A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG825340.1, BM664190.1, BE560339.1 and CB240995.1. This sequence is a reference standard in the RefSeqGene project. On Nov 20, 2003 this sequence version replaced NM_006397.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.213570.1, SRR1803616.436431.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGATCTCA GCGAGCTGGA GAGAGACAAT ACAGGCCGCT GTCGCCTGAG TTCGCCTGTG 
CCCGCGGTGT GCCGCAAGGA GCCTTGCGTC CTGGGCGTCG ATGAGGCGGG CAGGGGCCCC 
GTGCTGGGCC CCATGGTCTA CGCCATCTGT TATTGTCCCC TGCCTCGCCT GGCAGATCTG 
GAGGCGCTGA AAGTGGCAGA CTCAAAGACC CTATTGGAGA GCGAGCGGGA AAGGCTGTTT 
GCGAAAATGG AGGACACGGA CTTTGTCGGC TGGGCGCTGG ATGTGCTGTC TCCAAACCTC 
ATCTCTACCA GCATGCTTGG GCGGGTCAAA TACAACCTGA ACTCCCTGTC ACATGATACA 
GCCACTGGGC TTATACAGTA TGCATTGGAC CAGGGCGTGA ACGTCACCCA GGTATTCGTG 
GACACCGTAG GGATGCCAGA GACATACCAG GCGCGGCTGC AGCAAAGTTT TCCCGGGATT 
GAGGTGACGG TCAAGGCCAA AGCAGATGCC CTCTACCCGG TGGTTAGTGC TGCCAGCATC 
TGTGCCAAGG TGGCCCGGGA CCAGGCCGTG AAGAAATGGC AGTTCGTGGA GAAACTGCAG 
GACTTGGATA CTGATTATGG CTCAGGCTAC CCCAATGATC CCAAGACAAA AGCGTGGTTG 
AAGGAGCACG TGGAGCCTGT GTTCGGCTTC CCCCAGTTTG TCCGGTTCAG CTGGCGCACG 
GCCCAGACCA TCCTGGAGAA AGAGGCGGAA GATGTTATAT GGGAGGACTC AGCATCCGAG 
AATCAGGAGG GACTCAGGAA GATCACATCC TACTTCCTCA ATGAAGGGTC CCAAGCCCGT 
CCCCGTTCTT CCCACCGATA TTTCCTGGAA CGCGGCCTGG AGTCAGCAAC CAGCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006388.2
CDS	61..960
Translation	MDLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVLGPMVYAICYCPLPRLADLEALKVADSKTLLESERERLFAKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKADALYPVVSAASICAKVARDQAVKKWQFVEKLQDLDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQTILEKEAEDVIWEDSASENQEGLRKITSYFLNEGSQARPRSSHRYFLERGLESATSL

Target ORF information:

RefSeq Version	NM_006397.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease H2 subunit A (RNASEH2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006397.2

ORF Insert Sequence:

ATGGATCTCA GCGAGCTGGA GAGAGACAAT ACAGGCCGCT GTCGCCTGAG TTCGCCTGTG 
CCCGCGGTGT GCCGCAAGGA GCCTTGCGTC CTGGGCGTCG ATGAGGCGGG CAGGGGCCCC 
GTGCTGGGCC CCATGGTCTA CGCCATCTGT TATTGTCCCC TGCCTCGCCT GGCAGATCTG 
GAGGCGCTGA AAGTGGCAGA CTCAAAGACC CTATTGGAGA GCGAGCGGGA AAGGCTGTTT 
GCGAAAATGG AGGACACGGA CTTTGTCGGC TGGGCGCTGG ATGTGCTGTC TCCAAACCTC 
ATCTCTACCA GCATGCTTGG GCGGGTCAAA TACAACCTGA ACTCCCTGTC ACATGATACA 
GCCACTGGGC TTATACAGTA TGCATTGGAC CAGGGCGTGA ACGTCACCCA GGTATTCGTG 
GACACCGTAG GGATGCCAGA GACATACCAG GCGCGGCTGC AGCAAAGTTT TCCCGGGATT 
GAGGTGACGG TCAAGGCCAA AGCAGATGCC CTCTACCCGG TGGTTAGTGC TGCCAGCATC 
TGTGCCAAGG TGGCCCGGGA CCAGGCCGTG AAGAAATGGC AGTTCGTGGA GAAACTGCAG 
GACTTGGATA CTGATTATGG CTCAGGCTAC CCCAATGATC CCAAGACAAA AGCGTGGTTG 
AAGGAGCACG TGGAGCCTGT GTTCGGCTTC CCCCAGTTTG TCCGGTTCAG CTGGCGCACG 
GCCCAGACCA TCCTGGAGAA AGAGGCGGAA GATGTTATAT GGGAGGACTC AGCATCCGAG 
AATCAGGAGG GACTCAGGAA GATCACATCC TACTTCCTCA ATGAAGGGTC CCAAGCCCGT 
CCCCGTTCTT CCCACCGATA TTTCCTGGAA CGCGGCCTGG AGTCAGCAAC CAGCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RNASEH2A ( XM_006722619.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006722682.1 Homo sapiens ribonuclease H2 subunit A (RNASEH2A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu51404
Clone ID Related Accession (Same CDS sequence)	XM_006722619.2
Accession Version	XM_006722619.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ribonuclease H2 subunit A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006722619.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCTACG CCATCTGTTA TTGTCCCCTG CCTCGCCTGG CAGATCTGGA GGCGCTGAAA 
GTGGCAGACT CAAAGACCCT ATTGGAGAGC GAGCGGGAAA GGCTGTTTGC GAAAATGGAG 
GACACGGACT TTGTCGGCTG GGCGCTGGAT GTGCTGTCTC CAAACCTCAT CTCTACCAGC 
ATGCTTGGGC GGGTCAAATA CAACCTGAAC TCCCTGTCAC ATGATACAGC CACTGGGCTT 
ATACAGTATG CATTGGACCA GGGCGTGAAC GTCACCCAGG TATTCGTGGA CACCGTAGGG 
ATGCCAGAGA CATACCAGGC GCGGCTGCAG CAAAGTTTTC CCGGGATTGA GGTGACGGTC 
AAGGCCAAAG CAGATGCCCT CTACCCGGTG GTTAGTGCTG CCAGCATCTG TGCCAAGGTG 
GCCCGGGACC AGGCCGTGAA GAAATGGCAG TTCGTGGAGA AACTGCAGGA CTTGGATACT 
GATTATGGCT CAGGCTACCC CAATGATCCC AAGACAAAAG CGTGGTTGAA GGAGCACGTG 
GAGCCTGTGT TCGGCTTCCC CCAGTTTGTC CGGTTCAGCT GGCGCACGGC CCAGACCATC 
CTGGAGAAAG AGGCGGAAGA TGTTATATGG GAGGACTCAG CATCCGAGAA TCAGGAGGGA 
CTCAGGAAGA TCACATCCTA CTTCCTCAAT GAAGGGTCCC AAGCCCGTCC CCGTTCTTCC 
CACCGATATT TCCTGGAACG CGGCCTGGAG TCAGCAACCA GCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006722682.1
CDS	378..1145
Translation	MVYAICYCPLPRLADLEALKVADSKTLLESERERLFAKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKADALYPVVSAASICAKVARDQAVKKWQFVEKLQDLDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQTILEKEAEDVIWEDSASENQEGLRKITSYFLNEGSQARPRSSHRYFLERGLESATSL

Target ORF information:

RefSeq Version	XM_006722619.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease H2 subunit A (RNASEH2A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006722619.2

ORF Insert Sequence:

ATGGTCTACG CCATCTGTTA TTGTCCCCTG CCTCGCCTGG CAGATCTGGA GGCGCTGAAA 
GTGGCAGACT CAAAGACCCT ATTGGAGAGC GAGCGGGAAA GGCTGTTTGC GAAAATGGAG 
GACACGGACT TTGTCGGCTG GGCGCTGGAT GTGCTGTCTC CAAACCTCAT CTCTACCAGC 
ATGCTTGGGC GGGTCAAATA CAACCTGAAC TCCCTGTCAC ATGATACAGC CACTGGGCTT 
ATACAGTATG CATTGGACCA GGGCGTGAAC GTCACCCAGG TATTCGTGGA CACCGTAGGG 
ATGCCAGAGA CATACCAGGC GCGGCTGCAG CAAAGTTTTC CCGGGATTGA GGTGACGGTC 
AAGGCCAAAG CAGATGCCCT CTACCCGGTG GTTAGTGCTG CCAGCATCTG TGCCAAGGTG 
GCCCGGGACC AGGCCGTGAA GAAATGGCAG TTCGTGGAGA AACTGCAGGA CTTGGATACT 
GATTATGGCT CAGGCTACCC CAATGATCCC AAGACAAAAG CGTGGTTGAA GGAGCACGTG 
GAGCCTGTGT TCGGCTTCCC CCAGTTTGTC CGGTTCAGCT GGCGCACGGC CCAGACCATC 
CTGGAGAAAG AGGCGGAAGA TGTTATATGG GAGGACTCAG CATCCGAGAA TCAGGAGGGA 
CTCAGGAAGA TCACATCCTA CTTCCTCAAT GAAGGGTCCC AAGCCCGTCC CCGTTCTTCC 
CACCGATATT TCCTGGAACG CGGCCTGGAG TCAGCAACCA GCCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Gouti?res Syndrome and Beyond.
Neuropediatrics47(6)355-360(2016 Dec)
Livingston JH,Crow YJ

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RNASEH2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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