CEBPE cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CEBPE
Entrez Gene ID	1053
Full Name	CCAAT/enhancer binding protein epsilon
Synonyms	C/EBP-epsilon,CRP1
General protein information	Preferred Names CCAAT/enhancer binding protein epsilon Names CCAAT/enhancer-binding protein epsilon CCAAT/enhancer binding protein (C/EBP), epsilon c/EBP epsilon
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	600749
Disorder Html:	Specific granule deficiency, 245480 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001805.3	NP_001796.2	CCAAT/enhancer-binding protein epsilon

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CEBPE	XP_547729.1
Rattus norvegicus (Norway rat)	Cebpe	NP_058791.1
Xenopus tropicalis (tropical clawed frog)	cebpe	XP_002939064.1
Homo sapiens (human)	CEBPE	NP_001796.2
Bos taurus (cattle)	CEBPE	NP_001179737.1
Pan troglodytes (chimpanzee)	CEBPE	XP_001161080.2
Mus musculus (house mouse)	Cebpe	NP_997014.1
	CEBPE	XP_001106328.1

Gene Ontology
Bibliography

Related articles in PubMed

Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 Gene Polymorphisms to Acute Lymphoblastic Leukemia in a Yemeni Population.
Al-Absi B, Razif MFM, Noor SM, Saif-Ali R, Aqlan M, Salem SD, Ahmed RH, Muniandy S
Genetic testing and molecular biomarkers21(10)592-599(2017 Oct)

SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBP? dependent mechanism.
Priam P, Krasteva V, Rousseau P, D'Angelo G, Gaboury L, Sauvageau G, Lessard JA
Nature genetics49(5)753-764(2017 May)

ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A?MIGICCL Study.
Bekker-M?ndez VC, N??ez-Enr?quez JC, Torres Escalante JL, Alvarez-Olmos E, Gonz?lez-Montalvoc PM, Jim?nez-Hern?ndez E, Sans?n AM, Leal YA, Ramos-Cervantes MT, Guerra-Castillo FX, Ortiz-Maganda MP, Flores-Lujano J, P?rez-Saldivar ML, Velazquez-Avi?a MM, Bolea-Murga V, Torres-Nava JR, Amador-Sanchez R, Solis-Labastida KA, R?mirez-Bello J, Fragoso JM, Mej?a-Arangur? JM,
Archives of medical research47(8)623-628(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that both CEBPE and SMARCD2 loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD) abolish the interaction with SWI/SNF and secondary granule gene expression, thus providing a molecular basis for this disease.
Title: SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBP? dependent mechanism.

The minor allele of the CEBPE variant associated with lower basophil count has been previously associated with Amerindian ancestry and higher risk of acute lymphoblastic leukemia in Hispanics.
Title: Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.

identified the rs45496295 (C > T) polymorphism in the heterozygous state in 73.9% of beta-thalassemia intermedia patients.
Title: First description of the rs45496295 polymorphism of the C/EBPE gene in ?-thalassemia intermedia patients.

the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk.
Title: ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A?MIGICCL Study.

Genotypic and allelic frequencies differed significantly between cases and controls at IKZF1-rs4132601 (p=0.039, p=0.015) and ARID5B-rs10821936 (p=0.028, p=0.026).
Title: Association of Genetic Variants in ARID5B, IKZF1 and CEBPE with Risk of Childhood de novo B-Lineage Acute Lymphoblastic Leukemia in India.

The following CEBPE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CEBPE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu27253	NM_001805.3 Latest version!	Homo sapiens CCAAT enhancer binding protein epsilon (CEBPE), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CEBPE ( NM_001805.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001796.2 Homo sapiens CCAAT enhancer binding protein epsilon (CEBPE), mRNA.

Price & Availability↑

CloneID	OHu27253
Clone ID Related Accession (Same CDS sequence)	NM_001805.3
Accession Version	NM_001805.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	CCAAT/enhancer-binding protein epsilon
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX346756.2, BY995857.1 and BC035797.1. On Nov 10, 2011 this sequence version replaced NM_001805.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035797.1, U48866.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCACG GGACCTACTA CGAGTGTGAG CCCCGGGGTG GCCAGCAGCC ACTCGAGTTC 
TCAGGGGGCC GAGCTGGGCC CGGGGAGCTA GGGGACATGT GTGAGCATGA GGCCTCCATT 
GACCTCTCCG CCTACATCGA GTCTGGGGAA GAGCAGCTTC TCTCCGATCT CTTTGCCGTG 
AAGCCAGCGC CTGAGGCCAG AGGCCTCAAG GGCCCCGGAA CCCCTGCCTT CCCCCACTAC 
TTGCCGCCTG ACCCTCGGCC CTTTGCCTAC CCTCCACATA CCTTCGGCCC AGACAGGAAG 
GCGCTGGGGC CTGGCATCTA CAGCAGCCCA GGGAGCTACG ACCCCAGGGC TGTGGCGGTG 
AAGGAGGAGC CCCGGGGGCC AGAGGGCAGC CGAGCTGCCA GCCGAGGCAG CTACAATCCC 
CTGCAGTACC AAGTGGCACA CTGTGGGCAG ACAGCCATGC ACCTGCCCCC AACTCTGGCA 
GCACCCGGCC AGCCTCTGCG CGTTCTCAAG GCCCCTTTGG CCACTGCCGC ACCCCCCTGC 
AGTCCCCTCC TGAAGGCGCC CTCCCCGGCT GGCCCCTTAC ACAAGGGCAA GAAGGCAGTG 
AACAAAGATA GCCTTGAGTA CCGGCTGAGG CGGGAGCGCA ACAACATCGC CGTGCGCAAG 
AGCCGAGACA AGGCCAAGAG GCGCATTCTG GAGACGCAGC AGAAGGTGCT GGAGTACATG 
GCAGAGAACG AGCGCCTCCG CAGCCGCGTG GAGCAGCTCA CCCAGGAGCT AGACACCCTC 
CGCAACCTCT TCCGCCAGAT TCCTGAGGCG GCCAACCTCA TCAAGGGCGT GGGGGGTTGC 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001796.2
CDS	521..1366
Translation	MSHGTYYECEPRGGQQPLEFSGGRAGPGELGDMCEHEASIDLSAYIESGEEQLLSDLFAVKPAPEARGLKGPGTPAFPHYLPPDPRPFAYPPHTFGPDRKALGPGIYSSPGSYDPRAVAVKEEPRGPEGSRAASRGSYNPLQYQVAHCGQTAMHLPPTLAAPGQPLRVLKAPLATAAPPCSPLLKAPSPAGPLHKGKKAVNKDSLEYRLRRERNNIAVRKSRDKAKRRILETQQKVLEYMAENERLRSRVEQLTQELDTLRNLFRQIPEAANLIKGVGGCS

Target ORF information:

RefSeq Version	NM_001805.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CCAAT enhancer binding protein epsilon (CEBPE), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001805.3

ORF Insert Sequence:

ATGTCCCACG GGACCTACTA CGAGTGTGAG CCCCGGGGTG GCCAGCAGCC ACTCGAGTTC 
TCAGGGGGCC GAGCTGGGCC CGGGGAGCTA GGGGACATGT GTGAGCATGA GGCCTCCATT 
GACCTCTCCG CCTACATCGA GTCTGGGGAA GAGCAGCTTC TCTCCGATCT CTTTGCCGTG 
AAGCCAGCGC CTGAGGCCAG AGGCCTCAAG GGCCCCGGAA CCCCTGCCTT CCCCCACTAC 
TTGCCGCCTG ACCCTCGGCC CTTTGCCTAC CCTCCACATA CCTTCGGCCC AGACAGGAAG 
GCGCTGGGGC CTGGCATCTA CAGCAGCCCA GGGAGCTACG ACCCCAGGGC TGTGGCGGTG 
AAGGAGGAGC CCCGGGGGCC AGAGGGCAGC CGAGCTGCCA GCCGAGGCAG CTACAATCCC 
CTGCAGTACC AAGTGGCACA CTGTGGGCAG ACAGCCATGC ACCTGCCCCC AACTCTGGCA 
GCACCCGGCC AGCCTCTGCG CGTTCTCAAG GCCCCTTTGG CCACTGCCGC ACCCCCCTGC 
AGTCCCCTCC TGAAGGCGCC CTCCCCGGCT GGCCCCTTAC ACAAGGGCAA GAAGGCAGTG 
AACAAAGATA GCCTTGAGTA CCGGCTGAGG CGGGAGCGCA ACAACATCGC CGTGCGCAAG 
AGCCGAGACA AGGCCAAGAG GCGCATTCTG GAGACGCAGC AGAAGGTGCT GGAGTACATG 
GCAGAGAACG AGCGCCTCCG CAGCCGCGTG GAGCAGCTCA CCCAGGAGCT AGACACCCTC 
CGCAACCTCT TCCGCCAGAT TCCTGAGGCG GCCAACCTCA TCAAGGGCGT GGGGGGTTGC 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 Gene Polymorphisms to Acute Lymphoblastic Leukemia in a Yemeni Population.
Genetic testing and molecular biomarkers21(10)592-599(2017 Oct)
Al-Absi B,Razif MFM,Noor SM,Saif-Ali R,Aqlan M,Salem SD,Ahmed RH,Muniandy S

SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBP? dependent mechanism.
Nature genetics49(5)753-764(2017 May)
Priam P,Krasteva V,Rousseau P,D'Angelo G,Gaboury L,Sauvageau G,Lessard JA

ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A?MIGICCL Study.
Archives of medical research47(8)623-628(2016 Nov)
Bekker-M?ndez VC,N??ez-Enr?quez JC,Torres Escalante JL,Alvarez-Olmos E,Gonz?lez-Montalvoc PM,Jim?nez-Hern?ndez E,Sans?n AM,Leal YA,Ramos-Cervantes MT,Guerra-Castillo FX,Ortiz-Maganda MP,Flores-Lujano J,P?rez-Saldivar ML,Velazquez-Avi?a MM,Bolea-Murga V,Torres-Nava JR,Amador-Sanchez R,Solis-Labastida KA,R?mirez-Bello J,Fragoso JM,Mej?a-Arangur? JM,

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CEBPE cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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