TIMM44 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIMM44
Entrez Gene ID	10469
Full Name	translocase of inner mitochondrial membrane 44
Synonyms	TIM44
General protein information	Preferred Names translocase of inner mitochondrial membrane 44 Names mitochondrial import inner membrane translocase subunit TIM44 translocase of inner mitochondrial membrane 44 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016].
Disorder MIM:	605058

mRNA and Protein(s)

mRNA	Protein	Name
NM_006351.3	NP_006342.2	mitochondrial import inner membrane translocase subunit TIM44
NM_006351.4	NP_006342.2	mitochondrial import inner membrane translocase subunit TIM44

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TIMM44	XP_418174.2
Homo sapiens (human)	TIMM44	NP_006342.2
Canis lupus familiaris (dog)	TIMM44	XP_542123.2
Rattus norvegicus (Norway rat)	Timm44	NP_058963.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000291	XP_310830.4
Caenorhabditis elegans (roundworm)	T09B4.9	NP_491780.1
Eremothecium gossypii	AGOS_ADL118C	NP_983978.1
Bos taurus (cattle)	TIMM44	NP_001179583.1
Danio rerio (zebrafish)	LOC100537910	XP_003201001.1
Magnaporthe oryzae (rice blast fungus)	MGG_11419	XP_003713412.1
	TIMM44	XP_001098363.2
Danio rerio (zebrafish)	timm44	NP_001013525.1
Kluyveromyces lactis	KLLA0D16214g	XP_453775.1
Schizosaccharomyces pombe (fission yeast)	tim44	NP_595905.1
Xenopus tropicalis (tropical clawed frog)	timm44	NP_001120395.1
Pan troglodytes (chimpanzee)	TIMM44	XP_003316109.1
Mus musculus (house mouse)	Timm44	NP_035722.2
Drosophila melanogaster (fruit fly)	CG11779	NP_001027193.2
Saccharomyces cerevisiae (baker's yeast)	TIM44	NP_012242.1
Neurospora crassa	NCU03229	XP_965329.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44.
Huang Y, Zhou J, Luo S, Wang Y, He J, Luo P, Chen Z, Liu T, Tan X, Ou J, Miao H, Liang H, Shi C
Gut67(2)307-319(2018 Feb)

Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes.
Wang Y, Katayama A, Terami T, Han X, Nunoue T, Zhang D, Teshigawara S, Eguchi J, Nakatsuka A, Murakami K, Ogawa D, Furuta Y, Makino H, Wada J
Metabolism: clinical and experimental64(6)677-88(2015 Jun)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13.
Aguileta MA, Korac J, Durcan TM, Trempe JF, Haber M, Gehring K, Elsasser S, Waidmann O, Fon EA, Husnjak K
The Journal of biological chemistry290(12)7492-505(2015 Mar)

Mitochondrial Ion Channels in Cancer Transformation.
Madamba SM, Damri KN, Dejean LM, Peixoto PM
Frontiers in oncology5120(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Timm44 gene may be a new target for the treatment of type 2 diabetes
Title: Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes.

This protein has been found differentially expressed in thalami from patients with schizophrenia.
Title: Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following TIMM44 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIMM44 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu08130	NM_006351.4 Latest version!	Homo sapiens translocase of inner mitochondrial membrane 44 (TIMM44), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu08130	NM_006351.3	Homo sapiens translocase of inner mitochondrial membrane 44 (TIMM44), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIMM44 ( NM_006351.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006342.2 Homo sapiens translocase of inner mitochondrial membrane 44 (TIMM44), mRNA.

Price & Availability↑

CloneID	OHu08130
Clone ID Related Accession (Same CDS sequence)	NM_006351.3 , NM_006351.4
Accession Version	NM_006351.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit TIM44
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289634.1, BC033628.1 and AC010336.8. This sequence is a reference standard in the RefSeqGene project. On Mar 3, 2010 this sequence version replaced NM_006351.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.265515.1, SRR1163658.231733.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCCCTGCG GAGTGGCTGG TGCCGCTGTC CACGGAGATG CCTCGGCAGT 
GGAATCCAAT TTCTTTCCAG CCACAACCTA CCCCATGGGT CGACCTATCA GATGCGCCGG 
CCGGGCGGAG AGCTGCCACT GTCCAAATCA TATTCTTCTG GAAACAGAAA AGGCTTTCTG 
TCCGGCTTGC TAGATAATGT CAAACAAGAA TTAGCCAAAA ACAAAGAAAT GAAAGAAAGT 
ATAAAAAAAT TCCGTGACGA GGCCAGAAGG CTAGAAGAAT CAGACGTGCT CCAGGAGGCC 
AGAAGGAAAT ACAAAACCAT CGAGTCAGAA ACCGTGCGGA CGAGCGAGGT GCTACGGAAG 
AAGCTTGGGG AGCTGACGGG CACCGTGAAG GAGAGCCTTC ACGAAGTCAG TAAAAGTGAT 
CTCGGCCGGA AAATCAAGGA GGGCGTGGAG GAAGCAGCCA AGACGGCCAA GCAGTCGGCC 
GAGTCGGTAT CCAAAGGCGG GGAGAAGCTG GGCAGGACAG CGGCCTTCAG AGCCCTCTCC 
CAGGGGGTGG AGTCCGTGAA GAAGGAAATT GACGACAGCG TCCTGGGACA GACCGGGCCC 
TACCGGAGGC CCCAGCGACT CCGGAAGAGA ACGGAGTTTG CGGGAGATAA GTTCAAGGAG 
GAGAAAGTGT TTGAGCCAAA CGAGGAGGCC CTGGGGGTCG TGCTGCACAA GGACTCCAAG 
TGGTACCAGC AGTGGAAGGA CTTCAAGGAG AACAACGTGG TGTTTAACCG GTTCTTCGAG 
ATGAAGATGA AGTATGACGA AAGCGACAAC GCGTTCATCC GGGCATCCCG GGCCCTTACG 
GACAAGGTCA CCGACTTGCT GGGGGGCCTG TTCTCCAAGA CAGAGATGTC GGAGGTGCTC 
ACGGAGATCC TCCGGGTGGA CCCGGCCTTT GACAAGGACC GGTTTCTGAA ACAGTGCGAG 
AACGACATCA TCCCCAATGT CCTGGAGGCC ATGATTTCTG GAGAGCTTGA CATTCTCAAA 
GACTGGTGCT ATGAAGCTAC TTACAGCCAG CTGGCCCACC CCATCCAGCA GGCCAAGGCA 
CTGGGTCTCC AGTTCCATTC TCGCATCCTA GACATTGACA ACGTCGACCT GGCCATGGGC 
AAGATGATGG AGCAGGGGCC GGTGCTGATC ATCACCTTCC AGGCACAGCT GGTGATGGTG 
GTCAGGAACC CCAAAGGCGA GGTGGTGGAG GGTGACCCGG ACAAGGTGCT GCGGATGCTG 
TACGTGTGGG CGCTCTGCCG AGACCAGGAC GAGCTCAACC CCTACGCGGC CTGGCGGCTC 
CTGGACATCT CGGCCTCCAG CACCGAGCAG ATTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006342.2
CDS	173..1531
Translation	MAAAALRSGWCRCPRRCLGSGIQFLSSHNLPHGSTYQMRRPGGELPLSKSYSSGNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKFKEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDNVDLAMGKMMEQGPVLIITFQAQLVMVVRNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQIL

Target ORF information:

RefSeq Version	NM_006351.3
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 44 (TIMM44), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006351.3

ORF Insert Sequence:

ATGGCGGCGG CGGCCCTGCG GAGTGGCTGG TGCCGCTGTC CACGGAGATG CCTCGGCAGT 
GGAATCCAAT TTCTTTCCAG CCACAACCTA CCCCATGGGT CGACCTATCA GATGCGCCGG 
CCGGGCGGAG AGCTGCCACT GTCCAAATCA TATTCTTCTG GAAACAGAAA AGGCTTTCTG 
TCCGGCTTGC TAGATAATGT CAAACAAGAA TTAGCCAAAA ACAAAGAAAT GAAAGAAAGT 
ATAAAAAAAT TCCGTGACGA GGCCAGAAGG CTAGAAGAAT CAGACGTGCT CCAGGAGGCC 
AGAAGGAAAT ACAAAACCAT CGAGTCAGAA ACCGTGCGGA CGAGCGAGGT GCTACGGAAG 
AAGCTTGGGG AGCTGACGGG CACCGTGAAG GAGAGCCTTC ACGAAGTCAG TAAAAGTGAT 
CTCGGCCGGA AAATCAAGGA GGGCGTGGAG GAAGCAGCCA AGACGGCCAA GCAGTCGGCC 
GAGTCGGTAT CCAAAGGCGG GGAGAAGCTG GGCAGGACAG CGGCCTTCAG AGCCCTCTCC 
CAGGGGGTGG AGTCCGTGAA GAAGGAAATT GACGACAGCG TCCTGGGACA GACCGGGCCC 
TACCGGAGGC CCCAGCGACT CCGGAAGAGA ACGGAGTTTG CGGGAGATAA GTTCAAGGAG 
GAGAAAGTGT TTGAGCCAAA CGAGGAGGCC CTGGGGGTCG TGCTGCACAA GGACTCCAAG 
TGGTACCAGC AGTGGAAGGA CTTCAAGGAG AACAACGTGG TGTTTAACCG GTTCTTCGAG 
ATGAAGATGA AGTATGACGA AAGCGACAAC GCGTTCATCC GGGCATCCCG GGCCCTTACG 
GACAAGGTCA CCGACTTGCT GGGGGGCCTG TTCTCCAAGA CAGAGATGTC GGAGGTGCTC 
ACGGAGATCC TCCGGGTGGA CCCGGCCTTT GACAAGGACC GGTTTCTGAA ACAGTGCGAG 
AACGACATCA TCCCCAATGT CCTGGAGGCC ATGATTTCTG GAGAGCTTGA CATTCTCAAA 
GACTGGTGCT ATGAAGCTAC TTACAGCCAG CTGGCCCACC CCATCCAGCA GGCCAAGGCA 
CTGGGTCTCC AGTTCCATTC TCGCATCCTA GACATTGACA ACGTCGACCT GGCCATGGGC 
AAGATGATGG AGCAGGGGCC GGTGCTGATC ATCACCTTCC AGGCACAGCT GGTGATGGTG 
GTCAGGAACC CCAAAGGCGA GGTGGTGGAG GGTGACCCGG ACAAGGTGCT GCGGATGCTG 
TACGTGTGGG CGCTCTGCCG AGACCAGGAC GAGCTCAACC CCTACGCGGC CTGGCGGCTC 
CTGGACATCT CGGCCTCCAG CACCGAGCAG ATTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMM44 ( NM_006351.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006342.2 Homo sapiens translocase of inner mitochondrial membrane 44 (TIMM44), mRNA.

Price & Availability↑

CloneID	OHu08130
Clone ID Related Accession (Same CDS sequence)	NM_006351.3 , NM_006351.4
Accession Version	NM_006351.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	mitochondrial import inner membrane translocase subunit TIM44
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289634.1, BC033628.1 and AC010336.8. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006351.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.259519.1, SRR3476690.415820.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000270538.8/ ENSP00000270538.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGG CGGCCCTGCG GAGTGGCTGG TGCCGCTGTC CACGGAGATG CCTCGGCAGT 
GGAATCCAAT TTCTTTCCAG CCACAACCTA CCCCATGGGT CGACCTATCA GATGCGCCGG 
CCGGGCGGAG AGCTGCCACT GTCCAAATCA TATTCTTCTG GAAACAGAAA AGGCTTTCTG 
TCCGGCTTGC TAGATAATGT CAAACAAGAA TTAGCCAAAA ACAAAGAAAT GAAAGAAAGT 
ATAAAAAAAT TCCGTGACGA GGCCAGAAGG CTAGAAGAAT CAGACGTGCT CCAGGAGGCC 
AGAAGGAAAT ACAAAACCAT CGAGTCAGAA ACCGTGCGGA CGAGCGAGGT GCTACGGAAG 
AAGCTTGGGG AGCTGACGGG CACCGTGAAG GAGAGCCTTC ACGAAGTCAG TAAAAGTGAT 
CTCGGCCGGA AAATCAAGGA GGGCGTGGAG GAAGCAGCCA AGACGGCCAA GCAGTCGGCC 
GAGTCGGTAT CCAAAGGCGG GGAGAAGCTG GGCAGGACAG CGGCCTTCAG AGCCCTCTCC 
CAGGGGGTGG AGTCCGTGAA GAAGGAAATT GACGACAGCG TCCTGGGACA GACCGGGCCC 
TACCGGAGGC CCCAGCGACT CCGGAAGAGA ACGGAGTTTG CGGGAGATAA GTTCAAGGAG 
GAGAAAGTGT TTGAGCCAAA CGAGGAGGCC CTGGGGGTCG TGCTGCACAA GGACTCCAAG 
TGGTACCAGC AGTGGAAGGA CTTCAAGGAG AACAACGTGG TGTTTAACCG GTTCTTCGAG 
ATGAAGATGA AGTATGACGA AAGCGACAAC GCGTTCATCC GGGCATCCCG GGCCCTTACG 
GACAAGGTCA CCGACTTGCT GGGGGGCCTG TTCTCCAAGA CAGAGATGTC GGAGGTGCTC 
ACGGAGATCC TCCGGGTGGA CCCGGCCTTT GACAAGGACC GGTTTCTGAA ACAGTGCGAG 
AACGACATCA TCCCCAATGT CCTGGAGGCC ATGATTTCTG GAGAGCTTGA CATTCTCAAA 
GACTGGTGCT ATGAAGCTAC TTACAGCCAG CTGGCCCACC CCATCCAGCA GGCCAAGGCA 
CTGGGTCTCC AGTTCCATTC TCGCATCCTA GACATTGACA ACGTCGACCT GGCCATGGGC 
AAGATGATGG AGCAGGGGCC GGTGCTGATC ATCACCTTCC AGGCACAGCT GGTGATGGTG 
GTCAGGAACC CCAAAGGCGA GGTGGTGGAG GGTGACCCGG ACAAGGTGCT GCGGATGCTG 
TACGTGTGGG CGCTCTGCCG AGACCAGGAC GAGCTCAACC CCTACGCGGC CTGGCGGCTC 
CTGGACATCT CGGCCTCCAG CACCGAGCAG ATTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006342.2
CDS	16..1374
Translation	MAAAALRSGWCRCPRRCLGSGIQFLSSHNLPHGSTYQMRRPGGELPLSKSYSSGNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKFKEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCENDIIPNVLEAMISGELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDNVDLAMGKMMEQGPVLIITFQAQLVMVVRNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQIL

Target ORF information:

RefSeq Version	NM_006351.4
Organism	Homo sapiens(human)
Definition	Homo sapiens translocase of inner mitochondrial membrane 44 (TIMM44), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006351.4

ORF Insert Sequence:

ATGGCGGCGG CGGCCCTGCG GAGTGGCTGG TGCCGCTGTC CACGGAGATG CCTCGGCAGT 
GGAATCCAAT TTCTTTCCAG CCACAACCTA CCCCATGGGT CGACCTATCA GATGCGCCGG 
CCGGGCGGAG AGCTGCCACT GTCCAAATCA TATTCTTCTG GAAACAGAAA AGGCTTTCTG 
TCCGGCTTGC TAGATAATGT CAAACAAGAA TTAGCCAAAA ACAAAGAAAT GAAAGAAAGT 
ATAAAAAAAT TCCGTGACGA GGCCAGAAGG CTAGAAGAAT CAGACGTGCT CCAGGAGGCC 
AGAAGGAAAT ACAAAACCAT CGAGTCAGAA ACCGTGCGGA CGAGCGAGGT GCTACGGAAG 
AAGCTTGGGG AGCTGACGGG CACCGTGAAG GAGAGCCTTC ACGAAGTCAG TAAAAGTGAT 
CTCGGCCGGA AAATCAAGGA GGGCGTGGAG GAAGCAGCCA AGACGGCCAA GCAGTCGGCC 
GAGTCGGTAT CCAAAGGCGG GGAGAAGCTG GGCAGGACAG CGGCCTTCAG AGCCCTCTCC 
CAGGGGGTGG AGTCCGTGAA GAAGGAAATT GACGACAGCG TCCTGGGACA GACCGGGCCC 
TACCGGAGGC CCCAGCGACT CCGGAAGAGA ACGGAGTTTG CGGGAGATAA GTTCAAGGAG 
GAGAAAGTGT TTGAGCCAAA CGAGGAGGCC CTGGGGGTCG TGCTGCACAA GGACTCCAAG 
TGGTACCAGC AGTGGAAGGA CTTCAAGGAG AACAACGTGG TGTTTAACCG GTTCTTCGAG 
ATGAAGATGA AGTATGACGA AAGCGACAAC GCGTTCATCC GGGCATCCCG GGCCCTTACG 
GACAAGGTCA CCGACTTGCT GGGGGGCCTG TTCTCCAAGA CAGAGATGTC GGAGGTGCTC 
ACGGAGATCC TCCGGGTGGA CCCGGCCTTT GACAAGGACC GGTTTCTGAA ACAGTGCGAG 
AACGACATCA TCCCCAATGT CCTGGAGGCC ATGATTTCTG GAGAGCTTGA CATTCTCAAA 
GACTGGTGCT ATGAAGCTAC TTACAGCCAG CTGGCCCACC CCATCCAGCA GGCCAAGGCA 
CTGGGTCTCC AGTTCCATTC TCGCATCCTA GACATTGACA ACGTCGACCT GGCCATGGGC 
AAGATGATGG AGCAGGGGCC GGTGCTGATC ATCACCTTCC AGGCACAGCT GGTGATGGTG 
GTCAGGAACC CCAAAGGCGA GGTGGTGGAG GGTGACCCGG ACAAGGTGCT GCGGATGCTG 
TACGTGTGGG CGCTCTGCCG AGACCAGGAC GAGCTCAACC CCTACGCGGC CTGGCGGCTC 
CTGGACATCT CGGCCTCCAG CACCGAGCAG ATTCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44.
Gut67(2)307-319(2018 Feb)
Huang Y,Zhou J,Luo S,Wang Y,He J,Luo P,Chen Z,Liu T,Tan X,Ou J,Miao H,Liang H,Shi C

Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes.
Metabolism: clinical and experimental64(6)677-88(2015 Jun)
Wang Y,Katayama A,Terami T,Han X,Nunoue T,Zhang D,Teshigawara S,Eguchi J,Nakatsuka A,Murakami K,Ogawa D,Furuta Y,Makino H,Wada J

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13.
The Journal of biological chemistry290(12)7492-505(2015 Mar)
Aguileta MA,Korac J,Durcan TM,Trempe JF,Haber M,Gehring K,Elsasser S,Waidmann O,Fon EA,Husnjak K

Mitochondrial Ion Channels in Cancer Transformation.
Frontiers in oncology5120(2015)
Madamba SM,Damri KN,Dejean LM,Peixoto PM

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TIMM44 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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