HAX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HAX1
Entrez Gene ID	10456
Full Name	HCLS1 associated protein X-1
Synonyms	HCLSBP1,HS1BP1,SCN3
General protein information	Preferred Names HCLS1 associated protein X-1 Names HCLS1-associated protein X-1 HAX-1 HCLS1 (and PKD2) associated protein HS1 binding protein HS1-associating protein X-1 HS1-binding protein 1 HSP1BP-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	605998
Disorder Html:	Neutropenia, severe congenital 3, autosomal recessive, 610738 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006118.3	NP_006109.2	HCLS1-associated protein X-1 isoform a
NM_006118.4	NP_006109.2	HCLS1-associated protein X-1 isoform a
NM_001018837.1	NP_001018238.1	HCLS1-associated protein X-1 isoform b
NM_001018837.2	NP_001018238.1	HCLS1-associated protein X-1 isoform b

Pathways from BioSystems

Homologies

Bos taurus (cattle)	HAX1	NP_001039418.2
Danio rerio (zebrafish)	hax1	NP_001002337.1
	HAX1	XP_002801842.1
Pan troglodytes (chimpanzee)	HAX1	XP_001150932.1
Canis lupus familiaris (dog)	HAX1	XP_005622847.1
Mus musculus (house mouse)	Hax1	NP_035956.1
Xenopus tropicalis (tropical clawed frog)	LOC100485912	XP_002943156.2
Homo sapiens (human)	HAX1	NP_006109.2
Rattus norvegicus (Norway rat)	Hax1	NP_853658.1

Gene Ontology
Bibliography

Related articles in PubMed

HAX-1 regulates SERCA2a oxidation and degradation.
Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, Sanoudou D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J, Kranias EG
Journal of molecular and cellular cardiology114220-233(2017 Nov)

Abnormal expression of HAX?1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma.
Wu H, Chen J, Wang Q, Yin Y, Da P, Le H, Zhang Z, Qiu X
Molecular medicine reports16(4)4664-4670(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors describe the first case series of patients with CN caused by HAX1 mutation who presented with HLH. They hypothesize that severe neutropenia persists after an HLH episode in children without FHLH mutations (especially infants) because these patients have CN caused by HAX1 mutations.
Title: HAX1 mutation positive children presenting with haemophagocytic lymphohistiocytosis.

Study indicates that the overexpression of HAX-1 is essential in the development of chemoresistance in breast cancer.
Title: Chemoresistance is associated with overexpression of HAX-1, inhibition of which resensitizes drug-resistant breast cancer cells to chemotherapy.

Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13.
Title: Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.

Oncogenic HAX-1 increases the proliferation, migration, and angiogenic activity of HUVECs. Findings provide unique insight into the pathogenesis of NPC.
Title: Clinical and biological significance of HAX-1 overexpression in nasopharyngeal carcinoma.

results suggest that miR-223 increases the sensitivity of TNBCSCs to TRAIL-induced apoptosis by targeting HAX-1
Title: MicroRNA-223 Increases the Sensitivity of Triple-Negative Breast Cancer Stem Cells to TRAIL-Induced Apoptosis by Targeting HAX-1.

The following HAX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HAX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20000	NM_001018837.2 Latest version!	Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu19870	NM_006118.4 Latest version!	Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu19870	NM_006118.3	Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OHu20000	NM_001018837.1	Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HAX1 ( NM_006118.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006109.2 Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19870
Clone ID Related Accession (Same CDS sequence)	NM_006118.3 , NM_006118.4
Accession Version	NM_006118.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Homo sapiens(human)
Product	HCLS1-associated protein X-1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005240.1 and U68566.1. This sequence is a reference standard in the RefSeqGene project. On May 20, 2005 this sequence version replaced NM_006118.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U68566.1, BC005240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCCTCT TTGATCTCTT CCGGGGCTTT TTCGGCTTTC CTGGACCTCG GAGCCACAGA 
GATCCCTTTT TTGGAGGGAT GACTCGAGAT GAAGATGATG ATGAGGAAGA AGAAGAAGAA 
GGGGGCTCAT GGGGCCGTGG GAACCCAAGG TTCCATAGTC CTCAGCACCC CCCTGAGGAA 
TTTGGCTTCG GCTTCAGCTT CAGCCCAGGA GGAGGGATAC GTTTCCACGA TAACTTCGGC 
TTTGATGACC TAGTACGAGA TTTCAATAGC ATCTTCAGCG ATATGGGGGC CTGGACCTTG 
CCTTCCCATC CTCCTGAACT TCCAGGTCCT GAGTCAGAGA CACCTGGTGA GAGACTACGG 
GAGGGACAGA CACTTCGGGA CTCAATGCTT AAGTATCCAG ATAGTCACCA GCCCAGGATC 
TTTGGGGGGG TCTTGGAGAG TGATGCAAGA AGTGAATCCC CCCAACCAGC ACCAGACTGG 
GGCTCCCAGA GGCCATTTCA TAGGTTTGAT GATGTATGGC CTATGGACCC CCATCCTAGA 
ACCAGAGAGG ACAATGATCT TGATTCCCAG GTTTCCCAGG AGGGTCTTGG CCCGGTTCTA 
CAGCCCCAGC CCAAATCCTA TTTCAAGAGC ATCTCTGTGA CCAAGATCAC TAAACCAGAT 
GGGATAGTGG AGGAGCGCCG GACTGTGGTG GACAGTGAGG GCCGGACAGA GACTACAGTA 
ACCCGACACG AAGCAGATAG CAGTCCTAGG GGTGATCCAG AATCACCAAG ACCTCCAGCC 
CTGGATGATG CCTTTTCCAT CCTGGACTTA TTCCTGGGAC GTTGGTTCCG GTCCCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006109.2
CDS	162..1001
Translation	MSLFDLFRGFFGFPGPRSHRDPFFGGMTRDEDDDEEEEEEGGSWGRGNPRFHSPQHPPEEFGFGFSFSPGGGIRFHDNFGFDDLVRDFNSIFSDMGAWTLPSHPPELPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRTETTVTRHEADSSPRGDPESPRPPALDDAFSILDLFLGRWFRSR

Target ORF information:

RefSeq Version	NM_006118.3
Organism	Homo sapiens(human)
Definition	Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006118.3

ORF Insert Sequence:

ATGAGCCTCT TTGATCTCTT CCGGGGCTTT TTCGGCTTTC CTGGACCTCG GAGCCACAGA 
GATCCCTTTT TTGGAGGGAT GACTCGAGAT GAAGATGATG ATGAGGAAGA AGAAGAAGAA 
GGGGGCTCAT GGGGCCGTGG GAACCCAAGG TTCCATAGTC CTCAGCACCC CCCTGAGGAA 
TTTGGCTTCG GCTTCAGCTT CAGCCCAGGA GGAGGGATAC GTTTCCACGA TAACTTCGGC 
TTTGATGACC TAGTACGAGA TTTCAATAGC ATCTTCAGCG ATATGGGGGC CTGGACCTTG 
CCTTCCCATC CTCCTGAACT TCCAGGTCCT GAGTCAGAGA CACCTGGTGA GAGACTACGG 
GAGGGACAGA CACTTCGGGA CTCAATGCTT AAGTATCCAG ATAGTCACCA GCCCAGGATC 
TTTGGGGGGG TCTTGGAGAG TGATGCAAGA AGTGAATCCC CCCAACCAGC ACCAGACTGG 
GGCTCCCAGA GGCCATTTCA TAGGTTTGAT GATGTATGGC CTATGGACCC CCATCCTAGA 
ACCAGAGAGG ACAATGATCT TGATTCCCAG GTTTCCCAGG AGGGTCTTGG CCCGGTTCTA 
CAGCCCCAGC CCAAATCCTA TTTCAAGAGC ATCTCTGTGA CCAAGATCAC TAAACCAGAT 
GGGATAGTGG AGGAGCGCCG GACTGTGGTG GACAGTGAGG GCCGGACAGA GACTACAGTA 
ACCCGACACG AAGCAGATAG CAGTCCTAGG GGTGATCCAG AATCACCAAG ACCTCCAGCC 
CTGGATGATG CCTTTTCCAT CCTGGACTTA TTCCTGGGAC GTTGGTTCCG GTCCCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HAX1 ( NM_001018837.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001018238.1 Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20000
Clone ID Related Accession (Same CDS sequence)	NM_001018837.1 , NM_001018837.2
Accession Version	NM_001018837.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Homo sapiens(human)
Product	HCLS1-associated protein X-1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005240.1, BF668367.1 and U68566.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.496927.1, SRR1163657.335700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCTCT TTGATCTCTT CCGGGGCTTT TTCGGCTTTC CTGGACCTCG GAGCTTCAGC 
CCAGGAGGAG GGATACGTTT CCACGATAAC TTCGGCTTTG ATGACCTAGT ACGAGATTTC 
AATAGCATCT TCAGCGATAT GGGGGCCTGG ACCTTGCCTT CCCATCCTCC TGAACTTCCA 
GGTCCTGAGT CAGAGACACC TGGTGAGAGA CTACGGGAGG GACAGACACT TCGGGACTCA 
ATGCTTAAGT ATCCAGATAG TCACCAGCCC AGGATCTTTG GGGGGGTCTT GGAGAGTGAT 
GCAAGAAGTG AATCCCCCCA ACCAGCACCA GACTGGGGCT CCCAGAGGCC ATTTCATAGG 
TTTGATGATG TATGGCCTAT GGACCCCCAT CCTAGAACCA GAGAGGACAA TGATCTTGAT 
TCCCAGGTTT CCCAGGAGGG TCTTGGCCCG GTTCTACAGC CCCAGCCCAA ATCCTATTTC 
AAGAGCATCT CTGTGACCAA GATCACTAAA CCAGATGGGA TAGTGGAGGA GCGCCGGACT 
GTGGTGGACA GTGAGGGCCG GACAGAGACT ACAGTAACCC GACACGAAGC AGATAGCAGT 
CCTAGGGGTG ATCCAGAATC ACCAAGACCT CCAGCCCTGG ATGATGCCTT TTCCATCCTG 
GACTTATTCC TGGGACGTTG GTTCCGGTCC CGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018238.1
CDS	162..857
Translation	MSLFDLFRGFFGFPGPRSFSPGGGIRFHDNFGFDDLVRDFNSIFSDMGAWTLPSHPPELPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRTETTVTRHEADSSPRGDPESPRPPALDDAFSILDLFLGRWFRSR

Target ORF information:

RefSeq Version	NM_001018837.1
Organism	Homo sapiens(human)
Definition	Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018837.1

ORF Insert Sequence:

ATGAGCCTCT TTGATCTCTT CCGGGGCTTT TTCGGCTTTC CTGGACCTCG GAGCTTCAGC 
CCAGGAGGAG GGATACGTTT CCACGATAAC TTCGGCTTTG ATGACCTAGT ACGAGATTTC 
AATAGCATCT TCAGCGATAT GGGGGCCTGG ACCTTGCCTT CCCATCCTCC TGAACTTCCA 
GGTCCTGAGT CAGAGACACC TGGTGAGAGA CTACGGGAGG GACAGACACT TCGGGACTCA 
ATGCTTAAGT ATCCAGATAG TCACCAGCCC AGGATCTTTG GGGGGGTCTT GGAGAGTGAT 
GCAAGAAGTG AATCCCCCCA ACCAGCACCA GACTGGGGCT CCCAGAGGCC ATTTCATAGG 
TTTGATGATG TATGGCCTAT GGACCCCCAT CCTAGAACCA GAGAGGACAA TGATCTTGAT 
TCCCAGGTTT CCCAGGAGGG TCTTGGCCCG GTTCTACAGC CCCAGCCCAA ATCCTATTTC 
AAGAGCATCT CTGTGACCAA GATCACTAAA CCAGATGGGA TAGTGGAGGA GCGCCGGACT 
GTGGTGGACA GTGAGGGCCG GACAGAGACT ACAGTAACCC GACACGAAGC AGATAGCAGT 
CCTAGGGGTG ATCCAGAATC ACCAAGACCT CCAGCCCTGG ATGATGCCTT TTCCATCCTG 
GACTTATTCC TGGGACGTTG GTTCCGGTCC CGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HAX1 ( NM_001018837.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001018238.1 Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20000
Clone ID Related Accession (Same CDS sequence)	NM_001018837.1 , NM_001018837.2
Accession Version	NM_001018837.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Homo sapiens(human)
Product	HCLS1-associated protein X-1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005240.1, BF668367.1 and U68566.1. On Jun 2, 2019 this sequence version replaced NM_001018837.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.543563.1, SRR1163658.496927.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCTCT TTGATCTCTT CCGGGGCTTT TTCGGCTTTC CTGGACCTCG GAGCTTCAGC 
CCAGGAGGAG GGATACGTTT CCACGATAAC TTCGGCTTTG ATGACCTAGT ACGAGATTTC 
AATAGCATCT TCAGCGATAT GGGGGCCTGG ACCTTGCCTT CCCATCCTCC TGAACTTCCA 
GGTCCTGAGT CAGAGACACC TGGTGAGAGA CTACGGGAGG GACAGACACT TCGGGACTCA 
ATGCTTAAGT ATCCAGATAG TCACCAGCCC AGGATCTTTG GGGGGGTCTT GGAGAGTGAT 
GCAAGAAGTG AATCCCCCCA ACCAGCACCA GACTGGGGCT CCCAGAGGCC ATTTCATAGG 
TTTGATGATG TATGGCCTAT GGACCCCCAT CCTAGAACCA GAGAGGACAA TGATCTTGAT 
TCCCAGGTTT CCCAGGAGGG TCTTGGCCCG GTTCTACAGC CCCAGCCCAA ATCCTATTTC 
AAGAGCATCT CTGTGACCAA GATCACTAAA CCAGATGGGA TAGTGGAGGA GCGCCGGACT 
GTGGTGGACA GTGAGGGCCG GACAGAGACT ACAGTAACCC GACACGAAGC AGATAGCAGT 
CCTAGGGGTG ATCCAGAATC ACCAAGACCT CCAGCCCTGG ATGATGCCTT TTCCATCCTG 
GACTTATTCC TGGGACGTTG GTTCCGGTCC CGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001018238.1
CDS	96..791
Translation	MSLFDLFRGFFGFPGPRSFSPGGGIRFHDNFGFDDLVRDFNSIFSDMGAWTLPSHPPELPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRTETTVTRHEADSSPRGDPESPRPPALDDAFSILDLFLGRWFRSR

Target ORF information:

RefSeq Version	NM_001018837.2
Organism	Homo sapiens(human)
Definition	Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001018837.2

ORF Insert Sequence:

ATGAGCCTCT TTGATCTCTT CCGGGGCTTT TTCGGCTTTC CTGGACCTCG GAGCTTCAGC 
CCAGGAGGAG GGATACGTTT CCACGATAAC TTCGGCTTTG ATGACCTAGT ACGAGATTTC 
AATAGCATCT TCAGCGATAT GGGGGCCTGG ACCTTGCCTT CCCATCCTCC TGAACTTCCA 
GGTCCTGAGT CAGAGACACC TGGTGAGAGA CTACGGGAGG GACAGACACT TCGGGACTCA 
ATGCTTAAGT ATCCAGATAG TCACCAGCCC AGGATCTTTG GGGGGGTCTT GGAGAGTGAT 
GCAAGAAGTG AATCCCCCCA ACCAGCACCA GACTGGGGCT CCCAGAGGCC ATTTCATAGG 
TTTGATGATG TATGGCCTAT GGACCCCCAT CCTAGAACCA GAGAGGACAA TGATCTTGAT 
TCCCAGGTTT CCCAGGAGGG TCTTGGCCCG GTTCTACAGC CCCAGCCCAA ATCCTATTTC 
AAGAGCATCT CTGTGACCAA GATCACTAAA CCAGATGGGA TAGTGGAGGA GCGCCGGACT 
GTGGTGGACA GTGAGGGCCG GACAGAGACT ACAGTAACCC GACACGAAGC AGATAGCAGT 
CCTAGGGGTG ATCCAGAATC ACCAAGACCT CCAGCCCTGG ATGATGCCTT TTCCATCCTG 
GACTTATTCC TGGGACGTTG GTTCCGGTCC CGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HAX1 ( NM_006118.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006109.2 Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19870
Clone ID Related Accession (Same CDS sequence)	NM_006118.3 , NM_006118.4
Accession Version	NM_006118.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	HCLS1-associated protein X-1 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005240.1 and U68566.1. On Aug 31, 2019 this sequence version replaced NM_006118.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016730.1, U68566.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCCTCT TTGATCTCTT CCGGGGCTTT TTCGGCTTTC CTGGACCTCG GAGCCACAGA 
GATCCCTTTT TTGGAGGGAT GACTCGAGAT GAAGATGATG ATGAGGAAGA AGAAGAAGAA 
GGGGGCTCAT GGGGCCGTGG GAACCCAAGG TTCCATAGTC CTCAGCACCC CCCTGAGGAA 
TTTGGCTTCG GCTTCAGCTT CAGCCCAGGA GGAGGGATAC GTTTCCACGA TAACTTCGGC 
TTTGATGACC TAGTACGAGA TTTCAATAGC ATCTTCAGCG ATATGGGGGC CTGGACCTTG 
CCTTCCCATC CTCCTGAACT TCCAGGTCCT GAGTCAGAGA CACCTGGTGA GAGACTACGG 
GAGGGACAGA CACTTCGGGA CTCAATGCTT AAGTATCCAG ATAGTCACCA GCCCAGGATC 
TTTGGGGGGG TCTTGGAGAG TGATGCAAGA AGTGAATCCC CCCAACCAGC ACCAGACTGG 
GGCTCCCAGA GGCCATTTCA TAGGTTTGAT GATGTATGGC CTATGGACCC CCATCCTAGA 
ACCAGAGAGG ACAATGATCT TGATTCCCAG GTTTCCCAGG AGGGTCTTGG CCCGGTTCTA 
CAGCCCCAGC CCAAATCCTA TTTCAAGAGC ATCTCTGTGA CCAAGATCAC TAAACCAGAT 
GGGATAGTGG AGGAGCGCCG GACTGTGGTG GACAGTGAGG GCCGGACAGA GACTACAGTA 
ACCCGACACG AAGCAGATAG CAGTCCTAGG GGTGATCCAG AATCACCAAG ACCTCCAGCC 
CTGGATGATG CCTTTTCCAT CCTGGACTTA TTCCTGGGAC GTTGGTTCCG GTCCCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006109.2
CDS	96..935
Translation	MSLFDLFRGFFGFPGPRSHRDPFFGGMTRDEDDDEEEEEEGGSWGRGNPRFHSPQHPPEEFGFGFSFSPGGGIRFHDNFGFDDLVRDFNSIFSDMGAWTLPSHPPELPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRTETTVTRHEADSSPRGDPESPRPPALDDAFSILDLFLGRWFRSR

Target ORF information:

RefSeq Version	NM_006118.4
Organism	Homo sapiens(human)
Definition	Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006118.4

ORF Insert Sequence:

ATGAGCCTCT TTGATCTCTT CCGGGGCTTT TTCGGCTTTC CTGGACCTCG GAGCCACAGA 
GATCCCTTTT TTGGAGGGAT GACTCGAGAT GAAGATGATG ATGAGGAAGA AGAAGAAGAA 
GGGGGCTCAT GGGGCCGTGG GAACCCAAGG TTCCATAGTC CTCAGCACCC CCCTGAGGAA 
TTTGGCTTCG GCTTCAGCTT CAGCCCAGGA GGAGGGATAC GTTTCCACGA TAACTTCGGC 
TTTGATGACC TAGTACGAGA TTTCAATAGC ATCTTCAGCG ATATGGGGGC CTGGACCTTG 
CCTTCCCATC CTCCTGAACT TCCAGGTCCT GAGTCAGAGA CACCTGGTGA GAGACTACGG 
GAGGGACAGA CACTTCGGGA CTCAATGCTT AAGTATCCAG ATAGTCACCA GCCCAGGATC 
TTTGGGGGGG TCTTGGAGAG TGATGCAAGA AGTGAATCCC CCCAACCAGC ACCAGACTGG 
GGCTCCCAGA GGCCATTTCA TAGGTTTGAT GATGTATGGC CTATGGACCC CCATCCTAGA 
ACCAGAGAGG ACAATGATCT TGATTCCCAG GTTTCCCAGG AGGGTCTTGG CCCGGTTCTA 
CAGCCCCAGC CCAAATCCTA TTTCAAGAGC ATCTCTGTGA CCAAGATCAC TAAACCAGAT 
GGGATAGTGG AGGAGCGCCG GACTGTGGTG GACAGTGAGG GCCGGACAGA GACTACAGTA 
ACCCGACACG AAGCAGATAG CAGTCCTAGG GGTGATCCAG AATCACCAAG ACCTCCAGCC 
CTGGATGATG CCTTTTCCAT CCTGGACTTA TTCCTGGGAC GTTGGTTCCG GTCCCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HAX-1 regulates SERCA2a oxidation and degradation.
Journal of molecular and cellular cardiology114220-233(2017 Nov)
Bidwell PA,Liu GS,Nagarajan N,Lam CK,Haghighi K,Gardner G,Cai WF,Zhao W,Mugge L,Vafiadaki E,Sanoudou D,Rubinstein J,Lebeche D,Hajjar R,Sadoshima J,Kranias EG

Abnormal expression of HAX?1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma.
Molecular medicine reports16(4)4664-4670(2017 Oct)
Wu H,Chen J,Wang Q,Yin Y,Da P,Le H,Zhang Z,Qiu X

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HAX1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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