SPON1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPON1
Entrez Gene ID	10418
Full Name	spondin 1
Synonyms	VSGP/F-spondin,f-spondin
General protein information	Preferred Names spondin 1 Names spondin-1 spondin 1, (f-spondin) extracellular matrix protein spondin 1, extracellular matrix protein vascular smooth muscle cell growth-promoting factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.2
Disorder MIM:	604989

mRNA and Protein(s)

mRNA	Protein	Name
NM_006108.3	NP_006099.2	spondin-1 precursor
NM_006108.4	NP_006099.2	spondin-1 precursor

Pathways from BioSystems

Homologies

	SPON1	XP_001093336.1
Mus musculus (house mouse)	Spon1	NP_663559.1
Xenopus tropicalis (tropical clawed frog)	spon1	NP_001090741.1
Homo sapiens (human)	SPON1	NP_006099.2
Rattus norvegicus (Norway rat)	Spon1	NP_742064.1
Gallus gallus (chicken)	SPON1	NP_990182.1
Danio rerio (zebrafish)	spon1a	NP_571590.1
Drosophila melanogaster (fruit fly)	CG17739	NP_610757.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012307	XP_320234.3
Pan troglodytes (chimpanzee)	SPON1	XP_508295.3
Canis lupus familiaris (dog)	SPON1	XP_534067.2
Bos taurus (cattle)	SPON1	NP_777168.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.
Yang HC, Chu SK, Huang CL, Kuo HW, Wang SC, Liu SW, Ho IK, Liu YL
PLoS genetics12(3)e1005910(2016 Mar)

Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.
Chang H, Dong T, Ma X, Zhang T, Chen Z, Yang Z, Zhang Y
Biochemical and biophysical research communications464(1)45-50(2015 Aug)

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
Chimusa ER, Zaitlen N, Daya M, M?ller M, van Helden PD, Mulder NJ, Price AL, Hoal EG
Human molecular genetics23(3)796-809(2014 Feb)

Experimental validation of 5 in-silico predicted glioma biomarkers.
Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD
Neuro-oncology15(12)1625-34(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

gene expression experiment revealed that CYP2B6, SPON1, and GSG1L can be activated concomitantly through a constitutive androstane receptor (CAR) activation pathway
Title: Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.

SPON1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.
Title: Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.

These data suggest that SPON1 may be associated with the differential rate of cognitive decline in Alzheimer disease.
Title: Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.

High SPON1 expression is associated with high-grade gliomas.
Title: Experimental validation of 5 in-silico predicted glioma biomarkers.

Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity
Title: Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.

The following SPON1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPON1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15605	NM_006108.4 Latest version!	Homo sapiens spondin 1 (SPON1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu15605	NM_006108.3	Homo sapiens spondin 1 (SPON1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPON1 ( NM_006108.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006099.2 Homo sapiens spondin 1 (SPON1), mRNA.

Price & Availability↑

CloneID	OHu15605
Clone ID Related Accession (Same CDS sequence)	NM_006108.3 , NM_006108.4
Accession Version	NM_006108.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2424bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	spondin-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK291780.1, AB018305.2 and BQ026865.1. On Nov 22, 2018 this sequence version replaced NM_006108.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.147701.1, SRR1803611.213743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000576479.4/ ENSP00000460236.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGCTGT CCCCGGCGCC CCTGAAGCTG AGCCGGACTC CGGCACTGCT GGCCCTGGCG 
CTGCCCCTGG CCGCGGCGCT GGCCTTCTCC GACGAGACCC TGGACAAAGT GCCCAAGTCA 
GAGGGCTACT GCAGCCGTAT CCTGCGCGCC CAGGGCACGC GGCGCGAGGG CTACACCGAG 
TTCAGCCTCC GCGTGGAGGG CGACCCCGAC TTCTACAAGC CGGGAACCAG CTACCGCGTA 
ACACTTTCAG CTGCTCCTCC CTCCTACTTC AGAGGATTCA CATTAATTGC CCTCAGAGAG 
AACAGAGAGG GTGATAAGGA AGAAGACCAT GCTGGGACCT TCCAGATCAT AGACGAAGAA 
GAAACTCAGT TTATGAGCAA TTGCCCTGTT GCAGTCACTG AAAGCACTCC ACGGAGGAGG 
ACCCGGATCC AGGTGTTTTG GATAGCACCA CCAGCGGGAA CAGGCTGCGT GATTCTGAAG 
GCCAGCATCG TACAAAAACG CATTATTTAT TTTCAAGATG AGGGCTCTCT GACCAAGAAA 
CTTTGTGAAC AAGATTCCAC ATTTGATGGG GTGACTGACA AACCCATCTT AGACTGCTGT 
GCCTGCGGAA CTGCCAAGTA CAGACTCACA TTTTATGGGA ATTGGTCCGA GAAGACACAC 
CCAAAGGATT ACCCTCGTCG GGCCAACCAC TGGTCTGCGA TCATCGGAGG ATCCCACTCC 
AAGAATTATG TACTGTGGGA ATATGGAGGA TATGCCAGCG AAGGCGTCAA ACAAGTTGCA 
GAATTGGGCT CACCCGTGAA AATGGAGGAA GAAATTCGAC AACAGAGTGA TGAGGTCCTC 
ACCGTCATCA AAGCCAAAGC CCAATGGCCA GCCTGGCAGC CTCTCAACGT GAGAGCAGCA 
CCTTCAGCTG AATTTTCCGT GGACAGAACG CGCCATTTAA TGTCCTTCCT GACCATGATG 
GGCCCTAGTC CCGACTGGAA CGTAGGCTTA TCTGCAGAAG ATCTGTGCAC CAAGGAATGT 
GGCTGGGTCC AGAAGGTGGT GCAAGACCTG ATTCCCTGGG ACGCTGGCAC CGACAGCGGG 
GTGACCTATG AGTCACCCAA CAAACCCACC ATTCCCCAGG AGAAAATCCG GCCCCTGACC 
AGCCTGGACC ATCCTCAGAG TCCTTTCTAT GACCCAGAGG GTGGGTCCAT CACTCAAGTA 
GCCAGAGTTG TCATCGAGAG AATCGCACGG AAGGGTGAAC AATGCAATAT TGTACCTGAC 
AATGTCGATG ATATTGTAGC TGACCTGGCT CCAGAAGAGA AAGATGAAGA TGACACCCCT 
GAAACCTGCA TCTACTCCAA CTGGTCCCCA TGGTCCGCCT GCAGCTCCTC CACCTGTGAC 
AAAGGCAAGA GGATGCGACA GCGCATGCTG AAAGCACAGC TGGACCTCAG CGTCCCCTGC 
CCTGACACCC AGGACTTCCA GCCCTGCATG GGCCCTGGCT GCAGTGACGA AGACGGCTCC 
ACCTGCACCA TGTCCGAGTG GATCACCTGG TCGCCCTGCA GCATCTCCTG CGGCATGGGC 
ATGAGGTCCC GGGAGAGGTA TGTGAAGCAG TTCCCGGAGG ACGGCTCCGT GTGCACGCTG 
CCCACTGAGG AAACGGAGAA GTGCACGGTC AACGAGGAGT GCTCTCCCAG CAGCTGCCTG 
ATGACCGAGT GGGGCGAGTG GGACGAGTGC AGCGCCACCT GCGGCATGGG CATGAAGAAG 
CGGCACCGCA TGATCAAGAT GAACCCCGCA GATGGCTCCA TGTGCAAAGC CGAGACATCA 
CAGGCAGAGA AGTGCATGAT GCCAGAGTGC CACACCATCC CATGCTTGCT GTCCCCATGG 
TCCGAGTGGA GTGACTGCAG CGTGACCTGC GGGAAGGGCA TGCGAACCCG ACAGCGGATG 
CTCAAGTCTC TGGCAGAACT TGGAGACTGC AATGAGGATC TGGAGCAGGT GGAGAAGTGC 
ATGCTCCCTG AATGCCCCAT TGACTGTGAG CTCACCGAGT GGTCCCAGTG GTCGGAATGT 
AACAAGTCAT GTGGGAAAGG CCACGTGATT CGAACCCGGA TGATCCAAAT GGAGCCTCAG 
TTTGGAGGTG CACCCTGCCC AGAGACTGTG CAGCGAAAAA AGTGCCGCAT CCGAAAATGC 
CTTCGAAATC CATCCATCCA AAAGCTACGC TGGAGGGAGG CCCGAGAGAG CCGGCGGAGT 
GAGCAGCTGA AGGAAGAGTC TGAAGGGGAG CAGTTCCCAG GTTGTAGGAT GCGCCCATGG 
ACGGCCTGGT CAGAATGCAC CAAACTGTGC GGAGGTGGAA TTCAGGAACG TTACATGACT 
GTAAAGAAGA GATTCAAAAG CTCCCAGTTT ACCAGCTGCA AAGACAAGAA GGAGATCAGA 
GCATGCAATG TTCATCCTTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006099.2
CDS	183..2606
Translation	MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC

Target ORF information:

RefSeq Version	NM_006108.4
Organism	Homo sapiens(human)
Definition	Homo sapiens spondin 1 (SPON1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006108.4

ORF Insert Sequence:

ATGAGGCTGT CCCCGGCGCC CCTGAAGCTG AGCCGGACTC CGGCACTGCT GGCCCTGGCG 
CTGCCCCTGG CCGCGGCGCT GGCCTTCTCC GACGAGACCC TGGACAAAGT GCCCAAGTCA 
GAGGGCTACT GCAGCCGTAT CCTGCGCGCC CAGGGCACGC GGCGCGAGGG CTACACCGAG 
TTCAGCCTCC GCGTGGAGGG CGACCCCGAC TTCTACAAGC CGGGAACCAG CTACCGCGTA 
ACACTTTCAG CTGCTCCTCC CTCCTACTTC AGAGGATTCA CATTAATTGC CCTCAGAGAG 
AACAGAGAGG GTGATAAGGA AGAAGACCAT GCTGGGACCT TCCAGATCAT AGACGAAGAA 
GAAACTCAGT TTATGAGCAA TTGCCCTGTT GCAGTCACTG AAAGCACTCC ACGGAGGAGG 
ACCCGGATCC AGGTGTTTTG GATAGCACCA CCAGCGGGAA CAGGCTGCGT GATTCTGAAG 
GCCAGCATCG TACAAAAACG CATTATTTAT TTTCAAGATG AGGGCTCTCT GACCAAGAAA 
CTTTGTGAAC AAGATTCCAC ATTTGATGGG GTGACTGACA AACCCATCTT AGACTGCTGT 
GCCTGCGGAA CTGCCAAGTA CAGACTCACA TTTTATGGGA ATTGGTCCGA GAAGACACAC 
CCAAAGGATT ACCCTCGTCG GGCCAACCAC TGGTCTGCGA TCATCGGAGG ATCCCACTCC 
AAGAATTATG TACTGTGGGA ATATGGAGGA TATGCCAGCG AAGGCGTCAA ACAAGTTGCA 
GAATTGGGCT CACCCGTGAA AATGGAGGAA GAAATTCGAC AACAGAGTGA TGAGGTCCTC 
ACCGTCATCA AAGCCAAAGC CCAATGGCCA GCCTGGCAGC CTCTCAACGT GAGAGCAGCA 
CCTTCAGCTG AATTTTCCGT GGACAGAACG CGCCATTTAA TGTCCTTCCT GACCATGATG 
GGCCCTAGTC CCGACTGGAA CGTAGGCTTA TCTGCAGAAG ATCTGTGCAC CAAGGAATGT 
GGCTGGGTCC AGAAGGTGGT GCAAGACCTG ATTCCCTGGG ACGCTGGCAC CGACAGCGGG 
GTGACCTATG AGTCACCCAA CAAACCCACC ATTCCCCAGG AGAAAATCCG GCCCCTGACC 
AGCCTGGACC ATCCTCAGAG TCCTTTCTAT GACCCAGAGG GTGGGTCCAT CACTCAAGTA 
GCCAGAGTTG TCATCGAGAG AATCGCACGG AAGGGTGAAC AATGCAATAT TGTACCTGAC 
AATGTCGATG ATATTGTAGC TGACCTGGCT CCAGAAGAGA AAGATGAAGA TGACACCCCT 
GAAACCTGCA TCTACTCCAA CTGGTCCCCA TGGTCCGCCT GCAGCTCCTC CACCTGTGAC 
AAAGGCAAGA GGATGCGACA GCGCATGCTG AAAGCACAGC TGGACCTCAG CGTCCCCTGC 
CCTGACACCC AGGACTTCCA GCCCTGCATG GGCCCTGGCT GCAGTGACGA AGACGGCTCC 
ACCTGCACCA TGTCCGAGTG GATCACCTGG TCGCCCTGCA GCATCTCCTG CGGCATGGGC 
ATGAGGTCCC GGGAGAGGTA TGTGAAGCAG TTCCCGGAGG ACGGCTCCGT GTGCACGCTG 
CCCACTGAGG AAACGGAGAA GTGCACGGTC AACGAGGAGT GCTCTCCCAG CAGCTGCCTG 
ATGACCGAGT GGGGCGAGTG GGACGAGTGC AGCGCCACCT GCGGCATGGG CATGAAGAAG 
CGGCACCGCA TGATCAAGAT GAACCCCGCA GATGGCTCCA TGTGCAAAGC CGAGACATCA 
CAGGCAGAGA AGTGCATGAT GCCAGAGTGC CACACCATCC CATGCTTGCT GTCCCCATGG 
TCCGAGTGGA GTGACTGCAG CGTGACCTGC GGGAAGGGCA TGCGAACCCG ACAGCGGATG 
CTCAAGTCTC TGGCAGAACT TGGAGACTGC AATGAGGATC TGGAGCAGGT GGAGAAGTGC 
ATGCTCCCTG AATGCCCCAT TGACTGTGAG CTCACCGAGT GGTCCCAGTG GTCGGAATGT 
AACAAGTCAT GTGGGAAAGG CCACGTGATT CGAACCCGGA TGATCCAAAT GGAGCCTCAG 
TTTGGAGGTG CACCCTGCCC AGAGACTGTG CAGCGAAAAA AGTGCCGCAT CCGAAAATGC 
CTTCGAAATC CATCCATCCA AAAGCTACGC TGGAGGGAGG CCCGAGAGAG CCGGCGGAGT 
GAGCAGCTGA AGGAAGAGTC TGAAGGGGAG CAGTTCCCAG GTTGTAGGAT GCGCCCATGG 
ACGGCCTGGT CAGAATGCAC CAAACTGTGC GGAGGTGGAA TTCAGGAACG TTACATGACT 
GTAAAGAAGA GATTCAAAAG CTCCCAGTTT ACCAGCTGCA AAGACAAGAA GGAGATCAGA 
GCATGCAATG TTCATCCTTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPON1 ( NM_006108.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006099.2 Homo sapiens spondin 1 (SPON1), mRNA.

Price & Availability↑

CloneID	OHu15605
Clone ID Related Accession (Same CDS sequence)	NM_006108.3 , NM_006108.4
Accession Version	NM_006108.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2424bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	spondin-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA965056.1, AK291780.1, AB018305.2 and BQ026865.1. On Aug 23, 2011 this sequence version replaced NM_006108.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.213743.1, SRR1803616.250876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCTGT CCCCGGCGCC CCTGAAGCTG AGCCGGACTC CGGCACTGCT GGCCCTGGCG 
CTGCCCCTGG CCGCGGCGCT GGCCTTCTCC GACGAGACCC TGGACAAAGT GCCCAAGTCA 
GAGGGCTACT GCAGCCGTAT CCTGCGCGCC CAGGGCACGC GGCGCGAGGG CTACACCGAG 
TTCAGCCTCC GCGTGGAGGG CGACCCCGAC TTCTACAAGC CGGGAACCAG CTACCGCGTA 
ACACTTTCAG CTGCTCCTCC CTCCTACTTC AGAGGATTCA CATTAATTGC CCTCAGAGAG 
AACAGAGAGG GTGATAAGGA AGAAGACCAT GCTGGGACCT TCCAGATCAT AGACGAAGAA 
GAAACTCAGT TTATGAGCAA TTGCCCTGTT GCAGTCACTG AAAGCACTCC ACGGAGGAGG 
ACCCGGATCC AGGTGTTTTG GATAGCACCA CCAGCGGGAA CAGGCTGCGT GATTCTGAAG 
GCCAGCATCG TACAAAAACG CATTATTTAT TTTCAAGATG AGGGCTCTCT GACCAAGAAA 
CTTTGTGAAC AAGATTCCAC ATTTGATGGG GTGACTGACA AACCCATCTT AGACTGCTGT 
GCCTGCGGAA CTGCCAAGTA CAGACTCACA TTTTATGGGA ATTGGTCCGA GAAGACACAC 
CCAAAGGATT ACCCTCGTCG GGCCAACCAC TGGTCTGCGA TCATCGGAGG ATCCCACTCC 
AAGAATTATG TACTGTGGGA ATATGGAGGA TATGCCAGCG AAGGCGTCAA ACAAGTTGCA 
GAATTGGGCT CACCCGTGAA AATGGAGGAA GAAATTCGAC AACAGAGTGA TGAGGTCCTC 
ACCGTCATCA AAGCCAAAGC CCAATGGCCA GCCTGGCAGC CTCTCAACGT GAGAGCAGCA 
CCTTCAGCTG AATTTTCCGT GGACAGAACG CGCCATTTAA TGTCCTTCCT GACCATGATG 
GGCCCTAGTC CCGACTGGAA CGTAGGCTTA TCTGCAGAAG ATCTGTGCAC CAAGGAATGT 
GGCTGGGTCC AGAAGGTGGT GCAAGACCTG ATTCCCTGGG ACGCTGGCAC CGACAGCGGG 
GTGACCTATG AGTCACCCAA CAAACCCACC ATTCCCCAGG AGAAAATCCG GCCCCTGACC 
AGCCTGGACC ATCCTCAGAG TCCTTTCTAT GACCCAGAGG GTGGGTCCAT CACTCAAGTA 
GCCAGAGTTG TCATCGAGAG AATCGCACGG AAGGGTGAAC AATGCAATAT TGTACCTGAC 
AATGTCGATG ATATTGTAGC TGACCTGGCT CCAGAAGAGA AAGATGAAGA TGACACCCCT 
GAAACCTGCA TCTACTCCAA CTGGTCCCCA TGGTCCGCCT GCAGCTCCTC CACCTGTGAC 
AAAGGCAAGA GGATGCGACA GCGCATGCTG AAAGCACAGC TGGACCTCAG CGTCCCCTGC 
CCTGACACCC AGGACTTCCA GCCCTGCATG GGCCCTGGCT GCAGTGACGA AGACGGCTCC 
ACCTGCACCA TGTCCGAGTG GATCACCTGG TCGCCCTGCA GCATCTCCTG CGGCATGGGC 
ATGAGGTCCC GGGAGAGGTA TGTGAAGCAG TTCCCGGAGG ACGGCTCCGT GTGCACGCTG 
CCCACTGAGG AAACGGAGAA GTGCACGGTC AACGAGGAGT GCTCTCCCAG CAGCTGCCTG 
ATGACCGAGT GGGGCGAGTG GGACGAGTGC AGCGCCACCT GCGGCATGGG CATGAAGAAG 
CGGCACCGCA TGATCAAGAT GAACCCCGCA GATGGCTCCA TGTGCAAAGC CGAGACATCA 
CAGGCAGAGA AGTGCATGAT GCCAGAGTGC CACACCATCC CATGCTTGCT GTCCCCATGG 
TCCGAGTGGA GTGACTGCAG CGTGACCTGC GGGAAGGGCA TGCGAACCCG ACAGCGGATG 
CTCAAGTCTC TGGCAGAACT TGGAGACTGC AATGAGGATC TGGAGCAGGT GGAGAAGTGC 
ATGCTCCCTG AATGCCCCAT TGACTGTGAG CTCACCGAGT GGTCCCAGTG GTCGGAATGT 
AACAAGTCAT GTGGGAAAGG CCACGTGATT CGAACCCGGA TGATCCAAAT GGAGCCTCAG 
TTTGGAGGTG CACCCTGCCC AGAGACTGTG CAGCGAAAAA AGTGCCGCAT CCGAAAATGC 
CTTCGAAATC CATCCATCCA AAAGCTACGC TGGAGGGAGG CCCGAGAGAG CCGGCGGAGT 
GAGCAGCTGA AGGAAGAGTC TGAAGGGGAG CAGTTCCCAG GTTGTAGGAT GCGCCCATGG 
ACGGCCTGGT CAGAATGCAC CAAACTGTGC GGAGGTGGAA TTCAGGAACG TTACATGACT 
GTAAAGAAGA GATTCAAAAG CTCCCAGTTT ACCAGCTGCA AAGACAAGAA GGAGATCAGA 
GCATGCAATG TTCATCCTTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006099.2
CDS	269..2692
Translation	MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC

Target ORF information:

RefSeq Version	NM_006108.3
Organism	Homo sapiens(human)
Definition	Homo sapiens spondin 1 (SPON1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006108.3

ORF Insert Sequence:

ATGAGGCTGT CCCCGGCGCC CCTGAAGCTG AGCCGGACTC CGGCACTGCT GGCCCTGGCG 
CTGCCCCTGG CCGCGGCGCT GGCCTTCTCC GACGAGACCC TGGACAAAGT GCCCAAGTCA 
GAGGGCTACT GCAGCCGTAT CCTGCGCGCC CAGGGCACGC GGCGCGAGGG CTACACCGAG 
TTCAGCCTCC GCGTGGAGGG CGACCCCGAC TTCTACAAGC CGGGAACCAG CTACCGCGTA 
ACACTTTCAG CTGCTCCTCC CTCCTACTTC AGAGGATTCA CATTAATTGC CCTCAGAGAG 
AACAGAGAGG GTGATAAGGA AGAAGACCAT GCTGGGACCT TCCAGATCAT AGACGAAGAA 
GAAACTCAGT TTATGAGCAA TTGCCCTGTT GCAGTCACTG AAAGCACTCC ACGGAGGAGG 
ACCCGGATCC AGGTGTTTTG GATAGCACCA CCAGCGGGAA CAGGCTGCGT GATTCTGAAG 
GCCAGCATCG TACAAAAACG CATTATTTAT TTTCAAGATG AGGGCTCTCT GACCAAGAAA 
CTTTGTGAAC AAGATTCCAC ATTTGATGGG GTGACTGACA AACCCATCTT AGACTGCTGT 
GCCTGCGGAA CTGCCAAGTA CAGACTCACA TTTTATGGGA ATTGGTCCGA GAAGACACAC 
CCAAAGGATT ACCCTCGTCG GGCCAACCAC TGGTCTGCGA TCATCGGAGG ATCCCACTCC 
AAGAATTATG TACTGTGGGA ATATGGAGGA TATGCCAGCG AAGGCGTCAA ACAAGTTGCA 
GAATTGGGCT CACCCGTGAA AATGGAGGAA GAAATTCGAC AACAGAGTGA TGAGGTCCTC 
ACCGTCATCA AAGCCAAAGC CCAATGGCCA GCCTGGCAGC CTCTCAACGT GAGAGCAGCA 
CCTTCAGCTG AATTTTCCGT GGACAGAACG CGCCATTTAA TGTCCTTCCT GACCATGATG 
GGCCCTAGTC CCGACTGGAA CGTAGGCTTA TCTGCAGAAG ATCTGTGCAC CAAGGAATGT 
GGCTGGGTCC AGAAGGTGGT GCAAGACCTG ATTCCCTGGG ACGCTGGCAC CGACAGCGGG 
GTGACCTATG AGTCACCCAA CAAACCCACC ATTCCCCAGG AGAAAATCCG GCCCCTGACC 
AGCCTGGACC ATCCTCAGAG TCCTTTCTAT GACCCAGAGG GTGGGTCCAT CACTCAAGTA 
GCCAGAGTTG TCATCGAGAG AATCGCACGG AAGGGTGAAC AATGCAATAT TGTACCTGAC 
AATGTCGATG ATATTGTAGC TGACCTGGCT CCAGAAGAGA AAGATGAAGA TGACACCCCT 
GAAACCTGCA TCTACTCCAA CTGGTCCCCA TGGTCCGCCT GCAGCTCCTC CACCTGTGAC 
AAAGGCAAGA GGATGCGACA GCGCATGCTG AAAGCACAGC TGGACCTCAG CGTCCCCTGC 
CCTGACACCC AGGACTTCCA GCCCTGCATG GGCCCTGGCT GCAGTGACGA AGACGGCTCC 
ACCTGCACCA TGTCCGAGTG GATCACCTGG TCGCCCTGCA GCATCTCCTG CGGCATGGGC 
ATGAGGTCCC GGGAGAGGTA TGTGAAGCAG TTCCCGGAGG ACGGCTCCGT GTGCACGCTG 
CCCACTGAGG AAACGGAGAA GTGCACGGTC AACGAGGAGT GCTCTCCCAG CAGCTGCCTG 
ATGACCGAGT GGGGCGAGTG GGACGAGTGC AGCGCCACCT GCGGCATGGG CATGAAGAAG 
CGGCACCGCA TGATCAAGAT GAACCCCGCA GATGGCTCCA TGTGCAAAGC CGAGACATCA 
CAGGCAGAGA AGTGCATGAT GCCAGAGTGC CACACCATCC CATGCTTGCT GTCCCCATGG 
TCCGAGTGGA GTGACTGCAG CGTGACCTGC GGGAAGGGCA TGCGAACCCG ACAGCGGATG 
CTCAAGTCTC TGGCAGAACT TGGAGACTGC AATGAGGATC TGGAGCAGGT GGAGAAGTGC 
ATGCTCCCTG AATGCCCCAT TGACTGTGAG CTCACCGAGT GGTCCCAGTG GTCGGAATGT 
AACAAGTCAT GTGGGAAAGG CCACGTGATT CGAACCCGGA TGATCCAAAT GGAGCCTCAG 
TTTGGAGGTG CACCCTGCCC AGAGACTGTG CAGCGAAAAA AGTGCCGCAT CCGAAAATGC 
CTTCGAAATC CATCCATCCA AAAGCTACGC TGGAGGGAGG CCCGAGAGAG CCGGCGGAGT 
GAGCAGCTGA AGGAAGAGTC TGAAGGGGAG CAGTTCCCAG GTTGTAGGAT GCGCCCATGG 
ACGGCCTGGT CAGAATGCAC CAAACTGTGC GGAGGTGGAA TTCAGGAACG TTACATGACT 
GTAAAGAAGA GATTCAAAAG CTCCCAGTTT ACCAGCTGCA AAGACAAGAA GGAGATCAGA 
GCATGCAATG TTCATCCTTG TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.
PLoS genetics12(3)e1005910(2016 Mar)
Yang HC,Chu SK,Huang CL,Kuo HW,Wang SC,Liu SW,Ho IK,Liu YL

Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.
Biochemical and biophysical research communications464(1)45-50(2015 Aug)
Chang H,Dong T,Ma X,Zhang T,Chen Z,Yang Z,Zhang Y

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
Human molecular genetics23(3)796-809(2014 Feb)
Chimusa ER,Zaitlen N,Daya M,M?ller M,van Helden PD,Mulder NJ,Price AL,Hoal EG

Experimental validation of 5 in-silico predicted glioma biomarkers.
Neuro-oncology15(12)1625-34(2013 Dec)
Towner RA,Jensen RL,Vaillant B,Colman H,Saunders D,Giles CB,Wren JD

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SPON1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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