PIAS3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIAS3
Entrez Gene ID	10401
Full Name	protein inhibitor of activated STAT 3
Synonyms	ZMIZ5
General protein information	Preferred Names protein inhibitor of activated STAT 3 Names E3 SUMO-protein ligase PIAS3 protein inhibitor of activated STAT protein 3 zinc finger, MIZ-type containing 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.1
Summary	This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	605987

mRNA and Protein(s)

mRNA	Protein	Name
NM_006099.3	NP_006090.2	E3 SUMO-protein ligase PIAS3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PIAS3	NP_001095655.1
Mus musculus (house mouse)	Pias3	NP_001159421.1
Pan troglodytes (chimpanzee)	PIAS3	XP_003949540.1
	PIAS3	XP_001095153.2
Canis lupus familiaris (dog)	PIAS3	XP_859310.2
Rattus norvegicus (Norway rat)	Pias3	NP_113972.2
Homo sapiens (human)	PIAS3	NP_006090.2
Xenopus tropicalis (tropical clawed frog)	pias3	NP_001116890.1

Gene Ontology

The following PIAS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIAS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu05295	NM_006099.3 Latest version!	Homo sapiens protein inhibitor of activated STAT 3 (PIAS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIAS3 ( NM_006099.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006090.2 Homo sapiens protein inhibitor of activated STAT 3 (PIAS3), mRNA.

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CloneID	OHu05295
Clone ID Related Accession (Same CDS sequence)	NM_006099.3
Accession Version	NM_006099.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1887bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	E3 SUMO-protein ligase PIAS3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE247489.1, AK027557.1 and AL160282.18. On Sep 22, 2006 this sequence version replaced NM_006099.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK027557.1, SRR1803613.216897.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000393045.7/ ENSP00000376765.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAGC TGGGCGAATT AAAGCACATG GTGATGAGTT TCCGGGTGTC TGAGCTCCAG 
GTGCTTCTTG GCTTTGCTGG CCGGAACAAG AGTGGACGGA AGCACGAGCT CCTGGCCAAG 
GCTCTGCACC TCCTGAAGTC CAGCTGTGCC CCTAGTGTCC AGATGAAGAT CAAAGAGCTT 
TACCGACGAC GCTTTCCCCG GAAGACCCTG GGGCCCTCTG ATCTCTCCCT TCTCTCTTTG 
CCCCCTGGCA CCTCTCCTGT AGGCTCCCCT GGTCCTCTAG CTCCCATTCC CCCAACGCTG 
TTGGCCCCTG GCACCCTGCT GGGCCCCAAG CGTGAGGTGG ACATGCACCC CCCTCTGCCC 
CAGCCTGTGC ACCCTGATGT CACCATGAAA CCATTGCCCT TCTATGAAGT CTATGGGGAG 
CTCATCCGGC CCACCACCCT TGCATCCACT TCTAGCCAGC GGTTTGAGGA AGCGCACTTT 
ACCTTTGCCC TCACACCCCA GCAAGTGCAG CAGATTCTTA CATCCAGAGA GGTTCTGCCA 
GGAGCCAAAT GTGATTATAC CATACAGGTG CAGCTAAGGT TCTGTCTCTG TGAGACCAGC 
TGCCCCCAGG AAGATTATTT TCCCCCCAAC CTCTTTGTCA AGGTCAATGG GAAACTGTGC 
CCCCTGCCGG GTTACCTTCC CCCAACCAAG AATGGGGCCG AGCCCAAGAG GCCCAGCCGC 
CCCATCAACA TCACACCCCT GGCTCGACTC TCAGCCACTG TTCCCAACAC CATTGTGGTC 
AATTGGTCAT CTGAGTTCGG ACGGAATTAC TCCTTGTCTG TGTACCTGGT GAGGCAGTTG 
ACTGCAGGAA CCCTTCTACA AAAACTCAGA GCAAAGGGTA TCCGGAACCC AGACCACTCG 
CGGGCACTGA TCAAGGAGAA ATTGACTGCT GACCCTGACA GTGAGGTGGC CACTACAAGT 
CTCCGGGTGT CACTCATGTG CCCGCTAGGG AAGATGCGCC TGACTGTCCC TTGTCGTGCC 
CTCACCTGCG CCCACCTGCA GAGCTTCGAT GCTGCCCTTT ATCTACAGAT GAATGAGAAG 
AAGCCTACAT GGACATGTCC TGTGTGTGAC AAGAAGGCTC CCTATGAATC TCTTATCATT 
GATGGTTTAT TTATGGAGAT TCTTAGTTCC TGTTCAGATT GTGATGAGAT CCAATTCATG 
GAAGATGGAT CCTGGTGCCC AATGAAACCC AAGAAGGAGG CATCTGAGGT TTGCCCCCCG 
CCAGGGTATG GGCTGGATGG CCTCCAGTAC AGCCCAGTCC AGGGGGGAGA TCCATCAGAG 
AATAAGAAGA AGGTCGAAGT TATTGACTTG ACAATAGAAA GCTCATCAGA TGAGGAGGAT 
CTGCCCCCTA CCAAGAAGCA CTGTTCTGTC ACCTCAGCTG CCATCCCGGC CCTACCTGGA 
AGCAAAGGAG TCCTGACATC TGGCCACCAG CCATCCTCGG TGCTAAGGAG CCCTGCTATG 
GGCACGTTGG GTGGGGATTT CCTGTCCAGT CTCCCACTAC ATGAGTACCC ACCTGCCTTC 
CCACTGGGAG CCGACATCCA AGGTTTAGAT TTATTTTCAT TTCTTCAGAC AGAGAGTCAG 
CACTATGGCC CCTCTGTCAT CACCTCACTA GATGAACAGG ATGCCCTTGG CCACTTCTTC 
CAGTACCGAG GGACCCCTTC TCACTTTCTG GGCCCACTGG CCCCCACGCT GGGGAGCTCC 
CACTGCAGCG CCACTCCGGC GCCCCCTCCT GGCCGTGTCA GCAGCATTGT GGCCCCTGGG 
GGGGCCTTGA GGGAGGGGCA TGGAGGACCC CTGCCCTCAG GTCCCTCTTT GACTGGCTGT 
CGGTCAGACA TCATTTCCCT GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006090.2
CDS	92..1978
Translation	MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLTSGHQPSSVLRSPAMGTLGGDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYGPSVITSLDEQDALGHFFQYRGTPSHFLGPLAPTLGSSHCSATPAPPPGRVSSIVAPGGALREGHGGPLPSGPSLTGCRSDIISLD

Target ORF information:

RefSeq Version	NM_006099.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein inhibitor of activated STAT 3 (PIAS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006099.3

ORF Insert Sequence:

ATGGCGGAGC TGGGCGAATT AAAGCACATG GTGATGAGTT TCCGGGTGTC TGAGCTCCAG 
GTGCTTCTTG GCTTTGCTGG CCGGAACAAG AGTGGACGGA AGCACGAGCT CCTGGCCAAG 
GCTCTGCACC TCCTGAAGTC CAGCTGTGCC CCTAGTGTCC AGATGAAGAT CAAAGAGCTT 
TACCGACGAC GCTTTCCCCG GAAGACCCTG GGGCCCTCTG ATCTCTCCCT TCTCTCTTTG 
CCCCCTGGCA CCTCTCCTGT AGGCTCCCCT GGTCCTCTAG CTCCCATTCC CCCAACGCTG 
TTGGCCCCTG GCACCCTGCT GGGCCCCAAG CGTGAGGTGG ACATGCACCC CCCTCTGCCC 
CAGCCTGTGC ACCCTGATGT CACCATGAAA CCATTGCCCT TCTATGAAGT CTATGGGGAG 
CTCATCCGGC CCACCACCCT TGCATCCACT TCTAGCCAGC GGTTTGAGGA AGCGCACTTT 
ACCTTTGCCC TCACACCCCA GCAAGTGCAG CAGATTCTTA CATCCAGAGA GGTTCTGCCA 
GGAGCCAAAT GTGATTATAC CATACAGGTG CAGCTAAGGT TCTGTCTCTG TGAGACCAGC 
TGCCCCCAGG AAGATTATTT TCCCCCCAAC CTCTTTGTCA AGGTCAATGG GAAACTGTGC 
CCCCTGCCGG GTTACCTTCC CCCAACCAAG AATGGGGCCG AGCCCAAGAG GCCCAGCCGC 
CCCATCAACA TCACACCCCT GGCTCGACTC TCAGCCACTG TTCCCAACAC CATTGTGGTC 
AATTGGTCAT CTGAGTTCGG ACGGAATTAC TCCTTGTCTG TGTACCTGGT GAGGCAGTTG 
ACTGCAGGAA CCCTTCTACA AAAACTCAGA GCAAAGGGTA TCCGGAACCC AGACCACTCG 
CGGGCACTGA TCAAGGAGAA ATTGACTGCT GACCCTGACA GTGAGGTGGC CACTACAAGT 
CTCCGGGTGT CACTCATGTG CCCGCTAGGG AAGATGCGCC TGACTGTCCC TTGTCGTGCC 
CTCACCTGCG CCCACCTGCA GAGCTTCGAT GCTGCCCTTT ATCTACAGAT GAATGAGAAG 
AAGCCTACAT GGACATGTCC TGTGTGTGAC AAGAAGGCTC CCTATGAATC TCTTATCATT 
GATGGTTTAT TTATGGAGAT TCTTAGTTCC TGTTCAGATT GTGATGAGAT CCAATTCATG 
GAAGATGGAT CCTGGTGCCC AATGAAACCC AAGAAGGAGG CATCTGAGGT TTGCCCCCCG 
CCAGGGTATG GGCTGGATGG CCTCCAGTAC AGCCCAGTCC AGGGGGGAGA TCCATCAGAG 
AATAAGAAGA AGGTCGAAGT TATTGACTTG ACAATAGAAA GCTCATCAGA TGAGGAGGAT 
CTGCCCCCTA CCAAGAAGCA CTGTTCTGTC ACCTCAGCTG CCATCCCGGC CCTACCTGGA 
AGCAAAGGAG TCCTGACATC TGGCCACCAG CCATCCTCGG TGCTAAGGAG CCCTGCTATG 
GGCACGTTGG GTGGGGATTT CCTGTCCAGT CTCCCACTAC ATGAGTACCC ACCTGCCTTC 
CCACTGGGAG CCGACATCCA AGGTTTAGAT TTATTTTCAT TTCTTCAGAC AGAGAGTCAG 
CACTATGGCC CCTCTGTCAT CACCTCACTA GATGAACAGG ATGCCCTTGG CCACTTCTTC 
CAGTACCGAG GGACCCCTTC TCACTTTCTG GGCCCACTGG CCCCCACGCT GGGGAGCTCC 
CACTGCAGCG CCACTCCGGC GCCCCCTCCT GGCCGTGTCA GCAGCATTGT GGCCCCTGGG 
GGGGCCTTGA GGGAGGGGCA TGGAGGACCC CTGCCCTCAG GTCCCTCTTT GACTGGCTGT 
CGGTCAGACA TCATTTCCCT GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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PIAS3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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