TUBB4B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TUBB4B
Entrez Gene ID	10383
Full Name	tubulin beta 4B class IVb
Synonyms	Beta2,TUBB2,TUBB2C
General protein information	Preferred Names tubulin beta 4B class IVb Names tubulin beta-4B chain class IVb beta tubulin tubulin beta-2 chain tubulin beta-2C chain tubulin, beta 2C tubulin, beta, 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q34.3
Disorder MIM:	602660

mRNA and Protein(s)

mRNA	Protein	Name
NM_006088.6	NP_006079.1	tubulin beta-4B chain
NM_006088.5	NP_006079.1	tubulin beta-4B chain

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TUBB4B	NP_001029835.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010929	XP_309765.4
Eremothecium gossypii	AGOS_ACR225C	NP_983627.1
Magnaporthe oryzae (rice blast fungus)	MGG_00604	XP_003718429.1
Arabidopsis thaliana (thale cress)	TUB1	NP_177706.1
Gallus gallus (chicken)	TUBB2C	NP_001074329.2
Caenorhabditis elegans (roundworm)	tbb-4	NP_509585.1
Saccharomyces cerevisiae (baker's yeast)	TUB2	NP_116616.1
Neurospora crassa	NCU04054	XP_957669.2
Oryza sativa (rice)	Os03g0780600	NP_001051451.1
Pan troglodytes (chimpanzee)	TUBB2C	NP_001233307.1
Canis lupus familiaris (dog)	LOC102153202	XP_005625117.1
Rattus norvegicus (Norway rat)	Tubb4b	NP_954525.1
Drosophila melanogaster (fruit fly)	betaTub56D	NP_523795.2
Schizosaccharomyces pombe (fission yeast)	nda3	NP_596650.1
Arabidopsis thaliana (thale cress)	TUB5	NP_564101.1
Danio rerio (zebrafish)	tubb4b	NP_942104.2
Homo sapiens (human)	TUBB4B	NP_006079.1
	TUBB2C	XP_002799957.1
Mus musculus (house mouse)	Tubb4b	NP_666228.1
Danio rerio (zebrafish)	zgc:55461	NP_998655.1
Kluyveromyces lactis	KLLA0D05269g	XP_453295.1
Oryza sativa (rice)	Os02g0167300	NP_001046006.1
Xenopus tropicalis (tropical clawed frog)	tubb4b	NP_001072450.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in TUBB4B Cause a Distinctive Sensorineural Disease.
Luscan R, Mechaussier S, Paul A, Tian G, G?rard X, Defoort-Dellhemmes S, Loundon N, Audo I, Bonnin S, LeGargasson JF, Dumont J, Goudin N, Garfa-Traor? M, Bras M, Pouliet A, Bessi?res B, Boddaert N, Sahel JA, Lyonnet S, Kaplan J, Cowan NJ, Rozet JM, Marlin S, Perrault I
American journal of human genetics101(6)1006-1012(2017 Dec)

Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages.
Wawro ME, Sobierajska K, Ciszewski WM, Wagner W, Frontczak M, Wieczorek K, Niewiarowska J
Cellular signalling3826-38(2017 Oct)

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A, Teunissen CE, de Wit H, Jim?nez CR
Journal of proteomics106191-204(2014 Jun)

A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation.
Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Blanca Ram?rez M, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, Harvey K
The Journal of biological chemistry289(2)895-908(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors identified TUBB4B mutations as the cause of a previously unreported autosomal-dominant syndrome manifesting as early-onset and severe photoreceptor and cochlear cell loss.
Title: Mutations in TUBB4B Cause a Distinctive Sensorineural Disease.

A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.

The results od this study found that betaI-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia.
Title: Regional differences in expression of ?-tubulin isoforms in schizophrenia.

Data suggest that increased expression of hnRNP A1, Ezrin, tubulin beta-2C and Annexin A1 in SLNMM indicate a significantly elevated early colorectal cancer metastasis.
Title: Up-regulation of hnRNP A1, Ezrin, tubulin ?-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.

Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl.
Title: Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin at Cys 12 and suppression of microtubule dynamics.

The following TUBB4B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TUBB4B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29613	NM_006088.6 Latest version!	Homo sapiens tubulin beta 4B class IVb (TUBB4B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu29613	NM_006088.5	Homo sapiens tubulin beta 4B class IVb (TUBB4B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TUBB4B ( NM_006088.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_006079.1 Homo sapiens tubulin beta 4B class IVb (TUBB4B), mRNA.

Price & Availability↑

CloneID	OHu29613
Clone ID Related Accession (Same CDS sequence)	NM_006088.6 , NM_006088.5
Accession Version	NM_006088.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	tubulin beta-4B chain
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB139156.1 and BC004188.2. On Nov 22, 2018 this sequence version replaced NM_006088.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029529.1, AK000560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000340384.5/ ENSP00000341289.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGGAAA TCGTGCACTT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTT 
TGGGAGGTGA TCAGCGATGA GCACGGCATC GACCCCACGG GCACCTACCA CGGGGACAGC 
GACCTGCAGC TGGAACGCAT CAACGTGTAC TACAATGAGG CCACCGGCGG CAAGTACGTG 
CCCCGCGCCG TGCTCGTGGA TCTGGAGCCC GGCACCATGG ACTCCGTGCG CTCGGGGCCC 
TTCGGGCAGA TCTTCCGGCC GGACAACTTC GTTTTCGGTC AGAGTGGTGC TGGGAACAAC 
TGGGCCAAGG GGCACTACAC AGAAGGCGCG GAGCTGGTGG ACTCGGTGCT GGATGTTGTG 
AGAAAGGAGG CTGAGAGCTG TGACTGCCTG CAGGGTTTCC AGCTGACCCA CTCCCTGGGT 
GGGGGGACTG GGTCTGGGAT GGGTACCCTC CTCATCAGCA AGATCCGGGA GGAGTACCCA 
GACAGGATCA TGAACACGTT TAGTGTGGTG CCTTCGCCCA AAGTGTCAGA CACAGTGGTG 
GAGCCCTACA ACGCCACCCT CTCAGTCCAC CAGCTCGTAG AAAACACAGA CGAGACCTAC 
TGCATTGATA ACGAAGCTCT CTACGACATT TGCTTCAGAA CCCTAAAGCT GACCACGCCC 
ACCTATGGTG ACCTGAACCA CCTGGTGTCT GCTACCATGA GTGGGGTCAC CACCTGCCTG 
CGCTTCCCAG GCCAGCTCAA TGCTGACCTG CGGAAGCTGG CTGTGAACAT GGTCCCGTTT 
CCCCGGCTGC ACTTCTTCAT GCCCGGCTTT GCCCCACTGA CCAGCCGGGG CAGCCAGCAG 
TACCGGGCGC TGACCGTGCC CGAGCTCACC CAGCAGATGT TTGATGCCAA GAACATGATG 
GCTGCCTGCG ACCCCCGCCA TGGCCGCTAC CTGACGGTTG CCGCCGTGTT CAGGGGCCGC 
ATGTCCATGA AGGAGGTGGA TGAGCAAATG CTTAATGTCC AAAACAAAAA CAGCAGCTAT 
TTTGTTGAGT GGATCCCCAA CAATGTGAAA ACGGCTGTCT GTGACATCCC ACCTCGGGGG 
CTAAAAATGT CCGCCACCTT CATTGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAATGA CCTGGTGTCC 
GAGTACCAGC AGTACCAGGA TGCCACAGCC GAGGAGGAGG GCGAGTTCGA GGAGGAGGCT 
GAGGAGGAGG TGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006079.1
CDS	75..1412
Translation	MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA

Target ORF information:

RefSeq Version	NM_006088.6
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 4B class IVb (TUBB4B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006088.6

ORF Insert Sequence:

ATGAGGGAAA TCGTGCACTT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTT 
TGGGAGGTGA TCAGCGATGA GCACGGCATC GACCCCACGG GCACCTACCA CGGGGACAGC 
GACCTGCAGC TGGAACGCAT CAACGTGTAC TACAATGAGG CCACCGGCGG CAAGTACGTG 
CCCCGCGCCG TGCTCGTGGA TCTGGAGCCC GGCACCATGG ACTCCGTGCG CTCGGGGCCC 
TTCGGGCAGA TCTTCCGGCC GGACAACTTC GTTTTCGGTC AGAGTGGTGC TGGGAACAAC 
TGGGCCAAGG GGCACTACAC AGAAGGCGCG GAGCTGGTGG ACTCGGTGCT GGATGTTGTG 
AGAAAGGAGG CTGAGAGCTG TGACTGCCTG CAGGGTTTCC AGCTGACCCA CTCCCTGGGT 
GGGGGGACTG GGTCTGGGAT GGGTACCCTC CTCATCAGCA AGATCCGGGA GGAGTACCCA 
GACAGGATCA TGAACACGTT TAGTGTGGTG CCTTCGCCCA AAGTGTCAGA CACAGTGGTG 
GAGCCCTACA ACGCCACCCT CTCAGTCCAC CAGCTCGTAG AAAACACAGA CGAGACCTAC 
TGCATTGATA ACGAAGCTCT CTACGACATT TGCTTCAGAA CCCTAAAGCT GACCACGCCC 
ACCTATGGTG ACCTGAACCA CCTGGTGTCT GCTACCATGA GTGGGGTCAC CACCTGCCTG 
CGCTTCCCAG GCCAGCTCAA TGCTGACCTG CGGAAGCTGG CTGTGAACAT GGTCCCGTTT 
CCCCGGCTGC ACTTCTTCAT GCCCGGCTTT GCCCCACTGA CCAGCCGGGG CAGCCAGCAG 
TACCGGGCGC TGACCGTGCC CGAGCTCACC CAGCAGATGT TTGATGCCAA GAACATGATG 
GCTGCCTGCG ACCCCCGCCA TGGCCGCTAC CTGACGGTTG CCGCCGTGTT CAGGGGCCGC 
ATGTCCATGA AGGAGGTGGA TGAGCAAATG CTTAATGTCC AAAACAAAAA CAGCAGCTAT 
TTTGTTGAGT GGATCCCCAA CAATGTGAAA ACGGCTGTCT GTGACATCCC ACCTCGGGGG 
CTAAAAATGT CCGCCACCTT CATTGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAATGA CCTGGTGTCC 
GAGTACCAGC AGTACCAGGA TGCCACAGCC GAGGAGGAGG GCGAGTTCGA GGAGGAGGCT 
GAGGAGGAGG TGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TUBB4B ( NM_006088.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006079.1 Homo sapiens tubulin beta 4B class IVb (TUBB4B), mRNA.

Price & Availability↑

CloneID	OHu29613
Clone ID Related Accession (Same CDS sequence)	NM_006088.6 , NM_006088.5
Accession Version	NM_006088.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	tubulin beta-4B chain
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB139156.1 and BC004188.2. On Jun 21, 2005 this sequence version replaced NM_006088.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.183641.1, SRR1163658.384490.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGAGGGAAA TCGTGCACTT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTT 
TGGGAGGTGA TCAGCGATGA GCACGGCATC GACCCCACGG GCACCTACCA CGGGGACAGC 
GACCTGCAGC TGGAACGCAT CAACGTGTAC TACAATGAGG CCACCGGCGG CAAGTACGTG 
CCCCGCGCCG TGCTCGTGGA TCTGGAGCCC GGCACCATGG ACTCCGTGCG CTCGGGGCCC 
TTCGGGCAGA TCTTCCGGCC GGACAACTTC GTTTTCGGTC AGAGTGGTGC TGGGAACAAC 
TGGGCCAAGG GGCACTACAC AGAAGGCGCG GAGCTGGTGG ACTCGGTGCT GGATGTTGTG 
AGAAAGGAGG CTGAGAGCTG TGACTGCCTG CAGGGTTTCC AGCTGACCCA CTCCCTGGGT 
GGGGGGACTG GGTCTGGGAT GGGTACCCTC CTCATCAGCA AGATCCGGGA GGAGTACCCA 
GACAGGATCA TGAACACGTT TAGTGTGGTG CCTTCGCCCA AAGTGTCAGA CACAGTGGTG 
GAGCCCTACA ACGCCACCCT CTCAGTCCAC CAGCTCGTAG AAAACACAGA CGAGACCTAC 
TGCATTGATA ACGAAGCTCT CTACGACATT TGCTTCAGAA CCCTAAAGCT GACCACGCCC 
ACCTATGGTG ACCTGAACCA CCTGGTGTCT GCTACCATGA GTGGGGTCAC CACCTGCCTG 
CGCTTCCCAG GCCAGCTCAA TGCTGACCTG CGGAAGCTGG CTGTGAACAT GGTCCCGTTT 
CCCCGGCTGC ACTTCTTCAT GCCCGGCTTT GCCCCACTGA CCAGCCGGGG CAGCCAGCAG 
TACCGGGCGC TGACCGTGCC CGAGCTCACC CAGCAGATGT TTGATGCCAA GAACATGATG 
GCTGCCTGCG ACCCCCGCCA TGGCCGCTAC CTGACGGTTG CCGCCGTGTT CAGGGGCCGC 
ATGTCCATGA AGGAGGTGGA TGAGCAAATG CTTAATGTCC AAAACAAAAA CAGCAGCTAT 
TTTGTTGAGT GGATCCCCAA CAATGTGAAA ACGGCTGTCT GTGACATCCC ACCTCGGGGG 
CTAAAAATGT CCGCCACCTT CATTGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAATGA CCTGGTGTCC 
GAGTACCAGC AGTACCAGGA TGCCACAGCC GAGGAGGAGG GCGAGTTCGA GGAGGAGGCT 
GAGGAGGAGG TGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006079.1
CDS	103..1440
Translation	MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA

Target ORF information:

RefSeq Version	NM_006088.5
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin beta 4B class IVb (TUBB4B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006088.5

ORF Insert Sequence:

ATGAGGGAAA TCGTGCACTT GCAGGCCGGG CAGTGCGGCA ACCAAATCGG CGCCAAGTTT 
TGGGAGGTGA TCAGCGATGA GCACGGCATC GACCCCACGG GCACCTACCA CGGGGACAGC 
GACCTGCAGC TGGAACGCAT CAACGTGTAC TACAATGAGG CCACCGGCGG CAAGTACGTG 
CCCCGCGCCG TGCTCGTGGA TCTGGAGCCC GGCACCATGG ACTCCGTGCG CTCGGGGCCC 
TTCGGGCAGA TCTTCCGGCC GGACAACTTC GTTTTCGGTC AGAGTGGTGC TGGGAACAAC 
TGGGCCAAGG GGCACTACAC AGAAGGCGCG GAGCTGGTGG ACTCGGTGCT GGATGTTGTG 
AGAAAGGAGG CTGAGAGCTG TGACTGCCTG CAGGGTTTCC AGCTGACCCA CTCCCTGGGT 
GGGGGGACTG GGTCTGGGAT GGGTACCCTC CTCATCAGCA AGATCCGGGA GGAGTACCCA 
GACAGGATCA TGAACACGTT TAGTGTGGTG CCTTCGCCCA AAGTGTCAGA CACAGTGGTG 
GAGCCCTACA ACGCCACCCT CTCAGTCCAC CAGCTCGTAG AAAACACAGA CGAGACCTAC 
TGCATTGATA ACGAAGCTCT CTACGACATT TGCTTCAGAA CCCTAAAGCT GACCACGCCC 
ACCTATGGTG ACCTGAACCA CCTGGTGTCT GCTACCATGA GTGGGGTCAC CACCTGCCTG 
CGCTTCCCAG GCCAGCTCAA TGCTGACCTG CGGAAGCTGG CTGTGAACAT GGTCCCGTTT 
CCCCGGCTGC ACTTCTTCAT GCCCGGCTTT GCCCCACTGA CCAGCCGGGG CAGCCAGCAG 
TACCGGGCGC TGACCGTGCC CGAGCTCACC CAGCAGATGT TTGATGCCAA GAACATGATG 
GCTGCCTGCG ACCCCCGCCA TGGCCGCTAC CTGACGGTTG CCGCCGTGTT CAGGGGCCGC 
ATGTCCATGA AGGAGGTGGA TGAGCAAATG CTTAATGTCC AAAACAAAAA CAGCAGCTAT 
TTTGTTGAGT GGATCCCCAA CAATGTGAAA ACGGCTGTCT GTGACATCCC ACCTCGGGGG 
CTAAAAATGT CCGCCACCTT CATTGGCAAC AGCACGGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCCGAGC AGTTCACGGC CATGTTCCGG CGCAAGGCCT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAATGA CCTGGTGTCC 
GAGTACCAGC AGTACCAGGA TGCCACAGCC GAGGAGGAGG GCGAGTTCGA GGAGGAGGCT 
GAGGAGGAGG TGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in TUBB4B Cause a Distinctive Sensorineural Disease.
American journal of human genetics101(6)1006-1012(2017 Dec)
Luscan R,Mechaussier S,Paul A,Tian G,G?rard X,Defoort-Dellhemmes S,Loundon N,Audo I,Bonnin S,LeGargasson JF,Dumont J,Goudin N,Garfa-Traor? M,Bras M,Pouliet A,Bessi?res B,Boddaert N,Sahel JA,Lyonnet S,Kaplan J,Cowan NJ,Rozet JM,Marlin S,Perrault I

Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages.
Cellular signalling3826-38(2017 Oct)
Wawro ME,Sobierajska K,Ciszewski WM,Wagner W,Frontczak M,Wieczorek K,Niewiarowska J

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Journal of proteomics106191-204(2014 Jun)
Chiasserini D,van Weering JR,Piersma SR,Pham TV,Malekzadeh A,Teunissen CE,de Wit H,Jim?nez CR

A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation.
The Journal of biological chemistry289(2)895-908(2014 Jan)
Law BM,Spain VA,Leinster VH,Chia R,Beilina A,Cho HJ,Taymans JM,Urban MK,Sancho RM,Blanca Ram?rez M,Biskup S,Baekelandt V,Cai H,Cookson MR,Berwick DC,Harvey K

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TUBB4B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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