CACNG3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CACNG3
Entrez Gene ID	10368
Full Name	calcium voltage-gated channel auxiliary subunit gamma 3
General protein information	Preferred Names calcium voltage-gated channel auxiliary subunit gamma 3 Names voltage-dependent calcium channel gamma-3 subunit TARP gamma-3 calcium channel, voltage-dependent, gamma subunit 3 neuronal voltage-gated calcium channel gamma-3 subunit transmembrane AMPAR regulatory protein gamma-3 voltage-gated calcium channel gamma subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p12.1
Summary	The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010].
Disorder MIM:	606403

mRNA and Protein(s)

mRNA	Protein	Name
NM_006539.4	NP_006530.1	voltage-dependent calcium channel gamma-3 subunit
NM_006539.3	NP_006530.1	voltage-dependent calcium channel gamma-3 subunit

Pathways from BioSystems

Homologies

Homo sapiens (human)	CACNG3	NP_006530.1
Bos taurus (cattle)	CACNG3	NP_001071482.1
Gallus gallus (chicken)	CACNG3	NP_989991.1
Danio rerio (zebrafish)	cacng3b	XP_693299.1
Xenopus tropicalis (tropical clawed frog)	cacng3	XP_002932480.1
Canis lupus familiaris (dog)	CACNG3	XP_850259.1
Rattus norvegicus (Norway rat)	Cacng3	NP_542422.1
	CACNG3	XP_001096560.1
Mus musculus (house mouse)	Cacng3	NP_062303.2

Gene Ontology
Bibliography

Related articles in PubMed

Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility.
Spencer KL, Olson LM, Schnetz-Boutaud N, Gallins P, Wang G, Scott WK, Agarwal A, Jakobsdottir J, Conley Y, Weeks DE, Gorin MB, Pericak-Vance MA, Haines JL
Investigative ophthalmology & visual science52(3)1748-54(2011 Mar)

TARPs differentially decorate AMPA receptors to specify neuropharmacology.
Kato AS, Gill MB, Yu H, Nisenbaum ES, Bredt DS
Trends in neurosciences33(5)241-8(2010 May)

Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins.
Sager C, Tapken D, Kott S, Hollmann M
Neuroscience158(1)45-54(2009 Jan)

Linkage and association analysis of CACNG3 in childhood absence epilepsy.
Everett KV, Chioza B, Aicardi J, Aschauer H, Brouwer O, Callenbach P, Covanis A, Dulac O, Eeg-Olofsson O, Feucht M, Friis M, Goutieres F, Guerrini R, Heils A, Kjeldsen M, Lehesjoki AE, Makoff A, Nabbout R, Olsson I, Sander T, Sir?n A, McKeigue P, Robinson R, Taske N, Rees M, Gardiner M
European journal of human genetics : EJHG15(4)463-72(2007 Apr)

Calcium channel gamma subunits: a functionally diverse protein family.
Chen RS, Deng TC, Garcia T, Sellers ZM, Best PM
Cell biochemistry and biophysics47(2)178-86(2007)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that CACNG3 is the best candidate for an age-related macular degeneration risk gene within the 16p12 linkage peak.
Title: Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility.

CACNG3 on chromosome 16p12-p13.1 may represent susceptibility loci for CAE.
Title: Linkage and association analysis of CACNG3 in childhood absence epilepsy.

examined distribution of the stargazin-like proteins gamma2, gamma3, and gamma4 in human CNS: gamma2 is expressed in cerebellum, cerebral cortex, hippocampus and thalamus, whereas gamma3 abounds in cerebral cortex & amygdala and gamma4 in basal ganglia
Title: Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.

The following CACNG3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CACNG3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07954	NM_006539.4 Latest version!	Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 3 (CACNG3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu07954	NM_006539.3	Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 3 (CACNG3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CACNG3 ( NM_006539.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006530.1 Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 3 (CACNG3), mRNA.

Price & Availability↑

CloneID	OHu07954
Clone ID Related Accession (Same CDS sequence)	NM_006539.4 , NM_006539.3
Accession Version	NM_006539.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	voltage-dependent calcium channel gamma-3 subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC037899.1, AC004125.1 and H04803.1. On Dec 3, 2010 this sequence version replaced NM_006539.2. ##Evidence-Data-START## Transcript exon combination :: BC037899.1, AK095553.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGATGT GTGACAGAGG TATCCAGATG TTGATCACCA CTGTAGGAGC CTTTGCCGCT 
TTTAGTTTAA TGACCATTGC AGTGGGCACG GACTACTGGT TATATTCCAG AGGTGTGTGC 
AGGACTAAAT CTACAAGTGA TAATGAAACC AGCAGGAAGA ATGAAGAAGT AATGACCCAT 
TCGGGGCTGT GGAGGACCTG CTGCCTAGAA GGGGCTTTCC GAGGCGTGTG CAAGAAAATC 
GATCACTTCC CTGAAGATGC TGACTACGAA CAGGACACAG CCGAATATCT CCTGCGAGCT 
GTGAGGGCCT CCAGTGTCTT CCCCATCCTC AGTGTCACGC TGCTGTTCTT CGGCGGGCTC 
TGCGTGGCAG CCAGTGAGTT CCACCGCAGC AGACACAACG TCATTCTCAG CGCGGGCATC 
TTTTTTGTCT CTGCAGGGTT AAGCAACATC ATTGGCATCA TAGTTTATAT ATCAGCCAAC 
GCCGGAGACC CCGGGCAGCG TGACTCCAAA AAAAGTTACT CCTATGGTTG GTCCTTTTAT 
TTCGGAGCCT TCTCTTTCAT CATCGCAGAA ATTGTAGGAG TGGTTGCCGT GCACATCTAT 
ATTGAAAAAC ATCAGCAGTT ACGAGCCAAA TCCCACTCGG AGTTCCTGAA GAAATCTACT 
TTTGCCCGCC TCCCACCCTA CAGGTATCGA TTCCGGAGGC GGTCAAGTTC TCGCTCCACC 
GAGCCCAGAT CCCGAGACCT GTCCCCCATC AGCAAAGGCT TCCACACCAT CCCTTCCACT 
GACATCTCGA TGTTCACCCT CTCCCGGGAC CCCTCAAAGA TCACCATGGG GACCCTCCTC 
AACTCCGACC GGGACCACGC TTTTCTACAG TTCCACAATT CCACACCCAA AGAGTTCAAA 
GAGTCACTGC ATAATAATCC GGCCAACAGG CGCACCACGC CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006530.1
CDS	1203..2150
Translation	MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHNVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAKSHSEFLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKITMGTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV

Target ORF information:

RefSeq Version	NM_006539.3
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 3 (CACNG3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006539.3

ORF Insert Sequence:

ATGAGGATGT GTGACAGAGG TATCCAGATG TTGATCACCA CTGTAGGAGC CTTTGCCGCT 
TTTAGTTTAA TGACCATTGC AGTGGGCACG GACTACTGGT TATATTCCAG AGGTGTGTGC 
AGGACTAAAT CTACAAGTGA TAATGAAACC AGCAGGAAGA ATGAAGAAGT AATGACCCAT 
TCGGGGCTGT GGAGGACCTG CTGCCTAGAA GGGGCTTTCC GAGGCGTGTG CAAGAAAATC 
GATCACTTCC CTGAAGATGC TGACTACGAA CAGGACACAG CCGAATATCT CCTGCGAGCT 
GTGAGGGCCT CCAGTGTCTT CCCCATCCTC AGTGTCACGC TGCTGTTCTT CGGCGGGCTC 
TGCGTGGCAG CCAGTGAGTT CCACCGCAGC AGACACAACG TCATTCTCAG CGCGGGCATC 
TTTTTTGTCT CTGCAGGGTT AAGCAACATC ATTGGCATCA TAGTTTATAT ATCAGCCAAC 
GCCGGAGACC CCGGGCAGCG TGACTCCAAA AAAAGTTACT CCTATGGTTG GTCCTTTTAT 
TTCGGAGCCT TCTCTTTCAT CATCGCAGAA ATTGTAGGAG TGGTTGCCGT GCACATCTAT 
ATTGAAAAAC ATCAGCAGTT ACGAGCCAAA TCCCACTCGG AGTTCCTGAA GAAATCTACT 
TTTGCCCGCC TCCCACCCTA CAGGTATCGA TTCCGGAGGC GGTCAAGTTC TCGCTCCACC 
GAGCCCAGAT CCCGAGACCT GTCCCCCATC AGCAAAGGCT TCCACACCAT CCCTTCCACT 
GACATCTCGA TGTTCACCCT CTCCCGGGAC CCCTCAAAGA TCACCATGGG GACCCTCCTC 
AACTCCGACC GGGACCACGC TTTTCTACAG TTCCACAATT CCACACCCAA AGAGTTCAAA 
GAGTCACTGC ATAATAATCC GGCCAACAGG CGCACCACGC CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CACNG3 ( NM_006539.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006530.1 Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 3 (CACNG3), mRNA.

Price & Availability↑

CloneID	OHu07954
Clone ID Related Accession (Same CDS sequence)	NM_006539.4 , NM_006539.3
Accession Version	NM_006539.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	voltage-dependent calcium channel gamma-3 subunit
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004125.1. On Aug 14, 2019 this sequence version replaced NM_006539.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.263009.1, SRR1803613.49646.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGATGT GTGACAGAGG TATCCAGATG TTGATCACCA CTGTAGGAGC CTTTGCCGCT 
TTTAGTTTAA TGACCATTGC AGTGGGCACG GACTACTGGT TATATTCCAG AGGTGTGTGC 
AGGACTAAAT CTACAAGTGA TAATGAAACC AGCAGGAAGA ATGAAGAAGT AATGACCCAT 
TCGGGGCTGT GGAGGACCTG CTGCCTAGAA GGGGCTTTCC GAGGCGTGTG CAAGAAAATC 
GATCACTTCC CTGAAGATGC TGACTACGAA CAGGACACAG CCGAATATCT CCTGCGAGCT 
GTGAGGGCCT CCAGTGTCTT CCCCATCCTC AGTGTCACGC TGCTGTTCTT CGGCGGGCTC 
TGCGTGGCAG CCAGTGAGTT CCACCGCAGC AGACACAACG TCATTCTCAG CGCGGGCATC 
TTTTTTGTCT CTGCAGGGTT AAGCAACATC ATTGGCATCA TAGTTTATAT ATCAGCCAAC 
GCCGGAGACC CCGGGCAGCG TGACTCCAAA AAAAGTTACT CCTATGGTTG GTCCTTTTAT 
TTCGGAGCCT TCTCTTTCAT CATCGCAGAA ATTGTAGGAG TGGTTGCCGT GCACATCTAT 
ATTGAAAAAC ATCAGCAGTT ACGAGCCAAA TCCCACTCGG AGTTCCTGAA GAAATCTACT 
TTTGCCCGCC TCCCACCCTA CAGGTATCGA TTCCGGAGGC GGTCAAGTTC TCGCTCCACC 
GAGCCCAGAT CCCGAGACCT GTCCCCCATC AGCAAAGGCT TCCACACCAT CCCTTCCACT 
GACATCTCGA TGTTCACCCT CTCCCGGGAC CCCTCAAAGA TCACCATGGG GACCCTCCTC 
AACTCCGACC GGGACCACGC TTTTCTACAG TTCCACAATT CCACACCCAA AGAGTTCAAA 
GAGTCACTGC ATAATAATCC GGCCAACAGG CGCACCACGC CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006530.1
CDS	421..1368
Translation	MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHNVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAKSHSEFLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKITMGTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV

Target ORF information:

RefSeq Version	NM_006539.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calcium voltage-gated channel auxiliary subunit gamma 3 (CACNG3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006539.4

ORF Insert Sequence:

ATGAGGATGT GTGACAGAGG TATCCAGATG TTGATCACCA CTGTAGGAGC CTTTGCCGCT 
TTTAGTTTAA TGACCATTGC AGTGGGCACG GACTACTGGT TATATTCCAG AGGTGTGTGC 
AGGACTAAAT CTACAAGTGA TAATGAAACC AGCAGGAAGA ATGAAGAAGT AATGACCCAT 
TCGGGGCTGT GGAGGACCTG CTGCCTAGAA GGGGCTTTCC GAGGCGTGTG CAAGAAAATC 
GATCACTTCC CTGAAGATGC TGACTACGAA CAGGACACAG CCGAATATCT CCTGCGAGCT 
GTGAGGGCCT CCAGTGTCTT CCCCATCCTC AGTGTCACGC TGCTGTTCTT CGGCGGGCTC 
TGCGTGGCAG CCAGTGAGTT CCACCGCAGC AGACACAACG TCATTCTCAG CGCGGGCATC 
TTTTTTGTCT CTGCAGGGTT AAGCAACATC ATTGGCATCA TAGTTTATAT ATCAGCCAAC 
GCCGGAGACC CCGGGCAGCG TGACTCCAAA AAAAGTTACT CCTATGGTTG GTCCTTTTAT 
TTCGGAGCCT TCTCTTTCAT CATCGCAGAA ATTGTAGGAG TGGTTGCCGT GCACATCTAT 
ATTGAAAAAC ATCAGCAGTT ACGAGCCAAA TCCCACTCGG AGTTCCTGAA GAAATCTACT 
TTTGCCCGCC TCCCACCCTA CAGGTATCGA TTCCGGAGGC GGTCAAGTTC TCGCTCCACC 
GAGCCCAGAT CCCGAGACCT GTCCCCCATC AGCAAAGGCT TCCACACCAT CCCTTCCACT 
GACATCTCGA TGTTCACCCT CTCCCGGGAC CCCTCAAAGA TCACCATGGG GACCCTCCTC 
AACTCCGACC GGGACCACGC TTTTCTACAG TTCCACAATT CCACACCCAA AGAGTTCAAA 
GAGTCACTGC ATAATAATCC GGCCAACAGG CGCACCACGC CCGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility.
Investigative ophthalmology & visual science52(3)1748-54(2011 Mar)
Spencer KL,Olson LM,Schnetz-Boutaud N,Gallins P,Wang G,Scott WK,Agarwal A,Jakobsdottir J,Conley Y,Weeks DE,Gorin MB,Pericak-Vance MA,Haines JL

TARPs differentially decorate AMPA receptors to specify neuropharmacology.
Trends in neurosciences33(5)241-8(2010 May)
Kato AS,Gill MB,Yu H,Nisenbaum ES,Bredt DS

Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins.
Neuroscience158(1)45-54(2009 Jan)
Sager C,Tapken D,Kott S,Hollmann M

Linkage and association analysis of CACNG3 in childhood absence epilepsy.
European journal of human genetics : EJHG15(4)463-72(2007 Apr)
Everett KV,Chioza B,Aicardi J,Aschauer H,Brouwer O,Callenbach P,Covanis A,Dulac O,Eeg-Olofsson O,Feucht M,Friis M,Goutieres F,Guerrini R,Heils A,Kjeldsen M,Lehesjoki AE,Makoff A,Nabbout R,Olsson I,Sander T,Sir?n A,McKeigue P,Robinson R,Taske N,Rees M,Gardiner M

Calcium channel gamma subunits: a functionally diverse protein family.
Cell biochemistry and biophysics47(2)178-86(2007)
Chen RS,Deng TC,Garcia T,Sellers ZM,Best PM

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CACNG3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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