CDKN2C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDKN2C
Entrez Gene ID	1031
Full Name	cyclin dependent kinase inhibitor 2C
Synonyms	INK4C,p18,p18-INK4C
General protein information	Preferred Names cyclin dependent kinase inhibitor 2C Names cyclin-dependent kinase 4 inhibitor C CDK6 inhibitor p18 cyclin-dependent inhibitor cyclin-dependent kinase 6 inhibitor p18 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) p18-INK6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p32.3
Summary	The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].
Disorder MIM:	603369

mRNA and Protein(s)

mRNA	Protein	Name
NM_078626.2	NP_523240.1	cyclin-dependent kinase 4 inhibitor C
NM_078626.3	NP_523240.1	cyclin-dependent kinase 4 inhibitor C
NM_001262.2	NP_001253.1	cyclin-dependent kinase 4 inhibitor C

Pathways from BioSystems

Homologies

	CDKN2C	XP_001110979.1
Bos taurus (cattle)	CDKN2C	NP_001094524.1
Rattus norvegicus (Norway rat)	Cdkn2c	NP_571977.1
Gallus gallus (chicken)	CDKN2C	XP_004936837.1
Homo sapiens (human)	CDKN2C	NP_001253.1
Pan troglodytes (chimpanzee)	CDKN2C	XP_524704.2
Canis lupus familiaris (dog)	CDKN2C	XP_849772.1
Mus musculus (house mouse)	Cdkn2c	NP_031697.1
Danio rerio (zebrafish)	cdkn2c	NP_001186923.1
Xenopus tropicalis (tropical clawed frog)	cdkn2c	NP_001116932.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of p27
Conemans EB, Raicu-Ionita GM, Pieterman CRC, Dreijerink KMA, Dekkers OM, Hermus AR, de Herder WW, Drent ML, van der Horst-Schrivers ANA, Havekes B, Bisschop PH, Offerhaus GJ, Borel Rinkes IHM, Valk GD, Timmers HTM, Vriens MR
Journal of endocrinological investigation(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of P18 through claudin7.
Liu H, Jiang F, Jia X, Lan J, Guo H, Li E, Yan A, Wang Y
Oncotarget8(6)10298-10311(2017 Feb)

Repression of CDKN2C caused by PML/RAR? binding promotes the proliferation and differentiation block in acute promyelocytic leukemia.
Wang X, Tan Y, Li Y, Li J, Jin W, Wang K
Frontiers of medicine10(4)420-429(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CDKN2C gene deletion is associated with plasma cell post-transplantation lymphoproliferative disorders.
Title: Array-CGH predicts prognosis in plasma cell post-transplantation lymphoproliferative disorders.

CDKN2C inactivation contributes to the leukemogenesis in acute promyelocytic leukemia.
Title: Repression of CDKN2C caused by PML/RAR? binding promotes the proliferation and differentiation block in acute promyelocytic leukemia.

Our study suggests that p18 is a limiting factor for the noncanonical HSC differentiation path in lymphoid lineages.
Title: A novel lymphoid progenitor cell population (LSK(low)) is restricted by p18(INK4c).

The differences in p18(INK4c)and p57(Kip2)activities in chronic myeloid leukemia and normal stem cells suggest a different cell cycle regulation.
Title: CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.

Data suggest that cell cycle-dependent kinase inhibitors CDKN2C/p18 and CDKN1A/p21 facilitate cell cycle entry/cell proliferation of quiescent adult human pancreatic beta cells in primary culture (from tissues obtained from organ donors).
Title: High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation.

The following CDKN2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29564	NM_078626.3 Latest version!	Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29564	NM_001262.2 Latest version!	Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29564	NM_078626.2	Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDKN2C ( NM_078626.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_523240.1 Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29564
Clone ID Related Accession (Same CDS sequence)	NM_078626.2 , NM_078626.3 , NM_001262.2
Accession Version	NM_078626.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 4 inhibitor C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE831176.1, U17074.1 and BE783451.1. On Mar 16, 2006 this sequence version replaced NM_078626.1. Transcript Variant: This variant (2) contains a different 5' UTR region, and encodes an identical protein, when compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279829.1992.1, SRR1803613.471888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGC CTTGGGGGAA CGAGTTGGCG TCCGCAGCTG CCAGGGGGGA CCTAGAGCAA 
CTTACTAGTT TGTTGCAAAA TAATGTAAAC GTCAATGCAC AAAATGGATT TGGAAGGACT 
GCGCTGCAGG TTATGAAACT TGGAAATCCC GAGATTGCCA GGAGACTGCT ACTTAGAGGT 
GCTAATCCCG ATTTGAAAGA CCGAACTGGT TTCGCTGTCA TTCATGATGC GGCCAGAGCA 
GGTTTCCTGG ACACTTTACA GACTTTGCTG GAGTTTCAAG CTGATGTTAA CATCGAGGAT 
AATGAAGGGA ACCTGCCCTT GCACTTGGCT GCCAAAGAAG GCCACCTCCG GGTGGTGGAG 
TTCCTGGTGA AGCACACGGC CAGCAATGTG GGGCATCGGA ACCATAAGGG GGACACCGCC 
TGTGATTTGG CCAGGCTCTA TGGGAGGAAT GAGGTTGTTA GCCTGATGCA GGCAAACGGG 
GCTGGGGGAG CCACAAATCT TCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523240.1
CDS	400..906
Translation	MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ

Target ORF information:

RefSeq Version	NM_078626.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078626.2

ORF Insert Sequence:

ATGGCCGAGC CTTGGGGGAA CGAGTTGGCG TCCGCAGCTG CCAGGGGGGA CCTAGAGCAA 
CTTACTAGTT TGTTGCAAAA TAATGTAAAC GTCAATGCAC AAAATGGATT TGGAAGGACT 
GCGCTGCAGG TTATGAAACT TGGAAATCCC GAGATTGCCA GGAGACTGCT ACTTAGAGGT 
GCTAATCCCG ATTTGAAAGA CCGAACTGGT TTCGCTGTCA TTCATGATGC GGCCAGAGCA 
GGTTTCCTGG ACACTTTACA GACTTTGCTG GAGTTTCAAG CTGATGTTAA CATCGAGGAT 
AATGAAGGGA ACCTGCCCTT GCACTTGGCT GCCAAAGAAG GCCACCTCCG GGTGGTGGAG 
TTCCTGGTGA AGCACACGGC CAGCAATGTG GGGCATCGGA ACCATAAGGG GGACACCGCC 
TGTGATTTGG CCAGGCTCTA TGGGAGGAAT GAGGTTGTTA GCCTGATGCA GGCAAACGGG 
GCTGGGGGAG CCACAAATCT TCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDKN2C ( NM_078626.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_523240.1 Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29564
Clone ID Related Accession (Same CDS sequence)	NM_078626.2 , NM_078626.3 , NM_001262.2
Accession Version	NM_078626.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 4 inhibitor C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE831176.1, U17074.1 and BE783451.1. On Nov 23, 2018 this sequence version replaced NM_078626.2. Transcript Variant: This variant (2) contains a different 5' UTR region, and encodes an identical protein, when compared to variant 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.178934.1, SRR5189658.127989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371761.4/ ENSP00000360826.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAGC CTTGGGGGAA CGAGTTGGCG TCCGCAGCTG CCAGGGGGGA CCTAGAGCAA 
CTTACTAGTT TGTTGCAAAA TAATGTAAAC GTCAATGCAC AAAATGGATT TGGAAGGACT 
GCGCTGCAGG TTATGAAACT TGGAAATCCC GAGATTGCCA GGAGACTGCT ACTTAGAGGT 
GCTAATCCCG ATTTGAAAGA CCGAACTGGT TTCGCTGTCA TTCATGATGC GGCCAGAGCA 
GGTTTCCTGG ACACTTTACA GACTTTGCTG GAGTTTCAAG CTGATGTTAA CATCGAGGAT 
AATGAAGGGA ACCTGCCCTT GCACTTGGCT GCCAAAGAAG GCCACCTCCG GGTGGTGGAG 
TTCCTGGTGA AGCACACGGC CAGCAATGTG GGGCATCGGA ACCATAAGGG GGACACCGCC 
TGTGATTTGG CCAGGCTCTA TGGGAGGAAT GAGGTTGTTA GCCTGATGCA GGCAAACGGG 
GCTGGGGGAG CCACAAATCT TCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523240.1
CDS	125..631
Translation	MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ

Target ORF information:

RefSeq Version	NM_078626.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078626.3

ORF Insert Sequence:

ATGGCCGAGC CTTGGGGGAA CGAGTTGGCG TCCGCAGCTG CCAGGGGGGA CCTAGAGCAA 
CTTACTAGTT TGTTGCAAAA TAATGTAAAC GTCAATGCAC AAAATGGATT TGGAAGGACT 
GCGCTGCAGG TTATGAAACT TGGAAATCCC GAGATTGCCA GGAGACTGCT ACTTAGAGGT 
GCTAATCCCG ATTTGAAAGA CCGAACTGGT TTCGCTGTCA TTCATGATGC GGCCAGAGCA 
GGTTTCCTGG ACACTTTACA GACTTTGCTG GAGTTTCAAG CTGATGTTAA CATCGAGGAT 
AATGAAGGGA ACCTGCCCTT GCACTTGGCT GCCAAAGAAG GCCACCTCCG GGTGGTGGAG 
TTCCTGGTGA AGCACACGGC CAGCAATGTG GGGCATCGGA ACCATAAGGG GGACACCGCC 
TGTGATTTGG CCAGGCTCTA TGGGAGGAAT GAGGTTGTTA GCCTGATGCA GGCAAACGGG 
GCTGGGGGAG CCACAAATCT TCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDKN2C ( NM_001262.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001253.1 Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29564
Clone ID Related Accession (Same CDS sequence)	NM_078626.2 , NM_078626.3 , NM_001262.2
Accession Version	NM_001262.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 4 inhibitor C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF041248.1. On or before Mar 16, 2006 this sequence version replaced XM_932741.1, XM_945305.1, NM_001262.1. Transcript Variant: This variant (1) contains a different 5' UTR region, and encodes an identical protein, when compared to variant 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF041248.1, BC005041.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGC CTTGGGGGAA CGAGTTGGCG TCCGCAGCTG CCAGGGGGGA CCTAGAGCAA 
CTTACTAGTT TGTTGCAAAA TAATGTAAAC GTCAATGCAC AAAATGGATT TGGAAGGACT 
GCGCTGCAGG TTATGAAACT TGGAAATCCC GAGATTGCCA GGAGACTGCT ACTTAGAGGT 
GCTAATCCCG ATTTGAAAGA CCGAACTGGT TTCGCTGTCA TTCATGATGC GGCCAGAGCA 
GGTTTCCTGG ACACTTTACA GACTTTGCTG GAGTTTCAAG CTGATGTTAA CATCGAGGAT 
AATGAAGGGA ACCTGCCCTT GCACTTGGCT GCCAAAGAAG GCCACCTCCG GGTGGTGGAG 
TTCCTGGTGA AGCACACGGC CAGCAATGTG GGGCATCGGA ACCATAAGGG GGACACCGCC 
TGTGATTTGG CCAGGCTCTA TGGGAGGAAT GAGGTTGTTA GCCTGATGCA GGCAAACGGG 
GCTGGGGGAG CCACAAATCT TCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001253.1
CDS	1217..1723
Translation	MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ

Target ORF information:

RefSeq Version	NM_001262.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001262.2

ORF Insert Sequence:

ATGGCCGAGC CTTGGGGGAA CGAGTTGGCG TCCGCAGCTG CCAGGGGGGA CCTAGAGCAA 
CTTACTAGTT TGTTGCAAAA TAATGTAAAC GTCAATGCAC AAAATGGATT TGGAAGGACT 
GCGCTGCAGG TTATGAAACT TGGAAATCCC GAGATTGCCA GGAGACTGCT ACTTAGAGGT 
GCTAATCCCG ATTTGAAAGA CCGAACTGGT TTCGCTGTCA TTCATGATGC GGCCAGAGCA 
GGTTTCCTGG ACACTTTACA GACTTTGCTG GAGTTTCAAG CTGATGTTAA CATCGAGGAT 
AATGAAGGGA ACCTGCCCTT GCACTTGGCT GCCAAAGAAG GCCACCTCCG GGTGGTGGAG 
TTCCTGGTGA AGCACACGGC CAGCAATGTG GGGCATCGGA ACCATAAGGG GGACACCGCC 
TGTGATTTGG CCAGGCTCTA TGGGAGGAAT GAGGTTGTTA GCCTGATGCA GGCAAACGGG 
GCTGGGGGAG CCACAAATCT TCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of p27
Journal of endocrinological investigation(2017 Nov)
Conemans EB,Raicu-Ionita GM,Pieterman CRC,Dreijerink KMA,Dekkers OM,Hermus AR,de Herder WW,Drent ML,van der Horst-Schrivers ANA,Havekes B,Bisschop PH,Offerhaus GJ,Borel Rinkes IHM,Valk GD,Timmers HTM,Vriens MR

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of P18 through claudin7.
Oncotarget8(6)10298-10311(2017 Feb)
Liu H,Jiang F,Jia X,Lan J,Guo H,Li E,Yan A,Wang Y

Repression of CDKN2C caused by PML/RAR? binding promotes the proliferation and differentiation block in acute promyelocytic leukemia.
Frontiers of medicine10(4)420-429(2016 Dec)
Wang X,Tan Y,Li Y,Li J,Jin W,Wang K

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CDKN2C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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