CDKN2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDKN2B
Entrez Gene ID	1030
Full Name	cyclin dependent kinase inhibitor 2B
Synonyms	CDK4I,INK4B,MTS2,P15,TP15,p15INK4b
General protein information	Preferred Names cyclin dependent kinase inhibitor 2B Names cyclin-dependent kinase 4 inhibitor B CDK inhibitory protein CDK4B inhibitor MTS-2 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) cyclin-dependent kinases 4 and 6 binding protein multiple tumor suppressor 2 p14-INK4b p14_CDK inhibitor p14_INK4B p15 CDK inhibitor p15-INK4b p15_INK4B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.3
Summary	This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
Disorder MIM:	600431

mRNA and Protein(s)

mRNA	Protein	Name
NM_004936.3	NP_004927.2	cyclin-dependent kinase 4 inhibitor B isoform 1
NM_004936.4	NP_004927.2	cyclin-dependent kinase 4 inhibitor B isoform 1
NM_078487.2	NP_511042.1	cyclin-dependent kinase 4 inhibitor B isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CDKN2B	NP_001139741.1
Mus musculus (house mouse)	Cdkn2b	NP_031696.1
Rattus norvegicus (Norway rat)	Cdkn2b	NP_570825.1
Bos taurus (cattle)	CDKN2B	NP_001069362.1
Homo sapiens (human)	CDKN2B	NP_004927.2
Pan troglodytes (chimpanzee)	CDKN2B	XP_003312069.1
	CDKN2B	XP_001107263.1
Gallus gallus (chicken)	CDKN2B	NP_989764.1

Gene Ontology

The following CDKN2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10080	NM_004936.4 Latest version!	Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18518	NM_078487.2 Latest version!	Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu10080	NM_004936.3	Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDKN2B ( NM_004936.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004927.2 Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10080
Clone ID Related Accession (Same CDS sequence)	NM_004936.3 , NM_004936.4
Accession Version	NM_004936.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 4 inhibitor B isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI560960.1, BC014469.1, BC018984.2 and AF488731.1. On May 12, 2004 this sequence version replaced NM_004936.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.249517.1, SRR1803611.50497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC 
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTCA TGATGATGGG CAGCGCCCGC 
GTGGCGGAGC TGCTGCTGCT CCACGGCGCG GAGCCCAACT GCGCAGACCC TGCCACTCTC 
ACCCGACCGG TGCATGATGC TGCCCGGGAG GGCTTCCTGG ACACGCTGGT GGTGCTGCAC 
CGGGCCGGGG CGCGGCTGGA CGTGCGCGAT GCCTGGGGTC GTCTGCCCGT GGACTTGGCC 
GAGGAGCGGG GCCACCGCGA CGTTGCAGGG TACCTGCGCA CAGCCACGGG GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004927.2
CDS	361..777
Translation	MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD

Target ORF information:

RefSeq Version	NM_004936.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004936.3

ORF Insert Sequence:

ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC 
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTCA TGATGATGGG CAGCGCCCGC 
GTGGCGGAGC TGCTGCTGCT CCACGGCGCG GAGCCCAACT GCGCAGACCC TGCCACTCTC 
ACCCGACCGG TGCATGATGC TGCCCGGGAG GGCTTCCTGG ACACGCTGGT GGTGCTGCAC 
CGGGCCGGGG CGCGGCTGGA CGTGCGCGAT GCCTGGGGTC GTCTGCCCGT GGACTTGGCC 
GAGGAGCGGG GCCACCGCGA CGTTGCAGGG TACCTGCGCA CAGCCACGGG GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDKN2B ( NM_004936.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004927.2 Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu10080
Clone ID Related Accession (Same CDS sequence)	NM_004936.3 , NM_004936.4
Accession Version	NM_004936.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 4 inhibitor B isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI560960.1, BC014469.1, BC018984.2 and AF488731.1. On Nov 23, 2018 this sequence version replaced NM_004936.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA583791.1, SRR1660809.249517.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000276925.7/ ENSP00000276925.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC 
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTCA TGATGATGGG CAGCGCCCGC 
GTGGCGGAGC TGCTGCTGCT CCACGGCGCG GAGCCCAACT GCGCAGACCC TGCCACTCTC 
ACCCGACCGG TGCATGATGC TGCCCGGGAG GGCTTCCTGG ACACGCTGGT GGTGCTGCAC 
CGGGCCGGGG CGCGGCTGGA CGTGCGCGAT GCCTGGGGTC GTCTGCCCGT GGACTTGGCC 
GAGGAGCGGG GCCACCGCGA CGTTGCAGGG TACCTGCGCA CAGCCACGGG GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004927.2
CDS	353..769
Translation	MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD

Target ORF information:

RefSeq Version	NM_004936.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004936.4

ORF Insert Sequence:

ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC 
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTCA TGATGATGGG CAGCGCCCGC 
GTGGCGGAGC TGCTGCTGCT CCACGGCGCG GAGCCCAACT GCGCAGACCC TGCCACTCTC 
ACCCGACCGG TGCATGATGC TGCCCGGGAG GGCTTCCTGG ACACGCTGGT GGTGCTGCAC 
CGGGCCGGGG CGCGGCTGGA CGTGCGCGAT GCCTGGGGTC GTCTGCCCGT GGACTTGGCC 
GAGGAGCGGG GCCACCGCGA CGTTGCAGGG TACCTGCGCA CAGCCACGGG GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDKN2B ( NM_078487.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_511042.1 Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18518
Clone ID Related Accession (Same CDS sequence)	NM_078487.2
Accession Version	NM_078487.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 237bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	cyclin-dependent kinase 4 inhibitor B isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI560960.1, AF004819.1, BC014469.1, BC018984.2 and AF488731.1. This sequence is a reference standard in the RefSeqGene project. On May 12, 2004 this sequence version replaced NM_078487.1. Transcript Variant: This variant (2) uses a different splice site, which leads to a translation frame shift, when compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus when compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.223035.1, AF004819.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152568, SAMEA2153980 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC 
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTAG CTGGGGCCCC AGGGCCTCGC 
CGGCAGGGGG CGCGCGAACG CGGGGCGCGG CCTCGGCGGA TCGGGGCTGG AACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_511042.1
CDS	361..597
Translation	MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVAGAPGPRRQGARERGARPRRIGAGT

Target ORF information:

RefSeq Version	NM_078487.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078487.2

ORF Insert Sequence:

ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC 
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTAG CTGGGGCCCC AGGGCCTCGC 
CGGCAGGGGG CGCGCGAACG CGGGGCGCGG CCTCGGCGGA TCGGGGCTGG AACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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CDKN2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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