BCAS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BCAS2
Entrez Gene ID	10286
Full Name	BCAS2, pre-mRNA processing factor
Synonyms	DAM1,SPF27,Snt309
General protein information	Preferred Names BCAS2, pre-mRNA processing factor Names pre-mRNA-splicing factor SPF27 DNA amplified in mammary carcinoma 1 protein breast carcinoma amplified sequence 2 spliceosome associated protein, amplified in breast cancer spliceosome-associated protein SPF 27
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.2
Disorder MIM:	605783

mRNA and Protein(s)

mRNA	Protein	Name
NM_005872.3	NP_005863.1	pre-mRNA-splicing factor SPF27
NM_005872.2	NP_005863.1	pre-mRNA-splicing factor SPF27

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Bcas2	NP_001099928.1
Gallus gallus (chicken)	BCAS2	NP_001244224.1
Danio rerio (zebrafish)	bcas2	NP_001007775.1
Arabidopsis thaliana (thale cress)	MOS4	NP_566599.1
Homo sapiens (human)	BCAS2	NP_005863.1
Drosophila melanogaster (fruit fly)	CG4980	NP_651596.1
Xenopus tropicalis (tropical clawed frog)	bcas2	NP_988924.1
Canis lupus familiaris (dog)	BCAS2	XP_533014.1
Bos taurus (cattle)	BCAS2	NP_001015540.1
Mus musculus (house mouse)	Bcas2	NP_080878.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002305	XP_312666.3
Pan troglodytes (chimpanzee)	BCAS2	XP_003308351.1
Caenorhabditis elegans (roundworm)	T12A2.7	NP_498360.2

Gene Ontology
Bibliography

Related articles in PubMed

miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2.
Lang B, Zhao S
Oncology reports39(1)71-80(2018 Jan)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Bertram K, Agafonov DE, Liu WT, Dybkov O, Will CL, Hartmuth K, Urlaub H, Kastner B, Stark H, L?hrmann R
Nature542(7641)318-323(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Chromosomal breakpoints involved the BCAS2 gene in 1q31 is associated with Diffuse Large B-Cell Lymphomas.
Title: Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas.

BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
Title: BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.

These results demonstrate that Aurora B inhibits both direct interaction with the microtubule and oligomerization of the Dam1 complex to drive error correction during mitosis.
Title: The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling.

BCAS2 is a novel androgen receptor-interacting protein.
Title: BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability.

ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin
Title: ERR? signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells.

The following BCAS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCAS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05009	NM_005872.3 Latest version!	Homo sapiens BCAS2 pre-mRNA processing factor (BCAS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05009	NM_005872.2	Homo sapiens BCAS2, pre-mRNA processing factor (BCAS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BCAS2 ( NM_005872.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005863.1 Homo sapiens BCAS2 pre-mRNA processing factor (BCAS2), mRNA.

Price & Availability↑

CloneID	OHu05009
Clone ID Related Accession (Same CDS sequence)	NM_005872.3 , NM_005872.2
Accession Version	NM_005872.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	pre-mRNA-splicing factor SPF27
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF184377.1, BC039238.1 and BC022880.1. On Nov 22, 2018 this sequence version replaced NM_005872.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222637.1, SRR3476690.118041.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000369541.4/ ENSP00000358554.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGGCA CAGGTTTGGT GGCTGGAGAG GTTGTGGTGG ATGCGCTGCC GTATTTTGAT 
CAAGGTTATG AAGCCCCTGG TGTGCGGGAA GCGGCTGCAG CGCTGGTGGA GGAGGAAACT 
CGCAGATACC GACCTACTAA GAACTACCTG AGCTACCTGA CAGCCCCGGA TTATTCTGCC 
TTTGAAACTG ACATAATGAG AAATGAATTT GAAAGACTGG CTGCTCGACA ACCAATTGAA 
TTGCTCAGTA TGAAACGATA TGAGCTTCCA GCCCCCTCCT CTGGTCAAAA AAATGACATT 
ACTGCATGGC AAGAATGTGT AAACAATTCT ATGGCCCAGT TAGAGCATCA AGCAGTTAGA 
ATTGAGAATC TGGAACTAAT GTCACAGCAT GGATGTAATG CCTGGAAAGT ATACAATGAA 
AATCTAGTTC ATATGATTGA ACACGCACAG AAGGAACTTC AGAAGTTAAG AAAACATATT 
CAAGATTTAA ACTGGCAGAG AAAGAACATG CAACTCACAG CTGGATCTAA ATTGAGAGAA 
ATGGAGTCAA ATTGGGTATC CCTGGTCAGT AAGAATTATG AGATTGAACG GACTATTGTT 
CAGCTAGAAA ATGAAATCTA TCAAATTAAG CAGCAACATG GAGAGGCAAA CAAAGAAAAC 
ATCCGGCAAG ACTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005863.1
CDS	25..702
Translation	MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF

Target ORF information:

RefSeq Version	NM_005872.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BCAS2 pre-mRNA processing factor (BCAS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005872.3

ORF Insert Sequence:

ATGGCGGGCA CAGGTTTGGT GGCTGGAGAG GTTGTGGTGG ATGCGCTGCC GTATTTTGAT 
CAAGGTTATG AAGCCCCTGG TGTGCGGGAA GCGGCTGCAG CGCTGGTGGA GGAGGAAACT 
CGCAGATACC GACCTACTAA GAACTACCTG AGCTACCTGA CAGCCCCGGA TTATTCTGCC 
TTTGAAACTG ACATAATGAG AAATGAATTT GAAAGACTGG CTGCTCGACA ACCAATTGAA 
TTGCTCAGTA TGAAACGATA TGAGCTTCCA GCCCCCTCCT CTGGTCAAAA AAATGACATT 
ACTGCATGGC AAGAATGTGT AAACAATTCT ATGGCCCAGT TAGAGCATCA AGCAGTTAGA 
ATTGAGAATC TGGAACTAAT GTCACAGCAT GGATGTAATG CCTGGAAAGT ATACAATGAA 
AATCTAGTTC ATATGATTGA ACACGCACAG AAGGAACTTC AGAAGTTAAG AAAACATATT 
CAAGATTTAA ACTGGCAGAG AAAGAACATG CAACTCACAG CTGGATCTAA ATTGAGAGAA 
ATGGAGTCAA ATTGGGTATC CCTGGTCAGT AAGAATTATG AGATTGAACG GACTATTGTT 
CAGCTAGAAA ATGAAATCTA TCAAATTAAG CAGCAACATG GAGAGGCAAA CAAAGAAAAC 
ATCCGGCAAG ACTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCAS2 ( NM_005872.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005863.1 Homo sapiens BCAS2, pre-mRNA processing factor (BCAS2), mRNA.

Price & Availability↑

CloneID	OHu05009
Clone ID Related Accession (Same CDS sequence)	NM_005872.3 , NM_005872.2
Accession Version	NM_005872.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	pre-mRNA-splicing factor SPF27
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF184377.1, BC039238.1 and BC022880.1. On Jun 30, 2004 this sequence version replaced NM_005872.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222637.1, AB020623.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGGCA CAGGTTTGGT GGCTGGAGAG GTTGTGGTGG ATGCGCTGCC GTATTTTGAT 
CAAGGTTATG AAGCCCCTGG TGTGCGGGAA GCGGCTGCAG CGCTGGTGGA GGAGGAAACT 
CGCAGATACC GACCTACTAA GAACTACCTG AGCTACCTGA CAGCCCCGGA TTATTCTGCC 
TTTGAAACTG ACATAATGAG AAATGAATTT GAAAGACTGG CTGCTCGACA ACCAATTGAA 
TTGCTCAGTA TGAAACGATA TGAGCTTCCA GCCCCCTCCT CTGGTCAAAA AAATGACATT 
ACTGCATGGC AAGAATGTGT AAACAATTCT ATGGCCCAGT TAGAGCATCA AGCAGTTAGA 
ATTGAGAATC TGGAACTAAT GTCACAGCAT GGATGTAATG CCTGGAAAGT ATACAATGAA 
AATCTAGTTC ATATGATTGA ACACGCACAG AAGGAACTTC AGAAGTTAAG AAAACATATT 
CAAGATTTAA ACTGGCAGAG AAAGAACATG CAACTCACAG CTGGATCTAA ATTGAGAGAA 
ATGGAGTCAA ATTGGGTATC CCTGGTCAGT AAGAATTATG AGATTGAACG GACTATTGTT 
CAGCTAGAAA ATGAAATCTA TCAAATTAAG CAGCAACATG GAGAGGCAAA CAAAGAAAAC 
ATCCGGCAAG ACTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005863.1
CDS	54..731
Translation	MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF

Target ORF information:

RefSeq Version	NM_005872.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BCAS2, pre-mRNA processing factor (BCAS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005872.2

ORF Insert Sequence:

ATGGCGGGCA CAGGTTTGGT GGCTGGAGAG GTTGTGGTGG ATGCGCTGCC GTATTTTGAT 
CAAGGTTATG AAGCCCCTGG TGTGCGGGAA GCGGCTGCAG CGCTGGTGGA GGAGGAAACT 
CGCAGATACC GACCTACTAA GAACTACCTG AGCTACCTGA CAGCCCCGGA TTATTCTGCC 
TTTGAAACTG ACATAATGAG AAATGAATTT GAAAGACTGG CTGCTCGACA ACCAATTGAA 
TTGCTCAGTA TGAAACGATA TGAGCTTCCA GCCCCCTCCT CTGGTCAAAA AAATGACATT 
ACTGCATGGC AAGAATGTGT AAACAATTCT ATGGCCCAGT TAGAGCATCA AGCAGTTAGA 
ATTGAGAATC TGGAACTAAT GTCACAGCAT GGATGTAATG CCTGGAAAGT ATACAATGAA 
AATCTAGTTC ATATGATTGA ACACGCACAG AAGGAACTTC AGAAGTTAAG AAAACATATT 
CAAGATTTAA ACTGGCAGAG AAAGAACATG CAACTCACAG CTGGATCTAA ATTGAGAGAA 
ATGGAGTCAA ATTGGGTATC CCTGGTCAGT AAGAATTATG AGATTGAACG GACTATTGTT 
CAGCTAGAAA ATGAAATCTA TCAAATTAAG CAGCAACATG GAGAGGCAAA CAAAGAAAAC 
ATCCGGCAAG ACTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2.
Oncology reports39(1)71-80(2018 Jan)
Lang B,Zhao S

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature542(7641)318-323(2017 02)
Bertram K,Agafonov DE,Liu WT,Dybkov O,Will CL,Hartmuth K,Urlaub H,Kastner B,Stark H,L?hrmann R

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

BCAS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報