RAMP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAMP3
Entrez Gene ID	10268
Full Name	receptor activity modifying protein 3
General protein information	Preferred Names receptor activity modifying protein 3 Names receptor activity-modifying protein 3 CRLR activity-modifying protein 3 calcitonin receptor-like receptor activity modifying protein 3 receptor (G protein-coupled) activity modifying protein 3 receptor (calcitonin) activity modifying protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p13
Summary	The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008].
Disorder MIM:	605155

mRNA and Protein(s)

mRNA	Protein	Name
NM_005856.2	NP_005847.1	receptor activity-modifying protein 3 precursor
XM_006715631.3	XP_006715694.1	receptor activity-modifying protein 3 isoform X1
XM_017011666.1	XP_016867155.1	receptor activity-modifying protein 3 isoform X2
NM_005856.3	NP_005847.1	receptor activity-modifying protein 3 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ramp3	NP_062384.1
Gallus gallus (chicken)	RAMP3	NP_001138445.1
Bos taurus (cattle)	RAMP3	NP_001076974.1
Rattus norvegicus (Norway rat)	Ramp3	NP_064485.2
Pan troglodytes (chimpanzee)	RAMP3	XP_001151180.1
Xenopus tropicalis (tropical clawed frog)	ramp3	NP_001107376.1
Homo sapiens (human)	RAMP3	NP_005847.1
	RAMP3	XP_001086394.1
Canis lupus familiaris (dog)	LOC100855938	XP_003640332.1

Gene Ontology
Bibliography

Related articles in PubMed

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
Watkins HA, Chakravarthy M, Abhayawardana RS, Gingell JJ, Garelja M, Pardamwar M, McElhinney JM, Lathbridge A, Constantine A, Harris PW, Yuen TY, Brimble MA, Barwell J, Poyner DR, Woolley MJ, Conner AC, Pioszak AA, Reynolds CA, Hay DL
The Journal of biological chemistry291(22)11657-75(2016 May)

Genome-wide analysis of hepatic lipid content in extreme obesity.
DiStefano JK, Kingsley C, Craig Wood G, Chu X, Argyropoulos G, Still CD, Don? SC, Legendre C, Tembe W, Gerhard GS
Acta diabetologica52(2)373-82(2015 Apr)

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.
Watkins HA, Walker CS, Ly KN, Bailey RJ, Barwell J, Poyner DR, Hay DL
British journal of pharmacology171(3)772-88(2014 Feb)

Expression and distribution of the adrenomedullin system in newborn human thymus.
De Martin S, Paliuri G, Belloni A, Orso G, Zanarella E, Stellin G, Milanesi O, Basso G, Ruga EM, Frasson C, Gabbia D, Perdoncin G, Palatini P, Bova S
PloS one9(5)e97592(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

interaction of RAMP2 or RAMP3 with CLR induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism.
Title: Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.

Data suggest isoforms of RAMP modulate accessibility of peptides to residues situated on CALCRL (calcitonin receptor-like receptor) N-terminal domain; RAMP3/RAMP2/RAMP1 appear to alter accessibility of specific residues at CALCRL-RAMP interface.
Title: Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.

the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus
Title: Expression and distribution of the adrenomedullin system in newborn human thymus.

The expression of RAMP3 is downregulated in the fetal lung with increasing gestational age.
Title: Adrenomedullin expression in the developing human fetal lung.

the RAMP3 TMD participates in the negative regulation of CLR/RAMP3 internalization.
Title: Characterization of the single transmembrane domain of human receptor activity-modifying protein 3 in adrenomedullin receptor internalization.

The following RAMP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAMP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30210	NM_005856.3 Latest version!	Homo sapiens receptor activity modifying protein 3 (RAMP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu41048	XM_006715631.3 Latest version!	Homo sapiens receptor activity modifying protein 3 (RAMP3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu97001	XM_017011666.1 Latest version!	Homo sapiens receptor activity modifying protein 3 (RAMP3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30210	NM_005856.2	Homo sapiens receptor activity modifying protein 3 (RAMP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAMP3 ( NM_005856.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005847.1 Homo sapiens receptor activity modifying protein 3 (RAMP3), mRNA.

Price & Availability↑

CloneID	OHu30210
Clone ID Related Accession (Same CDS sequence)	NM_005856.2 , NM_005856.3
Accession Version	NM_005856.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	receptor activity-modifying protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP347072.1 and BC053852.1. On Dec 1, 2006 this sequence version replaced NM_005856.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053852.1, BC022304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGACTG GAGCGCTGCG GCGCCCGCAA CTTCTCCCGT TGCTGCTGCT GCTCTGCGGT 
GGGTGTCCCA GAGCAGGCGG CTGCAACGAG ACAGGCATGT TGGAGAGGCT GCCCCTGTGT 
GGGAAGGCTT TCGCAGACAT GATGGGCAAG GTGGACGTCT GGAAGTGGTG CAACCTGTCC 
GAGTTCATCG TGTACTATGA GAGTTTCACC AACTGCACCG AGATGGAGGC CAATGTCGTG 
GGCTGCTACT GGCCCAACCC CCTGGCCCAG GGCTTCATCA CCGGCATCCA CAGGCAGTTC 
TTCTCCAACT GCACCGTGGA CAGGGTCCAC TTGGAGGACC CCCCAGACGA GGTTCTCATC 
CCGCTGATCG TTATACCCGT CGTTCTGACT GTCGCCATGG CTGGCCTGGT GGTGTGGCGC 
AGCAAACGCA CCGACACGCT GCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005847.1
CDS	62..508
Translation	METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

Target ORF information:

RefSeq Version	NM_005856.2
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor activity modifying protein 3 (RAMP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005856.2

ORF Insert Sequence:

ATGGAGACTG GAGCGCTGCG GCGCCCGCAA CTTCTCCCGT TGCTGCTGCT GCTCTGCGGT 
GGGTGTCCCA GAGCAGGCGG CTGCAACGAG ACAGGCATGT TGGAGAGGCT GCCCCTGTGT 
GGGAAGGCTT TCGCAGACAT GATGGGCAAG GTGGACGTCT GGAAGTGGTG CAACCTGTCC 
GAGTTCATCG TGTACTATGA GAGTTTCACC AACTGCACCG AGATGGAGGC CAATGTCGTG 
GGCTGCTACT GGCCCAACCC CCTGGCCCAG GGCTTCATCA CCGGCATCCA CAGGCAGTTC 
TTCTCCAACT GCACCGTGGA CAGGGTCCAC TTGGAGGACC CCCCAGACGA GGTTCTCATC 
CCGCTGATCG TTATACCCGT CGTTCTGACT GTCGCCATGG CTGGCCTGGT GGTGTGGCGC 
AGCAAACGCA CCGACACGCT GCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAMP3 ( NM_005856.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005847.1 Homo sapiens receptor activity modifying protein 3 (RAMP3), mRNA.

Price & Availability↑

CloneID	OHu30210
Clone ID Related Accession (Same CDS sequence)	NM_005856.2 , NM_005856.3
Accession Version	NM_005856.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	receptor activity-modifying protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP347072.1 and BC053852.1. On Nov 23, 2018 this sequence version replaced NM_005856.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.309688.1, SRR5189667.82182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000242249.8/ ENSP00000242249.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGACTG GAGCGCTGCG GCGCCCGCAA CTTCTCCCGT TGCTGCTGCT GCTCTGCGGT 
GGGTGTCCCA GAGCAGGCGG CTGCAACGAG ACAGGCATGT TGGAGAGGCT GCCCCTGTGT 
GGGAAGGCTT TCGCAGACAT GATGGGCAAG GTGGACGTCT GGAAGTGGTG CAACCTGTCC 
GAGTTCATCG TGTACTATGA GAGTTTCACC AACTGCACCG AGATGGAGGC CAATGTCGTG 
GGCTGCTACT GGCCCAACCC CCTGGCCCAG GGCTTCATCA CCGGCATCCA CAGGCAGTTC 
TTCTCCAACT GCACCGTGGA CAGGGTCCAC TTGGAGGACC CCCCAGACGA GGTTCTCATC 
CCGCTGATCG TTATACCCGT CGTTCTGACT GTCGCCATGG CTGGCCTGGT GGTGTGGCGC 
AGCAAACGCA CCGACACGCT GCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005847.1
CDS	39..485
Translation	METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

Target ORF information:

RefSeq Version	NM_005856.3
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor activity modifying protein 3 (RAMP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005856.3

ORF Insert Sequence:

ATGGAGACTG GAGCGCTGCG GCGCCCGCAA CTTCTCCCGT TGCTGCTGCT GCTCTGCGGT 
GGGTGTCCCA GAGCAGGCGG CTGCAACGAG ACAGGCATGT TGGAGAGGCT GCCCCTGTGT 
GGGAAGGCTT TCGCAGACAT GATGGGCAAG GTGGACGTCT GGAAGTGGTG CAACCTGTCC 
GAGTTCATCG TGTACTATGA GAGTTTCACC AACTGCACCG AGATGGAGGC CAATGTCGTG 
GGCTGCTACT GGCCCAACCC CCTGGCCCAG GGCTTCATCA CCGGCATCCA CAGGCAGTTC 
TTCTCCAACT GCACCGTGGA CAGGGTCCAC TTGGAGGACC CCCCAGACGA GGTTCTCATC 
CCGCTGATCG TTATACCCGT CGTTCTGACT GTCGCCATGG CTGGCCTGGT GGTGTGGCGC 
AGCAAACGCA CCGACACGCT GCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAMP3 ( XM_006715631.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_006715694.1 Homo sapiens receptor activity modifying protein 3 (RAMP3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu41048
Clone ID Related Accession (Same CDS sequence)	XM_006715631.3
Accession Version	XM_006715631.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	receptor activity-modifying protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006715631.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACTG GAGCGCTGCG GCGCCCGCAA CTTCTCCCGT TGCTGCTGCT GCTCTGCGGC 
CCTTCCCAGG ATCAATGCCG ACCTGTACTC CAGAATCTGT TGCAGAGCCC AGGCTTGACA 
TGGAGCTTGG AAGTGCCCAC TGGGAGAGAA GGAAAGGAAG GTGGGGATCG GGGACCAGGG 
CTAAGTGGGG CCACTCCAGC CAGGAGCCCT CAGGGCAAGG AGATGGGGAG ACAAAGGACC 
AGAAAGGTGA AGGGCCCTGC TTGGAGTCAC ACAGCAAATC AGGAACTAAA CAGGATGAGG 
TCTCTGTCTT CTGGCTCCGT GCCAGTGGGG CATCTGGAGG GTGGCACGGT CAAGCTTCAG 
AAGGACACGG GCCTCCATTC CTGCAGAGAT GGTGGGTGTC CCAGAGCAGG CGGCTGCAAC 
GAGACAGGCA TGTTGGAGAG GCTGCCCCTG TGTGGGAAGG CTTTCGCAGA CATGATGGGC 
AAGGTGGACG TCTGGAAGTG GTGCAACCTG TCCGAGTTCA TCGTGTACTA TGAGAGTTTC 
ACCAACTGCA CCGAGATGGA GGCCAATGTC GTGGGCTGCT ACTGGCCCAA CCCCCTGGCC 
CAGGGCTTCA TCACCGGCAT CCACAGGCAG TTCTTCTCCA ACTGCACCGT GGACAGGGTC 
CACTTGGAGG ACCCCCCAGA CGAGGTTCTC ATCCCGCTGA TCGTTATACC CGTCGTTCTG 
ACTGTCGCCA TGGCTGGCCT GGTGGTGTGG CGCAGCAAAC GCACCGACAC GCTGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006715694.1
CDS	52..831
Translation	METGALRRPQLLPLLLLLCGPSQDQCRPVLQNLLQSPGLTWSLEVPTGREGKEGGDRGPGLSGATPARSPQGKEMGRQRTRKVKGPAWSHTANQELNRMRSLSSGSVPVGHLEGGTVKLQKDTGLHSCRDGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

Target ORF information:

RefSeq Version	XM_006715631.3
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor activity modifying protein 3 (RAMP3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006715631.3

ORF Insert Sequence:

ATGGAGACTG GAGCGCTGCG GCGCCCGCAA CTTCTCCCGT TGCTGCTGCT GCTCTGCGGC 
CCTTCCCAGG ATCAATGCCG ACCTGTACTC CAGAATCTGT TGCAGAGCCC AGGCTTGACA 
TGGAGCTTGG AAGTGCCCAC TGGGAGAGAA GGAAAGGAAG GTGGGGATCG GGGACCAGGG 
CTAAGTGGGG CCACTCCAGC CAGGAGCCCT CAGGGCAAGG AGATGGGGAG ACAAAGGACC 
AGAAAGGTGA AGGGCCCTGC TTGGAGTCAC ACAGCAAATC AGGAACTAAA CAGGATGAGG 
TCTCTGTCTT CTGGCTCCGT GCCAGTGGGG CATCTGGAGG GTGGCACGGT CAAGCTTCAG 
AAGGACACGG GCCTCCATTC CTGCAGAGAT GGTGGGTGTC CCAGAGCAGG CGGCTGCAAC 
GAGACAGGCA TGTTGGAGAG GCTGCCCCTG TGTGGGAAGG CTTTCGCAGA CATGATGGGC 
AAGGTGGACG TCTGGAAGTG GTGCAACCTG TCCGAGTTCA TCGTGTACTA TGAGAGTTTC 
ACCAACTGCA CCGAGATGGA GGCCAATGTC GTGGGCTGCT ACTGGCCCAA CCCCCTGGCC 
CAGGGCTTCA TCACCGGCAT CCACAGGCAG TTCTTCTCCA ACTGCACCGT GGACAGGGTC 
CACTTGGAGG ACCCCCCAGA CGAGGTTCTC ATCCCGCTGA TCGTTATACC CGTCGTTCTG 
ACTGTCGCCA TGGCTGGCCT GGTGGTGTGG CGCAGCAAAC GCACCGACAC GCTGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAMP3 ( XM_017011666.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867155.1 Homo sapiens receptor activity modifying protein 3 (RAMP3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu97001
Clone ID Related Accession (Same CDS sequence)	XM_017011666.1
Accession Version	XM_017011666.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	receptor activity-modifying protein 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGGAGA GGCTGCCCCT GTGTGGGAAG GCTTTCGCAG ACATGATGGG CAAGGTGGAC 
GTCTGGAAGT GGTGCAACCT GTCCGAGTTC ATCGTGTACT ATGAGAGTTT CACCAACTGC 
ACCGAGATGG AGGCCAATGT CGTGGGCTGC TACTGGCCCA ACCCCCTGGC CCAGGGCTTC 
ATCACCGGCA TCCACAGGCA GTTCTTCTCC AACTGCACCG TGGACAGGGT CCACTTGGAG 
GACCCCCCAG ACGAGGTTCT CATCCCGCTG ATCGTTATAC CCGTCGTTCT GACTGTCGCC 
ATGGCTGGCC TGGTGGTGTG GCGCAGCAAA CGCACCGACA CGCTGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867155.1
CDS	522..872
Translation	MLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

Target ORF information:

RefSeq Version	XM_017011666.1
Organism	Homo sapiens(human)
Definition	Homo sapiens receptor activity modifying protein 3 (RAMP3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011666.1

ORF Insert Sequence:

ATGTTGGAGA GGCTGCCCCT GTGTGGGAAG GCTTTCGCAG ACATGATGGG CAAGGTGGAC 
GTCTGGAAGT GGTGCAACCT GTCCGAGTTC ATCGTGTACT ATGAGAGTTT CACCAACTGC 
ACCGAGATGG AGGCCAATGT CGTGGGCTGC TACTGGCCCA ACCCCCTGGC CCAGGGCTTC 
ATCACCGGCA TCCACAGGCA GTTCTTCTCC AACTGCACCG TGGACAGGGT CCACTTGGAG 
GACCCCCCAG ACGAGGTTCT CATCCCGCTG ATCGTTATAC CCGTCGTTCT GACTGTCGCC 
ATGGCTGGCC TGGTGGTGTG GCGCAGCAAA CGCACCGACA CGCTGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties.
The Journal of biological chemistry291(22)11657-75(2016 May)
Watkins HA,Chakravarthy M,Abhayawardana RS,Gingell JJ,Garelja M,Pardamwar M,McElhinney JM,Lathbridge A,Constantine A,Harris PW,Yuen TY,Brimble MA,Barwell J,Poyner DR,Woolley MJ,Conner AC,Pioszak AA,Reynolds CA,Hay DL

Genome-wide analysis of hepatic lipid content in extreme obesity.
Acta diabetologica52(2)373-82(2015 Apr)
DiStefano JK,Kingsley C,Craig Wood G,Chu X,Argyropoulos G,Still CD,Don? SC,Legendre C,Tembe W,Gerhard GS

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.
British journal of pharmacology171(3)772-88(2014 Feb)
Watkins HA,Walker CS,Ly KN,Bailey RJ,Barwell J,Poyner DR,Hay DL

Expression and distribution of the adrenomedullin system in newborn human thymus.
PloS one9(5)e97592(2014)
De Martin S,Paliuri G,Belloni A,Orso G,Zanarella E,Stellin G,Milanesi O,Basso G,Ruga EM,Frasson C,Gabbia D,Perdoncin G,Palatini P,Bova S

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

RAMP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報