SF3B4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SF3B4
Entrez Gene ID	10262
Full Name	splicing factor 3b subunit 4
Synonyms	AFD1,Hsh49,SAP49,SF3b49
General protein information	Preferred Names splicing factor 3b subunit 4 Names splicing factor 3B subunit 4 SAP 49 SF3b50 pre-mRNA-splicing factor SF3b 49 kDa subunit spliceosomal protein spliceosome-associated protein (U2 snRNP) spliceosome-associated protein 49 splicing factor 3b, subunit 4, 49kD splicing factor 3b, subunit 4, 49kDa
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.2
Summary	This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008].
Disorder MIM:	605593
Disorder Html:	Acrofacial dysostosis 1, Nager type, 154400 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005850.4	NP_005841.1	splicing factor 3B subunit 4
NM_005850.5	NP_005841.1	splicing factor 3B subunit 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	SF3B4	NP_005841.1
Pan troglodytes (chimpanzee)	SF3B4	XP_513768.2
Mus musculus (house mouse)	Sf3b4	NP_694693.1
	SF3B4	XP_001097793.1
Bos taurus (cattle)	SF3B4	NP_001192513.1
Canis lupus familiaris (dog)	SF3B4	XP_540295.3
Rattus norvegicus (Norway rat)	Sf3b4	NP_001011951.1
Gallus gallus (chicken)	SF3B4	XP_423721.2
Danio rerio (zebrafish)	sf3b4	NP_705947.3

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the human activated spliceosome in three conformational states.
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Cell research(2018 Jan)

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Teng T, Tsai JH, Puyang X, Seiler M, Peng S, Prajapati S, Aird D, Buonamici S, Caleb B, Chan B, Corson L, Feala J, Fekkes P, Gerard B, Karr C, Korpal M, Liu X, T Lowe J, Mizui Y, Palacino J, Park E, Smith PG, Subramanian V, Wu ZJ, Zou J, Yu L, Chicas A, Warmuth M, Larsen N, Zhu P
Nature communications815522(2017 May)

SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells.
Zhou W, Ma N, Jiang H, Rong Y, Deng Y, Feng Y, Zhu H, Kuang T, Lou W, Xie D, Wang D
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317695913(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

splicing factor 3b subunit 4 was found to inhibit the activity of signal transducer and activator of transcription 3 signaling via downregulating the phosphorylation of signal transducer and activator of transcription 3 on a tyrosine residue at position 705.
Title: SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells.

Chemical shift mapping showed that the SF3b145 fragment spanning residues 598-631 interacts with SF3b49 RRM1, which adopts a canonical RRM fold with a topology of beta1-alpha1-beta2-beta3-alpha2-beta4.
Title: Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment.

A novel synonymous variant within exon 3 of the SF3B4 gene was identified in three members of a family affected by Nager syndrome.
Title: A synonymous splicing mutation in the SF3B4 gene segregates in a family with highly variable Nager syndrome.

We identified two heterozygous frameshift mutations in the SF3B4 gene in three of the four fetuses investigated. The observed mutation was apparently de novo in one fetus for whom parental DNA was available. Thus, Acrofacial dysostosis syndrome of Rodriguez is an autosomal dominant condition and the recurrences identified in the initial report were likely due to gonadal mosaicism.
Title: Rodriguez acrofacial dysostosis is caused by apparently de novo heterozygous mutations in the SF3B4 gene.

SF3B4 mutations identified in Rodriguez Acrofacial Dysostosis patients disrupted mRNA splicing and reduced expression of DLX5, DLX6, SOX9, and SOX6 in cultured chondrocytes.
Title: Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis.

The following SF3B4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SF3B4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26484	NM_005850.5 Latest version!	Homo sapiens splicing factor 3b subunit 4 (SF3B4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu26484	NM_005850.4	Homo sapiens splicing factor 3b subunit 4 (SF3B4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SF3B4 ( NM_005850.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005841.1 Homo sapiens splicing factor 3b subunit 4 (SF3B4), mRNA.

Price & Availability↑

CloneID	OHu26484
Clone ID Related Accession (Same CDS sequence)	NM_005850.4 , NM_005850.5
Accession Version	NM_005850.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Homo sapiens(human)
Product	splicing factor 3B subunit 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK097315.1, DA535996.1, BC004273.1 and AI925089.1. This sequence is a reference standard in the RefSeqGene project. On Mar 10, 2011 this sequence version replaced NM_005850.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.1548.1, AK097315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCG GGCCGATCTC CGAGCGGAAT CAGGATGCCA CTGTGTACGT GGGGGGCCTG 
GATGAGAAGG TTAGTGAACC GCTGCTGTGG GAACTGTTTC TCCAGGCTGG ACCAGTAGTC 
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTGGAA 
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATCA TGAACATGAT CAAACTCTAT 
GGGAAGCCAA TACGGGTGAA CAAAGCATCA GCTCACAACA AAAACCTGGA TGTAGGGGCC 
AACATTTTCA TTGGGAACCT GGACCCTGAG ATTGATGAGA AGTTGCTTTA TGATACTTTC 
AGCGCCTTTG GGGTCATCTT ACAAACCCCC AAAATTATGC GGGACCCTGA CACAGGCAAC 
TCCAAAGGTT ATGCCTTTAT TAATTTTGCT TCATTTGATG CTTCGGATGC AGCAATTGAA 
GCCATGAATG GGCAGTACCT CTGTAACCGT CCTATCACCG TATCTTATGC CTTCAAGAAG 
GACTCCAAGG GTGAGCGCCA TGGCTCAGCA GCCGAACGAC TTCTGGCAGC TCAGAACCCG 
CTCTCCCAGG CTGATCGCCC TCATCAGCTG TTTGCAGATG CACCTCCTCC ACCCTCTGCT 
CCCAATCCTG TGGTATCATC ATTGGGGTCT GGGCTTCCTC CACCAGGCAT GCCTCCTCCT 
GGCTCCTTCC CACCCCCAGT GCCACCTCCT GGAGCCCTCC CACCTGGGAT ACCCCCAGCC 
ATGCCCCCAC CACCTATGCC TCCTGGGGCT GCAGGACATG GCCCCCCATC GGCAGGAACC 
CCAGGGGCAG GACATCCTGG TCATGGACAC TCACATCCTC ACCCATTCCC ACCGGGTGGG 
ATGCCCCATC CAGGGATGTC TCAGATGCAG CTTGCACACC ATGGCCCTCA TGGCTTAGGA 
CATCCCCACG CTGGACCCCC AGGCTCTGGG GGCCAGCCAC CGCCCCGACC ACCACCTGGA 
ATGCCTCATC CTGGACCTCC TCCAATGGGC ATGCCCCCCC GAGGGCCTCC ATTCGGATCT 
CCCATGGGTC ACCCAGGTCC TATGCCTCCG CATGGTATGC GTGGACCTCC TCCACTGATG 
CCCCCCCATG GATACACTGG CCCTCCACGA CCCCCACCCT ATGGCTACCA GCGGGGGCCT 
CTCCCTCCAC CCAGACCCAC TCCCCGGCCA CCAGTTCCCC CTCGAGGCCC ACTTCGAGGC 
CCTCTCCCTC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005841.1
CDS	494..1768
Translation	MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ

Target ORF information:

RefSeq Version	NM_005850.4
Organism	Homo sapiens(human)
Definition	Homo sapiens splicing factor 3b subunit 4 (SF3B4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005850.4

ORF Insert Sequence:

ATGGCTGCCG GGCCGATCTC CGAGCGGAAT CAGGATGCCA CTGTGTACGT GGGGGGCCTG 
GATGAGAAGG TTAGTGAACC GCTGCTGTGG GAACTGTTTC TCCAGGCTGG ACCAGTAGTC 
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTGGAA 
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATCA TGAACATGAT CAAACTCTAT 
GGGAAGCCAA TACGGGTGAA CAAAGCATCA GCTCACAACA AAAACCTGGA TGTAGGGGCC 
AACATTTTCA TTGGGAACCT GGACCCTGAG ATTGATGAGA AGTTGCTTTA TGATACTTTC 
AGCGCCTTTG GGGTCATCTT ACAAACCCCC AAAATTATGC GGGACCCTGA CACAGGCAAC 
TCCAAAGGTT ATGCCTTTAT TAATTTTGCT TCATTTGATG CTTCGGATGC AGCAATTGAA 
GCCATGAATG GGCAGTACCT CTGTAACCGT CCTATCACCG TATCTTATGC CTTCAAGAAG 
GACTCCAAGG GTGAGCGCCA TGGCTCAGCA GCCGAACGAC TTCTGGCAGC TCAGAACCCG 
CTCTCCCAGG CTGATCGCCC TCATCAGCTG TTTGCAGATG CACCTCCTCC ACCCTCTGCT 
CCCAATCCTG TGGTATCATC ATTGGGGTCT GGGCTTCCTC CACCAGGCAT GCCTCCTCCT 
GGCTCCTTCC CACCCCCAGT GCCACCTCCT GGAGCCCTCC CACCTGGGAT ACCCCCAGCC 
ATGCCCCCAC CACCTATGCC TCCTGGGGCT GCAGGACATG GCCCCCCATC GGCAGGAACC 
CCAGGGGCAG GACATCCTGG TCATGGACAC TCACATCCTC ACCCATTCCC ACCGGGTGGG 
ATGCCCCATC CAGGGATGTC TCAGATGCAG CTTGCACACC ATGGCCCTCA TGGCTTAGGA 
CATCCCCACG CTGGACCCCC AGGCTCTGGG GGCCAGCCAC CGCCCCGACC ACCACCTGGA 
ATGCCTCATC CTGGACCTCC TCCAATGGGC ATGCCCCCCC GAGGGCCTCC ATTCGGATCT 
CCCATGGGTC ACCCAGGTCC TATGCCTCCG CATGGTATGC GTGGACCTCC TCCACTGATG 
CCCCCCCATG GATACACTGG CCCTCCACGA CCCCCACCCT ATGGCTACCA GCGGGGGCCT 
CTCCCTCCAC CCAGACCCAC TCCCCGGCCA CCAGTTCCCC CTCGAGGCCC ACTTCGAGGC 
CCTCTCCCTC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SF3B4 ( NM_005850.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005841.1 Homo sapiens splicing factor 3b subunit 4 (SF3B4), mRNA.

Price & Availability↑

CloneID	OHu26484
Clone ID Related Accession (Same CDS sequence)	NM_005850.4 , NM_005850.5
Accession Version	NM_005850.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	splicing factor 3B subunit 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA535996.1, BC004273.1 and AI925089.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005850.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.596165.1, AK097315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000271628.9/ ENSP00000271628.8 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGCCG GGCCGATCTC CGAGCGGAAT CAGGATGCCA CTGTGTACGT GGGGGGCCTG 
GATGAGAAGG TTAGTGAACC GCTGCTGTGG GAACTGTTTC TCCAGGCTGG ACCAGTAGTC 
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTGGAA 
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATCA TGAACATGAT CAAACTCTAT 
GGGAAGCCAA TACGGGTGAA CAAAGCATCA GCTCACAACA AAAACCTGGA TGTAGGGGCC 
AACATTTTCA TTGGGAACCT GGACCCTGAG ATTGATGAGA AGTTGCTTTA TGATACTTTC 
AGCGCCTTTG GGGTCATCTT ACAAACCCCC AAAATTATGC GGGACCCTGA CACAGGCAAC 
TCCAAAGGTT ATGCCTTTAT TAATTTTGCT TCATTTGATG CTTCGGATGC AGCAATTGAA 
GCCATGAATG GGCAGTACCT CTGTAACCGT CCTATCACCG TATCTTATGC CTTCAAGAAG 
GACTCCAAGG GTGAGCGCCA TGGCTCAGCA GCCGAACGAC TTCTGGCAGC TCAGAACCCG 
CTCTCCCAGG CTGATCGCCC TCATCAGCTG TTTGCAGATG CACCTCCTCC ACCCTCTGCT 
CCCAATCCTG TGGTATCATC ATTGGGGTCT GGGCTTCCTC CACCAGGCAT GCCTCCTCCT 
GGCTCCTTCC CACCCCCAGT GCCACCTCCT GGAGCCCTCC CACCTGGGAT ACCCCCAGCC 
ATGCCCCCAC CACCTATGCC TCCTGGGGCT GCAGGACATG GCCCCCCATC GGCAGGAACC 
CCAGGGGCAG GACATCCTGG TCATGGACAC TCACATCCTC ACCCATTCCC ACCGGGTGGG 
ATGCCCCATC CAGGGATGTC TCAGATGCAG CTTGCACACC ATGGCCCTCA TGGCTTAGGA 
CATCCCCACG CTGGACCCCC AGGCTCTGGG GGCCAGCCAC CGCCCCGACC ACCACCTGGA 
ATGCCTCATC CTGGACCTCC TCCAATGGGC ATGCCCCCCC GAGGGCCTCC ATTCGGATCT 
CCCATGGGTC ACCCAGGTCC TATGCCTCCG CATGGTATGC GTGGACCTCC TCCACTGATG 
CCCCCCCATG GATACACTGG CCCTCCACGA CCCCCACCCT ATGGCTACCA GCGGGGGCCT 
CTCCCTCCAC CCAGACCCAC TCCCCGGCCA CCAGTTCCCC CTCGAGGCCC ACTTCGAGGC 
CCTCTCCCTC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005841.1
CDS	45..1319
Translation	MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ

Target ORF information:

RefSeq Version	NM_005850.5
Organism	Homo sapiens(human)
Definition	Homo sapiens splicing factor 3b subunit 4 (SF3B4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005850.5

ORF Insert Sequence:

ATGGCTGCCG GGCCGATCTC CGAGCGGAAT CAGGATGCCA CTGTGTACGT GGGGGGCCTG 
GATGAGAAGG TTAGTGAACC GCTGCTGTGG GAACTGTTTC TCCAGGCTGG ACCAGTAGTC 
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTGGAA 
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATCA TGAACATGAT CAAACTCTAT 
GGGAAGCCAA TACGGGTGAA CAAAGCATCA GCTCACAACA AAAACCTGGA TGTAGGGGCC 
AACATTTTCA TTGGGAACCT GGACCCTGAG ATTGATGAGA AGTTGCTTTA TGATACTTTC 
AGCGCCTTTG GGGTCATCTT ACAAACCCCC AAAATTATGC GGGACCCTGA CACAGGCAAC 
TCCAAAGGTT ATGCCTTTAT TAATTTTGCT TCATTTGATG CTTCGGATGC AGCAATTGAA 
GCCATGAATG GGCAGTACCT CTGTAACCGT CCTATCACCG TATCTTATGC CTTCAAGAAG 
GACTCCAAGG GTGAGCGCCA TGGCTCAGCA GCCGAACGAC TTCTGGCAGC TCAGAACCCG 
CTCTCCCAGG CTGATCGCCC TCATCAGCTG TTTGCAGATG CACCTCCTCC ACCCTCTGCT 
CCCAATCCTG TGGTATCATC ATTGGGGTCT GGGCTTCCTC CACCAGGCAT GCCTCCTCCT 
GGCTCCTTCC CACCCCCAGT GCCACCTCCT GGAGCCCTCC CACCTGGGAT ACCCCCAGCC 
ATGCCCCCAC CACCTATGCC TCCTGGGGCT GCAGGACATG GCCCCCCATC GGCAGGAACC 
CCAGGGGCAG GACATCCTGG TCATGGACAC TCACATCCTC ACCCATTCCC ACCGGGTGGG 
ATGCCCCATC CAGGGATGTC TCAGATGCAG CTTGCACACC ATGGCCCTCA TGGCTTAGGA 
CATCCCCACG CTGGACCCCC AGGCTCTGGG GGCCAGCCAC CGCCCCGACC ACCACCTGGA 
ATGCCTCATC CTGGACCTCC TCCAATGGGC ATGCCCCCCC GAGGGCCTCC ATTCGGATCT 
CCCATGGGTC ACCCAGGTCC TATGCCTCCG CATGGTATGC GTGGACCTCC TCCACTGATG 
CCCCCCCATG GATACACTGG CCCTCCACGA CCCCCACCCT ATGGCTACCA GCGGGGGCCT 
CTCCCTCCAC CCAGACCCAC TCCCCGGCCA CCAGTTCCCC CTCGAGGCCC ACTTCGAGGC 
CCTCTCCCTC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the human activated spliceosome in three conformational states.
Cell research(2018 Jan)
Zhang X,Yan C,Zhan X,Li L,Lei J,Shi Y

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nature communications815522(2017 May)
Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ,Zou J,Yu L,Chicas A,Warmuth M,Larsen N,Zhu P

SF3B4 is decreased in pancreatic cancer and inhibits the growth and migration of cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317695913(2017 Mar)
Zhou W,Ma N,Jiang H,Rong Y,Deng Y,Feng Y,Zhu H,Kuang T,Lou W,Xie D,Wang D

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SF3B4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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