STAM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	STAM2
Entrez Gene ID	10254
Full Name	signal transducing adaptor molecule 2
Synonyms	Hbp,STAM2A,STAM2B
General protein information	Preferred Names signal transducing adaptor molecule 2 Names signal transducing adapter molecule 2 HSE1 homolog Hrs-binding protein STAM-2 STAM-like protein containing SH3 and ITAM domains 2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q23.3
Summary	The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008].
Disorder MIM:	606244

mRNA and Protein(s)

mRNA	Protein	Name
NM_005843.6	NP_005834.4	signal transducing adapter molecule 2
NM_005843.5	NP_005834.4	signal transducing adapter molecule 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Stam2	NP_001012085.1
Homo sapiens (human)	STAM2	NP_005834.4
Pan troglodytes (chimpanzee)	STAM2	XP_515834.2
	STAM2	XP_002808053.1
Bos taurus (cattle)	STAM2	NP_001069574.1
Mus musculus (house mouse)	Stam2	NP_062641.1
Canis lupus familiaris (dog)	STAM2	XP_005632050.1
Gallus gallus (chicken)	STAM2	NP_001012940.1
Drosophila melanogaster (fruit fly)	Stam	NP_477448.1
Xenopus tropicalis (tropical clawed frog)	stam2	XP_002936702.1

Gene Ontology
Bibliography

Related articles in PubMed

NMR Reveals the Interplay among the AMSH SH3 Binding Motif, STAM2, and Lys63-Linked Diubiquitin.
Hologne M, Cantrelle FX, Riviere G, Guilli?re F, Trivelli X, Walker O
Journal of molecular biology428(22)4544-4558(2016 Nov)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.
Baiady N, Padala P, Mashahreh B, Cohen-Kfir E, Todd EA, Du Pont KE, Berndsen CE, Wiener R
The Journal of biological chemistry291(4)2033-42(2016 Jan)

Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0.
Lee J, Oh KJ, Lee D, Kim BY, Choi JS, Ku B, Kim SJ
PloS one11(2)e0149113(2016)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage.
Title: NMR Reveals the Interplay among the AMSH SH3 Binding Motif, STAM2, and Lys63-Linked Diubiquitin.

The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
Title: The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.

homologous domain of human Bro1 domain-containing proteins, Alix and Brox, binds CHMP4B but not STAM2, despite their high structural similarity
Title: Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0.

correlation between the percentage of STAM2-positive cells and mitotic count was statistically significant in Gastrointestinal stromal tumors
Title: Immunohistochemical expression of STAM2 in gastrointestinal stromal tumors.

the SH3 domain of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting
Title: Competitive binding of UBPY and ubiquitin to the STAM2 SH3 domain revealed by NMR.

The following STAM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STAM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17476	NM_005843.6 Latest version!	Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu17476	NM_005843.5	Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

STAM2 ( NM_005843.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005834.4 Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA.

Price & Availability↑

CloneID	OHu17476
Clone ID Related Accession (Same CDS sequence)	NM_005843.6 , NM_005843.5
Accession Version	NM_005843.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	signal transducing adapter molecule 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC028740.2, AC079790.6 and BU619301.1. On Nov 22, 2018 this sequence version replaced NM_005843.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.33883.1, SRR1660807.86413.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000263904.5/ ENSP00000263904.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTTTGT TCACCGCCAA CCCCTTCGAG CAAGACGTGG AAAAAGCCAC GAATGAGTAC 
AACACTACAG AAGATTGGAG TCTTATTATG GACATATGTG ACAAAGTTGG AAGTACTCCT 
AATGGAGCGA AAGATTGCCT AAAAGCCATA ATGAAAAGGG TAAATCATAA GGTTCCACAT 
GTTGCTCTGC AAGCACTAAC TCTTCTTGGG GCTTGTGTGG CAAACTGTGG AAAGATATTT 
CATTTAGAAG TATGTTCCCG TGATTTTGCA ACAGAAGTAC GTGCTGTGAT TAAAAATAAG 
GCACATCCTA AAGTATGTGA AAAACTGAAA TCTTTAATGG TGGAGTGGTC AGAAGAATTT 
CAGAAGGACC CTCAGTTTAG TCTGATATCT GCAACTATTA AATCTATGAA AGAAGAAGGA 
ATTACTTTTC CTCCAGCAGG TTCTCAGACT GTCTCAGCTG CTGCCAAGAA TGGTACGTCA 
TCGAACAAAA ACAAAGAGGA TGAAGACATA GCTAAAGCTA TTGAATTATC GCTGCAAGAA 
CAGAAACAGC AACACACAGA AACAAAATCC TTATATCCAT CTTCAGAAAT TCAGTTAAAT 
AATAAGGTTG CACGGAAAGT GAGAGCTTTA TATGATTTTG AAGCTGTTGA GGACAATGAA 
CTCACCTTTA AACATGGTGA AATAATTATT GTTTTGGATG ACAGTGATGC CAATTGGTGG 
AAAGGAGAAA ATCACAGAGG AATAGGACTT TTCCCATCCA ATTTTGTAAC AACTAATTTA 
AACATAGAGA CTGAGGCAGC GGCTGTGGAC AAATTGAATG TAATTGATGA TGATGTGGAG 
GAAATTAAGA AATCAGAGCC TGAGCCTGTT TATATAGATG AGGATAAGAT GGATAGAGCC 
CTGCAGGTAC TTCAGAGTAT AGATCCAACA GATTCAAAAC CAGACTCCCA AGACCTTTTG 
GATTTAGAAG ATATCTGCCA ACAGATGGGT CCAATGATAG ATGAAAAACT TGAAGAAATT 
GATAGGAAGC ATTCAGAATT GTCTGAATTG AATGTTAAAG TCCTGGAAGC TCTGGAACTA 
TATAACAAAT TGGTGAATGA AGCACCAGTG TACTCAGTCT ATTCAAAGCT CCACCCTCCA 
GCACATTACC CACCTGCATC ATCTGGGGTT CCAATGCAGA CATATCCAGT TCAATCACAT 
GGTGGAAACT ATATGGGTCA GAGCATTCAC CAAGTAACTG TTGCCCAAAG CTATAGCCTA 
GGACCCGATC AAATTGGTCC ACTGAGATCT CTGCCTCCAA ATGTGAATTC CTCAGTGACA 
GCACAGCCTG CTCAAACTTC ATATTTAAGC ACTGGACAAG ACACTGTTTC CAATCCTACT 
TATATGAACC AGAACTCTAA CCTACAGTCA GCTACTGGTA CAACTGCTTA CACACAGCAA 
ATGGGGATGT CTGTGGATAT GTCATCTTAT CAGAACACTA CTTCCAATTT GCCTCAACTG 
GCAGGCTTTC CGGTGACAGT TCCAGCTCAT CCAGTTGCAC AGCAGCACAC AAATTACCAT 
CAGCAGCCTC TCCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005834.4
CDS	122..1699
Translation	MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL

Target ORF information:

RefSeq Version	NM_005843.6
Organism	Homo sapiens(human)
Definition	Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005843.6

ORF Insert Sequence:

ATGCCTTTGT TCACCGCCAA CCCCTTCGAG CAAGACGTGG AAAAAGCCAC GAATGAGTAC 
AACACTACAG AAGATTGGAG TCTTATTATG GACATATGTG ACAAAGTTGG AAGTACTCCT 
AATGGAGCGA AAGATTGCCT AAAAGCCATA ATGAAAAGGG TAAATCATAA GGTTCCACAT 
GTTGCTCTGC AAGCACTAAC TCTTCTTGGG GCTTGTGTGG CAAACTGTGG AAAGATATTT 
CATTTAGAAG TATGTTCCCG TGATTTTGCA ACAGAAGTAC GTGCTGTGAT TAAAAATAAG 
GCACATCCTA AAGTATGTGA AAAACTGAAA TCTTTAATGG TGGAGTGGTC AGAAGAATTT 
CAGAAGGACC CTCAGTTTAG TCTGATATCT GCAACTATTA AATCTATGAA AGAAGAAGGA 
ATTACTTTTC CTCCAGCAGG TTCTCAGACT GTCTCAGCTG CTGCCAAGAA TGGTACGTCA 
TCGAACAAAA ACAAAGAGGA TGAAGACATA GCTAAAGCTA TTGAATTATC GCTGCAAGAA 
CAGAAACAGC AACACACAGA AACAAAATCC TTATATCCAT CTTCAGAAAT TCAGTTAAAT 
AATAAGGTTG CACGGAAAGT GAGAGCTTTA TATGATTTTG AAGCTGTTGA GGACAATGAA 
CTCACCTTTA AACATGGTGA AATAATTATT GTTTTGGATG ACAGTGATGC CAATTGGTGG 
AAAGGAGAAA ATCACAGAGG AATAGGACTT TTCCCATCCA ATTTTGTAAC AACTAATTTA 
AACATAGAGA CTGAGGCAGC GGCTGTGGAC AAATTGAATG TAATTGATGA TGATGTGGAG 
GAAATTAAGA AATCAGAGCC TGAGCCTGTT TATATAGATG AGGATAAGAT GGATAGAGCC 
CTGCAGGTAC TTCAGAGTAT AGATCCAACA GATTCAAAAC CAGACTCCCA AGACCTTTTG 
GATTTAGAAG ATATCTGCCA ACAGATGGGT CCAATGATAG ATGAAAAACT TGAAGAAATT 
GATAGGAAGC ATTCAGAATT GTCTGAATTG AATGTTAAAG TCCTGGAAGC TCTGGAACTA 
TATAACAAAT TGGTGAATGA AGCACCAGTG TACTCAGTCT ATTCAAAGCT CCACCCTCCA 
GCACATTACC CACCTGCATC ATCTGGGGTT CCAATGCAGA CATATCCAGT TCAATCACAT 
GGTGGAAACT ATATGGGTCA GAGCATTCAC CAAGTAACTG TTGCCCAAAG CTATAGCCTA 
GGACCCGATC AAATTGGTCC ACTGAGATCT CTGCCTCCAA ATGTGAATTC CTCAGTGACA 
GCACAGCCTG CTCAAACTTC ATATTTAAGC ACTGGACAAG ACACTGTTTC CAATCCTACT 
TATATGAACC AGAACTCTAA CCTACAGTCA GCTACTGGTA CAACTGCTTA CACACAGCAA 
ATGGGGATGT CTGTGGATAT GTCATCTTAT CAGAACACTA CTTCCAATTT GCCTCAACTG 
GCAGGCTTTC CGGTGACAGT TCCAGCTCAT CCAGTTGCAC AGCAGCACAC AAATTACCAT 
CAGCAGCCTC TCCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

STAM2 ( NM_005843.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005834.4 Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA.

Price & Availability↑

CloneID	OHu17476
Clone ID Related Accession (Same CDS sequence)	NM_005843.6 , NM_005843.5
Accession Version	NM_005843.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	signal transducing adapter molecule 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC028740.2, AC079790.6 and BU619301.1. On Feb 13, 2015 this sequence version replaced NM_005843.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028740.2, SRR1660807.33883.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTTTGT TCACCGCCAA CCCCTTCGAG CAAGACGTGG AAAAAGCCAC GAATGAGTAC 
AACACTACAG AAGATTGGAG TCTTATTATG GACATATGTG ACAAAGTTGG AAGTACTCCT 
AATGGAGCGA AAGATTGCCT AAAAGCCATA ATGAAAAGGG TAAATCATAA GGTTCCACAT 
GTTGCTCTGC AAGCACTAAC TCTTCTTGGG GCTTGTGTGG CAAACTGTGG AAAGATATTT 
CATTTAGAAG TATGTTCCCG TGATTTTGCA ACAGAAGTAC GTGCTGTGAT TAAAAATAAG 
GCACATCCTA AAGTATGTGA AAAACTGAAA TCTTTAATGG TGGAGTGGTC AGAAGAATTT 
CAGAAGGACC CTCAGTTTAG TCTGATATCT GCAACTATTA AATCTATGAA AGAAGAAGGA 
ATTACTTTTC CTCCAGCAGG TTCTCAGACT GTCTCAGCTG CTGCCAAGAA TGGTACGTCA 
TCGAACAAAA ACAAAGAGGA TGAAGACATA GCTAAAGCTA TTGAATTATC GCTGCAAGAA 
CAGAAACAGC AACACACAGA AACAAAATCC TTATATCCAT CTTCAGAAAT TCAGTTAAAT 
AATAAGGTTG CACGGAAAGT GAGAGCTTTA TATGATTTTG AAGCTGTTGA GGACAATGAA 
CTCACCTTTA AACATGGTGA AATAATTATT GTTTTGGATG ACAGTGATGC CAATTGGTGG 
AAAGGAGAAA ATCACAGAGG AATAGGACTT TTCCCATCCA ATTTTGTAAC AACTAATTTA 
AACATAGAGA CTGAGGCAGC GGCTGTGGAC AAATTGAATG TAATTGATGA TGATGTGGAG 
GAAATTAAGA AATCAGAGCC TGAGCCTGTT TATATAGATG AGGATAAGAT GGATAGAGCC 
CTGCAGGTAC TTCAGAGTAT AGATCCAACA GATTCAAAAC CAGACTCCCA AGACCTTTTG 
GATTTAGAAG ATATCTGCCA ACAGATGGGT CCAATGATAG ATGAAAAACT TGAAGAAATT 
GATAGGAAGC ATTCAGAATT GTCTGAATTG AATGTTAAAG TCCTGGAAGC TCTGGAACTA 
TATAACAAAT TGGTGAATGA AGCACCAGTG TACTCAGTCT ATTCAAAGCT CCACCCTCCA 
GCACATTACC CACCTGCATC ATCTGGGGTT CCAATGCAGA CATATCCAGT TCAATCACAT 
GGTGGAAACT ATATGGGTCA GAGCATTCAC CAAGTAACTG TTGCCCAAAG CTATAGCCTA 
GGACCCGATC AAATTGGTCC ACTGAGATCT CTGCCTCCAA ATGTGAATTC CTCAGTGACA 
GCACAGCCTG CTCAAACTTC ATATTTAAGC ACTGGACAAG ACACTGTTTC CAATCCTACT 
TATATGAACC AGAACTCTAA CCTACAGTCA GCTACTGGTA CAACTGCTTA CACACAGCAA 
ATGGGGATGT CTGTGGATAT GTCATCTTAT CAGAACACTA CTTCCAATTT GCCTCAACTG 
GCAGGCTTTC CGGTGACAGT TCCAGCTCAT CCAGTTGCAC AGCAGCACAC AAATTACCAT 
CAGCAGCCTC TCCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005834.4
CDS	351..1928
Translation	MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSLGPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL

Target ORF information:

RefSeq Version	NM_005843.5
Organism	Homo sapiens(human)
Definition	Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005843.5

ORF Insert Sequence:

ATGCCTTTGT TCACCGCCAA CCCCTTCGAG CAAGACGTGG AAAAAGCCAC GAATGAGTAC 
AACACTACAG AAGATTGGAG TCTTATTATG GACATATGTG ACAAAGTTGG AAGTACTCCT 
AATGGAGCGA AAGATTGCCT AAAAGCCATA ATGAAAAGGG TAAATCATAA GGTTCCACAT 
GTTGCTCTGC AAGCACTAAC TCTTCTTGGG GCTTGTGTGG CAAACTGTGG AAAGATATTT 
CATTTAGAAG TATGTTCCCG TGATTTTGCA ACAGAAGTAC GTGCTGTGAT TAAAAATAAG 
GCACATCCTA AAGTATGTGA AAAACTGAAA TCTTTAATGG TGGAGTGGTC AGAAGAATTT 
CAGAAGGACC CTCAGTTTAG TCTGATATCT GCAACTATTA AATCTATGAA AGAAGAAGGA 
ATTACTTTTC CTCCAGCAGG TTCTCAGACT GTCTCAGCTG CTGCCAAGAA TGGTACGTCA 
TCGAACAAAA ACAAAGAGGA TGAAGACATA GCTAAAGCTA TTGAATTATC GCTGCAAGAA 
CAGAAACAGC AACACACAGA AACAAAATCC TTATATCCAT CTTCAGAAAT TCAGTTAAAT 
AATAAGGTTG CACGGAAAGT GAGAGCTTTA TATGATTTTG AAGCTGTTGA GGACAATGAA 
CTCACCTTTA AACATGGTGA AATAATTATT GTTTTGGATG ACAGTGATGC CAATTGGTGG 
AAAGGAGAAA ATCACAGAGG AATAGGACTT TTCCCATCCA ATTTTGTAAC AACTAATTTA 
AACATAGAGA CTGAGGCAGC GGCTGTGGAC AAATTGAATG TAATTGATGA TGATGTGGAG 
GAAATTAAGA AATCAGAGCC TGAGCCTGTT TATATAGATG AGGATAAGAT GGATAGAGCC 
CTGCAGGTAC TTCAGAGTAT AGATCCAACA GATTCAAAAC CAGACTCCCA AGACCTTTTG 
GATTTAGAAG ATATCTGCCA ACAGATGGGT CCAATGATAG ATGAAAAACT TGAAGAAATT 
GATAGGAAGC ATTCAGAATT GTCTGAATTG AATGTTAAAG TCCTGGAAGC TCTGGAACTA 
TATAACAAAT TGGTGAATGA AGCACCAGTG TACTCAGTCT ATTCAAAGCT CCACCCTCCA 
GCACATTACC CACCTGCATC ATCTGGGGTT CCAATGCAGA CATATCCAGT TCAATCACAT 
GGTGGAAACT ATATGGGTCA GAGCATTCAC CAAGTAACTG TTGCCCAAAG CTATAGCCTA 
GGACCCGATC AAATTGGTCC ACTGAGATCT CTGCCTCCAA ATGTGAATTC CTCAGTGACA 
GCACAGCCTG CTCAAACTTC ATATTTAAGC ACTGGACAAG ACACTGTTTC CAATCCTACT 
TATATGAACC AGAACTCTAA CCTACAGTCA GCTACTGGTA CAACTGCTTA CACACAGCAA 
ATGGGGATGT CTGTGGATAT GTCATCTTAT CAGAACACTA CTTCCAATTT GCCTCAACTG 
GCAGGCTTTC CGGTGACAGT TCCAGCTCAT CCAGTTGCAC AGCAGCACAC AAATTACCAT 
CAGCAGCCTC TCCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NMR Reveals the Interplay among the AMSH SH3 Binding Motif, STAM2, and Lys63-Linked Diubiquitin.
Journal of molecular biology428(22)4544-4558(2016 Nov)
Hologne M,Cantrelle FX,Riviere G,Guilli?re F,Trivelli X,Walker O

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.
The Journal of biological chemistry291(4)2033-42(2016 Jan)
Baiady N,Padala P,Mashahreh B,Cohen-Kfir E,Todd EA,Du Pont KE,Berndsen CE,Wiener R

Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0.
PloS one11(2)e0149113(2016)
Lee J,Oh KJ,Lee D,Kim BY,Choi JS,Ku B,Kim SJ

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

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STAM2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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