Gene Symbol | RASGRP2 |
Entrez Gene ID | 10235 |
Full Name | RAS guanyl releasing protein 2 |
Synonyms | CALDAG-GEFI,CDC25L |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]. |
Disorder MIM: | |
Disorder Html: | ?Bleeding disorder, platelet-type, 18, 615888 (3) |