CDK5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDK5
Entrez Gene ID	1020
Full Name	cyclin dependent kinase 5
Synonyms	LIS7,PSSALRE
General protein information	Preferred Names cyclin dependent kinase 5 Names cyclin-dependent-like kinase 5 TPKII catalytic subunit cell division protein kinase 5 protein kinase CDK5 splicing serine/threonine-protein kinase PSSALRE tau protein kinase II catalytic subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q36.1
Summary	This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Disorder MIM:	123831
Disorder Html:	?Lissencephaly 7 with cerebellar hypoplasia, 616342 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004935.4	NP_004926.1	cyclin-dependent-like kinase 5 isoform 1
NM_001164410.2	NP_001157882.1	cyclin-dependent-like kinase 5 isoform 2
NM_004935.3	NP_004926.1	cyclin-dependent-like kinase 5 isoform 1
NM_001164410.3	NP_001157882.1	cyclin-dependent-like kinase 5 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cdk5	NP_543161.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005772	XP_315787.4
Saccharomyces cerevisiae (baker's yeast)	PHO85	NP_015294.1
Neurospora crassa	NCU07580	XP_958274.1
Xenopus tropicalis (tropical clawed frog)	cdk5	NP_001072776.1
Homo sapiens (human)	CDK5	NP_004926.1
	CDK5	XP_001102523.1
Canis lupus familiaris (dog)	CDK5	XP_005629809.1
Bos taurus (cattle)	CDK5	NP_776442.1
Gallus gallus (chicken)	CDK5	NP_001129258.1
Eremothecium gossypii	AGOS_AGL242C	NP_986425.2
Pan troglodytes (chimpanzee)	CDK5	XP_519523.2
Mus musculus (house mouse)	Cdk5	NP_031694.1
Danio rerio (zebrafish)	cdk5	NP_571794.1
Drosophila melanogaster (fruit fly)	Cdk5	NP_477080.1
Caenorhabditis elegans (roundworm)	cdk-5	NP_499783.1
Kluyveromyces lactis	KLLA0D11990g	XP_453596.1
Schizosaccharomyces pombe (fission yeast)	pef1	NP_587921.1
Magnaporthe oryzae (rice blast fungus)	MGG_04660	XP_003713655.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphorylation of Drebrin and Its Role in Neuritogenesis.
Gordon-Weeks PR
Advances in experimental medicine and biology100649-60(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The CDK5 kinase activates the FAK/AKT signaling pathway to generate VM in a lung cancer cell line, which can help to develop potential therapeutic strategies against vessel-positive tumors.
Title: Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway.

the activated CDK5 kinase is involved in the EZH2 phosphorylation that is required for FBW7-mediated degradation.
Title: CDK5/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion.

CRM1 and CDK5 co-expression was an independent prognostic factors for gastric cancer (GC). Combined CRM1 and CDK5 expression could provide a prognostic model for overall survival of GC.
Title: Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer.

we supposed that EphA4 interacted with CDK5 and promoted its expression which in turn enhanced p-AKT expression and promoted cell adhesion-mediated drug resistance in multiple myeloma.
Title: EphA4 promotes cell proliferation and cell adhesion-mediated drug resistance via the AKT pathway in multiple myeloma.

One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified.
Title: Phosphorylation of Drebrin and Its Role in Neuritogenesis.

The following CDK5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12814	NM_004935.4 Latest version!	Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12869	NM_001164410.3 Latest version!	Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OHu12814	NM_004935.3	Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12869	NM_001164410.2	Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDK5 ( NM_004935.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004926.1 Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12814
Clone ID Related Accession (Same CDS sequence)	NM_004935.4 , NM_004935.3
Accession Version	NM_004935.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	cyclin-dependent-like kinase 5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP309068.1, BC005115.1, AK026533.1 and CA429180.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004935.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.86852.1, SRR1163655.229623.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000485972.6/ ENSP00000419782.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 
GAGATTGTAA AGTCATTCCT CTTCCAGCTA CTAAAAGGGC TGGGATTCTG TCATAGCCGC 
AATGTGCTAC ACAGGGACCT GAAGCCCCAG AACCTGCTAA TAAACAGGAA TGGGGAGCTG 
AAATTGGCTG ATTTTGGCCT GGCTCGAGCC TTTGGGATTC CCGTCCGCTG TTACTCAGCT 
GAGGTGGTCA CACTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC 
ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCTGGGCGG 
CCTCTTTTTC CCGGCAATGA TGTCGATGAC CAGTTGAAGA GGATCTTCCG ACTGCTGGGG 
ACGCCCACCG AGGAGCAGTG GCCCTCTATG ACCAAGCTGC CAGACTATAA GCCCTATCCG 
ATGTACCCGG CCACAACATC CCTGGTGAAC GTCGTGCCCA AACTCAATGC CACAGGGAGG 
GATCTGCTGC AGAACCTTCT GAAGTGTAAC CCTGTCCAGC GTATCTCAGC AGAAGAGGCC 
CTGCAGCACC CCTACTTCTC CGACTTCTGT CCGCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004926.1
CDS	50..928
Translation	MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP

Target ORF information:

RefSeq Version	NM_004935.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004935.4

ORF Insert Sequence:

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 
GAGATTGTAA AGTCATTCCT CTTCCAGCTA CTAAAAGGGC TGGGATTCTG TCATAGCCGC 
AATGTGCTAC ACAGGGACCT GAAGCCCCAG AACCTGCTAA TAAACAGGAA TGGGGAGCTG 
AAATTGGCTG ATTTTGGCCT GGCTCGAGCC TTTGGGATTC CCGTCCGCTG TTACTCAGCT 
GAGGTGGTCA CACTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC 
ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCTGGGCGG 
CCTCTTTTTC CCGGCAATGA TGTCGATGAC CAGTTGAAGA GGATCTTCCG ACTGCTGGGG 
ACGCCCACCG AGGAGCAGTG GCCCTCTATG ACCAAGCTGC CAGACTATAA GCCCTATCCG 
ATGTACCCGG CCACAACATC CCTGGTGAAC GTCGTGCCCA AACTCAATGC CACAGGGAGG 
GATCTGCTGC AGAACCTTCT GAAGTGTAAC CCTGTCCAGC GTATCTCAGC AGAAGAGGCC 
CTGCAGCACC CCTACTTCTC CGACTTCTGT CCGCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5 ( NM_004935.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004926.1 Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12814
Clone ID Related Accession (Same CDS sequence)	NM_004935.4 , NM_004935.3
Accession Version	NM_004935.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	cyclin-dependent-like kinase 5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB487008.1, AC010973.7, BP309068.1, BC005115.1, AK026533.1 and CA429180.1. This sequence is a reference standard in the RefSeqGene project. On Aug 26, 2009 this sequence version replaced NM_004935.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.310084.1, SRR1163655.481127.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 
GAGATTGTAA AGTCATTCCT CTTCCAGCTA CTAAAAGGGC TGGGATTCTG TCATAGCCGC 
AATGTGCTAC ACAGGGACCT GAAGCCCCAG AACCTGCTAA TAAACAGGAA TGGGGAGCTG 
AAATTGGCTG ATTTTGGCCT GGCTCGAGCC TTTGGGATTC CCGTCCGCTG TTACTCAGCT 
GAGGTGGTCA CACTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC 
ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCTGGGCGG 
CCTCTTTTTC CCGGCAATGA TGTCGATGAC CAGTTGAAGA GGATCTTCCG ACTGCTGGGG 
ACGCCCACCG AGGAGCAGTG GCCCTCTATG ACCAAGCTGC CAGACTATAA GCCCTATCCG 
ATGTACCCGG CCACAACATC CCTGGTGAAC GTCGTGCCCA AACTCAATGC CACAGGGAGG 
GATCTGCTGC AGAACCTTCT GAAGTGTAAC CCTGTCCAGC GTATCTCAGC AGAAGAGGCC 
CTGCAGCACC CCTACTTCTC CGACTTCTGT CCGCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004926.1
CDS	118..996
Translation	MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP

Target ORF information:

RefSeq Version	NM_004935.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004935.3

ORF Insert Sequence:

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 
GAGATTGTAA AGTCATTCCT CTTCCAGCTA CTAAAAGGGC TGGGATTCTG TCATAGCCGC 
AATGTGCTAC ACAGGGACCT GAAGCCCCAG AACCTGCTAA TAAACAGGAA TGGGGAGCTG 
AAATTGGCTG ATTTTGGCCT GGCTCGAGCC TTTGGGATTC CCGTCCGCTG TTACTCAGCT 
GAGGTGGTCA CACTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC 
ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCTGGGCGG 
CCTCTTTTTC CCGGCAATGA TGTCGATGAC CAGTTGAAGA GGATCTTCCG ACTGCTGGGG 
ACGCCCACCG AGGAGCAGTG GCCCTCTATG ACCAAGCTGC CAGACTATAA GCCCTATCCG 
ATGTACCCGG CCACAACATC CCTGGTGAAC GTCGTGCCCA AACTCAATGC CACAGGGAGG 
GATCTGCTGC AGAACCTTCT GAAGTGTAAC CCTGTCCAGC GTATCTCAGC AGAAGAGGCC 
CTGCAGCACC CCTACTTCTC CGACTTCTGT CCGCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5 ( NM_001164410.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001157882.1 Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12869
Clone ID Related Accession (Same CDS sequence)	NM_001164410.2 , NM_001164410.3
Accession Version	NM_001164410.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	cyclin-dependent-like kinase 5 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB487008.1, AC010973.7, AK026533.1, DQ411039.1 and CA429180.1. On Jan 6, 2015 this sequence version replaced NM_001164410.1. Transcript Variant: This variant (2), also known as CDK5-SV, omits an in-frame coding exon compared to variant 1 resulting in a shorter predicted protein (isoform 2). Expression of this transcript was described by Li et al. (2009; PubMed ID 19693690). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.291613.1, SRR1163657.361472.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 
GAGATTGTAA AGAATGGGGA GCTGAAATTG GCTGATTTTG GCCTGGCTCG AGCCTTTGGG 
ATTCCCGTCC GCTGTTACTC AGCTGAGGTG GTCACACTGT GGTACCGCCC ACCGGATGTC 
CTCTTTGGGG CCAAGCTGTA CTCCACGTCC ATCGACATGT GGTCAGCCGG CTGCATCTTT 
GCAGAGCTGG CCAATGCTGG GCGGCCTCTT TTTCCCGGCA ATGATGTCGA TGACCAGTTG 
AAGAGGATCT TCCGACTGCT GGGGACGCCC ACCGAGGAGC AGTGGCCCTC TATGACCAAG 
CTGCCAGACT ATAAGCCCTA TCCGATGTAC CCGGCCACAA CATCCCTGGT GAACGTCGTG 
CCCAAACTCA ATGCCACAGG GAGGGATCTG CTGCAGAACC TTCTGAAGTG TAACCCTGTC 
CAGCGTATCT CAGCAGAAGA GGCCCTGCAG CACCCCTACT TCTCCGACTT CTGTCCGCCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157882.1
CDS	118..900
Translation	MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP

Target ORF information:

RefSeq Version	NM_001164410.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164410.2

ORF Insert Sequence:

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 
GAGATTGTAA AGAATGGGGA GCTGAAATTG GCTGATTTTG GCCTGGCTCG AGCCTTTGGG 
ATTCCCGTCC GCTGTTACTC AGCTGAGGTG GTCACACTGT GGTACCGCCC ACCGGATGTC 
CTCTTTGGGG CCAAGCTGTA CTCCACGTCC ATCGACATGT GGTCAGCCGG CTGCATCTTT 
GCAGAGCTGG CCAATGCTGG GCGGCCTCTT TTTCCCGGCA ATGATGTCGA TGACCAGTTG 
AAGAGGATCT TCCGACTGCT GGGGACGCCC ACCGAGGAGC AGTGGCCCTC TATGACCAAG 
CTGCCAGACT ATAAGCCCTA TCCGATGTAC CCGGCCACAA CATCCCTGGT GAACGTCGTG 
CCCAAACTCA ATGCCACAGG GAGGGATCTG CTGCAGAACC TTCTGAAGTG TAACCCTGTC 
CAGCGTATCT CAGCAGAAGA GGCCCTGCAG CACCCCTACT TCTCCGACTT CTGTCCGCCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5 ( NM_001164410.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001157882.1 Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12869
Clone ID Related Accession (Same CDS sequence)	NM_001164410.2 , NM_001164410.3
Accession Version	NM_001164410.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	cyclin-dependent-like kinase 5 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB487008.1, AK026533.1, DQ411039.1 and CA429180.1. On May 31, 2019 this sequence version replaced NM_001164410.2. Transcript Variant: This variant (2), also known as CDK5-SV, omits an in-frame coding exon compared to variant 1 resulting in a shorter predicted protein (isoform 2). Expression of this transcript was described by Li et al. (2009; PubMed ID 19693690). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.361472.1, SRR1163657.291613.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 
GAGATTGTAA AGAATGGGGA GCTGAAATTG GCTGATTTTG GCCTGGCTCG AGCCTTTGGG 
ATTCCCGTCC GCTGTTACTC AGCTGAGGTG GTCACACTGT GGTACCGCCC ACCGGATGTC 
CTCTTTGGGG CCAAGCTGTA CTCCACGTCC ATCGACATGT GGTCAGCCGG CTGCATCTTT 
GCAGAGCTGG CCAATGCTGG GCGGCCTCTT TTTCCCGGCA ATGATGTCGA TGACCAGTTG 
AAGAGGATCT TCCGACTGCT GGGGACGCCC ACCGAGGAGC AGTGGCCCTC TATGACCAAG 
CTGCCAGACT ATAAGCCCTA TCCGATGTAC CCGGCCACAA CATCCCTGGT GAACGTCGTG 
CCCAAACTCA ATGCCACAGG GAGGGATCTG CTGCAGAACC TTCTGAAGTG TAACCCTGTC 
CAGCGTATCT CAGCAGAAGA GGCCCTGCAG CACCCCTACT TCTCCGACTT CTGTCCGCCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157882.1
CDS	50..832
Translation	MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP

Target ORF information:

RefSeq Version	NM_001164410.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164410.3

ORF Insert Sequence:

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 
GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 
GATGAGGGTG TGCCGAGTTC CGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 
AAGAACATCG TCAGGCTTCA TGACGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 
GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 
GAGATTGTAA AGAATGGGGA GCTGAAATTG GCTGATTTTG GCCTGGCTCG AGCCTTTGGG 
ATTCCCGTCC GCTGTTACTC AGCTGAGGTG GTCACACTGT GGTACCGCCC ACCGGATGTC 
CTCTTTGGGG CCAAGCTGTA CTCCACGTCC ATCGACATGT GGTCAGCCGG CTGCATCTTT 
GCAGAGCTGG CCAATGCTGG GCGGCCTCTT TTTCCCGGCA ATGATGTCGA TGACCAGTTG 
AAGAGGATCT TCCGACTGCT GGGGACGCCC ACCGAGGAGC AGTGGCCCTC TATGACCAAG 
CTGCCAGACT ATAAGCCCTA TCCGATGTAC CCGGCCACAA CATCCCTGGT GAACGTCGTG 
CCCAAACTCA ATGCCACAGG GAGGGATCTG CTGCAGAACC TTCTGAAGTG TAACCCTGTC 
CAGCGTATCT CAGCAGAAGA GGCCCTGCAG CACCCCTACT TCTCCGACTT CTGTCCGCCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphorylation of Drebrin and Its Role in Neuritogenesis.
Advances in experimental medicine and biology100649-60(2017)
Gordon-Weeks PR

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CDK5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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