ZASP cDNA ORF clone, Homo sapiens(human)

The intracellular fate of zonula occludens 2 is regulated by the phosphorylation of SR repeats and the phosphorylation/O-GlcNAcylation of S257.
Quiros M, Alarc?n L, Ponce A, Giannakouros T, Gonz?lez-Mariscal L
Molecular biology of the cell24(16)2528-43(2013 Aug)

Identification of ZASP, a novel protein associated to Zona occludens-2.
Lechuga S, Alarc?n L, Solano J, Huerta M, Lopez-Bayghen E, Gonz?lez-Mariscal L
Experimental cell research316(19)3124-39(2010 Nov)

The molecular basis for high-affinity binding of ZASP to G-Actin has been described.
Title: Expression and Purification of ZASP Subdomains and Clinically Important Isoforms: High-Affinity Binding to G-Actin.

A novel heterozygous missense mutation (p.N155H) in a highly conserved PDZ-like motif of ZASP was identified. The results indicate that typical ZASP-MFM presenting with late-onset distal myopathy is commonly associated with mutations in PDZ-like motif of ZASP.
Title: A novel mutation in the PDZ-like motif of ZASP causes distal ZASP-related myofibrillar myopathy.

p.(D117N) variant in Cypher/ZASP is not a causative mutation for dilated cardiomyopathy and ventricular arrhythmias.
Title: D117N in Cypher/ZASP may not be a causative mutation for dilated cardiomyopathy and ventricular arrhythmias.

Interaction is demonstrated between ZASP and two new binding partners both of which have roles in signalling, regulation of gene expression and muscle differentiation; the mechanosensing protein Ankrd2 and the tumour suppressor protein p53.
Title: ZASP interacts with the mechanosensing protein Ankrd2 and p53 in the signalling network of striated muscle.