RBM7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RBM7
Entrez Gene ID	10179
Full Name	RNA binding motif protein 7
General protein information	Preferred Names RNA binding motif protein 7 Names RNA-binding protein 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.2
Disorder MIM:	612413

mRNA and Protein(s)

mRNA	Protein	Name
NM_001286047.1	NP_001272976.1	RNA-binding protein 7 isoform c
NM_001286046.2	NP_001272975.1	RNA-binding protein 7 isoform c
NM_001286048.1	NP_001272977.1	RNA-binding protein 7 isoform c
NM_001286045.1	NP_001272974.1	RNA-binding protein 7 isoform a
NM_001286046.1	NP_001272975.1	RNA-binding protein 7 isoform c
NM_016090.3	NP_057174.1	RNA-binding protein 7 isoform b
NM_001286048.2	NP_001272977.1	RNA-binding protein 7 isoform c

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RBM7	XP_853905.2
Mus musculus (house mouse)	Rbm7	NP_659197.2
Pan troglodytes (chimpanzee)	RBM7	XP_001151010.1
Rattus norvegicus (Norway rat)	Rbm7	NP_001101613.2
Danio rerio (zebrafish)	zgc:77304	NP_956219.1
Xenopus tropicalis (tropical clawed frog)	rbm7	NP_001016096.1
Homo sapiens (human)	RBM7	NP_057174.1
	RBM7	XP_001088040.1
Gallus gallus (chicken)	RBM7	NP_001006318.1
Xenopus tropicalis (tropical clawed frog)	LOC101735152	XP_004916562.1
Bos taurus (cattle)	RBM7	NP_001029659.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.
Falk S, Finogenova K, Melko M, Benda C, Lykke-Andersen S, Jensen TH, Conti E
Nature communications713573(2016 Dec)

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.
Meola N, Domanski M, Karadoulama E, Chen Y, Gentil C, Pultz D, Vitting-Seerup K, Lykke-Andersen S, Andersen JS, Sandelin A, Jensen TH
Molecular cell64(3)520-533(2016 Nov)

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Giunta M, Edvardson S, Xu Y, Schuelke M, Gomez-Duran A, Boczonadi V, Elpeleg O, M?ller JS, Horvath R
Human molecular genetics25(14)2985-2996(2016 07)

RRM domain of human RBM7: purification, crystallization and structure determination.
Sofos N, Winkler MB, Brodersen DE
Acta crystallographica. Section F, Structural biology communications72(Pt 5)397-402(2016 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knock-down of rbm7, exosc8 and exosc3 in zebrafish showed a common pattern of defects in motor neurons and cerebellum. Our data indicate that impaired RNA metabolism may underlie the clinical phenotype by fine tuning gene expression which is essential for correct neuronal differentiation
Title: Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.

RBM8 and CBP20 RRM-domain crystal structures were used to successfully determine the RBM7 structure by molecular replacement. The structure reveals a ring-shaped pentameric assembly, which is most likely a consequence of crystal packing
Title: RRM domain of human RBM7: purification, crystallization and structure determination.

Phosphorylation of RBM7 by the p38(MAPK)/MK2 axis increases nuclear ncRNA stability by blocking their RBM7-binding and subsequent RNA exosome targeting to allow stress-dependent modulations of the noncoding transcriptome.
Title: p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex.

The following RBM7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RBM7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07699	NM_001286046.2 Latest version!	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07699	NM_001286048.2 Latest version!	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07699	NM_001286047.1 Latest version!	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12419	NM_016090.3 Latest version!	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu12240	NM_001286045.1 Latest version!	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu07699	NM_001286046.1	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu07699	NM_001286048.1	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RBM7 ( NM_001286047.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001272976.1 Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu07699
Clone ID Related Accession (Same CDS sequence)	NM_001286047.1 , NM_001286046.2 , NM_001286048.1 , NM_001286046.1 , NM_001286048.2
Accession Version	NM_001286047.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	RNA-binding protein 7 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA027521.1, CN308273.1, BC034381.1 and AP002373.3. Transcript Variant: This variant (4) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (c). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CN308273.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142363 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272976.1
CDS	344..784
Translation	MDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH

Target ORF information:

RefSeq Version	NM_001286047.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286047.1

ORF Insert Sequence:

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBM7 ( NM_001286046.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001272975.1 Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu07699
Clone ID Related Accession (Same CDS sequence)	NM_001286047.1 , NM_001286046.2 , NM_001286048.1 , NM_001286046.1 , NM_001286048.2
Accession Version	NM_001286046.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	RNA-binding protein 7 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA027521.1, BC013320.1, BC034381.1 and AP002373.3. On Jun 2, 2019 this sequence version replaced NM_001286046.1. Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (c). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.179243.1, BC013320.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272975.1
CDS	366..806
Translation	MDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH

Target ORF information:

RefSeq Version	NM_001286046.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286046.2

ORF Insert Sequence:

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBM7 ( NM_001286048.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001272977.1 Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu07699
Clone ID Related Accession (Same CDS sequence)	NM_001286047.1 , NM_001286046.2 , NM_001286048.1 , NM_001286046.1 , NM_001286048.2
Accession Version	NM_001286048.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-22
Organism	Homo sapiens(human)
Product	RNA-binding protein 7 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA027521.1, BQ067937.1, BC034381.1 and AP002373.3. Transcript Variant: This variant (5) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (c). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.26535.1, SRR1163655.239917.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272977.1
CDS	256..696
Translation	MDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH

Target ORF information:

RefSeq Version	NM_001286048.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286048.1

ORF Insert Sequence:

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBM7 ( NM_001286046.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001272975.1 Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu07699
Clone ID Related Accession (Same CDS sequence)	NM_001286047.1 , NM_001286046.2 , NM_001286048.1 , NM_001286046.1 , NM_001286048.2
Accession Version	NM_001286046.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-22
Organism	Homo sapiens(human)
Product	RNA-binding protein 7 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA027521.1, BC013320.1, BC034381.1 and AP002373.3. Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (c). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.179243.1, BC013320.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272975.1
CDS	503..943
Translation	MDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH

Target ORF information:

RefSeq Version	NM_001286046.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286046.1

ORF Insert Sequence:

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBM7 ( NM_001286048.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001272977.1 Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu07699
Clone ID Related Accession (Same CDS sequence)	NM_001286047.1 , NM_001286046.2 , NM_001286048.1 , NM_001286046.1 , NM_001286048.2
Accession Version	NM_001286048.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	RNA-binding protein 7 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA027521.1, BQ067937.1, BC034381.1 and AP002373.3. On Jun 2, 2019 this sequence version replaced NM_001286048.1. Transcript Variant: This variant (5) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a. Variants 3, 4, and 5 encode the same isoform (c). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.26535.1, SRR1163655.239917.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272977.1
CDS	119..559
Translation	MDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH

Target ORF information:

RefSeq Version	NM_001286048.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286048.2

ORF Insert Sequence:

ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBM7 ( NM_016090.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057174.1 Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12419
Clone ID Related Accession (Same CDS sequence)	NM_016090.3
Accession Version	NM_016090.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	RNA-binding protein 7 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA027521.1, BC034381.1 and AP002373.3. On Oct 30, 2013 this sequence version replaced NM_016090.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.167239.1, SRR1660805.157043.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGCGG CGGCGGCGGA AGCGGATCGC ACTCTCTTTG TGGGCAACCT TGAAACGAAA 
GTGACCGAGG AGCTCCTTTT CGAGCTTTTC CACCAGGCTG GGCCAGTAAT AAAGGTGAAA 
ATTCCAAAAG ATAAGGATGG TAAACCAAAG CAGTTTGCGT TTGTGAATTT CAAACATGAA 
GTGTCTGTTC CTTATGCAAT GAATCTACTT AATGGAATCA AACTTTATGG AAGGCCTATC 
AAAATTCAAT TTAGATCAGG AAGTAGTCAT GCCCCACAAG ATGTCAGTTT GTCATATCCC 
CAACATCATG TTGGAAATTC AAGCCCTACC TCCACATCTC CTAGCAGGTA CGAAAGGACT 
ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057174.1
CDS	144..944
Translation	MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLYGRPIKIQFRSGSSHAPQDVSLSYPQHHVGNSSPTSTSPSRYERTMDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH

Target ORF information:

RefSeq Version	NM_016090.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016090.3

ORF Insert Sequence:

ATGGGGGCGG CGGCGGCGGA AGCGGATCGC ACTCTCTTTG TGGGCAACCT TGAAACGAAA 
GTGACCGAGG AGCTCCTTTT CGAGCTTTTC CACCAGGCTG GGCCAGTAAT AAAGGTGAAA 
ATTCCAAAAG ATAAGGATGG TAAACCAAAG CAGTTTGCGT TTGTGAATTT CAAACATGAA 
GTGTCTGTTC CTTATGCAAT GAATCTACTT AATGGAATCA AACTTTATGG AAGGCCTATC 
AAAATTCAAT TTAGATCAGG AAGTAGTCAT GCCCCACAAG ATGTCAGTTT GTCATATCCC 
CAACATCATG TTGGAAATTC AAGCCCTACC TCCACATCTC CTAGCAGGTA CGAAAGGACT 
ATGGATAACA TGACTTCATC AGCACAGATA ATTCAGAGAT CTTTCTCTTC TCCAGAAAAT 
TTTCAGAGAC AAGCAGTGAT GAACAGTGCT TTGAGACAAA TGTCATATGG TGGAAAATTT 
GGTTCTTCAC CTCTGGATCA ATCAGGATTT TCACCATCAG TTCAATCACA CAGTCATAGT 
TTCAATCAGT CTTCAAGCTC CCAGTGGCGC CAAGGTACAC CATCATCACA GCGTAAAGTC 
AGAATGAATT CTTATCCCTA CCTAGCAGAT AGACATTATA GCCGGGAACA GCGTTACACT 
GATCATGGGT CTGACCATCA TTACAGAGGA AAGAGAGATG ATTTCTTCTA TGAAGACAGG 
AATCATGATG ACTGGAGCCA TGACTATGAT AACAGAAGAG ACAGTAGTAG AGATGGAAAA 
TGGCGCTCAT CTCGACACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBM7 ( NM_001286045.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001272974.1 Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12240
Clone ID Related Accession (Same CDS sequence)	NM_001286045.1
Accession Version	NM_001286045.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Homo sapiens(human)
Product	RNA-binding protein 7 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA027521.1, AK002015.1, AK225615.1 and AP002373.3. On Oct 29, 2013 this sequence version replaced XM_005271377.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.193988.1, SRR1660809.28039.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGGCGG CGGCGGCGGA AGCGGATCGC ACTCTCTTTG TGGGCAACCT TGAAACGAAA 
GTGACCGAGG AGCTCCTTTT CGAGCTTTTC CACCAGGCTG GGCCAGTAAT AAAGGTGAAA 
ATTCCAAAAG ATAAGGATGG TAAACCAAAG CAGTTTGCGT TTGTGAATTT CAAACATGAA 
GTGTCTGTTC CTTATGCAAT GAATCTACTT AATGGAATCA AACTTTATGG AAGGCCTATC 
AAAATTCAAT TTAGATCAGG AAGTAGTCAT GCCCCACAAG ATGTCAGTTT GTCATATCCC 
CAACATCATG TTGGAAATTC AAGCCCTACC TCCACATCTC CTAGCAGCAG GTACGAAAGG 
ACTATGGATA ACATGACTTC ATCAGCACAG ATAATTCAGA GATCTTTCTC TTCTCCAGAA 
AATTTTCAGA GACAAGCAGT GATGAACAGT GCTTTGAGAC AAATGTCATA TGGTGGAAAA 
TTTGGTTCTT CACCTCTGGA TCAATCAGGA TTTTCACCAT CAGTTCAATC ACACAGTCAT 
AGTTTCAATC AGTCTTCAAG CTCCCAGTGG CGCCAAGGTA CACCATCATC ACAGCGTAAA 
GTCAGAATGA ATTCTTATCC CTACCTAGCA GATAGACATT ATAGCCGGGA ACAGCGTTAC 
ACTGATCATG GGTCTGACCA TCATTACAGA GGAAAGAGAG ATGATTTCTT CTATGAAGAC 
AGGAATCATG ATGACTGGAG CCATGACTAT GATAACAGAA GAGACAGTAG TAGAGATGGA 
AAATGGCGCT CATCTCGACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272974.1
CDS	144..947
Translation	MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKPKQFAFVNFKHEVSVPYAMNLLNGIKLYGRPIKIQFRSGSSHAPQDVSLSYPQHHVGNSSPTSTSPSSRYERTMDNMTSSAQIIQRSFSSPENFQRQAVMNSALRQMSYGGKFGSSPLDQSGFSPSVQSHSHSFNQSSSSQWRQGTPSSQRKVRMNSYPYLADRHYSREQRYTDHGSDHHYRGKRDDFFYEDRNHDDWSHDYDNRRDSSRDGKWRSSRH

Target ORF information:

RefSeq Version	NM_001286045.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RNA binding motif protein 7 (RBM7), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286045.1

ORF Insert Sequence:

ATGGGGGCGG CGGCGGCGGA AGCGGATCGC ACTCTCTTTG TGGGCAACCT TGAAACGAAA 
GTGACCGAGG AGCTCCTTTT CGAGCTTTTC CACCAGGCTG GGCCAGTAAT AAAGGTGAAA 
ATTCCAAAAG ATAAGGATGG TAAACCAAAG CAGTTTGCGT TTGTGAATTT CAAACATGAA 
GTGTCTGTTC CTTATGCAAT GAATCTACTT AATGGAATCA AACTTTATGG AAGGCCTATC 
AAAATTCAAT TTAGATCAGG AAGTAGTCAT GCCCCACAAG ATGTCAGTTT GTCATATCCC 
CAACATCATG TTGGAAATTC AAGCCCTACC TCCACATCTC CTAGCAGCAG GTACGAAAGG 
ACTATGGATA ACATGACTTC ATCAGCACAG ATAATTCAGA GATCTTTCTC TTCTCCAGAA 
AATTTTCAGA GACAAGCAGT GATGAACAGT GCTTTGAGAC AAATGTCATA TGGTGGAAAA 
TTTGGTTCTT CACCTCTGGA TCAATCAGGA TTTTCACCAT CAGTTCAATC ACACAGTCAT 
AGTTTCAATC AGTCTTCAAG CTCCCAGTGG CGCCAAGGTA CACCATCATC ACAGCGTAAA 
GTCAGAATGA ATTCTTATCC CTACCTAGCA GATAGACATT ATAGCCGGGA ACAGCGTTAC 
ACTGATCATG GGTCTGACCA TCATTACAGA GGAAAGAGAG ATGATTTCTT CTATGAAGAC 
AGGAATCATG ATGACTGGAG CCATGACTAT GATAACAGAA GAGACAGTAG TAGAGATGGA 
AAATGGCGCT CATCTCGACA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.
Nature communications713573(2016 Dec)
Falk S,Finogenova K,Melko M,Benda C,Lykke-Andersen S,Jensen TH,Conti E

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.
Molecular cell64(3)520-533(2016 Nov)
Meola N,Domanski M,Karadoulama E,Chen Y,Gentil C,Pultz D,Vitting-Seerup K,Lykke-Andersen S,Andersen JS,Sandelin A,Jensen TH

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Human molecular genetics25(14)2985-2996(2016 07)
Giunta M,Edvardson S,Xu Y,Schuelke M,Gomez-Duran A,Boczonadi V,Elpeleg O,M?ller JS,Horvath R

RRM domain of human RBM7: purification, crystallization and structure determination.
Acta crystallographica. Section F, Structural biology communications72(Pt 5)397-402(2016 05)
Sofos N,Winkler MB,Brodersen DE

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RBM7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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