LPCAT3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LPCAT3
Entrez Gene ID	10162
Full Name	lysophosphatidylcholine acyltransferase 3
Synonyms	C3F,LPCAT,LPLAT 5,LPSAT,MBOAT5,OACT5,nessy
General protein information	Preferred Names lysophosphatidylcholine acyltransferase 3 Names lysophospholipid acyltransferase 5 1-acylglycerophosphocholine O-acyltransferase 1-acylglycerophosphoserine O-acyltransferase O-acyltransferase (membrane bound) domain containing 5 O-acyltransferase domain-containing protein 5 lyso-PC acyltransferase 3 lyso-PS acyltransferase lysophosphatidylserine acyltransferase membrane bound O-acyltransferase domain containing 5 membrane-bound O-acyltransferase domain-containing protein 5 putative protein similar to nessy
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Disorder MIM:	611950

mRNA and Protein(s)

mRNA	Protein	Name
NM_005768.5	NP_005759.4	lysophospholipid acyltransferase 5
XM_024448793.1	XP_024304561.1	lysophospholipid acyltransferase 5 isoform X1
NM_005768.6	NP_005759.4	lysophospholipid acyltransferase 5

Pathways from BioSystems

Homologies

	LPCAT3	XP_001111775.1
Canis lupus familiaris (dog)	LPCAT3	XP_543842.2
Bos taurus (cattle)	LPCAT3	NP_001019717.2
Danio rerio (zebrafish)	lpcat3	XP_683208.1
Drosophila melanogaster (fruit fly)	nes	NP_524157.2
Homo sapiens (human)	LPCAT3	NP_005759.4
Caenorhabditis elegans (roundworm)	mboa-6	NP_001022735.1
Pan troglodytes (chimpanzee)	LPCAT3	XP_508979.2
Gallus gallus (chicken)	LPCAT3	XP_416516.4
Xenopus tropicalis (tropical clawed frog)	lpcat3	XP_002941254.1
Mus musculus (house mouse)	Lpcat3	NP_660112.1
Rattus norvegicus (Norway rat)	Lpcat3	NP_001012189.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012258	XP_320281.4

Gene Ontology
Bibliography

Related articles in PubMed

Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.
Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Yata T, Iwaki T, Umemura K, Sano H, Suzuki Y, Urano T, Setou M, Unno N
Journal of vascular research54(4)200-208(2017)

Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor ?.
Singh AB, Liu J
The Journal of biological chemistry292(3)884-897(2017 01)

Essential Role of Lysophosphatidylcholine Acyltransferase 3 in the Induction of Macrophage Polarization in PMA-Treated U937 Cells.
Taniguchi K, Hikiji H, Okinaga T, Hashidate-Yoshida T, Shindou H, Ariyoshi W, Shimizu T, Tominaga K, Nishihara T
Journal of cellular biochemistry116(12)2840-8(2015 Dec)

Liver x receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3.
Ishibashi M, Varin A, Filomenko R, Lopez T, Athias A, Gambert P, Blache D, Thomas C, Gautier T, Lagrost L, Masson D
Arteriosclerosis, thrombosis, and vascular biology33(6)1171-9(2013 Jun)

Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression.
Li Z, Ding T, Pan X, Li Y, Li R, Sanders PE, Kuo MS, Hussain MM, Cao G, Jiang XC
The Journal of biological chemistry287(24)20122-31(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Regulation of LPCAT3 expression might be associated with atherosclerotic progression in humans.
Title: Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.

findings identify LPCAT3 as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3.
Title: Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor ?.

Our findings suggest that LPCAT3 plays an important role in M1/M2-macrophage polarization, providing novel potential therapeutic targets for the regulation of immune and inflammatory disorders
Title: Essential Role of Lysophosphatidylcholine Acyltransferase 3 in the Induction of Macrophage Polarization in PMA-Treated U937 Cells.

LPCAT3 a key contributor to the human macrophages inflammatory response.
Title: Liver x receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3.

Results establish for the first time that LPCAT3 is specifically regulated by LXRalpha.
Title: Regulation of LPCAT3 by LXR.

The following LPCAT3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LPCAT3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05005	NM_005768.6 Latest version!	Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu103673	XM_024448793.1 Latest version!	Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu05005	NM_005768.5	Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LPCAT3 ( NM_005768.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005759.4 Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), mRNA.

Price & Availability↑

CloneID	OHu05005
Clone ID Related Accession (Same CDS sequence)	NM_005768.5 , NM_005768.6
Accession Version	NM_005768.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1464bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-14
Organism	Homo sapiens(human)
Product	lysophospholipid acyltransferase 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AU125262.1 and BX648009.1. On Feb 12, 2004 this sequence version replaced NM_005768.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX648009.1, SRR1803616.219487.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCGTCCT CAGCGGAGGG GGACGAGGGG ACTGTGGTGG CGCTGGCGGG GGTTCTGCAG 
TCGGGTTTCC AGGAGCTGAG CCTTAACAAG TTGGCGACGT CCCTGGGCGC GTCAGAACAG 
GCGCTGCGGC TGATCATCTC CATCTTCCTG GGTTACCCCT TTGCTTTGTT TTATCGGCAT 
TACCTTTTCT ACAAGGAGAC CTACCTCATC CACCTCTTCC ATACCTTTAC AGGCCTCTCA 
ATTGCTTATT TTAACTTTGG AAACCAGCTC TACCACTCCC TGCTGTGTAT TGTGCTTCAG 
TTCCTCATCC TTCGACTAAT GGGCCGCACC ATCACTGCCG TCCTCACTAC CTTTTGCTTC 
CAGATGGCCT ACCTTCTGGC TGGATACTAT TACACTGCCA CCGGCAACTA CGATATCAAG 
TGGACAATGC CACATTGTGT TCTGACTTTG AAGCTGATTG GTTTGGCTGT TGACTACTTT 
GACGGAGGGA AAGATCAGAA TTCCTTGTCC TCTGAGCAAC AGAAATATGC CATACGTGGT 
GTTCCTTCCC TGCTGGAAGT TGCTGGTTTC TCCTACTTCT ATGGGGCCTT CTTGGTAGGG 
CCCCAGTTCT CAATGAATCA CTACATGAAG CTGGTGCAGG GAGAGCTGAT TGACATACCA 
GGAAAGATAC CAAACAGCAT CATTCCTGCT CTCAAGCGCC TGAGTCTGGG CCTTTTCTAC 
CTAGTGGGCT ACACACTGCT CAGCCCCCAC ATCACAGAAG ACTATCTCCT CACTGAAGAC 
TATGACAACC ACCCCTTCTG GTTCCGCTGC ATGTACATGC TGATCTGGGG CAAGTTTGTG 
CTGTACAAAT ATGTCACCTG TTGGCTGGTC ACAGAAGGAG TATGCATTTT GACGGGCCTG 
GGCTTCAATG GCTTTGAAGA AAAGGGCAAG GCAAAGTGGG ATGCCTGTGC CAACATGAAG 
GTGTGGCTCT TTGAAACAAA CCCCCGCTTC ACTGGCACCA TTGCCTCATT CAACATCAAC 
ACCAACGCCT GGGTGGCCCG CTACATCTTC AAACGACTCA AGTTCCTTGG AAATAAAGAA 
CTCTCTCAGG GTCTCTCGTT GCTATTCCTG GCCCTCTGGC ACGGCCTGCA CTCAGGATAC 
CTGGTCTGCT TCCAGATGGA ATTCCTCATT GTTATTGTGG AAAGACAGGC TGCCAGGCTC 
ATTCAAGAGA GCCCCACCCT GAGCAAGCTG GCCGCCATTA CTGTCCTCCA GCCCTTCTAC 
TATTTGGTGC AACAGACCAT CCACTGGCTC TTCATGGGTT ACTCCATGAC TGCCTTCTGC 
CTCTTCACGT GGGACAAATG GCTTAAGGTG TATAAATCCA TCTATTTCCT TGGCCACATC 
TTCTTCCTGA GCCTACTATT CATATTGCCT TATATTCACA AAGCAATGGT GCCAAGGAAA 
GAGAAGTTAA AGAAGATGGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005759.4
CDS	115..1578
Translation	MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRHYLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRKEKLKKME

Target ORF information:

RefSeq Version	NM_005768.5
Organism	Homo sapiens(human)
Definition	Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005768.5

ORF Insert Sequence:

ATGGCGTCCT CAGCGGAGGG GGACGAGGGG ACTGTGGTGG CGCTGGCGGG GGTTCTGCAG 
TCGGGTTTCC AGGAGCTGAG CCTTAACAAG TTGGCGACGT CCCTGGGCGC GTCAGAACAG 
GCGCTGCGGC TGATCATCTC CATCTTCCTG GGTTACCCCT TTGCTTTGTT TTATCGGCAT 
TACCTTTTCT ACAAGGAGAC CTACCTCATC CACCTCTTCC ATACCTTTAC AGGCCTCTCA 
ATTGCTTATT TTAACTTTGG AAACCAGCTC TACCACTCCC TGCTGTGTAT TGTGCTTCAG 
TTCCTCATCC TTCGACTAAT GGGCCGCACC ATCACTGCCG TCCTCACTAC CTTTTGCTTC 
CAGATGGCCT ACCTTCTGGC TGGATACTAT TACACTGCCA CCGGCAACTA CGATATCAAG 
TGGACAATGC CACATTGTGT TCTGACTTTG AAGCTGATTG GTTTGGCTGT TGACTACTTT 
GACGGAGGGA AAGATCAGAA TTCCTTGTCC TCTGAGCAAC AGAAATATGC CATACGTGGT 
GTTCCTTCCC TGCTGGAAGT TGCTGGTTTC TCCTACTTCT ATGGGGCCTT CTTGGTAGGG 
CCCCAGTTCT CAATGAATCA CTACATGAAG CTGGTGCAGG GAGAGCTGAT TGACATACCA 
GGAAAGATAC CAAACAGCAT CATTCCTGCT CTCAAGCGCC TGAGTCTGGG CCTTTTCTAC 
CTAGTGGGCT ACACACTGCT CAGCCCCCAC ATCACAGAAG ACTATCTCCT CACTGAAGAC 
TATGACAACC ACCCCTTCTG GTTCCGCTGC ATGTACATGC TGATCTGGGG CAAGTTTGTG 
CTGTACAAAT ATGTCACCTG TTGGCTGGTC ACAGAAGGAG TATGCATTTT GACGGGCCTG 
GGCTTCAATG GCTTTGAAGA AAAGGGCAAG GCAAAGTGGG ATGCCTGTGC CAACATGAAG 
GTGTGGCTCT TTGAAACAAA CCCCCGCTTC ACTGGCACCA TTGCCTCATT CAACATCAAC 
ACCAACGCCT GGGTGGCCCG CTACATCTTC AAACGACTCA AGTTCCTTGG AAATAAAGAA 
CTCTCTCAGG GTCTCTCGTT GCTATTCCTG GCCCTCTGGC ACGGCCTGCA CTCAGGATAC 
CTGGTCTGCT TCCAGATGGA ATTCCTCATT GTTATTGTGG AAAGACAGGC TGCCAGGCTC 
ATTCAAGAGA GCCCCACCCT GAGCAAGCTG GCCGCCATTA CTGTCCTCCA GCCCTTCTAC 
TATTTGGTGC AACAGACCAT CCACTGGCTC TTCATGGGTT ACTCCATGAC TGCCTTCTGC 
CTCTTCACGT GGGACAAATG GCTTAAGGTG TATAAATCCA TCTATTTCCT TGGCCACATC 
TTCTTCCTGA GCCTACTATT CATATTGCCT TATATTCACA AAGCAATGGT GCCAAGGAAA 
GAGAAGTTAA AGAAGATGGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LPCAT3 ( NM_005768.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005759.4 Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), mRNA.

Price & Availability↑

CloneID	OHu05005
Clone ID Related Accession (Same CDS sequence)	NM_005768.5 , NM_005768.6
Accession Version	NM_005768.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1464bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	lysophospholipid acyltransferase 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AU125262.1 and BX648009.1. On Nov 22, 2018 this sequence version replaced NM_005768.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX648009.1, SRR1660807.154208.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261407.9/ ENSP00000261407.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTCCT CAGCGGAGGG GGACGAGGGG ACTGTGGTGG CGCTGGCGGG GGTTCTGCAG 
TCGGGTTTCC AGGAGCTGAG CCTTAACAAG TTGGCGACGT CCCTGGGCGC GTCAGAACAG 
GCGCTGCGGC TGATCATCTC CATCTTCCTG GGTTACCCCT TTGCTTTGTT TTATCGGCAT 
TACCTTTTCT ACAAGGAGAC CTACCTCATC CACCTCTTCC ATACCTTTAC AGGCCTCTCA 
ATTGCTTATT TTAACTTTGG AAACCAGCTC TACCACTCCC TGCTGTGTAT TGTGCTTCAG 
TTCCTCATCC TTCGACTAAT GGGCCGCACC ATCACTGCCG TCCTCACTAC CTTTTGCTTC 
CAGATGGCCT ACCTTCTGGC TGGATACTAT TACACTGCCA CCGGCAACTA CGATATCAAG 
TGGACAATGC CACATTGTGT TCTGACTTTG AAGCTGATTG GTTTGGCTGT TGACTACTTT 
GACGGAGGGA AAGATCAGAA TTCCTTGTCC TCTGAGCAAC AGAAATATGC CATACGTGGT 
GTTCCTTCCC TGCTGGAAGT TGCTGGTTTC TCCTACTTCT ATGGGGCCTT CTTGGTAGGG 
CCCCAGTTCT CAATGAATCA CTACATGAAG CTGGTGCAGG GAGAGCTGAT TGACATACCA 
GGAAAGATAC CAAACAGCAT CATTCCTGCT CTCAAGCGCC TGAGTCTGGG CCTTTTCTAC 
CTAGTGGGCT ACACACTGCT CAGCCCCCAC ATCACAGAAG ACTATCTCCT CACTGAAGAC 
TATGACAACC ACCCCTTCTG GTTCCGCTGC ATGTACATGC TGATCTGGGG CAAGTTTGTG 
CTGTACAAAT ATGTCACCTG TTGGCTGGTC ACAGAAGGAG TATGCATTTT GACGGGCCTG 
GGCTTCAATG GCTTTGAAGA AAAGGGCAAG GCAAAGTGGG ATGCCTGTGC CAACATGAAG 
GTGTGGCTCT TTGAAACAAA CCCCCGCTTC ACTGGCACCA TTGCCTCATT CAACATCAAC 
ACCAACGCCT GGGTGGCCCG CTACATCTTC AAACGACTCA AGTTCCTTGG AAATAAAGAA 
CTCTCTCAGG GTCTCTCGTT GCTATTCCTG GCCCTCTGGC ACGGCCTGCA CTCAGGATAC 
CTGGTCTGCT TCCAGATGGA ATTCCTCATT GTTATTGTGG AAAGACAGGC TGCCAGGCTC 
ATTCAAGAGA GCCCCACCCT GAGCAAGCTG GCCGCCATTA CTGTCCTCCA GCCCTTCTAC 
TATTTGGTGC AACAGACCAT CCACTGGCTC TTCATGGGTT ACTCCATGAC TGCCTTCTGC 
CTCTTCACGT GGGACAAATG GCTTAAGGTG TATAAATCCA TCTATTTCCT TGGCCACATC 
TTCTTCCTGA GCCTACTATT CATATTGCCT TATATTCACA AAGCAATGGT GCCAAGGAAA 
GAGAAGTTAA AGAAGATGGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005759.4
CDS	53..1516
Translation	MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRHYLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRKEKLKKME

Target ORF information:

RefSeq Version	NM_005768.6
Organism	Homo sapiens(human)
Definition	Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005768.6

ORF Insert Sequence:

ATGGCGTCCT CAGCGGAGGG GGACGAGGGG ACTGTGGTGG CGCTGGCGGG GGTTCTGCAG 
TCGGGTTTCC AGGAGCTGAG CCTTAACAAG TTGGCGACGT CCCTGGGCGC GTCAGAACAG 
GCGCTGCGGC TGATCATCTC CATCTTCCTG GGTTACCCCT TTGCTTTGTT TTATCGGCAT 
TACCTTTTCT ACAAGGAGAC CTACCTCATC CACCTCTTCC ATACCTTTAC AGGCCTCTCA 
ATTGCTTATT TTAACTTTGG AAACCAGCTC TACCACTCCC TGCTGTGTAT TGTGCTTCAG 
TTCCTCATCC TTCGACTAAT GGGCCGCACC ATCACTGCCG TCCTCACTAC CTTTTGCTTC 
CAGATGGCCT ACCTTCTGGC TGGATACTAT TACACTGCCA CCGGCAACTA CGATATCAAG 
TGGACAATGC CACATTGTGT TCTGACTTTG AAGCTGATTG GTTTGGCTGT TGACTACTTT 
GACGGAGGGA AAGATCAGAA TTCCTTGTCC TCTGAGCAAC AGAAATATGC CATACGTGGT 
GTTCCTTCCC TGCTGGAAGT TGCTGGTTTC TCCTACTTCT ATGGGGCCTT CTTGGTAGGG 
CCCCAGTTCT CAATGAATCA CTACATGAAG CTGGTGCAGG GAGAGCTGAT TGACATACCA 
GGAAAGATAC CAAACAGCAT CATTCCTGCT CTCAAGCGCC TGAGTCTGGG CCTTTTCTAC 
CTAGTGGGCT ACACACTGCT CAGCCCCCAC ATCACAGAAG ACTATCTCCT CACTGAAGAC 
TATGACAACC ACCCCTTCTG GTTCCGCTGC ATGTACATGC TGATCTGGGG CAAGTTTGTG 
CTGTACAAAT ATGTCACCTG TTGGCTGGTC ACAGAAGGAG TATGCATTTT GACGGGCCTG 
GGCTTCAATG GCTTTGAAGA AAAGGGCAAG GCAAAGTGGG ATGCCTGTGC CAACATGAAG 
GTGTGGCTCT TTGAAACAAA CCCCCGCTTC ACTGGCACCA TTGCCTCATT CAACATCAAC 
ACCAACGCCT GGGTGGCCCG CTACATCTTC AAACGACTCA AGTTCCTTGG AAATAAAGAA 
CTCTCTCAGG GTCTCTCGTT GCTATTCCTG GCCCTCTGGC ACGGCCTGCA CTCAGGATAC 
CTGGTCTGCT TCCAGATGGA ATTCCTCATT GTTATTGTGG AAAGACAGGC TGCCAGGCTC 
ATTCAAGAGA GCCCCACCCT GAGCAAGCTG GCCGCCATTA CTGTCCTCCA GCCCTTCTAC 
TATTTGGTGC AACAGACCAT CCACTGGCTC TTCATGGGTT ACTCCATGAC TGCCTTCTGC 
CTCTTCACGT GGGACAAATG GCTTAAGGTG TATAAATCCA TCTATTTCCT TGGCCACATC 
TTCTTCCTGA GCCTACTATT CATATTGCCT TATATTCACA AAGCAATGGT GCCAAGGAAA 
GAGAAGTTAA AGAAGATGGA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LPCAT3 ( XM_024448793.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024304561.1 Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu103673
Clone ID Related Accession (Same CDS sequence)	XM_024448793.1
Accession Version	XM_024448793.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	lysophospholipid acyltransferase 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGTCCT CAGCGGAGGG GGACGAGGGG ACTGTGGTGG CGCTGGCGGG GGTTCTGCAG 
TCGGGTTTCC AGGAGCTGAG CCTTAACAAG TTGGCGACGT CCCTGGGCGC GTCAGAACAG 
GCGCTGCGGC TGATCATCTC CATCTTCCTG GGTTACCCCT TTGCTTTGTT TTATCGGCAT 
TACCTTTTCT ACAAGGAGAC CTACCTCATC CACCTCTTCC ATACCTTTAC AGGCCTCTCA 
ATTGCTTATT TTAACTTTGG AAACCAGCTC TACCACTCCC TGCTGTGTAT TGTGCTTCAG 
TTCCTCATCC TTCGACTAAT GGGCCGCACC ATCACTGCCG TCCTCACTAC CTTTTGCTTC 
CAGATGGCCT ACCTTCTGGC TGGATACTAT TACACTGCCA CCGGCAACTA CGATATCAAG 
TGGACAATGC CACATTGTGT TCTGACTTTG AAGCTGATTG GTTTGGCTGT TGACTACTTT 
GACGGAGGGA AAGATCAGAA TTCCTTGTCC TCTGAGCAAC AGAAATATGC CATACGTGGT 
GTTCCTTCCC TGCTGGAAGT TGCTGGTTTC TCCTACTTCT ATGGGGCCTT CTTGGTAGGG 
CCCCAGTTCT CAATGAATCA CTACATGAAG CTGGTGCAGG GAGAGCTGAT TGACATACCA 
GGAAAGATAC CAAACAGCAT CATTCCTGCT CTCAAGCGCC TGAGTCTGGG CCTTTTCTAC 
CTAGTGGGCT ACACACTGCT CAGCCCCCAC ATCACAGAAG ACTATCTCCT CACTGAAGAC 
TATGACAACC ACCCCTTCTG GTTCCGCTGC ATGTACATGC TGATCTGGGG CAAGTTTGTG 
CTGTACAAAT ATGTCACCTG TTGGCTGGTC ACAGAAGGAG TATGCATTTT GACGGGCCTG 
GGCTTCAATG GCTTTGAAGA AAAGGGCAAG GCAAAGTGGG ATGCCTGTGC CAACATGAAG 
GTGTGGCTCT TTGAAACAAA CCCCCGCTTC ACTGGCACCA TTGCCTCATT CAACATCAAC 
ACCAACGCCT GGGTGGCCCG CTACATCTTC AAACGACTCA AGTTCCTTGG AAATAAAGAA 
CTCTCTCAGG GTCTCTCGTT GCTATTCCTG GCCCTCTGGC ACGGCCTGCA CTCAGGATAC 
CTGGTCTGCT TCCAGATGGA ATTCCTCATT GTTATTGTGG AAAGACAGGT AGGCCTCCAG 
GGTGGGGGTG AAGGGGAATA TAAGGGACAA GATGCTGATG AGCTCCTCCT CCCTCCCCAG 
GCTGCCAGGC TCATTCAAGA GAGCCCCACC CTGAGCAAGC TGGCCGCCAT TACTGTCCTC 
CAGCCCTTCT ACTATTTGGT GCAACAGACC ATCCACTGGC TCTTCATGGG TTACTCCATG 
ACTGCCTTCT GCCTCTTCAC GTGGGACAAA TGGCTTAAGG TGTATAAATC CATCTATTTC 
CTTGGCCACA TCTTCTTCCT GAGCCTACTA TTCATATTGC CTTATATTCA CAAAGCAATG 
GTGCCAAGGA AAGAGAAGTT AAAGAAGATG GAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024304561.1
CDS	85..1620
Translation	MASSAEGDEGTVVALAGVLQSGFQELSLNKLATSLGASEQALRLIISIFLGYPFALFYRHYLFYKETYLIHLFHTFTGLSIAYFNFGNQLYHSLLCIVLQFLILRLMGRTITAVLTTFCFQMAYLLAGYYYTATGNYDIKWTMPHCVLTLKLIGLAVDYFDGGKDQNSLSSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVQGELIDIPGKIPNSIIPALKRLSLGLFYLVGYTLLSPHITEDYLLTEDYDNHPFWFRCMYMLIWGKFVLYKYVTCWLVTEGVCILTGLGFNGFEEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLVCFQMEFLIVIVERQVGLQGGGEGEYKGQDADELLLPPQAARLIQESPTLSKLAAITVLQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKVYKSIYFLGHIFFLSLLFILPYIHKAMVPRKEKLKKME

Target ORF information:

RefSeq Version	XM_024448793.1
Organism	Homo sapiens(human)
Definition	Homo sapiens lysophosphatidylcholine acyltransferase 3 (LPCAT3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024448793.1

ORF Insert Sequence:

ATGGCGTCCT CAGCGGAGGG GGACGAGGGG ACTGTGGTGG CGCTGGCGGG GGTTCTGCAG 
TCGGGTTTCC AGGAGCTGAG CCTTAACAAG TTGGCGACGT CCCTGGGCGC GTCAGAACAG 
GCGCTGCGGC TGATCATCTC CATCTTCCTG GGTTACCCCT TTGCTTTGTT TTATCGGCAT 
TACCTTTTCT ACAAGGAGAC CTACCTCATC CACCTCTTCC ATACCTTTAC AGGCCTCTCA 
ATTGCTTATT TTAACTTTGG AAACCAGCTC TACCACTCCC TGCTGTGTAT TGTGCTTCAG 
TTCCTCATCC TTCGACTAAT GGGCCGCACC ATCACTGCCG TCCTCACTAC CTTTTGCTTC 
CAGATGGCCT ACCTTCTGGC TGGATACTAT TACACTGCCA CCGGCAACTA CGATATCAAG 
TGGACAATGC CACATTGTGT TCTGACTTTG AAGCTGATTG GTTTGGCTGT TGACTACTTT 
GACGGAGGGA AAGATCAGAA TTCCTTGTCC TCTGAGCAAC AGAAATATGC CATACGTGGT 
GTTCCTTCCC TGCTGGAAGT TGCTGGTTTC TCCTACTTCT ATGGGGCCTT CTTGGTAGGG 
CCCCAGTTCT CAATGAATCA CTACATGAAG CTGGTGCAGG GAGAGCTGAT TGACATACCA 
GGAAAGATAC CAAACAGCAT CATTCCTGCT CTCAAGCGCC TGAGTCTGGG CCTTTTCTAC 
CTAGTGGGCT ACACACTGCT CAGCCCCCAC ATCACAGAAG ACTATCTCCT CACTGAAGAC 
TATGACAACC ACCCCTTCTG GTTCCGCTGC ATGTACATGC TGATCTGGGG CAAGTTTGTG 
CTGTACAAAT ATGTCACCTG TTGGCTGGTC ACAGAAGGAG TATGCATTTT GACGGGCCTG 
GGCTTCAATG GCTTTGAAGA AAAGGGCAAG GCAAAGTGGG ATGCCTGTGC CAACATGAAG 
GTGTGGCTCT TTGAAACAAA CCCCCGCTTC ACTGGCACCA TTGCCTCATT CAACATCAAC 
ACCAACGCCT GGGTGGCCCG CTACATCTTC AAACGACTCA AGTTCCTTGG AAATAAAGAA 
CTCTCTCAGG GTCTCTCGTT GCTATTCCTG GCCCTCTGGC ACGGCCTGCA CTCAGGATAC 
CTGGTCTGCT TCCAGATGGA ATTCCTCATT GTTATTGTGG AAAGACAGGT AGGCCTCCAG 
GGTGGGGGTG AAGGGGAATA TAAGGGACAA GATGCTGATG AGCTCCTCCT CCCTCCCCAG 
GCTGCCAGGC TCATTCAAGA GAGCCCCACC CTGAGCAAGC TGGCCGCCAT TACTGTCCTC 
CAGCCCTTCT ACTATTTGGT GCAACAGACC ATCCACTGGC TCTTCATGGG TTACTCCATG 
ACTGCCTTCT GCCTCTTCAC GTGGGACAAA TGGCTTAAGG TGTATAAATC CATCTATTTC 
CTTGGCCACA TCTTCTTCCT GAGCCTACTA TTCATATTGC CTTATATTCA CAAAGCAATG 
GTGCCAAGGA AAGAGAAGTT AAAGAAGATG GAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lysophosphatidylcholine Acyltransferase-3 Expression Is Associated with Atherosclerosis Progression.
Journal of vascular research54(4)200-208(2017)
Tanaka H,Zaima N,Sasaki T,Yamamoto N,Inuzuka K,Yata T,Iwaki T,Umemura K,Sano H,Suzuki Y,Urano T,Setou M,Unno N

Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor ?.
The Journal of biological chemistry292(3)884-897(2017 01)
Singh AB,Liu J

Essential Role of Lysophosphatidylcholine Acyltransferase 3 in the Induction of Macrophage Polarization in PMA-Treated U937 Cells.
Journal of cellular biochemistry116(12)2840-8(2015 Dec)
Taniguchi K,Hikiji H,Okinaga T,Hashidate-Yoshida T,Shindou H,Ariyoshi W,Shimizu T,Tominaga K,Nishihara T

Liver x receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3.
Arteriosclerosis, thrombosis, and vascular biology33(6)1171-9(2013 Jun)
Ishibashi M,Varin A,Filomenko R,Lopez T,Athias A,Gambert P,Blache D,Thomas C,Gautier T,Lagrost L,Masson D

Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver lysophosphatidylcholine accumulation promotes very low density lipoprotein production by enhancing microsomal triglyceride transfer protein expression.
The Journal of biological chemistry287(24)20122-31(2012 Jun)
Li Z,Ding T,Pan X,Li Y,Li R,Sanders PE,Kuo MS,Hussain MM,Cao G,Jiang XC

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LPCAT3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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