CDH15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDH15
Entrez Gene ID	1013
Full Name	cadherin 15
Synonyms	CDH14,CDH3,CDHM,MCAD,MRD3
General protein information	Preferred Names cadherin 15 Names cadherin-15 cadherin 15, type 1, M-cadherin (myotubule) cadherin-14 cadherin-3 muscle-cadherin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q24.3
Summary	This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008].
Disorder MIM:	114019
Disorder Html:	Mental retardation, autosomal dominant 3, 612580 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004933.2	NP_004924.1	cadherin-15 preproprotein
NM_004933.3	NP_004924.1	cadherin-15 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDH15	NP_004924.1
Bos taurus (cattle)	CDH15	NP_001095536.1
Canis lupus familiaris (dog)	CDH15	XP_536750.3
Rattus norvegicus (Norway rat)	Cdh15	NP_997496.1
Xenopus tropicalis (tropical clawed frog)	cdh15	XP_002933722.2
Mus musculus (house mouse)	Cdh15	NP_031688.2
Pan troglodytes (chimpanzee)	CDH15	XP_003315293.1
Danio rerio (zebrafish)	cdh15	NP_997771.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
International journal of molecular medicine25(4)649-56(2010 Apr)

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
American journal of hypertension23(1)70-7(2010 Jan)

Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability.
Bhalla K, Luo Y, Buchan T, Beachem MA, Guzauskas GF, Ladd S, Bratcher SJ, Schroer RJ, Balsamo J, DuPont BR, Lilien J, Srivastava AK
American journal of human genetics83(6)703-13(2008 Dec)

Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS
Journal of cell science118(Pt 11)2355-62(2005 Jun)

Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.
Kang JS, Feinleib JL, Knox S, Ketteringham MA, Krauss RS
Proceedings of the National Academy of Sciences of the United States of America100(7)3989-94(2003 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.

Observational study of gene-disease association. (HuGE Navigator)
Title: Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

Alterations in CDH15 in patients with mild to severe intellectual disability are reported.
Title: Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability.

The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.
Title: The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.

The following CDH15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDH15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18089	NM_004933.3 Latest version!	Homo sapiens cadherin 15 (CDH15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu18089	NM_004933.2	Homo sapiens cadherin 15 (CDH15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDH15 ( NM_004933.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004924.1 Homo sapiens cadherin 15 (CDH15), mRNA.

Price & Availability↑

CloneID	OHu18089
Clone ID Related Accession (Same CDS sequence)	NM_004933.2 , NM_004933.3
Accession Version	NM_004933.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2445bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	cadherin-15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009113.8, D83542.1 and AW452260.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_004933.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83542.1, BC008951.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155751, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000289746.3/ ENSP00000289746.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGCCG CGTTCCTCCT CGTCCTCGGG CTGTTGGCCC AGAGCCTCTG CCTGTCTTTG 
GGGGTTCCTG GATGGAGGAG GCCCACCACC CTGTACCCCT GGCGCCGGGC GCCTGCCCTG 
AGCCGCGTGC GGAGGGCCTG GGTCATCCCC CCGATCAGCG TATCCGAGAA CCACAAGCGT 
CTCCCCTACC CCCTGGTTCA GATCAAGTCG GACAAGCAGC AGCTGGGCAG CGTCATCTAC 
AGCATCCAGG GACCCGGCGT GGATGAGGAG CCCCGGGGCG TCTTCTCTAT CGACAAGTTC 
ACAGGGAAGG TCTTCCTCAA TGCCATGCTG GACCGCGAGA AGACTGATCG CTTCAGGCTA 
AGAGCGTTTG CCCTGGACCT GGGAGGATCC ACCCTGGAGG ACCCCACGGA CCTGGAGATT 
GTAGTTGTGG ATCAGAATGA CAACCGGCCA GCCTTCCTGC AGGAGGCGTT CACTGGCCGC 
GTGCTGGAGG GTGCAGTCCC AGGCACCTAT GTGACCAGGG CAGAGGCCAC AGATGCCGAC 
GACCCCGAGA CGGACAACGC AGCGCTGCGG TTCTCCATCC TGCAGCAGGG CAGCCCCGAG 
CTCTTCAGCA TCGACGAGCT CACAGGAGAG ATCCGCACAG TGCAAGTGGG GCTGGACCGC 
GAGGTGGTCG CGGTGTACAA TCTGACCCTG CAGGTGGCGG ACATGTCTGG AGACGGCCTC 
ACAGCCACTG CCTCAGCCAT CATCACCCTT GATGACATCA ATGACAATGC CCCCGAGTTC 
ACCAGGGATG AGTTCTTCAT GGAGGCCATA GAGGCCGTCA GCGGAGTGGA TGTGGGACGC 
CTGGAAGTGG AGGACAGGGA CCTGCCAGGC TCCCCAAACT GGGTGGCCAG GTTCACCATC 
CTGGAAGGCG ACCCCGATGG GCAGTTCACC ATCCGCACGG ACCCCAAGAC CAACGAGGGT 
GTTCTGTCCA TTGTGAAGGC CCTGGACTAT GAGAGCTGTG AACACTACGA ACTCAAAGTG 
TCGGTGCAGA ATGAGGCCCC GCTGCAGGCG GCTGCCCTTA GGGCTGAGCG GGGCCAGGCC 
AAGGTCCGCG TGCATGTGCA GGACACCAAC GAGCCCCCCG TGTTCCAGGA GAACCCACTT 
CGGACCAGCC TAGCAGAGGG GGCACCCCCA GGCACTCTGG TGGCCACCTT CTCTGCCCGG 
GACCCTGACA CAGAGCAGCT GCAGAGGCTC AGCTACTCCA AGGACTACGA CCCGGAAGAC 
TGGCTGCAAG TGGACGCAGC CACTGGCCGG ATCCAGACCC AGCACGTGCT CAGCCCGGCG 
TCCCCCTTCC TCAAGGGCGG CTGGTACAGA GCCATCGTCC TGGCCCAGGA TGACGCCTCC 
CAGCCCCGCA CCGCCACCGG CACCCTGTCC ATCGAGATCC TGGAGGTGAA CGACCATGCA 
CCTGTGCTGG CCCCGCCGCC GCCGGGCAGC CTGTGCAGCG AGCCACACCA AGGCCCAGGC 
CTCCTCCTGG GCGCCACGGA TGAGGACCTG CCCCCCCACG GGGCCCCCTT CCACTTCCAG 
CTGAGCCCCA GGCTCCCAGA GCTCGGCCGG AACTGGAGCC TCAGCCAGGT CAACGTGAGC 
CACGCGCGCC TGCGGCCGCG ACACCAGGTC CCCGAAGGCC TGCACCGCCT CAGCCTGCTG 
CTCCGGGACT CGGGGCAGCC GCCCCAGCAG CGCGAGCAGC CTCTGAACGT GACCGTGTGC 
CGCTGCGGCA AGGACGGCGT CTGCCTGCCG GGGGCCGCAG CGCTGCTGGC GGGGGGCACA 
GGCCTCAGCC TGGGCGCACT GGTCATCGTG CTGGCCAGCG CCCTCCTGCT GCTGGTGCTG 
GTCCTGCTCG TGGCACTCCG GGCGCGGTTC TGGAAGCAGT CTCGGGGCAA GGGGCTGCTG 
CACGGCCCCC AGGACGACCT TCGAGACAAT GTCCTCAACT ACGATGAGCA AGGAGGCGGG 
GAGGAGGACC AGGACGCCTA CGACATCAGC CAGCTGCGTC ACCCGACAGC GCTGAGCCTG 
CCTCTGGGAC CGCCGCCACT TCGCAGAGAT GCCCCGCAGG GCCGCCTGCA CCCCCAGCCA 
CCCCGAGTGC TGCCCACCAG CCCCCTGGAC ATCGCCGACT TCATCAATGA TGGCTTGGAG 
GCTGCAGATA GTGACCCCAG TGTGCCGCCT TACGACACAG CCCTCATCTA TGACTACGAG 
GGTGACGGCT CGGTGGCGGG GACGCTGAGC TCCATCCTGT CCAGCCAGGG CGATGAGGAC 
CAGGACTACG ACTACCTCAG AGACTGGGGG CCCCGCTTCG CCCGGCTGGC AGACATGTAT 
GGGCACCCGT GCGGGTTGGA GTACGGGGCC AGATGGGACC ACCAGGCCAG GGAGGGTCTT 
TCTCCTGGGG CACTGCTACC CAGACACAGA GGCCGGACAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004924.1
CDS	85..2529
Translation	MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYGHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA

Target ORF information:

RefSeq Version	NM_004933.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cadherin 15 (CDH15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004933.3

ORF Insert Sequence:

ATGGACGCCG CGTTCCTCCT CGTCCTCGGG CTGTTGGCCC AGAGCCTCTG CCTGTCTTTG 
GGGGTTCCTG GATGGAGGAG GCCCACCACC CTGTACCCCT GGCGCCGGGC GCCTGCCCTG 
AGCCGCGTGC GGAGGGCCTG GGTCATCCCC CCGATCAGCG TATCCGAGAA CCACAAGCGT 
CTCCCCTACC CCCTGGTTCA GATCAAGTCG GACAAGCAGC AGCTGGGCAG CGTCATCTAC 
AGCATCCAGG GACCCGGCGT GGATGAGGAG CCCCGGGGCG TCTTCTCTAT CGACAAGTTC 
ACAGGGAAGG TCTTCCTCAA TGCCATGCTG GACCGCGAGA AGACTGATCG CTTCAGGCTA 
AGAGCGTTTG CCCTGGACCT GGGAGGATCC ACCCTGGAGG ACCCCACGGA CCTGGAGATT 
GTAGTTGTGG ATCAGAATGA CAACCGGCCA GCCTTCCTGC AGGAGGCGTT CACTGGCCGC 
GTGCTGGAGG GTGCAGTCCC AGGCACCTAT GTGACCAGGG CAGAGGCCAC AGATGCCGAC 
GACCCCGAGA CGGACAACGC AGCGCTGCGG TTCTCCATCC TGCAGCAGGG CAGCCCCGAG 
CTCTTCAGCA TCGACGAGCT CACAGGAGAG ATCCGCACAG TGCAAGTGGG GCTGGACCGC 
GAGGTGGTCG CGGTGTACAA TCTGACCCTG CAGGTGGCGG ACATGTCTGG AGACGGCCTC 
ACAGCCACTG CCTCAGCCAT CATCACCCTT GATGACATCA ATGACAATGC CCCCGAGTTC 
ACCAGGGATG AGTTCTTCAT GGAGGCCATA GAGGCCGTCA GCGGAGTGGA TGTGGGACGC 
CTGGAAGTGG AGGACAGGGA CCTGCCAGGC TCCCCAAACT GGGTGGCCAG GTTCACCATC 
CTGGAAGGCG ACCCCGATGG GCAGTTCACC ATCCGCACGG ACCCCAAGAC CAACGAGGGT 
GTTCTGTCCA TTGTGAAGGC CCTGGACTAT GAGAGCTGTG AACACTACGA ACTCAAAGTG 
TCGGTGCAGA ATGAGGCCCC GCTGCAGGCG GCTGCCCTTA GGGCTGAGCG GGGCCAGGCC 
AAGGTCCGCG TGCATGTGCA GGACACCAAC GAGCCCCCCG TGTTCCAGGA GAACCCACTT 
CGGACCAGCC TAGCAGAGGG GGCACCCCCA GGCACTCTGG TGGCCACCTT CTCTGCCCGG 
GACCCTGACA CAGAGCAGCT GCAGAGGCTC AGCTACTCCA AGGACTACGA CCCGGAAGAC 
TGGCTGCAAG TGGACGCAGC CACTGGCCGG ATCCAGACCC AGCACGTGCT CAGCCCGGCG 
TCCCCCTTCC TCAAGGGCGG CTGGTACAGA GCCATCGTCC TGGCCCAGGA TGACGCCTCC 
CAGCCCCGCA CCGCCACCGG CACCCTGTCC ATCGAGATCC TGGAGGTGAA CGACCATGCA 
CCTGTGCTGG CCCCGCCGCC GCCGGGCAGC CTGTGCAGCG AGCCACACCA AGGCCCAGGC 
CTCCTCCTGG GCGCCACGGA TGAGGACCTG CCCCCCCACG GGGCCCCCTT CCACTTCCAG 
CTGAGCCCCA GGCTCCCAGA GCTCGGCCGG AACTGGAGCC TCAGCCAGGT CAACGTGAGC 
CACGCGCGCC TGCGGCCGCG ACACCAGGTC CCCGAAGGCC TGCACCGCCT CAGCCTGCTG 
CTCCGGGACT CGGGGCAGCC GCCCCAGCAG CGCGAGCAGC CTCTGAACGT GACCGTGTGC 
CGCTGCGGCA AGGACGGCGT CTGCCTGCCG GGGGCCGCAG CGCTGCTGGC GGGGGGCACA 
GGCCTCAGCC TGGGCGCACT GGTCATCGTG CTGGCCAGCG CCCTCCTGCT GCTGGTGCTG 
GTCCTGCTCG TGGCACTCCG GGCGCGGTTC TGGAAGCAGT CTCGGGGCAA GGGGCTGCTG 
CACGGCCCCC AGGACGACCT TCGAGACAAT GTCCTCAACT ACGATGAGCA AGGAGGCGGG 
GAGGAGGACC AGGACGCCTA CGACATCAGC CAGCTGCGTC ACCCGACAGC GCTGAGCCTG 
CCTCTGGGAC CGCCGCCACT TCGCAGAGAT GCCCCGCAGG GCCGCCTGCA CCCCCAGCCA 
CCCCGAGTGC TGCCCACCAG CCCCCTGGAC ATCGCCGACT TCATCAATGA TGGCTTGGAG 
GCTGCAGATA GTGACCCCAG TGTGCCGCCT TACGACACAG CCCTCATCTA TGACTACGAG 
GGTGACGGCT CGGTGGCGGG GACGCTGAGC TCCATCCTGT CCAGCCAGGG CGATGAGGAC 
CAGGACTACG ACTACCTCAG AGACTGGGGG CCCCGCTTCG CCCGGCTGGC AGACATGTAT 
GGGCACCCGT GCGGGTTGGA GTACGGGGCC AGATGGGACC ACCAGGCCAG GGAGGGTCTT 
TCTCCTGGGG CACTGCTACC CAGACACAGA GGCCGGACAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDH15 ( NM_004933.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004924.1 Homo sapiens cadherin 15 (CDH15), mRNA.

Price & Availability↑

CloneID	OHu18089
Clone ID Related Accession (Same CDS sequence)	NM_004933.2 , NM_004933.3
Accession Version	NM_004933.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2445bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	cadherin-15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D83542.1 and AW452260.1. This sequence is a reference standard in the RefSeqGene project. On Oct 29, 2001 this sequence version replaced NM_004933.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D83542.1, BC008951.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155751, SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGACGCCG CGTTCCTCCT CGTCCTCGGG CTGTTGGCCC AGAGCCTCTG CCTGTCTTTG 
GGGGTTCCTG GATGGAGGAG GCCCACCACC CTGTACCCCT GGCGCCGGGC GCCTGCCCTG 
AGCCGCGTGC GGAGGGCCTG GGTCATCCCC CCGATCAGCG TATCCGAGAA CCACAAGCGT 
CTCCCCTACC CCCTGGTTCA GATCAAGTCG GACAAGCAGC AGCTGGGCAG CGTCATCTAC 
AGCATCCAGG GACCCGGCGT GGATGAGGAG CCCCGGGGCG TCTTCTCTAT CGACAAGTTC 
ACAGGGAAGG TCTTCCTCAA TGCCATGCTG GACCGCGAGA AGACTGATCG CTTCAGGCTA 
AGAGCGTTTG CCCTGGACCT GGGAGGATCC ACCCTGGAGG ACCCCACGGA CCTGGAGATT 
GTAGTTGTGG ATCAGAATGA CAACCGGCCA GCCTTCCTGC AGGAGGCGTT CACTGGCCGC 
GTGCTGGAGG GTGCAGTCCC AGGCACCTAT GTGACCAGGG CAGAGGCCAC AGATGCCGAC 
GACCCCGAGA CGGACAACGC AGCGCTGCGG TTCTCCATCC TGCAGCAGGG CAGCCCCGAG 
CTCTTCAGCA TCGACGAGCT CACAGGAGAG ATCCGCACAG TGCAAGTGGG GCTGGACCGC 
GAGGTGGTCG CGGTGTACAA TCTGACCCTG CAGGTGGCGG ACATGTCTGG AGACGGCCTC 
ACAGCCACTG CCTCAGCCAT CATCACCCTT GATGACATCA ATGACAATGC CCCCGAGTTC 
ACCAGGGATG AGTTCTTCAT GGAGGCCATA GAGGCCGTCA GCGGAGTGGA TGTGGGACGC 
CTGGAAGTGG AGGACAGGGA CCTGCCAGGC TCCCCAAACT GGGTGGCCAG GTTCACCATC 
CTGGAAGGCG ACCCCGATGG GCAGTTCACC ATCCGCACGG ACCCCAAGAC CAACGAGGGT 
GTTCTGTCCA TTGTGAAGGC CCTGGACTAT GAGAGCTGTG AACACTACGA ACTCAAAGTG 
TCGGTGCAGA ATGAGGCCCC GCTGCAGGCG GCTGCCCTTA GGGCTGAGCG GGGCCAGGCC 
AAGGTCCGCG TGCATGTGCA GGACACCAAC GAGCCCCCCG TGTTCCAGGA GAACCCACTT 
CGGACCAGCC TAGCAGAGGG GGCACCCCCA GGCACTCTGG TGGCCACCTT CTCTGCCCGG 
GACCCTGACA CAGAGCAGCT GCAGAGGCTC AGCTACTCCA AGGACTACGA CCCGGAAGAC 
TGGCTGCAAG TGGACGCAGC CACTGGCCGG ATCCAGACCC AGCACGTGCT CAGCCCGGCG 
TCCCCCTTCC TCAAGGGCGG CTGGTACAGA GCCATCGTCC TGGCCCAGGA TGACGCCTCC 
CAGCCCCGCA CCGCCACCGG CACCCTGTCC ATCGAGATCC TGGAGGTGAA CGACCATGCA 
CCTGTGCTGG CCCCGCCGCC GCCGGGCAGC CTGTGCAGCG AGCCACACCA AGGCCCAGGC 
CTCCTCCTGG GCGCCACGGA TGAGGACCTG CCCCCCCACG GGGCCCCCTT CCACTTCCAG 
CTGAGCCCCA GGCTCCCAGA GCTCGGCCGG AACTGGAGCC TCAGCCAGGT CAACGTGAGC 
CACGCGCGCC TGCGGCCGCG ACACCAGGTC CCCGAAGGCC TGCACCGCCT CAGCCTGCTG 
CTCCGGGACT CGGGGCAGCC GCCCCAGCAG CGCGAGCAGC CTCTGAACGT GACCGTGTGC 
CGCTGCGGCA AGGACGGCGT CTGCCTGCCG GGGGCCGCAG CGCTGCTGGC GGGGGGCACA 
GGCCTCAGCC TGGGCGCACT GGTCATCGTG CTGGCCAGCG CCCTCCTGCT GCTGGTGCTG 
GTCCTGCTCG TGGCACTCCG GGCGCGGTTC TGGAAGCAGT CTCGGGGCAA GGGGCTGCTG 
CACGGCCCCC AGGACGACCT TCGAGACAAT GTCCTCAACT ACGATGAGCA AGGAGGCGGG 
GAGGAGGACC AGGACGCCTA CGACATCAGC CAGCTGCGTC ACCCGACAGC GCTGAGCCTG 
CCTCTGGGAC CGCCGCCACT TCGCAGAGAT GCCCCGCAGG GCCGCCTGCA CCCCCAGCCA 
CCCCGAGTGC TGCCCACCAG CCCCCTGGAC ATCGCCGACT TCATCAATGA TGGCTTGGAG 
GCTGCAGATA GTGACCCCAG TGTGCCGCCT TACGACACAG CCCTCATCTA TGACTACGAG 
GGTGACGGCT CGGTGGCGGG GACGCTGAGC TCCATCCTGT CCAGCCAGGG CGATGAGGAC 
CAGGACTACG ACTACCTCAG AGACTGGGGG CCCCGCTTCG CCCGGCTGGC AGACATGTAT 
GGGCACCCGT GCGGGTTGGA GTACGGGGCC AGATGGGACC ACCAGGCCAG GGAGGGTCTT 
TCTCCTGGGG CACTGCTACC CAGACACAGA GGCCGGACAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004924.1
CDS	78..2522
Translation	MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYGHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA

Target ORF information:

RefSeq Version	NM_004933.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cadherin 15 (CDH15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004933.2

ORF Insert Sequence:

ATGGACGCCG CGTTCCTCCT CGTCCTCGGG CTGTTGGCCC AGAGCCTCTG CCTGTCTTTG 
GGGGTTCCTG GATGGAGGAG GCCCACCACC CTGTACCCCT GGCGCCGGGC GCCTGCCCTG 
AGCCGCGTGC GGAGGGCCTG GGTCATCCCC CCGATCAGCG TATCCGAGAA CCACAAGCGT 
CTCCCCTACC CCCTGGTTCA GATCAAGTCG GACAAGCAGC AGCTGGGCAG CGTCATCTAC 
AGCATCCAGG GACCCGGCGT GGATGAGGAG CCCCGGGGCG TCTTCTCTAT CGACAAGTTC 
ACAGGGAAGG TCTTCCTCAA TGCCATGCTG GACCGCGAGA AGACTGATCG CTTCAGGCTA 
AGAGCGTTTG CCCTGGACCT GGGAGGATCC ACCCTGGAGG ACCCCACGGA CCTGGAGATT 
GTAGTTGTGG ATCAGAATGA CAACCGGCCA GCCTTCCTGC AGGAGGCGTT CACTGGCCGC 
GTGCTGGAGG GTGCAGTCCC AGGCACCTAT GTGACCAGGG CAGAGGCCAC AGATGCCGAC 
GACCCCGAGA CGGACAACGC AGCGCTGCGG TTCTCCATCC TGCAGCAGGG CAGCCCCGAG 
CTCTTCAGCA TCGACGAGCT CACAGGAGAG ATCCGCACAG TGCAAGTGGG GCTGGACCGC 
GAGGTGGTCG CGGTGTACAA TCTGACCCTG CAGGTGGCGG ACATGTCTGG AGACGGCCTC 
ACAGCCACTG CCTCAGCCAT CATCACCCTT GATGACATCA ATGACAATGC CCCCGAGTTC 
ACCAGGGATG AGTTCTTCAT GGAGGCCATA GAGGCCGTCA GCGGAGTGGA TGTGGGACGC 
CTGGAAGTGG AGGACAGGGA CCTGCCAGGC TCCCCAAACT GGGTGGCCAG GTTCACCATC 
CTGGAAGGCG ACCCCGATGG GCAGTTCACC ATCCGCACGG ACCCCAAGAC CAACGAGGGT 
GTTCTGTCCA TTGTGAAGGC CCTGGACTAT GAGAGCTGTG AACACTACGA ACTCAAAGTG 
TCGGTGCAGA ATGAGGCCCC GCTGCAGGCG GCTGCCCTTA GGGCTGAGCG GGGCCAGGCC 
AAGGTCCGCG TGCATGTGCA GGACACCAAC GAGCCCCCCG TGTTCCAGGA GAACCCACTT 
CGGACCAGCC TAGCAGAGGG GGCACCCCCA GGCACTCTGG TGGCCACCTT CTCTGCCCGG 
GACCCTGACA CAGAGCAGCT GCAGAGGCTC AGCTACTCCA AGGACTACGA CCCGGAAGAC 
TGGCTGCAAG TGGACGCAGC CACTGGCCGG ATCCAGACCC AGCACGTGCT CAGCCCGGCG 
TCCCCCTTCC TCAAGGGCGG CTGGTACAGA GCCATCGTCC TGGCCCAGGA TGACGCCTCC 
CAGCCCCGCA CCGCCACCGG CACCCTGTCC ATCGAGATCC TGGAGGTGAA CGACCATGCA 
CCTGTGCTGG CCCCGCCGCC GCCGGGCAGC CTGTGCAGCG AGCCACACCA AGGCCCAGGC 
CTCCTCCTGG GCGCCACGGA TGAGGACCTG CCCCCCCACG GGGCCCCCTT CCACTTCCAG 
CTGAGCCCCA GGCTCCCAGA GCTCGGCCGG AACTGGAGCC TCAGCCAGGT CAACGTGAGC 
CACGCGCGCC TGCGGCCGCG ACACCAGGTC CCCGAAGGCC TGCACCGCCT CAGCCTGCTG 
CTCCGGGACT CGGGGCAGCC GCCCCAGCAG CGCGAGCAGC CTCTGAACGT GACCGTGTGC 
CGCTGCGGCA AGGACGGCGT CTGCCTGCCG GGGGCCGCAG CGCTGCTGGC GGGGGGCACA 
GGCCTCAGCC TGGGCGCACT GGTCATCGTG CTGGCCAGCG CCCTCCTGCT GCTGGTGCTG 
GTCCTGCTCG TGGCACTCCG GGCGCGGTTC TGGAAGCAGT CTCGGGGCAA GGGGCTGCTG 
CACGGCCCCC AGGACGACCT TCGAGACAAT GTCCTCAACT ACGATGAGCA AGGAGGCGGG 
GAGGAGGACC AGGACGCCTA CGACATCAGC CAGCTGCGTC ACCCGACAGC GCTGAGCCTG 
CCTCTGGGAC CGCCGCCACT TCGCAGAGAT GCCCCGCAGG GCCGCCTGCA CCCCCAGCCA 
CCCCGAGTGC TGCCCACCAG CCCCCTGGAC ATCGCCGACT TCATCAATGA TGGCTTGGAG 
GCTGCAGATA GTGACCCCAG TGTGCCGCCT TACGACACAG CCCTCATCTA TGACTACGAG 
GGTGACGGCT CGGTGGCGGG GACGCTGAGC TCCATCCTGT CCAGCCAGGG CGATGAGGAC 
CAGGACTACG ACTACCTCAG AGACTGGGGG CCCCGCTTCG CCCGGCTGGC AGACATGTAT 
GGGCACCCGT GCGGGTTGGA GTACGGGGCC AGATGGGACC ACCAGGCCAG GGAGGGTCTT 
TCTCCTGGGG CACTGCTACC CAGACACAGA GGCCGGACAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.
International journal of molecular medicine25(4)649-56(2010 Apr)
Yoshida T,Kato K,Yokoi K,Oguri M,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nozawa Y,Yamada Y

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
American journal of hypertension23(1)70-7(2010 Jan)
Oguri M,Kato K,Yokoi K,Yoshida T,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nozawa Y,Yamada Y

Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability.
American journal of human genetics83(6)703-13(2008 Dec)
Bhalla K,Luo Y,Buchan T,Beachem MA,Guzauskas GF,Ladd S,Bratcher SJ,Schroer RJ,Balsamo J,DuPont BR,Lilien J,Srivastava AK

Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Journal of cell science118(Pt 11)2355-62(2005 Jun)
Krauss RS,Cole F,Gaio U,Takaesu G,Zhang W,Kang JS

Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.
Proceedings of the National Academy of Sciences of the United States of America100(7)3989-94(2003 Apr)
Kang JS,Feinleib JL,Knox S,Ketteringham MA,Krauss RS

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CDH15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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