RAD50 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAD50
Entrez Gene ID	10111
Full Name	RAD50 double strand break repair protein
Synonyms	NBSLD,RAD502,hRad50
General protein information	Preferred Names RAD50 double strand break repair protein Names DNA repair protein RAD50 RAD50 homolog, double strand break repair protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.1
Summary	The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010].
Disorder MIM:	604040
Disorder Html:	Nijmegen breakage syndrome-like disorder, 613078 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005732.3	NP_005723.2	DNA repair protein RAD50
NM_005732.4	NP_005723.2	DNA repair protein RAD50

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os02g0497500	NP_001046893.1
Xenopus tropicalis (tropical clawed frog)	rad50	XP_004912891.1
	RAD50	XP_001099384.2
Gallus gallus (chicken)	RAD50	XP_004945072.1
Arabidopsis thaliana (thale cress)	RAD50	NP_565733.1
Homo sapiens (human)	RAD50	NP_005723.2
Rattus norvegicus (Norway rat)	Rad50	NP_071582.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003676	XP_313457.4
Pan troglodytes (chimpanzee)	RAD50	XP_001163412.1
Canis lupus familiaris (dog)	RAD50	XP_531901.2
Neurospora crassa	NCU00901	XP_963818.1
Bos taurus (cattle)	RAD50	NP_001193797.1
Mus musculus (house mouse)	Rad50	NP_033038.2
Danio rerio (zebrafish)	rad50	XP_005167995.1
Drosophila melanogaster (fruit fly)	rad50	NP_001246461.1
Magnaporthe oryzae (rice blast fungus)	MGG_11387	XP_003713570.1

Gene Ontology
Bibliography

Related articles in PubMed

RAD50 Expression Is Associated with Poor Clinical Outcomes after Radiotherapy for Resected Non-small Cell Lung Cancer.
Wang Y, Gudikote J, Giri U, Yan J, Deng W, Ye R, Jiang W, Li N, Hobbs BP, Wang J, Swisher SG, Fujimoto J, Wistuba II, Komaki R, Heymach JV, Lin SH
Clinical cancer research : an official journal of the American Association for Cancer Research24(2)341-350(2018 Jan)

Targeting RAD50 increases sensitivity to radiotherapy in colorectal cancer cells.
Chen C, Wang Y, Mei JF, Li SS, Xu HX, Xiong HP, Wang XH, He X
Neoplasma65(1)75-80(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

although recruitment of the MRE11-RAD50-NBS1 (MRN) DSB-sensing complex to viral genomes and activation of the ATM kinase can promote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplification of viral DNA.
Title: Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.

Mre11-Rad50-Nbs1 complex initiates DNA double strand break repair.
Title: Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.

symmetrical engagement of the Rad50 catalytic head domains with ATP bound at both sites is important for MRN functions in eukaryotic cells.
Title: Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites.

the structure of the human Rad50 hook and coiled-coil domains, was determined.
Title: Eukaryotic Rad50 functions as a rod-shaped dimer.

Low RAD50 expression is associated with low-grade epithelial ovarian cancer.
Title: Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.

The following RAD50 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAD50 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21777	NM_005732.4 Latest version!	Homo sapiens RAD50 double strand break repair protein (RAD50), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$459.50-$643.30 $919.00
View Old Accession Versions >>
OHu21777	NM_005732.3	Homo sapiens RAD50 double strand break repair protein (RAD50), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$459.50-$643.30 $919.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAD50 ( NM_005732.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005723.2 Homo sapiens RAD50 double strand break repair protein (RAD50), mRNA.

Price & Availability↑

CloneID	OHu21777
Clone ID Related Accession (Same CDS sequence)	NM_005732.3 , NM_005732.4
Accession Version	NM_005732.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	DNA repair protein RAD50
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB112912.1, BC140005.1, U63139.1 and AC004041.1. This sequence is a reference standard in the RefSeqGene project. On Apr 30, 2010 this sequence version replaced NM_005732.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U63139.1, SRR1660805.70157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGGA TCGAAAAGAT GAGCATTCTG GGCGTGCGGA GTTTTGGAAT AGAGGACAAA 
GATAAGCAAA TTATCACTTT CTTCAGCCCC CTTACAATTT TGGTTGGACC CAATGGGGCG 
GGAAAGACGA CCATCATTGA ATGTCTAAAA TATATTTGTA CTGGAGATTT CCCTCCTGGA 
ACCAAAGGAA ATACATTTGT ACACGATCCC AAGGTTGCTC AAGAAACAGA TGTGAGAGCC 
CAGATTCGTC TGCAATTTCG TGATGTCAAT GGAGAACTTA TAGCTGTGCA AAGATCTATG 
GTGTGTACTC AGAAAAGCAA AAAGACAGAA TTTAAAACTC TGGAAGGAGT CATTACTAGA 
ACAAAGCATG GTGAAAAGGT CAGTCTGAGC TCTAAGTGTG CAGAAATTGA CCGAGAAATG 
ATCAGTTCTC TTGGGGTTTC CAAGGCTGTG CTAAATAATG TCATTTTCTG TCATCAAGAA 
GATTCTAATT GGCCTTTAAG TGAAGGAAAG GCTTTGAAGC AAAAGTTTGA TGAGATTTTT 
TCAGCAACAA GATACATTAA AGCCTTAGAA ACACTTCGGC AGGTACGTCA GACACAAGGT 
CAGAAAGTAA AAGAATATCA AATGGAACTA AAATATCTGA AGCAATATAA GGAAAAAGCT 
TGTGAGATTC GTGATCAGAT TACAAGTAAG GAAGCCCAGT TAACATCTTC AAAGGAAATT 
GTCAAATCCT ATGAGAATGA ACTTGATCCA TTGAAGAATC GTCTAAAAGA AATTGAACAT 
AATCTCTCTA AAATAATGAA ACTTGACAAT GAAATTAAAG CCTTGGATAG CCGAAAGAAG 
CAAATGGAGA AAGATAATAG TGAACTGGAA GAGAAAATGG AAAAGGTTTT TCAAGGGACT 
GATGAGCAAC TAAATGACTT ATATCACAAT CACCAGAGAA CAGTAAGGGA GAAAGAAAGG 
AAATTGGTAG ACTGTCATCG TGAACTGGAA AAACTAAATA AAGAATCTAG GCTTCTCAAT 
CAGGAAAAAT CAGAACTGCT TGTTGAACAG GGTCGTCTAC AGCTGCAAGC AGATCGCCAT 
CAAGAACATA TCCGAGCTAG AGATTCATTA ATTCAGTCTT TGGCAACACA GCTAGAATTG 
GATGGCTTTG AGCGTGGACC ATTCAGTGAA AGACAGATTA AAAATTTTCA CAAACTTGTG 
AGAGAGAGAC AAGAAGGGGA AGCAAAAACT GCCAACCAAC TGATGAATGA CTTTGCAGAA 
AAAGAGACTC TGAAACAAAA ACAGATAGAT GAGATAAGAG ATAAGAAAAC TGGACTGGGA 
AGAATAATTG AGTTAAAATC AGAAATCCTA AGTAAGAAGC AGAATGAGCT GAAAAATGTG 
AAGTATGAAT TACAGCAGTT GGAAGGATCT TCAGACAGGA TTCTTGAACT GGACCAGGAG 
CTCATAAAAG CTGAACGTGA GTTAAGCAAG GCTGAGAAAA ACAGCAATGT AGAAACCTTA 
AAAATGGAAG TAATAAGTCT CCAAAATGAA AAAGCAGACT TAGACAGGAC CCTGCGTAAA 
CTTGACCAGG AGATGGAGCA GTTAAACCAT CATACAACAA CACGTACCCA AATGGAGATG 
CTGACCAAAG ACAAAGCTGA CAAAGATGAA CAAATCAGAA AAATAAAATC TAGGCACAGT 
GATGAATTAA CCTCACTGTT GGGATATTTT CCCAACAAAA AACAGCTTGA AGACTGGCTA 
CATAGTAAAT CAAAAGAAAT TAATCAGACC AGGGACAGAC TTGCCAAATT GAACAAGGAA 
CTAGCTTCAT CTGAGCAGAA TAAAAATCAT ATAAATAATG AACTAAAAAG AAAGGAAGAG 
CAGTTGTCCA GTTACGAAGA CAAGCTGTTT GATGTTTGTG GTAGCCAGGA TTTTGAAAGT 
GATTTAGACA GGCTTAAAGA GGAAATTGAA AAATCATCAA AACAGCGAGC CATGCTGGCT 
GGAGCCACAG CAGTTTACTC CCAGTTCATT ACTCAGCTAA CAGACGAAAA CCAGTCATGT 
TGCCCCGTTT GTCAGAGAGT TTTTCAGACA GAGGCTGAGT TACAAGAAGT CATCAGTGAT 
TTGCAGTCTA AACTGCGACT TGCTCCAGAT AAACTCAAGT CAACAGAATC AGAGCTAAAA 
AAAAAGGAAA AGCGGCGTGA TGAAATGCTG GGACTTGTGC CCATGAGGCA AAGCATAATT 
GATTTGAAGG AGAAGGAAAT ACCAGAATTA AGAAACAAAC TGCAGAATGT CAATAGAGAC 
ATACAGCGCC TAAAGAACGA CATAGAAGAA CAAGAAACAC TCTTGGGTAC AATAATGCCT 
GAAGAAGAAA GTGCCAAAGT ATGCCTGACA GATGTTACAA TTATGGAGAG GTTCCAGATG 
GAACTTAAAG ATGTTGAAAG AAAAATTGCA CAACAAGCAG CTAAGCTACA AGGAATAGAC 
TTAGATCGAA CTGTCCAACA AGTCAACCAG GAGAAACAAG AGAAACAGCA CAAGTTAGAC 
ACAGTTTCTA GTAAGATTGA ATTGAATCGT AAGCTTATAC AGGACCAGCA GGAACAGATT 
CAACATCTAA AAAGTACAAC AAATGAGCTA AAATCTGAGA AACTTCAGAT ATCCACTAAT 
TTGCAACGTC GTCAGCAACT GGAGGAGCAG ACTGTGGAAT TATCCACTGA AGTTCAGTCT 
TTGTACAGAG AGATAAAGGA TGCTAAAGAG CAGGTAAGCC CTTTGGAAAC AACATTGGAA 
AAGTTCCAGC AAGAAAAAGA AGAATTAATC AACAAAAAAA ATACAAGCAA CAAAATAGCA 
CAGGATAAAC TGAATGATAT TAAAGAGAAG GTTAAAAATA TTCATGGCTA TATGAAAGAC 
ATTGAGAATT ATATTCAAGA TGGGAAAGAC GACTATAAGA AGCAAAAAGA AACTGAACTT 
AATAAAGTAA TAGCTCAACT AAGTGAATGC GAGAAACACA AAGAAAAGAT AAATGAAGAT 
ATGAGACTCA TGAGACAAGA TATTGATACA CAGAAGATAC AAGAAAGGTG GCTACAAGAT 
AACCTTACTT TAAGAAAAAG AAATGAGGAA CTAAAAGAAG TTGAAGAAGA AAGAAAACAA 
CATTTGAAGG AAATGGGTCA AATGCAGGTT TTGCAAATGA AAAGTGAACA TCAGAAGTTG 
GAAGAGAACA TAGACAATAT AAAAAGAAAT CATAATTTGG CATTAGGGCG ACAGAAAGGT 
TATGAAGAAG AAATTATTCA TTTTAAGAAA GAACTTCGAG AACCACAATT TCGGGATGCT 
GAGGAAAAGT ATAGAGAAAT GATGATTGTT ATGAGGACAA CAGAACTTGT GAACAAGGAT 
CTGGATATTT ATTATAAGAC TCTTGACCAA GCAATAATGA AATTTCACAG TATGAAAATG 
GAAGAAATCA ATAAAATTAT ACGTGACCTG TGGCGAAGTA CCTATCGTGG ACAAGATATT 
GAATACATAG AAATACGGTC TGATGCCGAT GAAAATGTAT CAGCTTCTGA TAAAAGGCGG 
AATTATAACT ACCGAGTGGT GATGCTGAAG GGAGACACAG CCTTGGATAT GCGAGGACGA 
TGCAGTGCTG GACAAAAGGT ATTAGCCTCA CTCATCATTC GCCTGGCCCT GGCTGAAACG 
TTCTGCCTCA ACTGTGGCAT CATTGCCTTG GATGAGCCAA CAACAAATCT TGACCGAGAA 
AACATTGAAT CTCTTGCACA TGCTCTGGTT GAGATAATAA AAAGTCGCTC ACAGCAGCGT 
AACTTCCAGC TTCTGGTAAT CACTCATGAT GAAGATTTTG TGGAGCTTTT AGGACGTTCT 
GAATATGTGG AGAAATTCTA CAGGATTAAA AAGAACATCG ATCAGTGCTC AGAGATTGTG 
AAATGCAGTG TTAGCTCCCT GGGATTCAAT GTTCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005723.2
CDS	402..4340
Translation	MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH

Target ORF information:

RefSeq Version	NM_005732.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAD50 double strand break repair protein (RAD50), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005732.3

ORF Insert Sequence:

ATGTCCCGGA TCGAAAAGAT GAGCATTCTG GGCGTGCGGA GTTTTGGAAT AGAGGACAAA 
GATAAGCAAA TTATCACTTT CTTCAGCCCC CTTACAATTT TGGTTGGACC CAATGGGGCG 
GGAAAGACGA CCATCATTGA ATGTCTAAAA TATATTTGTA CTGGAGATTT CCCTCCTGGA 
ACCAAAGGAA ATACATTTGT ACACGATCCC AAGGTTGCTC AAGAAACAGA TGTGAGAGCC 
CAGATTCGTC TGCAATTTCG TGATGTCAAT GGAGAACTTA TAGCTGTGCA AAGATCTATG 
GTGTGTACTC AGAAAAGCAA AAAGACAGAA TTTAAAACTC TGGAAGGAGT CATTACTAGA 
ACAAAGCATG GTGAAAAGGT CAGTCTGAGC TCTAAGTGTG CAGAAATTGA CCGAGAAATG 
ATCAGTTCTC TTGGGGTTTC CAAGGCTGTG CTAAATAATG TCATTTTCTG TCATCAAGAA 
GATTCTAATT GGCCTTTAAG TGAAGGAAAG GCTTTGAAGC AAAAGTTTGA TGAGATTTTT 
TCAGCAACAA GATACATTAA AGCCTTAGAA ACACTTCGGC AGGTACGTCA GACACAAGGT 
CAGAAAGTAA AAGAATATCA AATGGAACTA AAATATCTGA AGCAATATAA GGAAAAAGCT 
TGTGAGATTC GTGATCAGAT TACAAGTAAG GAAGCCCAGT TAACATCTTC AAAGGAAATT 
GTCAAATCCT ATGAGAATGA ACTTGATCCA TTGAAGAATC GTCTAAAAGA AATTGAACAT 
AATCTCTCTA AAATAATGAA ACTTGACAAT GAAATTAAAG CCTTGGATAG CCGAAAGAAG 
CAAATGGAGA AAGATAATAG TGAACTGGAA GAGAAAATGG AAAAGGTTTT TCAAGGGACT 
GATGAGCAAC TAAATGACTT ATATCACAAT CACCAGAGAA CAGTAAGGGA GAAAGAAAGG 
AAATTGGTAG ACTGTCATCG TGAACTGGAA AAACTAAATA AAGAATCTAG GCTTCTCAAT 
CAGGAAAAAT CAGAACTGCT TGTTGAACAG GGTCGTCTAC AGCTGCAAGC AGATCGCCAT 
CAAGAACATA TCCGAGCTAG AGATTCATTA ATTCAGTCTT TGGCAACACA GCTAGAATTG 
GATGGCTTTG AGCGTGGACC ATTCAGTGAA AGACAGATTA AAAATTTTCA CAAACTTGTG 
AGAGAGAGAC AAGAAGGGGA AGCAAAAACT GCCAACCAAC TGATGAATGA CTTTGCAGAA 
AAAGAGACTC TGAAACAAAA ACAGATAGAT GAGATAAGAG ATAAGAAAAC TGGACTGGGA 
AGAATAATTG AGTTAAAATC AGAAATCCTA AGTAAGAAGC AGAATGAGCT GAAAAATGTG 
AAGTATGAAT TACAGCAGTT GGAAGGATCT TCAGACAGGA TTCTTGAACT GGACCAGGAG 
CTCATAAAAG CTGAACGTGA GTTAAGCAAG GCTGAGAAAA ACAGCAATGT AGAAACCTTA 
AAAATGGAAG TAATAAGTCT CCAAAATGAA AAAGCAGACT TAGACAGGAC CCTGCGTAAA 
CTTGACCAGG AGATGGAGCA GTTAAACCAT CATACAACAA CACGTACCCA AATGGAGATG 
CTGACCAAAG ACAAAGCTGA CAAAGATGAA CAAATCAGAA AAATAAAATC TAGGCACAGT 
GATGAATTAA CCTCACTGTT GGGATATTTT CCCAACAAAA AACAGCTTGA AGACTGGCTA 
CATAGTAAAT CAAAAGAAAT TAATCAGACC AGGGACAGAC TTGCCAAATT GAACAAGGAA 
CTAGCTTCAT CTGAGCAGAA TAAAAATCAT ATAAATAATG AACTAAAAAG AAAGGAAGAG 
CAGTTGTCCA GTTACGAAGA CAAGCTGTTT GATGTTTGTG GTAGCCAGGA TTTTGAAAGT 
GATTTAGACA GGCTTAAAGA GGAAATTGAA AAATCATCAA AACAGCGAGC CATGCTGGCT 
GGAGCCACAG CAGTTTACTC CCAGTTCATT ACTCAGCTAA CAGACGAAAA CCAGTCATGT 
TGCCCCGTTT GTCAGAGAGT TTTTCAGACA GAGGCTGAGT TACAAGAAGT CATCAGTGAT 
TTGCAGTCTA AACTGCGACT TGCTCCAGAT AAACTCAAGT CAACAGAATC AGAGCTAAAA 
AAAAAGGAAA AGCGGCGTGA TGAAATGCTG GGACTTGTGC CCATGAGGCA AAGCATAATT 
GATTTGAAGG AGAAGGAAAT ACCAGAATTA AGAAACAAAC TGCAGAATGT CAATAGAGAC 
ATACAGCGCC TAAAGAACGA CATAGAAGAA CAAGAAACAC TCTTGGGTAC AATAATGCCT 
GAAGAAGAAA GTGCCAAAGT ATGCCTGACA GATGTTACAA TTATGGAGAG GTTCCAGATG 
GAACTTAAAG ATGTTGAAAG AAAAATTGCA CAACAAGCAG CTAAGCTACA AGGAATAGAC 
TTAGATCGAA CTGTCCAACA AGTCAACCAG GAGAAACAAG AGAAACAGCA CAAGTTAGAC 
ACAGTTTCTA GTAAGATTGA ATTGAATCGT AAGCTTATAC AGGACCAGCA GGAACAGATT 
CAACATCTAA AAAGTACAAC AAATGAGCTA AAATCTGAGA AACTTCAGAT ATCCACTAAT 
TTGCAACGTC GTCAGCAACT GGAGGAGCAG ACTGTGGAAT TATCCACTGA AGTTCAGTCT 
TTGTACAGAG AGATAAAGGA TGCTAAAGAG CAGGTAAGCC CTTTGGAAAC AACATTGGAA 
AAGTTCCAGC AAGAAAAAGA AGAATTAATC AACAAAAAAA ATACAAGCAA CAAAATAGCA 
CAGGATAAAC TGAATGATAT TAAAGAGAAG GTTAAAAATA TTCATGGCTA TATGAAAGAC 
ATTGAGAATT ATATTCAAGA TGGGAAAGAC GACTATAAGA AGCAAAAAGA AACTGAACTT 
AATAAAGTAA TAGCTCAACT AAGTGAATGC GAGAAACACA AAGAAAAGAT AAATGAAGAT 
ATGAGACTCA TGAGACAAGA TATTGATACA CAGAAGATAC AAGAAAGGTG GCTACAAGAT 
AACCTTACTT TAAGAAAAAG AAATGAGGAA CTAAAAGAAG TTGAAGAAGA AAGAAAACAA 
CATTTGAAGG AAATGGGTCA AATGCAGGTT TTGCAAATGA AAAGTGAACA TCAGAAGTTG 
GAAGAGAACA TAGACAATAT AAAAAGAAAT CATAATTTGG CATTAGGGCG ACAGAAAGGT 
TATGAAGAAG AAATTATTCA TTTTAAGAAA GAACTTCGAG AACCACAATT TCGGGATGCT 
GAGGAAAAGT ATAGAGAAAT GATGATTGTT ATGAGGACAA CAGAACTTGT GAACAAGGAT 
CTGGATATTT ATTATAAGAC TCTTGACCAA GCAATAATGA AATTTCACAG TATGAAAATG 
GAAGAAATCA ATAAAATTAT ACGTGACCTG TGGCGAAGTA CCTATCGTGG ACAAGATATT 
GAATACATAG AAATACGGTC TGATGCCGAT GAAAATGTAT CAGCTTCTGA TAAAAGGCGG 
AATTATAACT ACCGAGTGGT GATGCTGAAG GGAGACACAG CCTTGGATAT GCGAGGACGA 
TGCAGTGCTG GACAAAAGGT ATTAGCCTCA CTCATCATTC GCCTGGCCCT GGCTGAAACG 
TTCTGCCTCA ACTGTGGCAT CATTGCCTTG GATGAGCCAA CAACAAATCT TGACCGAGAA 
AACATTGAAT CTCTTGCACA TGCTCTGGTT GAGATAATAA AAAGTCGCTC ACAGCAGCGT 
AACTTCCAGC TTCTGGTAAT CACTCATGAT GAAGATTTTG TGGAGCTTTT AGGACGTTCT 
GAATATGTGG AGAAATTCTA CAGGATTAAA AAGAACATCG ATCAGTGCTC AGAGATTGTG 
AAATGCAGTG TTAGCTCCCT GGGATTCAAT GTTCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAD50 ( NM_005732.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005723.2 Homo sapiens RAD50 double strand break repair protein (RAD50), mRNA.

Price & Availability↑

CloneID	OHu21777
Clone ID Related Accession (Same CDS sequence)	NM_005732.3 , NM_005732.4
Accession Version	NM_005732.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	DNA repair protein RAD50
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC140005.1, AC116366.2, U63139.1 and AC004041.1. This sequence is a reference standard in the RefSeqGene project. On Jun 3, 2019 this sequence version replaced NM_005732.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.70157.1, U63139.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378823.8/ ENSP00000368100.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCCGGA TCGAAAAGAT GAGCATTCTG GGCGTGCGGA GTTTTGGAAT AGAGGACAAA 
GATAAGCAAA TTATCACTTT CTTCAGCCCC CTTACAATTT TGGTTGGACC CAATGGGGCG 
GGAAAGACGA CCATCATTGA ATGTCTAAAA TATATTTGTA CTGGAGATTT CCCTCCTGGA 
ACCAAAGGAA ATACATTTGT ACACGATCCC AAGGTTGCTC AAGAAACAGA TGTGAGAGCC 
CAGATTCGTC TGCAATTTCG TGATGTCAAT GGAGAACTTA TAGCTGTGCA AAGATCTATG 
GTGTGTACTC AGAAAAGCAA AAAGACAGAA TTTAAAACTC TGGAAGGAGT CATTACTAGA 
ACAAAGCATG GTGAAAAGGT CAGTCTGAGC TCTAAGTGTG CAGAAATTGA CCGAGAAATG 
ATCAGTTCTC TTGGGGTTTC CAAGGCTGTG CTAAATAATG TCATTTTCTG TCATCAAGAA 
GATTCTAATT GGCCTTTAAG TGAAGGAAAG GCTTTGAAGC AAAAGTTTGA TGAGATTTTT 
TCAGCAACAA GATACATTAA AGCCTTAGAA ACACTTCGGC AGGTACGTCA GACACAAGGT 
CAGAAAGTAA AAGAATATCA AATGGAACTA AAATATCTGA AGCAATATAA GGAAAAAGCT 
TGTGAGATTC GTGATCAGAT TACAAGTAAG GAAGCCCAGT TAACATCTTC AAAGGAAATT 
GTCAAATCCT ATGAGAATGA ACTTGATCCA TTGAAGAATC GTCTAAAAGA AATTGAACAT 
AATCTCTCTA AAATAATGAA ACTTGACAAT GAAATTAAAG CCTTGGATAG CCGAAAGAAG 
CAAATGGAGA AAGATAATAG TGAACTGGAA GAGAAAATGG AAAAGGTTTT TCAAGGGACT 
GATGAGCAAC TAAATGACTT ATATCACAAT CACCAGAGAA CAGTAAGGGA GAAAGAAAGG 
AAATTGGTAG ACTGTCATCG TGAACTGGAA AAACTAAATA AAGAATCTAG GCTTCTCAAT 
CAGGAAAAAT CAGAACTGCT TGTTGAACAG GGTCGTCTAC AGCTGCAAGC AGATCGCCAT 
CAAGAACATA TCCGAGCTAG AGATTCATTA ATTCAGTCTT TGGCAACACA GCTAGAATTG 
GATGGCTTTG AGCGTGGACC ATTCAGTGAA AGACAGATTA AAAATTTTCA CAAACTTGTG 
AGAGAGAGAC AAGAAGGGGA AGCAAAAACT GCCAACCAAC TGATGAATGA CTTTGCAGAA 
AAAGAGACTC TGAAACAAAA ACAGATAGAT GAGATAAGAG ATAAGAAAAC TGGACTGGGA 
AGAATAATTG AGTTAAAATC AGAAATCCTA AGTAAGAAGC AGAATGAGCT GAAAAATGTG 
AAGTATGAAT TACAGCAGTT GGAAGGATCT TCAGACAGGA TTCTTGAACT GGACCAGGAG 
CTCATAAAAG CTGAACGTGA GTTAAGCAAG GCTGAGAAAA ACAGCAATGT AGAAACCTTA 
AAAATGGAAG TAATAAGTCT CCAAAATGAA AAAGCAGACT TAGACAGGAC CCTGCGTAAA 
CTTGACCAGG AGATGGAGCA GTTAAACCAT CATACAACAA CACGTACCCA AATGGAGATG 
CTGACCAAAG ACAAAGCTGA CAAAGATGAA CAAATCAGAA AAATAAAATC TAGGCACAGT 
GATGAATTAA CCTCACTGTT GGGATATTTT CCCAACAAAA AACAGCTTGA AGACTGGCTA 
CATAGTAAAT CAAAAGAAAT TAATCAGACC AGGGACAGAC TTGCCAAATT GAACAAGGAA 
CTAGCTTCAT CTGAGCAGAA TAAAAATCAT ATAAATAATG AACTAAAAAG AAAGGAAGAG 
CAGTTGTCCA GTTACGAAGA CAAGCTGTTT GATGTTTGTG GTAGCCAGGA TTTTGAAAGT 
GATTTAGACA GGCTTAAAGA GGAAATTGAA AAATCATCAA AACAGCGAGC CATGCTGGCT 
GGAGCCACAG CAGTTTACTC CCAGTTCATT ACTCAGCTAA CAGACGAAAA CCAGTCATGT 
TGCCCCGTTT GTCAGAGAGT TTTTCAGACA GAGGCTGAGT TACAAGAAGT CATCAGTGAT 
TTGCAGTCTA AACTGCGACT TGCTCCAGAT AAACTCAAGT CAACAGAATC AGAGCTAAAA 
AAAAAGGAAA AGCGGCGTGA TGAAATGCTG GGACTTGTGC CCATGAGGCA AAGCATAATT 
GATTTGAAGG AGAAGGAAAT ACCAGAATTA AGAAACAAAC TGCAGAATGT CAATAGAGAC 
ATACAGCGCC TAAAGAACGA CATAGAAGAA CAAGAAACAC TCTTGGGTAC AATAATGCCT 
GAAGAAGAAA GTGCCAAAGT ATGCCTGACA GATGTTACAA TTATGGAGAG GTTCCAGATG 
GAACTTAAAG ATGTTGAAAG AAAAATTGCA CAACAAGCAG CTAAGCTACA AGGAATAGAC 
TTAGATCGAA CTGTCCAACA AGTCAACCAG GAGAAACAAG AGAAACAGCA CAAGTTAGAC 
ACAGTTTCTA GTAAGATTGA ATTGAATCGT AAGCTTATAC AGGACCAGCA GGAACAGATT 
CAACATCTAA AAAGTACAAC AAATGAGCTA AAATCTGAGA AACTTCAGAT ATCCACTAAT 
TTGCAACGTC GTCAGCAACT GGAGGAGCAG ACTGTGGAAT TATCCACTGA AGTTCAGTCT 
TTGTACAGAG AGATAAAGGA TGCTAAAGAG CAGGTAAGCC CTTTGGAAAC AACATTGGAA 
AAGTTCCAGC AAGAAAAAGA AGAATTAATC AACAAAAAAA ATACAAGCAA CAAAATAGCA 
CAGGATAAAC TGAATGATAT TAAAGAGAAG GTTAAAAATA TTCATGGCTA TATGAAAGAC 
ATTGAGAATT ATATTCAAGA TGGGAAAGAC GACTATAAGA AGCAAAAAGA AACTGAACTT 
AATAAAGTAA TAGCTCAACT AAGTGAATGC GAGAAACACA AAGAAAAGAT AAATGAAGAT 
ATGAGACTCA TGAGACAAGA TATTGATACA CAGAAGATAC AAGAAAGGTG GCTACAAGAT 
AACCTTACTT TAAGAAAAAG AAATGAGGAA CTAAAAGAAG TTGAAGAAGA AAGAAAACAA 
CATTTGAAGG AAATGGGTCA AATGCAGGTT TTGCAAATGA AAAGTGAACA TCAGAAGTTG 
GAAGAGAACA TAGACAATAT AAAAAGAAAT CATAATTTGG CATTAGGGCG ACAGAAAGGT 
TATGAAGAAG AAATTATTCA TTTTAAGAAA GAACTTCGAG AACCACAATT TCGGGATGCT 
GAGGAAAAGT ATAGAGAAAT GATGATTGTT ATGAGGACAA CAGAACTTGT GAACAAGGAT 
CTGGATATTT ATTATAAGAC TCTTGACCAA GCAATAATGA AATTTCACAG TATGAAAATG 
GAAGAAATCA ATAAAATTAT ACGTGACCTG TGGCGAAGTA CCTATCGTGG ACAAGATATT 
GAATACATAG AAATACGGTC TGATGCCGAT GAAAATGTAT CAGCTTCTGA TAAAAGGCGG 
AATTATAACT ACCGAGTGGT GATGCTGAAG GGAGACACAG CCTTGGATAT GCGAGGACGA 
TGCAGTGCTG GACAAAAGGT ATTAGCCTCA CTCATCATTC GCCTGGCCCT GGCTGAAACG 
TTCTGCCTCA ACTGTGGCAT CATTGCCTTG GATGAGCCAA CAACAAATCT TGACCGAGAA 
AACATTGAAT CTCTTGCACA TGCTCTGGTT GAGATAATAA AAAGTCGCTC ACAGCAGCGT 
AACTTCCAGC TTCTGGTAAT CACTCATGAT GAAGATTTTG TGGAGCTTTT AGGACGTTCT 
GAATATGTGG AGAAATTCTA CAGGATTAAA AAGAACATCG ATCAGTGCTC AGAGATTGTG 
AAATGCAGTG TTAGCTCCCT GGGATTCAAT GTTCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005723.2
CDS	349..4287
Translation	MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH

Target ORF information:

RefSeq Version	NM_005732.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAD50 double strand break repair protein (RAD50), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005732.4

ORF Insert Sequence:

ATGTCCCGGA TCGAAAAGAT GAGCATTCTG GGCGTGCGGA GTTTTGGAAT AGAGGACAAA 
GATAAGCAAA TTATCACTTT CTTCAGCCCC CTTACAATTT TGGTTGGACC CAATGGGGCG 
GGAAAGACGA CCATCATTGA ATGTCTAAAA TATATTTGTA CTGGAGATTT CCCTCCTGGA 
ACCAAAGGAA ATACATTTGT ACACGATCCC AAGGTTGCTC AAGAAACAGA TGTGAGAGCC 
CAGATTCGTC TGCAATTTCG TGATGTCAAT GGAGAACTTA TAGCTGTGCA AAGATCTATG 
GTGTGTACTC AGAAAAGCAA AAAGACAGAA TTTAAAACTC TGGAAGGAGT CATTACTAGA 
ACAAAGCATG GTGAAAAGGT CAGTCTGAGC TCTAAGTGTG CAGAAATTGA CCGAGAAATG 
ATCAGTTCTC TTGGGGTTTC CAAGGCTGTG CTAAATAATG TCATTTTCTG TCATCAAGAA 
GATTCTAATT GGCCTTTAAG TGAAGGAAAG GCTTTGAAGC AAAAGTTTGA TGAGATTTTT 
TCAGCAACAA GATACATTAA AGCCTTAGAA ACACTTCGGC AGGTACGTCA GACACAAGGT 
CAGAAAGTAA AAGAATATCA AATGGAACTA AAATATCTGA AGCAATATAA GGAAAAAGCT 
TGTGAGATTC GTGATCAGAT TACAAGTAAG GAAGCCCAGT TAACATCTTC AAAGGAAATT 
GTCAAATCCT ATGAGAATGA ACTTGATCCA TTGAAGAATC GTCTAAAAGA AATTGAACAT 
AATCTCTCTA AAATAATGAA ACTTGACAAT GAAATTAAAG CCTTGGATAG CCGAAAGAAG 
CAAATGGAGA AAGATAATAG TGAACTGGAA GAGAAAATGG AAAAGGTTTT TCAAGGGACT 
GATGAGCAAC TAAATGACTT ATATCACAAT CACCAGAGAA CAGTAAGGGA GAAAGAAAGG 
AAATTGGTAG ACTGTCATCG TGAACTGGAA AAACTAAATA AAGAATCTAG GCTTCTCAAT 
CAGGAAAAAT CAGAACTGCT TGTTGAACAG GGTCGTCTAC AGCTGCAAGC AGATCGCCAT 
CAAGAACATA TCCGAGCTAG AGATTCATTA ATTCAGTCTT TGGCAACACA GCTAGAATTG 
GATGGCTTTG AGCGTGGACC ATTCAGTGAA AGACAGATTA AAAATTTTCA CAAACTTGTG 
AGAGAGAGAC AAGAAGGGGA AGCAAAAACT GCCAACCAAC TGATGAATGA CTTTGCAGAA 
AAAGAGACTC TGAAACAAAA ACAGATAGAT GAGATAAGAG ATAAGAAAAC TGGACTGGGA 
AGAATAATTG AGTTAAAATC AGAAATCCTA AGTAAGAAGC AGAATGAGCT GAAAAATGTG 
AAGTATGAAT TACAGCAGTT GGAAGGATCT TCAGACAGGA TTCTTGAACT GGACCAGGAG 
CTCATAAAAG CTGAACGTGA GTTAAGCAAG GCTGAGAAAA ACAGCAATGT AGAAACCTTA 
AAAATGGAAG TAATAAGTCT CCAAAATGAA AAAGCAGACT TAGACAGGAC CCTGCGTAAA 
CTTGACCAGG AGATGGAGCA GTTAAACCAT CATACAACAA CACGTACCCA AATGGAGATG 
CTGACCAAAG ACAAAGCTGA CAAAGATGAA CAAATCAGAA AAATAAAATC TAGGCACAGT 
GATGAATTAA CCTCACTGTT GGGATATTTT CCCAACAAAA AACAGCTTGA AGACTGGCTA 
CATAGTAAAT CAAAAGAAAT TAATCAGACC AGGGACAGAC TTGCCAAATT GAACAAGGAA 
CTAGCTTCAT CTGAGCAGAA TAAAAATCAT ATAAATAATG AACTAAAAAG AAAGGAAGAG 
CAGTTGTCCA GTTACGAAGA CAAGCTGTTT GATGTTTGTG GTAGCCAGGA TTTTGAAAGT 
GATTTAGACA GGCTTAAAGA GGAAATTGAA AAATCATCAA AACAGCGAGC CATGCTGGCT 
GGAGCCACAG CAGTTTACTC CCAGTTCATT ACTCAGCTAA CAGACGAAAA CCAGTCATGT 
TGCCCCGTTT GTCAGAGAGT TTTTCAGACA GAGGCTGAGT TACAAGAAGT CATCAGTGAT 
TTGCAGTCTA AACTGCGACT TGCTCCAGAT AAACTCAAGT CAACAGAATC AGAGCTAAAA 
AAAAAGGAAA AGCGGCGTGA TGAAATGCTG GGACTTGTGC CCATGAGGCA AAGCATAATT 
GATTTGAAGG AGAAGGAAAT ACCAGAATTA AGAAACAAAC TGCAGAATGT CAATAGAGAC 
ATACAGCGCC TAAAGAACGA CATAGAAGAA CAAGAAACAC TCTTGGGTAC AATAATGCCT 
GAAGAAGAAA GTGCCAAAGT ATGCCTGACA GATGTTACAA TTATGGAGAG GTTCCAGATG 
GAACTTAAAG ATGTTGAAAG AAAAATTGCA CAACAAGCAG CTAAGCTACA AGGAATAGAC 
TTAGATCGAA CTGTCCAACA AGTCAACCAG GAGAAACAAG AGAAACAGCA CAAGTTAGAC 
ACAGTTTCTA GTAAGATTGA ATTGAATCGT AAGCTTATAC AGGACCAGCA GGAACAGATT 
CAACATCTAA AAAGTACAAC AAATGAGCTA AAATCTGAGA AACTTCAGAT ATCCACTAAT 
TTGCAACGTC GTCAGCAACT GGAGGAGCAG ACTGTGGAAT TATCCACTGA AGTTCAGTCT 
TTGTACAGAG AGATAAAGGA TGCTAAAGAG CAGGTAAGCC CTTTGGAAAC AACATTGGAA 
AAGTTCCAGC AAGAAAAAGA AGAATTAATC AACAAAAAAA ATACAAGCAA CAAAATAGCA 
CAGGATAAAC TGAATGATAT TAAAGAGAAG GTTAAAAATA TTCATGGCTA TATGAAAGAC 
ATTGAGAATT ATATTCAAGA TGGGAAAGAC GACTATAAGA AGCAAAAAGA AACTGAACTT 
AATAAAGTAA TAGCTCAACT AAGTGAATGC GAGAAACACA AAGAAAAGAT AAATGAAGAT 
ATGAGACTCA TGAGACAAGA TATTGATACA CAGAAGATAC AAGAAAGGTG GCTACAAGAT 
AACCTTACTT TAAGAAAAAG AAATGAGGAA CTAAAAGAAG TTGAAGAAGA AAGAAAACAA 
CATTTGAAGG AAATGGGTCA AATGCAGGTT TTGCAAATGA AAAGTGAACA TCAGAAGTTG 
GAAGAGAACA TAGACAATAT AAAAAGAAAT CATAATTTGG CATTAGGGCG ACAGAAAGGT 
TATGAAGAAG AAATTATTCA TTTTAAGAAA GAACTTCGAG AACCACAATT TCGGGATGCT 
GAGGAAAAGT ATAGAGAAAT GATGATTGTT ATGAGGACAA CAGAACTTGT GAACAAGGAT 
CTGGATATTT ATTATAAGAC TCTTGACCAA GCAATAATGA AATTTCACAG TATGAAAATG 
GAAGAAATCA ATAAAATTAT ACGTGACCTG TGGCGAAGTA CCTATCGTGG ACAAGATATT 
GAATACATAG AAATACGGTC TGATGCCGAT GAAAATGTAT CAGCTTCTGA TAAAAGGCGG 
AATTATAACT ACCGAGTGGT GATGCTGAAG GGAGACACAG CCTTGGATAT GCGAGGACGA 
TGCAGTGCTG GACAAAAGGT ATTAGCCTCA CTCATCATTC GCCTGGCCCT GGCTGAAACG 
TTCTGCCTCA ACTGTGGCAT CATTGCCTTG GATGAGCCAA CAACAAATCT TGACCGAGAA 
AACATTGAAT CTCTTGCACA TGCTCTGGTT GAGATAATAA AAAGTCGCTC ACAGCAGCGT 
AACTTCCAGC TTCTGGTAAT CACTCATGAT GAAGATTTTG TGGAGCTTTT AGGACGTTCT 
GAATATGTGG AGAAATTCTA CAGGATTAAA AAGAACATCG ATCAGTGCTC AGAGATTGTG 
AAATGCAGTG TTAGCTCCCT GGGATTCAAT GTTCATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RAD50 Expression Is Associated with Poor Clinical Outcomes after Radiotherapy for Resected Non-small Cell Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research24(2)341-350(2018 Jan)
Wang Y,Gudikote J,Giri U,Yan J,Deng W,Ye R,Jiang W,Li N,Hobbs BP,Wang J,Swisher SG,Fujimoto J,Wistuba II,Komaki R,Heymach JV,Lin SH

Targeting RAD50 increases sensitivity to radiotherapy in colorectal cancer cells.
Neoplasma65(1)75-80(2018)
Chen C,Wang Y,Mei JF,Li SS,Xu HX,Xiong HP,Wang XH,He X

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RAD50 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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