APOBEC3A_B cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	APOBEC3A_B
Entrez Gene ID	100913187
Full Name	APOBEC3A and APOBEC3B deletion hybrid
General protein information	Preferred Names APOBEC3A and APOBEC3B deletion hybrid Names probable DNA dC->dU-editing enzyme APOBEC-3A
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 22 Map Location: 22q13 alternate reference locus
Summary	This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. [provided by RefSeq, Jul 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001193289.1	NP_001180218.1	probable DNA dC->dU-editing enzyme APOBEC-3A
XM_011547045.1	XP_011545347.1	probable DNA dC->dU-editing enzyme APOBEC-3A isoform X2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

APOBEC3A/B deletion polymorphism and cancer risk.
Gansmo LB, Romundstad P, Hveem K, Vatten L, Nik-Zainal S, L?nning PE, Knappskog S
Carcinogenesis(2017 Nov)

Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions.
Henry M, Terzian C, Peeters M, Wain-Hobson S, Vartanian JP
PloS one7(1)e30036(2012)

Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.
Koning FA, Goujon C, Bauby H, Malim MH
Journal of virology85(24)13448-52(2011 Dec)

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest.
Landry S, Narvaiza I, Linfesty DC, Weitzman MD
EMBO reports12(5)444-50(2011 May)

Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection.
Abe H, Ochi H, Maekawa T, Hatakeyama T, Tsuge M, Kitamura S, Kimura T, Miki D, Mitsui F, Hiraga N, Imamura M, Fujimoto Y, Takahashi S, Nakamura Y, Kumada H, Chayama K
Hepatology research : the official journal of the Japan Society of Hepatology39(12)1159-68(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following APOBEC3A_B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOBEC3A_B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18813	NM_001193289.1 Latest version!	Homo sapiens APOBEC3A and APOBEC3B deletion hybrid (APOBEC3A_B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18813	XM_011547045.1 Latest version!	Homo sapiens APOBEC3A and APOBEC3B deletion hybrid (APOBEC3A_B), transcript variant X8, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APOBEC3A_B ( NM_001193289.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001180218.1 Homo sapiens APOBEC3A and APOBEC3B deletion hybrid (APOBEC3A_B), mRNA.

Price & Availability↑

CloneID	OHu18813
Clone ID Related Accession (Same CDS sequence)	NM_001193289.1 , XM_011547045.1
Accession Version	NM_001193289.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	probable DNA dC->dU-editing enzyme APOBEC-3A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC192820.1. On or before Dec 9, 2010 this sequence version replaced XM_003121009.1, XM_003121010.1, XM_003121011.1, XM_003118814.1, XM_003118815.1, XM_003118816.1, XM_003119848.1, XM_003119849.1, XM_003119850.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAGCCA GCCCAGCATC CGGGCCCAGA CACTTGATGG ATCCACACAT ATTCACTTCC 
AACTTTAACA ATGGCATTGG AAGGCATAAG ACCTACCTGT GCTACGAAGT GGAGCGCCTG 
GACAATGGCA CCTCGGTCAA GATGGACCAG CACAGGGGCT TTCTACACAA CCAGGCTAAG 
AATCTTCTCT GTGGCTTTTA CGGCCGCCAT GCGGAGCTGC GCTTCTTGGA CCTGGTTCCT 
TCTTTGCAGT TGGACCCGGC CCAGATCTAC AGGGTCACTT GGTTCATCTC CTGGAGCCCC 
TGCTTCTCCT GGGGCTGTGC CGGGGAAGTG CGTGCGTTCC TTCAGGAGAA CACACACGTG 
AGACTGCGTA TCTTCGCTGC CCGCATCTAT GATTACGACC CCCTATATAA GGAGGCACTG 
CAAATGCTGC GGGATGCTGG GGCCCAAGTC TCCATCATGA CCTACGATGA ATTTAAGCAC 
TGCTGGGACA CCTTTGTGGA CCACCAGGGA TGTCCCTTCC AGCCCTGGGA TGGACTAGAT 
GAGCACAGCC AAGCCCTGAG TGGGAGGCTG CGGGCCATTC TCCAGAATCA GGGAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001180218.1
CDS	171..770
Translation	MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN

Target ORF information:

RefSeq Version	NM_001193289.1
Organism	Homo sapiens(human)
Definition	Homo sapiens APOBEC3A and APOBEC3B deletion hybrid (APOBEC3A_B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001193289.1

ORF Insert Sequence:

ATGGAAGCCA GCCCAGCATC CGGGCCCAGA CACTTGATGG ATCCACACAT ATTCACTTCC 
AACTTTAACA ATGGCATTGG AAGGCATAAG ACCTACCTGT GCTACGAAGT GGAGCGCCTG 
GACAATGGCA CCTCGGTCAA GATGGACCAG CACAGGGGCT TTCTACACAA CCAGGCTAAG 
AATCTTCTCT GTGGCTTTTA CGGCCGCCAT GCGGAGCTGC GCTTCTTGGA CCTGGTTCCT 
TCTTTGCAGT TGGACCCGGC CCAGATCTAC AGGGTCACTT GGTTCATCTC CTGGAGCCCC 
TGCTTCTCCT GGGGCTGTGC CGGGGAAGTG CGTGCGTTCC TTCAGGAGAA CACACACGTG 
AGACTGCGTA TCTTCGCTGC CCGCATCTAT GATTACGACC CCCTATATAA GGAGGCACTG 
CAAATGCTGC GGGATGCTGG GGCCCAAGTC TCCATCATGA CCTACGATGA ATTTAAGCAC 
TGCTGGGACA CCTTTGTGGA CCACCAGGGA TGTCCCTTCC AGCCCTGGGA TGGACTAGAT 
GAGCACAGCC AAGCCCTGAG TGGGAGGCTG CGGGCCATTC TCCAGAATCA GGGAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

APOBEC3A_B ( XM_011547045.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011545347.1 Homo sapiens APOBEC3A and APOBEC3B deletion hybrid (APOBEC3A_B), transcript variant X8, mRNA.

Price & Availability↑

CloneID	OHu18813
Clone ID Related Accession (Same CDS sequence)	NM_001193289.1 , XM_011547045.1
Accession Version	XM_011547045.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	probable DNA dC->dU-editing enzyme APOBEC-3A isoform X2
Comment

ATGGAAGCCA GCCCAGCATC CGGGCCCAGA CACTTGATGG ATCCACACAT ATTCACTTCC 
AACTTTAACA ATGGCATTGG AAGGCATAAG ACCTACCTGT GCTACGAAGT GGAGCGCCTG 
GACAATGGCA CCTCGGTCAA GATGGACCAG CACAGGGGCT TTCTACACAA CCAGGCTAAG 
AATCTTCTCT GTGGCTTTTA CGGCCGCCAT GCGGAGCTGC GCTTCTTGGA CCTGGTTCCT 
TCTTTGCAGT TGGACCCGGC CCAGATCTAC AGGGTCACTT GGTTCATCTC CTGGAGCCCC 
TGCTTCTCCT GGGGCTGTGC CGGGGAAGTG CGTGCGTTCC TTCAGGAGAA CACACACGTG 
AGACTGCGTA TCTTCGCTGC CCGCATCTAT GATTACGACC CCCTATATAA GGAGGCACTG 
CAAATGCTGC GGGATGCTGG GGCCCAAGTC TCCATCATGA CCTACGATGA ATTTAAGCAC 
TGCTGGGACA CCTTTGTGGA CCACCAGGGA TGTCCCTTCC AGCCCTGGGA TGGACTAGAT 
GAGCACAGCC AAGCCCTGAG TGGGAGGCTG CGGGCCATTC TCCAGAATCA GGGAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011545347.1
Translation	MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN

Target ORF information:

RefSeq Version	XM_011547045.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens APOBEC3A and APOBEC3B deletion hybrid (APOBEC3A_B), transcript variant X8, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011547045.1

ORF Insert Sequence:

ATGGAAGCCA GCCCAGCATC CGGGCCCAGA CACTTGATGG ATCCACACAT ATTCACTTCC 
AACTTTAACA ATGGCATTGG AAGGCATAAG ACCTACCTGT GCTACGAAGT GGAGCGCCTG 
GACAATGGCA CCTCGGTCAA GATGGACCAG CACAGGGGCT TTCTACACAA CCAGGCTAAG 
AATCTTCTCT GTGGCTTTTA CGGCCGCCAT GCGGAGCTGC GCTTCTTGGA CCTGGTTCCT 
TCTTTGCAGT TGGACCCGGC CCAGATCTAC AGGGTCACTT GGTTCATCTC CTGGAGCCCC 
TGCTTCTCCT GGGGCTGTGC CGGGGAAGTG CGTGCGTTCC TTCAGGAGAA CACACACGTG 
AGACTGCGTA TCTTCGCTGC CCGCATCTAT GATTACGACC CCCTATATAA GGAGGCACTG 
CAAATGCTGC GGGATGCTGG GGCCCAAGTC TCCATCATGA CCTACGATGA ATTTAAGCAC 
TGCTGGGACA CCTTTGTGGA CCACCAGGGA TGTCCCTTCC AGCCCTGGGA TGGACTAGAT 
GAGCACAGCC AAGCCCTGAG TGGGAGGCTG CGGGCCATTC TCCAGAATCA GGGAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

APOBEC3A/B deletion polymorphism and cancer risk.
Carcinogenesis(2017 Nov)
Gansmo LB,Romundstad P,Hveem K,Vatten L,Nik-Zainal S,L?nning PE,Knappskog S

Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions.
PloS one7(1)e30036(2012)
Henry M,Terzian C,Peeters M,Wain-Hobson S,Vartanian JP

Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.
Journal of virology85(24)13448-52(2011 Dec)
Koning FA,Goujon C,Bauby H,Malim MH

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest.
EMBO reports12(5)444-50(2011 May)
Landry S,Narvaiza I,Linfesty DC,Weitzman MD

Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection.
Hepatology research : the official journal of the Japan Society of Hepatology39(12)1159-68(2009 Dec)
Abe H,Ochi H,Maekawa T,Hatakeyama T,Tsuge M,Kitamura S,Kimura T,Miki D,Mitsui F,Hiraga N,Imamura M,Fujimoto Y,Takahashi S,Nakamura Y,Kumada H,Chayama K

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APOBEC3A_B cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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