COX17 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COX17
Entrez Gene ID	10063
Full Name	COX17, cytochrome c oxidase copper chaperone
General protein information	Preferred Names COX17, cytochrome c oxidase copper chaperone Names cytochrome c oxidase copper chaperone COX17 cytochrome c oxidase assembly homolog cytochrome c oxidase 17 copper chaperone cytochrome c oxidase assembly homolog 17 human homolog of yeast mitochondrial copper recruitment
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q13.33
Summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008].
Disorder MIM:	604813

mRNA and Protein(s)

mRNA	Protein	Name
NM_005694.1	NP_005685.1	cytochrome c oxidase copper chaperone

Pathways from BioSystems

Homologies

Homo sapiens (human)	COX17	NP_005685.1
Pan troglodytes (chimpanzee)	COX17	NP_001239469.1
Mus musculus (house mouse)	Cox17	NP_001017429.1
Gallus gallus (chicken)	COX17	XP_001233520.1
Danio rerio (zebrafish)	cox17	NP_001004652.1
Bos taurus (cattle)	COX17	XP_002684780.2
Xenopus tropicalis (tropical clawed frog)	cox17	NP_001165070.1
	COX17	XP_001110218.2
Rattus norvegicus (Norway rat)	Cox17	NP_445992.1
Canis lupus familiaris (dog)	COX17	NP_001012754.1

Gene Ontology
Bibliography

Related articles in PubMed

Disulfide driven folding for a conditionally disordered protein.
Fraga H, Pujols J, Gil-Garcia M, Roque A, Bernardo-Seisdedos G, Santambrogio C, Bech-Serra JJ, Canals F, Bernad? P, Grandori R, Millet O, Ventura S
Scientific reports7(1)16994(2017 Dec)

A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry.
Li L, Guo W, Wu K, Wu X, Zhao L, Zhao Y, Luo Q, Wang Y, Liu Y, Zhang Q, Wang F
Journal of inorganic biochemistry16199-106(2016 Aug)

Direct structural evidence of protein redox regulation obtained by in-cell NMR.
Mercatelli E, Barbieri L, Luchinat E, Banci L
Biochimica et biophysica acta1863(2)198-204(2016 Feb)

Extended functional repertoire for human copper chaperones.
Matson Dzebo M, Ari?z C, Wittung-Stafshede P
Biomolecular concepts7(1)29-39(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results collectively indicate that Cox17 might not participate in the action of these anticancer organoruthenium complexes, and further verify the distinct anticancer mechanism of the organoruthenium(II) complexes from cisplatin.
Title: A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry.

Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1) in the cytoplasm were directly observed with in-cell NMR spectroscopy.
Title: Direct structural evidence of protein redox regulation obtained by in-cell NMR.

In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review]
Title: Extended functional repertoire for human copper chaperones.

Data suggest that Cox17 enhances the reactivity of some platinum/organoplatinum antineoplastic drugs but suppresses the reactivity of at least one platinum antineoplastic drug; glutathione modulates binding of platinum/organoplatinum drugs to Cox17.
Title: Glutathione selectively modulates the binding of platinum drugs to human copper chaperone Cox17.

CTR1 silencing increased the protein levels of copper chaperone ATOX1 and copper chaperone for superoxide dismutase 1 (CCS-1), but decreased copper chaperone for cytochrome c oxidase (COX17).
Title: Changes in copper concentrations affect the protein levels but not the mRNA levels of copper chaperones in human umbilical vein endothelial cells.

The following COX17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu16220	NM_005694.1 Latest version!	Homo sapiens cytochrome c oxidase copper chaperone COX17 (COX17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COX17 ( NM_005694.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_005685.1 Homo sapiens cytochrome c oxidase copper chaperone COX17 (COX17), mRNA.

Price & Availability↑

CloneID	OHu16220
Clone ID Related Accession (Same CDS sequence)	NM_005694.1
Accession Version	NM_005694.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Homo sapiens(human)
Product	cytochrome c oxidase copper chaperone
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L77701.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L77701.1, SRR1660805.297257.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149876, SAMEA2154405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGGTC TGGTTGACTC AAACCCTGCC CCGCCTGAGT CTCAGGAGAA GAAGCCGCTG 
AAGCCCTGCT GCGCTTGCCC GGAGACCAAG AAGGCGCGCG ATGCGTGTAT CATCGAGAAA 
GGAGAAGAAC ACTGTGGACA TCTAATTGAG GCCCACAAGG AATGCATGAG AGCCCTAGGA 
TTTAAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005685.1
CDS	87..278
Translation	MPGLVDSNPAPPESQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI

Target ORF information:

RefSeq Version	NM_005694.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cytochrome c oxidase copper chaperone COX17 (COX17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005694.1

ORF Insert Sequence:

ATGCCGGGTC TGGTTGACTC AAACCCTGCC CCGCCTGAGT CTCAGGAGAA GAAGCCGCTG 
AAGCCCTGCT GCGCTTGCCC GGAGACCAAG AAGGCGCGCG ATGCGTGTAT CATCGAGAAA 
GGAGAAGAAC ACTGTGGACA TCTAATTGAG GCCCACAAGG AATGCATGAG AGCCCTAGGA 
TTTAAAATAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disulfide driven folding for a conditionally disordered protein.
Scientific reports7(1)16994(2017 Dec)
Fraga H,Pujols J,Gil-Garcia M,Roque A,Bernardo-Seisdedos G,Santambrogio C,Bech-Serra JJ,Canals F,Bernad? P,Grandori R,Millet O,Ventura S

A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry.
Journal of inorganic biochemistry16199-106(2016 Aug)
Li L,Guo W,Wu K,Wu X,Zhao L,Zhao Y,Luo Q,Wang Y,Liu Y,Zhang Q,Wang F

Direct structural evidence of protein redox regulation obtained by in-cell NMR.
Biochimica et biophysica acta1863(2)198-204(2016 Feb)
Mercatelli E,Barbieri L,Luchinat E,Banci L

Extended functional repertoire for human copper chaperones.
Biomolecular concepts7(1)29-39(2016 Feb)
Matson Dzebo M,Ari?z C,Wittung-Stafshede P

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COX17 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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