FRAT1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FRAT1
Entrez Gene ID	10023
Full Name	FRAT1, WNT signaling pathway regulator
General protein information	Preferred Names FRAT1, WNT signaling pathway regulator Names proto-oncogene FRAT1 FRAT-1 frequently rearranged in advanced T-cell lymphomas 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q24.1
Summary	The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008].
Disorder MIM:	602503

mRNA and Protein(s)

mRNA	Protein	Name
NM_005479.4	NP_005470.2	proto-oncogene FRAT1
NM_005479.3	NP_005470.2	proto-oncogene FRAT1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Frat1	NP_032069.2
	FRAT1	XP_001101995.1
Bos taurus (cattle)	FRAT1	XP_002698461.1
Pan troglodytes (chimpanzee)	FRAT1	XP_521571.1
Canis lupus familiaris (dog)	FRAT1	XP_005637927.1
Rattus norvegicus (Norway rat)	Peg12	NP_001164033.1
Homo sapiens (human)	FRAT1	NP_005470.2

Gene Ontology
Bibliography

Related articles in PubMed

Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/?-catenin pathway in hepatocellular carcinoma cells.
Fan WH, Du FJ, Liu XJ, Chen N
Oncology reports36(5)2999-3004(2016 Nov)

Frequently rearranged in advanced T?cell lymphomas?1 demonstrates oncogenic properties in prostate cancer.
Zhang W, Xiong H, Zou Y, Xu S, Quan L, Yuan X, Xu N, Wang Y
Molecular medicine reports14(4)3551-8(2016 Oct)

The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.
Yuan Y, Yang Z, Miao X, Li D, Liu Z, Zou Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(12)9961-8(2015 Dec)

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M
Cell163(3)712-23(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest a potential role for targeting FRAT1 in the prevention of hypoxia-induced HCC cancer progression and metastasis mediated by epithelial-to-mesenchymal transition
Title: Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/?-catenin pathway in hepatocellular carcinoma cells.

The results of the present study suggest that nuclear FRAT1 activates the Wnt/beta-catenin signaling pathway and confers an increase in prostate cancer cell growth.
Title: Frequently rearranged in advanced T?cell lymphomas?1 demonstrates oncogenic properties in prostate cancer.

FRAT1 and ABCG2 overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with Pancreatic ductal adenocarcinoma.
Title: The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.

Positive ROR2 and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma.
Title: The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors.

FRAT1 overexpression correlates with pathologic grade, proliferation, invasion and angiogenesis in brain gliomas.
Title: Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.

The following FRAT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FRAT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24407	NM_005479.4 Latest version!	Homo sapiens FRAT regulator of WNT signaling pathway 1 (FRAT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
View Old Accession Versions >>
OHu24407	NM_005479.3	Homo sapiens FRAT regulator of WNT signaling pathway 1 (FRAT1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FRAT1 ( NM_005479.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005470.2 Homo sapiens FRAT regulator of WNT signaling pathway 1 (FRAT1), mRNA.

Price & Availability↑

CloneID	OHu24407
Clone ID Related Accession (Same CDS sequence)	NM_005479.4 , NM_005479.3
Accession Version	NM_005479.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	proto-oncogene FRAT1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355490.24. On May 17, 2019 this sequence version replaced NM_005479.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: U58975.2, AB074890.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371021.5/ ENSP00000360060.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGTGCC GGAGGGAGGA GGAAGAGGAA GCCGGCGAGG AGGCGGAGGG GGAGGAAGAG 
GAGGAGGACA GCTTCCTCCT ACTGCAGCAG TCAGTGGCGC TGGGCAGCTC GGGCGAGGTG 
GACCGGCTGG TGGCCCAGAT CGGCGAGACG CTGCAGCTGG ACGCGGCGCA GCACAGCCCG 
GCCTCGCCGT GCGGGCCCCC GGGGGCGCCG CTGCGGGCCC CGGGGCCCCT GGCTGCGGCG 
GTGCCGGCGG ACAAGGCCAG GTCCCCGGCG GTGCCGCTGC TGCTGCCGCC CGCGTTGGCG 
GAGACTGTGG GCCCGGCGCC CCCTGGGGTC CTGCGCTGCG CCCTGGGGGA CCGCGGCCGC 
GTGCGGGGCC GCGCTGCGCC CTACTGCGTG GCCGAGCTCG CCACAGGCCC CAGCGCGCTG 
TCCCCACTGC CCCCTCAGGC CGACCTTGAT GGGCCTCCGG GAGCTGGCAA GCAGGGCATC 
CCGCAGCCGC TGTCGGGTCC GTGCCGGCGA GGATGGCTCC GGGGCGCCGC CGCCTCCCGC 
CGCCTGCAGC AGCGACGCGG GTCCCAACCA GAAACCCGCA CAGGCGACGA CGACCCGCAC 
CGGCTTCTGC AGCAGCTAGT GCTCTCTGGA AACCTCATCA AGGAGGCCGT GCGAAGGCTT 
CATTCGCGAC GGCTGCAGTT ACGTGCAAAG CTTCCCCAAC GCCCGCTCCT GGGACCTCTG 
TCGGCCCCGG TGCATGAACC CCCTTCGCCT CGCAGCCCTC GCGCGGCCTG CAGTGACCCT 
GGCGCCTCCG GGAGGGCGCA GCTCAGAACT GGCGACGGCG TTCTTGTGCC TGGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005470.2
CDS	184..1023
Translation	MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS

Target ORF information:

RefSeq Version	NM_005479.4
Organism	Homo sapiens(human)
Definition	Homo sapiens FRAT regulator of WNT signaling pathway 1 (FRAT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005479.4

ORF Insert Sequence:

ATGCCGTGCC GGAGGGAGGA GGAAGAGGAA GCCGGCGAGG AGGCGGAGGG GGAGGAAGAG 
GAGGAGGACA GCTTCCTCCT ACTGCAGCAG TCAGTGGCGC TGGGCAGCTC GGGCGAGGTG 
GACCGGCTGG TGGCCCAGAT CGGCGAGACG CTGCAGCTGG ACGCGGCGCA GCACAGCCCG 
GCCTCGCCGT GCGGGCCCCC GGGGGCGCCG CTGCGGGCCC CGGGGCCCCT GGCTGCGGCG 
GTGCCGGCGG ACAAGGCCAG GTCCCCGGCG GTGCCGCTGC TGCTGCCGCC CGCGTTGGCG 
GAGACTGTGG GCCCGGCGCC CCCTGGGGTC CTGCGCTGCG CCCTGGGGGA CCGCGGCCGC 
GTGCGGGGCC GCGCTGCGCC CTACTGCGTG GCCGAGCTCG CCACAGGCCC CAGCGCGCTG 
TCCCCACTGC CCCCTCAGGC CGACCTTGAT GGGCCTCCGG GAGCTGGCAA GCAGGGCATC 
CCGCAGCCGC TGTCGGGTCC GTGCCGGCGA GGATGGCTCC GGGGCGCCGC CGCCTCCCGC 
CGCCTGCAGC AGCGACGCGG GTCCCAACCA GAAACCCGCA CAGGCGACGA CGACCCGCAC 
CGGCTTCTGC AGCAGCTAGT GCTCTCTGGA AACCTCATCA AGGAGGCCGT GCGAAGGCTT 
CATTCGCGAC GGCTGCAGTT ACGTGCAAAG CTTCCCCAAC GCCCGCTCCT GGGACCTCTG 
TCGGCCCCGG TGCATGAACC CCCTTCGCCT CGCAGCCCTC GCGCGGCCTG CAGTGACCCT 
GGCGCCTCCG GGAGGGCGCA GCTCAGAACT GGCGACGGCG TTCTTGTGCC TGGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FRAT1 ( NM_005479.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005470.2 Homo sapiens FRAT regulator of WNT signaling pathway 1 (FRAT1), mRNA.

Price & Availability↑

CloneID	OHu24407
Clone ID Related Accession (Same CDS sequence)	NM_005479.4 , NM_005479.3
Accession Version	NM_005479.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	proto-oncogene FRAT1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355490.24. On Aug 28, 2008 this sequence version replaced NM_005479.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCCGTGCC GGAGGGAGGA GGAAGAGGAA GCCGGCGAGG AGGCGGAGGG GGAGGAAGAG 
GAGGAGGACA GCTTCCTCCT ACTGCAGCAG TCAGTGGCGC TGGGCAGCTC GGGCGAGGTG 
GACCGGCTGG TGGCCCAGAT CGGCGAGACG CTGCAGCTGG ACGCGGCGCA GCACAGCCCG 
GCCTCGCCGT GCGGGCCCCC GGGGGCGCCG CTGCGGGCCC CGGGGCCCCT GGCTGCGGCG 
GTGCCGGCGG ACAAGGCCAG GTCCCCGGCG GTGCCGCTGC TGCTGCCGCC CGCGTTGGCG 
GAGACTGTGG GCCCGGCGCC CCCTGGGGTC CTGCGCTGCG CCCTGGGGGA CCGCGGCCGC 
GTGCGGGGCC GCGCTGCGCC CTACTGCGTG GCCGAGCTCG CCACAGGCCC CAGCGCGCTG 
TCCCCACTGC CCCCTCAGGC CGACCTTGAT GGGCCTCCGG GAGCTGGCAA GCAGGGCATC 
CCGCAGCCGC TGTCGGGTCC GTGCCGGCGA GGATGGCTCC GGGGCGCCGC CGCCTCCCGC 
CGCCTGCAGC AGCGACGCGG GTCCCAACCA GAAACCCGCA CAGGCGACGA CGACCCGCAC 
CGGCTTCTGC AGCAGCTAGT GCTCTCTGGA AACCTCATCA AGGAGGCCGT GCGAAGGCTT 
CATTCGCGAC GGCTGCAGTT ACGTGCAAAG CTTCCCCAAC GCCCGCTCCT GGGACCTCTG 
TCGGCCCCGG TGCATGAACC CCCTTCGCCT CGCAGCCCTC GCGCGGCCTG CAGTGACCCT 
GGCGCCTCCG GGAGGGCGCA GCTCAGAACT GGCGACGGCG TTCTTGTGCC TGGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005470.2
CDS	190..1029
Translation	MPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS

Target ORF information:

RefSeq Version	NM_005479.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FRAT regulator of WNT signaling pathway 1 (FRAT1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005479.3

ORF Insert Sequence:

ATGCCGTGCC GGAGGGAGGA GGAAGAGGAA GCCGGCGAGG AGGCGGAGGG GGAGGAAGAG 
GAGGAGGACA GCTTCCTCCT ACTGCAGCAG TCAGTGGCGC TGGGCAGCTC GGGCGAGGTG 
GACCGGCTGG TGGCCCAGAT CGGCGAGACG CTGCAGCTGG ACGCGGCGCA GCACAGCCCG 
GCCTCGCCGT GCGGGCCCCC GGGGGCGCCG CTGCGGGCCC CGGGGCCCCT GGCTGCGGCG 
GTGCCGGCGG ACAAGGCCAG GTCCCCGGCG GTGCCGCTGC TGCTGCCGCC CGCGTTGGCG 
GAGACTGTGG GCCCGGCGCC CCCTGGGGTC CTGCGCTGCG CCCTGGGGGA CCGCGGCCGC 
GTGCGGGGCC GCGCTGCGCC CTACTGCGTG GCCGAGCTCG CCACAGGCCC CAGCGCGCTG 
TCCCCACTGC CCCCTCAGGC CGACCTTGAT GGGCCTCCGG GAGCTGGCAA GCAGGGCATC 
CCGCAGCCGC TGTCGGGTCC GTGCCGGCGA GGATGGCTCC GGGGCGCCGC CGCCTCCCGC 
CGCCTGCAGC AGCGACGCGG GTCCCAACCA GAAACCCGCA CAGGCGACGA CGACCCGCAC 
CGGCTTCTGC AGCAGCTAGT GCTCTCTGGA AACCTCATCA AGGAGGCCGT GCGAAGGCTT 
CATTCGCGAC GGCTGCAGTT ACGTGCAAAG CTTCCCCAAC GCCCGCTCCT GGGACCTCTG 
TCGGCCCCGG TGCATGAACC CCCTTCGCCT CGCAGCCCTC GCGCGGCCTG CAGTGACCCT 
GGCGCCTCCG GGAGGGCGCA GCTCAGAACT GGCGACGGCG TTCTTGTGCC TGGCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/?-catenin pathway in hepatocellular carcinoma cells.
Oncology reports36(5)2999-3004(2016 Nov)
Fan WH,Du FJ,Liu XJ,Chen N

Frequently rearranged in advanced T?cell lymphomas?1 demonstrates oncogenic properties in prostate cancer.
Molecular medicine reports14(4)3551-8(2016 Oct)
Zhang W,Xiong H,Zou Y,Xu S,Quan L,Yuan X,Xu N,Wang Y

The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(12)9961-8(2015 Dec)
Yuan Y,Yang Z,Miao X,Li D,Liu Z,Zou Q

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Cell163(3)712-23(2015 Oct)
Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

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FRAT1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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