BCL2L10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BCL2L10
Entrez Gene ID	10017
Full Name	BCL2 like 10
Synonyms	BCL-B,Boo,Diva,bcl2-L-10
General protein information	Preferred Names BCL2 like 10 Names bcl-2-like protein 10 BCL2-like 10 (apoptosis facilitator) anti-apoptotic protein NrH apoptosis regulator Bcl-B death inducer binding to vBcl-2 and Apaf-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q21.2
Summary	The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008].
Disorder MIM:	606910

mRNA and Protein(s)

mRNA	Protein	Name
NM_001306168.1	NP_001293097.1	bcl-2-like protein 10 isoform 1
NM_020396.3	NP_065129.1	bcl-2-like protein 10 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Bcl2l10	NP_038507.1
Bos taurus (cattle)	BCL2L10	XP_002691010.2
Rattus norvegicus (Norway rat)	Bcl2l10	NP_446185.1
Homo sapiens (human)	BCL2L10	NP_065129.1
Pan troglodytes (chimpanzee)	BCL2L10	XP_523079.2
	BCL2L10	XP_001085850.1

Gene Ontology
Bibliography

Related articles in PubMed

Breast cancer targeting through inhibition of the endoplasmic reticulum-based apoptosis regulator Nrh/BCL2L10.
Nougarede A, Popgeorgiev N, Kassem L, Omarjee S, Borel S, Mikaelian I, Lopez J, Gadet R, Marcillat O, Treilleux I, Villoutreix BO, Rimokh R, Gillet G
Cancer research(2018 Jan)

BCL2L10 positive cells in bone marrow are an independent prognostic factor of azacitidine outcome in myelodysplastic syndrome and acute myeloid leukemia.
Vidal V, Robert G, Goursaud L, Durand L, Ginet C, Karsenti JM, Luciano F, Gastaud L, Garnier G, Braun T, Hirsch P, Raffoux E, Nloga AM, Padua RA, Dombret H, Rohrlich P, Ades L, Chomienne C, Auberger P, Fenaux P, Cluzeau T
Oncotarget8(29)47103-47109(2017 Jul)

BCLB, methylated in hepatocellular carcinoma, is a starvation stress?sensor that induces apoptosis and autophagy through the?AMPK-mTOR signaling cascade.
Liu X, Hu X, Kuang Y, Yan P, Li L, Li C, Tao Q, Cai X
Cancer letters39563-71(2017 Jun)

BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo.
Bai Y, Wang J, Han J, Xie XL, Ji CG, Yin J, Chen L, Wang CK, Jiang XY, Qi W, Jiang HQ
Molecular carcinogenesis56(3)1137-1149(2017 Mar)

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.
Bonneau B, Ando H, Kawaai K, Hirose M, Takahashi-Iwanaga H, Mikoshiba K
eLife5(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BCLB expression was a starvation stress sensor inducing apoptosis and autophagy simultaneously in HCC cells through the adenosine monophosphate-activated protein kinase AMPK-mTOR signaling cascade.
Title: BCLB, methylated in hepatocellular carcinoma, is a starvation stress?sensor that induces apoptosis and autophagy through the?AMPK-mTOR signaling cascade.

we describe the identification of a structural genetic variant segregating with affective psychosis in a family with multiple members suffering from bipolar I disorder. Using whole-genome sequencing, we delineated the translocation breakpoints as corresponding intragenic events disrupting BCL2L10 and PNLDC1. These data warrant further consideration for BCL2L10 and PNLDC1 as novel candidates for affective psychosis.
Title: A balanced translocation disrupting BCL2L10 and PNLDC1 segregates with affective psychosis.

Results found that BCL2L10 was down-regulated in human hepatocellular carcinoma (HCC) tissues; its overexpression suppresses cell growth and migration of HCC cell lines. These results suggested that BCL2L10 functions as a tumor-suppressor in HCC.
Title: BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo.

These results suggest that by inhibiting Bcl2l10 activity and promoting contact between endoplasmic reticulum and mitochondria, IRBIT facilitates massive Ca(2+) transfer to mitochondria and promotes apoptosis.
Title: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.

Identification of a variant in the BCL2L10 gene as a protective factor for the development of therapy-related myeloid neoplasms and de novo myelodysplastic syndrome.
Title: The BCL2L10 Leu21Arg variant and risk of therapy-related myeloid neoplasms and de novo myelodysplastic syndromes.

The following BCL2L10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCL2L10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu03270	NM_020396.3 Latest version!	Homo sapiens BCL2 like 10 (BCL2L10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu48048	NM_001306168.1 Latest version!	Homo sapiens BCL2 like 10 (BCL2L10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BCL2L10 ( NM_020396.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065129.1 Homo sapiens BCL2 like 10 (BCL2L10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03270
Clone ID Related Accession (Same CDS sequence)	NM_020396.3
Accession Version	NM_020396.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	bcl-2-like protein 10 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF326964.1 and BX119239.1. On Apr 16, 2015 this sequence version replaced NM_020396.2. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279854.238.1, SRR1163657.324728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTGACC AGTTGCGGGA GCGCACCACC ATGGCCGACC CGCTGCGGGA GCGCACCGAG 
CTGTTGCTGG CCGACTACCT GGGGTACTGC GCCCGGGAAC CCGGCACCCC CGAGCCGGCG 
CCATCCACGC CCGAGGCCGC CGTGCTGCGC TCCGCGGCCG CCAGGTTACG GCAGATTCAC 
CGGTCCTTTT TCTCCGCCTA CCTCGGCTAC CCCGGGAACC GCTTCGAGCT GGTGGCGCTG 
ATGGCGGATT CCGTGCTCTC CGACAGCCCC GGCCCCACCT GGGGCAGAGT GGTGACGCTC 
GTGACCTTCG CAGGGACGCT GCTGGAGAGA GGGCCGCTGG TGACCGCCCG GTGGAAGAAG 
TGGGGCTTCC AGCCGCGGCT AAAGGAGCAG GAGGGCGACG TCGCCCGGGA CTGCCAGCGC 
CTGGTGGCCT TGCTGAGCTC GCGGCTCATG GGGCAGCACC GCGCCTGGCT GCAGGCTCAG 
GGCGGCTGGG ATGGCTTTTG TCACTTCTTC AGGACCCCCT TTCCACTGGC TTTTTGGAGA 
AAACAGCTGG TCCAGGCTTT TCTGTCATGC TTGTTAACAA CAGCCTTCAT TTATCTCTGG 
ACACGATTAT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065129.1
CDS	50..664
Translation	MVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL

Target ORF information:

RefSeq Version	NM_020396.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 like 10 (BCL2L10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020396.3

ORF Insert Sequence:

ATGGTTGACC AGTTGCGGGA GCGCACCACC ATGGCCGACC CGCTGCGGGA GCGCACCGAG 
CTGTTGCTGG CCGACTACCT GGGGTACTGC GCCCGGGAAC CCGGCACCCC CGAGCCGGCG 
CCATCCACGC CCGAGGCCGC CGTGCTGCGC TCCGCGGCCG CCAGGTTACG GCAGATTCAC 
CGGTCCTTTT TCTCCGCCTA CCTCGGCTAC CCCGGGAACC GCTTCGAGCT GGTGGCGCTG 
ATGGCGGATT CCGTGCTCTC CGACAGCCCC GGCCCCACCT GGGGCAGAGT GGTGACGCTC 
GTGACCTTCG CAGGGACGCT GCTGGAGAGA GGGCCGCTGG TGACCGCCCG GTGGAAGAAG 
TGGGGCTTCC AGCCGCGGCT AAAGGAGCAG GAGGGCGACG TCGCCCGGGA CTGCCAGCGC 
CTGGTGGCCT TGCTGAGCTC GCGGCTCATG GGGCAGCACC GCGCCTGGCT GCAGGCTCAG 
GGCGGCTGGG ATGGCTTTTG TCACTTCTTC AGGACCCCCT TTCCACTGGC TTTTTGGAGA 
AAACAGCTGG TCCAGGCTTT TCTGTCATGC TTGTTAACAA CAGCCTTCAT TTATCTCTGG 
ACACGATTAT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2L10 ( NM_001306168.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001293097.1 Homo sapiens BCL2 like 10 (BCL2L10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu48048
Clone ID Related Accession (Same CDS sequence)	NM_001306168.1
Accession Version	NM_001306168.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	bcl-2-like protein 10 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023906.7, BC143227.1, AF326964.1 and BX119239.1. On Apr 16, 2015 this sequence version replaced XM_005254103.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.75360.1, SRR1163657.54983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTTGACC AGTTGCGGGA GCGCACCACC ATGGCCGACC CGCTGCGGGA GCGCACCGAG 
CTGTTGCTGG CCGACTACCT GGGGTACTGC GCCCGGGAAC CCGGCACCCC CGAGCCGGCG 
CCATCCACGC CCGAGGCCGC CGTGCTGCGC TCCGCGGCCG CCAGGTTACG GCAGATTCAC 
CGGTCCTTTT TCTCCGCCTA CCTCGGCTAC CCCGGGAACC GCTTCGAGCT GGTGGCGCTG 
ATGGCGGATT CCGTGCTCTC CGACAGCCCC GGCCCCACCT GGGGCAGAGT GGTGACGCTC 
GTGACCTTCG CAGGGACGCT GCTGGAGAGA GGGCCGCTGG TGACCGCCCG GTGGAAGAAG 
TGGGGCTTCC AGCCGCGGCT AAAGGAGCAG GAGGGCGACG TCGCCCGGGA CTGCCAGCGC 
CTGGTGGCCT TGCTGAGCTC GCGGCTCATG GGGCAGCACC GCGCCTGGCT GCAGGCTCAG 
GGCGGCTGGG TGAGCACGCG GCGGACACCG GGACACGGGG CGGGACGGGC AGCCGGGAAG 
CGCCCACGAG GCTGGCACGG ATGGCTTTTG TCACTTCTTC AGGACCCCCT TTCCACTGGC 
TTTTTGGAGA AAACAGCTGG TCCAGGCTTT TCTGTCATGC TTGTTAACAA CAGCCTTCAT 
TTATCTCTGG ACACGATTAT TATGAGTTTT AAAACTTTTA ACCCGCTTCT ACCTGCCCAA 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001293097.1
CDS	50..775
Translation	MVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWVSTRRTPGHGAGRAAGKRPRGWHGWLLSLLQDPLSTGFLEKTAGPGFSVMLVNNSLHLSLDTIIMSFKTFNPLLPAQL

Target ORF information:

RefSeq Version	NM_001306168.1
Organism	Homo sapiens(human)
Definition	Homo sapiens BCL2 like 10 (BCL2L10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001306168.1

ORF Insert Sequence:

ATGGTTGACC AGTTGCGGGA GCGCACCACC ATGGCCGACC CGCTGCGGGA GCGCACCGAG 
CTGTTGCTGG CCGACTACCT GGGGTACTGC GCCCGGGAAC CCGGCACCCC CGAGCCGGCG 
CCATCCACGC CCGAGGCCGC CGTGCTGCGC TCCGCGGCCG CCAGGTTACG GCAGATTCAC 
CGGTCCTTTT TCTCCGCCTA CCTCGGCTAC CCCGGGAACC GCTTCGAGCT GGTGGCGCTG 
ATGGCGGATT CCGTGCTCTC CGACAGCCCC GGCCCCACCT GGGGCAGAGT GGTGACGCTC 
GTGACCTTCG CAGGGACGCT GCTGGAGAGA GGGCCGCTGG TGACCGCCCG GTGGAAGAAG 
TGGGGCTTCC AGCCGCGGCT AAAGGAGCAG GAGGGCGACG TCGCCCGGGA CTGCCAGCGC 
CTGGTGGCCT TGCTGAGCTC GCGGCTCATG GGGCAGCACC GCGCCTGGCT GCAGGCTCAG 
GGCGGCTGGG TGAGCACGCG GCGGACACCG GGACACGGGG CGGGACGGGC AGCCGGGAAG 
CGCCCACGAG GCTGGCACGG ATGGCTTTTG TCACTTCTTC AGGACCCCCT TTCCACTGGC 
TTTTTGGAGA AAACAGCTGG TCCAGGCTTT TCTGTCATGC TTGTTAACAA CAGCCTTCAT 
TTATCTCTGG ACACGATTAT TATGAGTTTT AAAACTTTTA ACCCGCTTCT ACCTGCCCAA 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Breast cancer targeting through inhibition of the endoplasmic reticulum-based apoptosis regulator Nrh/BCL2L10.
Cancer research(2018 Jan)
Nougarede A,Popgeorgiev N,Kassem L,Omarjee S,Borel S,Mikaelian I,Lopez J,Gadet R,Marcillat O,Treilleux I,Villoutreix BO,Rimokh R,Gillet G

BCL2L10 positive cells in bone marrow are an independent prognostic factor of azacitidine outcome in myelodysplastic syndrome and acute myeloid leukemia.
Oncotarget8(29)47103-47109(2017 Jul)
Vidal V,Robert G,Goursaud L,Durand L,Ginet C,Karsenti JM,Luciano F,Gastaud L,Garnier G,Braun T,Hirsch P,Raffoux E,Nloga AM,Padua RA,Dombret H,Rohrlich P,Ades L,Chomienne C,Auberger P,Fenaux P,Cluzeau T

BCLB, methylated in hepatocellular carcinoma, is a starvation stress?sensor that induces apoptosis and autophagy through the?AMPK-mTOR signaling cascade.
Cancer letters39563-71(2017 Jun)
Liu X,Hu X,Kuang Y,Yan P,Li L,Li C,Tao Q,Cai X

BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo.
Molecular carcinogenesis56(3)1137-1149(2017 Mar)
Bai Y,Wang J,Han J,Xie XL,Ji CG,Yin J,Chen L,Wang CK,Jiang XY,Qi W,Jiang HQ

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.
eLife5(2016 12)
Bonneau B,Ando H,Kawaai K,Hirose M,Takahashi-Iwanaga H,Mikoshiba K

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BCL2L10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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