TEN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TEN1
Entrez Gene ID	100134934
Full Name	TEN1, CST complex subunit
Synonyms	C17orf106
General protein information	Preferred Names TEN1, CST complex subunit Names CST complex subunit TEN1 TEN1 telomerase capping complex subunit homolog protein telomeric pathways with STN1 homolog telomere length regulation protein TEN1 homolog telomeric pathways in association with Stn1, number 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.1
Summary	C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009].
Disorder MIM:	613130

mRNA and Protein(s)

mRNA	Protein	Name
NM_001113324.2	NP_001106795.2	CST complex subunit TEN1
NM_001113324.3	NP_001106795.2	CST complex subunit TEN1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TEN1	XP_005624136.1
Gallus gallus (chicken)	C18H17ORF106	NP_001186774.1
Danio rerio (zebrafish)	si:ch211-89i1.2	XP_005166224.1
Mus musculus (house mouse)	Ten1	NP_081383.1
Rattus norvegicus (Norway rat)	Ten1	NP_001101777.1
	LOC100425169	XP_002800653.1
Homo sapiens (human)	TEN1	NP_001106795.2
Pan troglodytes (chimpanzee)	TEN1	XP_003315787.1
Xenopus tropicalis (tropical clawed frog)	ten1	XP_002940035.1

Gene Ontology
Bibliography

Related articles in PubMed

Emerging roles of CST in maintaining genome stability and human disease.
Stewart JA, Wang Y, Ackerson SM, Schuck PL
Frontiers in bioscience (Landmark edition)231564-1586(2018 Mar)

The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.
Huang C, Jia P, Chastain M, Shiva O, Chai W
Experimental cell research355(2)95-104(2017 06)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells.
Title: The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.

TERT-mediated G-strand extension and Ctc1-Stn1-Ten1-mediated C-strand fill-in are equally important for telomere length maintenance.
Title: CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.

CTC1/STN1/TEN1 (CST) deficiency diminishes HU-induced RAD51 foci formation.
Title: Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress.

reveal a critical role for human Stn1 in telomere length maintenance and function, supporting the model that efficient replication of telomeric repeats is critical for long-term viability of normal somatic mammalian cells
Title: Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.

TEN1 likely functions in conjunction with CTC1 and STN1 at the telomere and elsewhere in the genome.
Title: Human TEN1 maintains telomere integrity and functions in genome-wide replication restart.

The following TEN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TEN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29186	NM_001113324.3 Latest version!	Homo sapiens TEN1 subunit of CST complex (TEN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29186	NM_001113324.2	Homo sapiens TEN1, CST complex subunit (TEN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TEN1 ( NM_001113324.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001106795.2 Homo sapiens TEN1, CST complex subunit (TEN1), mRNA.

Price & Availability↑

CloneID	OHu29186
Clone ID Related Accession (Same CDS sequence)	NM_001113324.2 , NM_001113324.3
Accession Version	NM_001113324.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	CST complex subunit TEN1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB216497.1 and BC047782.1. On Jan 22, 2011 this sequence version replaced NM_001113324.1. ##Evidence-Data-START## Transcript exon combination :: BC047782.1, SRR1163655.70280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGCTGC CCAAACCTGG GACCTATTAC CTCCCCTGGG AGGTTAGTGC AGGCCAAGTT 
CCTGATGGGA GCACGCTGAG AACATTTGGC AGGTTGTGCC TCTATGACAT GATTCAGTCC 
AGAGTAACAC TGATGGCTCA GCACGGATCC GATCAGCACC AGGTTCTTGT CTGTACCAAG 
TTGGTGGAGC CCTTCCACGC CCAGGTGGGC TCCCTGTACA TCGTCCTCGG GGAGCTCCAG 
CATCAGCAGG ACAGAGGCTC CGTGGTGAAG GCGCGCGTGC TGACCTGTGT GGAGGGGATG 
AACCTGCCCT TGTTGGAACA AGCCATCCGG GAGCAGAGAC TGTACAAGCA GGAGCGGGGC 
GGCAGCCAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106795.2
CDS	302..673
Translation	MMLPKPGTYYLPWEVSAGQVPDGSTLRTFGRLCLYDMIQSRVTLMAQHGSDQHQVLVCTKLVEPFHAQVGSLYIVLGELQHQQDRGSVVKARVLTCVEGMNLPLLEQAIREQRLYKQERGGSQ

Target ORF information:

RefSeq Version	NM_001113324.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TEN1, CST complex subunit (TEN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113324.2

ORF Insert Sequence:

ATGATGCTGC CCAAACCTGG GACCTATTAC CTCCCCTGGG AGGTTAGTGC AGGCCAAGTT 
CCTGATGGGA GCACGCTGAG AACATTTGGC AGGTTGTGCC TCTATGACAT GATTCAGTCC 
AGAGTAACAC TGATGGCTCA GCACGGATCC GATCAGCACC AGGTTCTTGT CTGTACCAAG 
TTGGTGGAGC CCTTCCACGC CCAGGTGGGC TCCCTGTACA TCGTCCTCGG GGAGCTCCAG 
CATCAGCAGG ACAGAGGCTC CGTGGTGAAG GCGCGCGTGC TGACCTGTGT GGAGGGGATG 
AACCTGCCCT TGTTGGAACA AGCCATCCGG GAGCAGAGAC TGTACAAGCA GGAGCGGGGC 
GGCAGCCAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TEN1 ( NM_001113324.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001106795.2 Homo sapiens TEN1 subunit of CST complex (TEN1), mRNA.

Price & Availability↑

CloneID	OHu29186
Clone ID Related Accession (Same CDS sequence)	NM_001113324.2 , NM_001113324.3
Accession Version	NM_001113324.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	CST complex subunit TEN1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC047782.1. On Nov 23, 2018 this sequence version replaced NM_001113324.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047782.1, SRR1163655.70280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000397640.6/ ENSP00000380762.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGCTGC CCAAACCTGG GACCTATTAC CTCCCCTGGG AGGTTAGTGC AGGCCAAGTT 
CCTGATGGGA GCACGCTGAG AACATTTGGC AGGTTGTGCC TCTATGACAT GATTCAGTCC 
AGAGTAACAC TGATGGCTCA GCACGGATCC GATCAGCACC AGGTTCTTGT CTGTACCAAG 
TTGGTGGAGC CCTTCCACGC CCAGGTGGGC TCCCTGTACA TCGTCCTCGG GGAGCTCCAG 
CATCAGCAGG ACAGAGGCTC CGTGGTGAAG GCGCGCGTGC TGACCTGTGT GGAGGGGATG 
AACCTGCCCT TGTTGGAACA AGCCATCCGG GAGCAGAGAC TGTACAAGCA GGAGCGGGGC 
GGCAGCCAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106795.2
CDS	279..650
Translation	MMLPKPGTYYLPWEVSAGQVPDGSTLRTFGRLCLYDMIQSRVTLMAQHGSDQHQVLVCTKLVEPFHAQVGSLYIVLGELQHQQDRGSVVKARVLTCVEGMNLPLLEQAIREQRLYKQERGGSQ

Target ORF information:

RefSeq Version	NM_001113324.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TEN1 subunit of CST complex (TEN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113324.3

ORF Insert Sequence:

ATGATGCTGC CCAAACCTGG GACCTATTAC CTCCCCTGGG AGGTTAGTGC AGGCCAAGTT 
CCTGATGGGA GCACGCTGAG AACATTTGGC AGGTTGTGCC TCTATGACAT GATTCAGTCC 
AGAGTAACAC TGATGGCTCA GCACGGATCC GATCAGCACC AGGTTCTTGT CTGTACCAAG 
TTGGTGGAGC CCTTCCACGC CCAGGTGGGC TCCCTGTACA TCGTCCTCGG GGAGCTCCAG 
CATCAGCAGG ACAGAGGCTC CGTGGTGAAG GCGCGCGTGC TGACCTGTGT GGAGGGGATG 
AACCTGCCCT TGTTGGAACA AGCCATCCGG GAGCAGAGAC TGTACAAGCA GGAGCGGGGC 
GGCAGCCAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Emerging roles of CST in maintaining genome stability and human disease.
Frontiers in bioscience (Landmark edition)231564-1586(2018 Mar)
Stewart JA,Wang Y,Ackerson SM,Schuck PL

The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.
Experimental cell research355(2)95-104(2017 06)
Huang C,Jia P,Chastain M,Shiva O,Chai W

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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TEN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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