FAM47E cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FAM47E
Entrez Gene ID	100129583
Full Name	family with sequence similarity 47 member E
General protein information	Preferred Names family with sequence similarity 47 member E Names protein FAM47E
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q21.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001136570.3	NP_001130042.1	protein FAM47E isoform a
NM_001242936.1	NP_001229865.1	protein FAM47E isoform b
NM_001136570.2	NP_001130042.1	protein FAM47E isoform a

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fam47e	XP_006250818.1
Danio rerio (zebrafish)	zgc:158260	NP_001073522.1
Danio rerio (zebrafish)	LOC100536753	XP_003198728.1
Homo sapiens (human)	FAM47E	NP_001130042.1
Pan troglodytes (chimpanzee)	FAM47E	XP_001149314.1
Canis lupus familiaris (dog)	FAM47E	XP_005639383.1
Bos taurus (cattle)	FAM47E	XP_002688417.1
Mus musculus (house mouse)	Fam47e	NP_001028650.2
Xenopus tropicalis (tropical clawed frog)	LOC100127812	NP_001106594.1
	LOC699865	XP_002808457.1

Gene Ontology
Bibliography

Related articles in PubMed

No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson's disease in a Chinese Han population.
Chen Y, Yuan X, Cao B, Wei Q, Ou R, Yang J, Chen X, Zhao B, Song W, Wu Y, Shang H
Journal of neural transmission (Vienna, Austria : 1996)122(11)1547-52(2015 Nov)

Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD.
Ledo N, Ko YA, Park AS, Kang HM, Han SY, Choi P, Susztak K
Journal of the American Society of Nephrology : JASN26(3)692-714(2015 Mar)

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, , , , , , , , , , , , , Ikram MA, Ioannidis JP, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB
Nature genetics46(9)989-93(2014 Sep)

Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
Do CB, Tung JY, Dorfman E, Kiefer AK, Drabant EM, Francke U, Mountain JL, Goldman SM, Tanner CM, Langston JW, Wojcicki A, Eriksson N
PLoS genetics7(6)e1002141(2011 Jun)

Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Sim?n-S?nchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Kr?ger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, Gwinn K, van der Brug M, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T
Nature genetics41(12)1308-12(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings suggested that STX1B rs4889603, FAM47E rs6812193 and SCARB2 rs6825004 do not confer a significant risk for Parkinson's disease
Title: No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson's disease in a Chinese Han population.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following FAM47E gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FAM47E cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00325	NM_001136570.3 Latest version!	Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu07263	NM_001242936.1 Latest version!	Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu00325	NM_001136570.2	Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FAM47E ( NM_001136570.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001130042.1 Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00325
Clone ID Related Accession (Same CDS sequence)	NM_001136570.3 , NM_001136570.2
Accession Version	NM_001136570.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	protein FAM47E isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB081518.1, AC034139.7 and N55430.1. On Nov 22, 2018 this sequence version replaced NM_001136570.2. Transcript Variant: This variant (1) encodes the longer isoform (a). ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000424749.7/ ENSP00000409423.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGACC GCAGGCGGCG GCTCCGGCCG GGGACGTTGG CCCCGGTGCG CGAGGGCGTG 
AACTGCAGGT CCAGATGTTT CACAAAGCAC AAGAACGGGC TGAAGTTCCC CACCTCTCTG 
CACAGCCGGC AGTTGGTATT TCCAAGAAAG GGGCTGGACG ACTTCAGGAA GGGCTGCCCG 
CCTTGCACTG GTCTGGTGAC TCAGGTCCCT GTGGAGGGCT TTCTGCCCCA GATTTATCAC 
AGAGCTCCCC AACTGGCCCC AAAGAAGAGG CAGATCAAGC TGCTCAAGGA AGCAGACGTG 
CTTTCCAAGC TCTCGCCAGC CCAGCAGGCT CGGAAGGCAT TCCTGGAGGA CGTGGAGGCC 
CACCTGACCC CACATCCCTT AGCGCTCTAC CTGAATCTGG AAGAAGCTAT GCCCATAGAG 
CTCTTATCAA AGGTGCTGGA AGTGCTTGAT CCTGACCGGA AGCTGGAGGA CACATGGGCT 
TATTGTCAGG ACACCAGGAA AGGAATGAAG GAACCCACGA AGCTTTTAAA AAAACATTCT 
ACCCAAGTCT ACCTGGGACC TTCCAAGAAG ACGTCTGTGT CAAACGCAGG CCAATGGCTT 
TATGAAGAAA AGCCACATAA AATGGATTTG CTCCATGAAA ATGGTCCTCG TCCTGGTCTT 
CATGAAAATG GAATTTCGGA CATCGATGAA GAGTTCATCT TGAAACAGTT TGACATTGAC 
TATGAGACCA AACCAAGCCA TGATGCGCTC CACACGATGA AGCTAAATCA GGTTCCTCTG 
GAGCTAAAGC GTAGTGTGGG GCTCAGTAAA CTGCAGGAGA CAGAGTTCTT CCAGAAACTA 
GGCTATGAGA GGAAACTCCA GAAACCACAG AATCCTTATA AGCCAAAGTG GGTGAAGATG 
AGGTATGGAG CATGGTATTT GAACCCCAAG TTGTGGAAAA AGCAAAGAGT AGACGAGCCT 
CTGGTTGACC CTGAGGTCTC ACATAAGGCT CAAGAGGAGA ATTTTAAAAA GGAGCTGCAG 
GAACAGGAGG AGTTACTTGC AGACCTTCAC GGAACAGTTG CCTTTAAGGA TTTCATTCTA 
AGCAGGGGCT ACAGGACGCC ACGTTTCCTT GAGAATATGT ATATCGGGAA GGAATGTAAA 
CGTGCATGTA ATAAGACTCC TATAAAACGA ACTCAAGCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001130042.1
CDS	27..1208
Translation	MADRRRRLRPGTLAPVREGVNCRSRCFTKHKNGLKFPTSLHSRQLVFPRKGLDDFRKGCPPCTGLVTQVPVEGFLPQIYHRAPQLAPKKRQIKLLKEADVLSKLSPAQQARKAFLEDVEAHLTPHPLALYLNLEEAMPIELLSKVLEVLDPDRKLEDTWAYCQDTRKGMKEPTKLLKKHSTQVYLGPSKKTSVSNAGQWLYEEKPHKMDLLHENGPRPGLHENGISDIDEEFILKQFDIDYETKPSHDALHTMKLNQVPLELKRSVGLSKLQETEFFQKLGYERKLQKPQNPYKPKWVKMRYGAWYLNPKLWKKQRVDEPLVDPEVSHKAQEENFKKELQEQEELLADLHGTVAFKDFILSRGYRTPRFLENMYIGKECKRACNKTPIKRTQA

Target ORF information:

RefSeq Version	NM_001136570.3
Organism	Homo sapiens(human)
Definition	Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136570.3

ORF Insert Sequence:

ATGGCGGACC GCAGGCGGCG GCTCCGGCCG GGGACGTTGG CCCCGGTGCG CGAGGGCGTG 
AACTGCAGGT CCAGATGTTT CACAAAGCAC AAGAACGGGC TGAAGTTCCC CACCTCTCTG 
CACAGCCGGC AGTTGGTATT TCCAAGAAAG GGGCTGGACG ACTTCAGGAA GGGCTGCCCG 
CCTTGCACTG GTCTGGTGAC TCAGGTCCCT GTGGAGGGCT TTCTGCCCCA GATTTATCAC 
AGAGCTCCCC AACTGGCCCC AAAGAAGAGG CAGATCAAGC TGCTCAAGGA AGCAGACGTG 
CTTTCCAAGC TCTCGCCAGC CCAGCAGGCT CGGAAGGCAT TCCTGGAGGA CGTGGAGGCC 
CACCTGACCC CACATCCCTT AGCGCTCTAC CTGAATCTGG AAGAAGCTAT GCCCATAGAG 
CTCTTATCAA AGGTGCTGGA AGTGCTTGAT CCTGACCGGA AGCTGGAGGA CACATGGGCT 
TATTGTCAGG ACACCAGGAA AGGAATGAAG GAACCCACGA AGCTTTTAAA AAAACATTCT 
ACCCAAGTCT ACCTGGGACC TTCCAAGAAG ACGTCTGTGT CAAACGCAGG CCAATGGCTT 
TATGAAGAAA AGCCACATAA AATGGATTTG CTCCATGAAA ATGGTCCTCG TCCTGGTCTT 
CATGAAAATG GAATTTCGGA CATCGATGAA GAGTTCATCT TGAAACAGTT TGACATTGAC 
TATGAGACCA AACCAAGCCA TGATGCGCTC CACACGATGA AGCTAAATCA GGTTCCTCTG 
GAGCTAAAGC GTAGTGTGGG GCTCAGTAAA CTGCAGGAGA CAGAGTTCTT CCAGAAACTA 
GGCTATGAGA GGAAACTCCA GAAACCACAG AATCCTTATA AGCCAAAGTG GGTGAAGATG 
AGGTATGGAG CATGGTATTT GAACCCCAAG TTGTGGAAAA AGCAAAGAGT AGACGAGCCT 
CTGGTTGACC CTGAGGTCTC ACATAAGGCT CAAGAGGAGA ATTTTAAAAA GGAGCTGCAG 
GAACAGGAGG AGTTACTTGC AGACCTTCAC GGAACAGTTG CCTTTAAGGA TTTCATTCTA 
AGCAGGGGCT ACAGGACGCC ACGTTTCCTT GAGAATATGT ATATCGGGAA GGAATGTAAA 
CGTGCATGTA ATAAGACTCC TATAAAACGA ACTCAAGCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM47E ( NM_001136570.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001130042.1 Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00325
Clone ID Related Accession (Same CDS sequence)	NM_001136570.3 , NM_001136570.2
Accession Version	NM_001136570.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	protein FAM47E isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB081518.1, AC034139.7 and N55430.1. On Jul 7, 2011 this sequence version replaced NM_001136570.1. Transcript Variant: This variant (1) encodes the longer isoform (a). ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACC GCAGGCGGCG GCTCCGGCCG GGGACGTTGG CCCCGGTGCG CGAGGGCGTG 
AACTGCAGGT CCAGATGTTT CACAAAGCAC AAGAACGGGC TGAAGTTCCC CACCTCTCTG 
CACAGCCGGC AGTTGGTATT TCCAAGAAAG GGGCTGGACG ACTTCAGGAA GGGCTGCCCG 
CCTTGCACTG GTCTGGTGAC TCAGGTCCCT GTGGAGGGCT TTCTGCCCCA GATTTATCAC 
AGAGCTCCCC AACTGGCCCC AAAGAAGAGG CAGATCAAGC TGCTCAAGGA AGCAGACGTG 
CTTTCCAAGC TCTCGCCAGC CCAGCAGGCT CGGAAGGCAT TCCTGGAGGA CGTGGAGGCC 
CACCTGACCC CACATCCCTT AGCGCTCTAC CTGAATCTGG AAGAAGCTAT GCCCATAGAG 
CTCTTATCAA AGGTGCTGGA AGTGCTTGAT CCTGACCGGA AGCTGGAGGA CACATGGGCT 
TATTGTCAGG ACACCAGGAA AGGAATGAAG GAACCCACGA AGCTTTTAAA AAAACATTCT 
ACCCAAGTCT ACCTGGGACC TTCCAAGAAG ACGTCTGTGT CAAACGCAGG CCAATGGCTT 
TATGAAGAAA AGCCACATAA AATGGATTTG CTCCATGAAA ATGGTCCTCG TCCTGGTCTT 
CATGAAAATG GAATTTCGGA CATCGATGAA GAGTTCATCT TGAAACAGTT TGACATTGAC 
TATGAGACCA AACCAAGCCA TGATGCGCTC CACACGATGA AGCTAAATCA GGTTCCTCTG 
GAGCTAAAGC GTAGTGTGGG GCTCAGTAAA CTGCAGGAGA CAGAGTTCTT CCAGAAACTA 
GGCTATGAGA GGAAACTCCA GAAACCACAG AATCCTTATA AGCCAAAGTG GGTGAAGATG 
AGGTATGGAG CATGGTATTT GAACCCCAAG TTGTGGAAAA AGCAAAGAGT AGACGAGCCT 
CTGGTTGACC CTGAGGTCTC ACATAAGGCT CAAGAGGAGA ATTTTAAAAA GGAGCTGCAG 
GAACAGGAGG AGTTACTTGC AGACCTTCAC GGAACAGTTG CCTTTAAGGA TTTCATTCTA 
AGCAGGGGCT ACAGGACGCC ACGTTTCCTT GAGAATATGT ATATCGGGAA GGAATGTAAA 
CGTGCATGTA ATAAGACTCC TATAAAACGA ACTCAAGCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001130042.1
CDS	48..1229
Translation	MADRRRRLRPGTLAPVREGVNCRSRCFTKHKNGLKFPTSLHSRQLVFPRKGLDDFRKGCPPCTGLVTQVPVEGFLPQIYHRAPQLAPKKRQIKLLKEADVLSKLSPAQQARKAFLEDVEAHLTPHPLALYLNLEEAMPIELLSKVLEVLDPDRKLEDTWAYCQDTRKGMKEPTKLLKKHSTQVYLGPSKKTSVSNAGQWLYEEKPHKMDLLHENGPRPGLHENGISDIDEEFILKQFDIDYETKPSHDALHTMKLNQVPLELKRSVGLSKLQETEFFQKLGYERKLQKPQNPYKPKWVKMRYGAWYLNPKLWKKQRVDEPLVDPEVSHKAQEENFKKELQEQEELLADLHGTVAFKDFILSRGYRTPRFLENMYIGKECKRACNKTPIKRTQA

Target ORF information:

RefSeq Version	NM_001136570.2
Organism	Homo sapiens(human)
Definition	Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136570.2

ORF Insert Sequence:

ATGGCGGACC GCAGGCGGCG GCTCCGGCCG GGGACGTTGG CCCCGGTGCG CGAGGGCGTG 
AACTGCAGGT CCAGATGTTT CACAAAGCAC AAGAACGGGC TGAAGTTCCC CACCTCTCTG 
CACAGCCGGC AGTTGGTATT TCCAAGAAAG GGGCTGGACG ACTTCAGGAA GGGCTGCCCG 
CCTTGCACTG GTCTGGTGAC TCAGGTCCCT GTGGAGGGCT TTCTGCCCCA GATTTATCAC 
AGAGCTCCCC AACTGGCCCC AAAGAAGAGG CAGATCAAGC TGCTCAAGGA AGCAGACGTG 
CTTTCCAAGC TCTCGCCAGC CCAGCAGGCT CGGAAGGCAT TCCTGGAGGA CGTGGAGGCC 
CACCTGACCC CACATCCCTT AGCGCTCTAC CTGAATCTGG AAGAAGCTAT GCCCATAGAG 
CTCTTATCAA AGGTGCTGGA AGTGCTTGAT CCTGACCGGA AGCTGGAGGA CACATGGGCT 
TATTGTCAGG ACACCAGGAA AGGAATGAAG GAACCCACGA AGCTTTTAAA AAAACATTCT 
ACCCAAGTCT ACCTGGGACC TTCCAAGAAG ACGTCTGTGT CAAACGCAGG CCAATGGCTT 
TATGAAGAAA AGCCACATAA AATGGATTTG CTCCATGAAA ATGGTCCTCG TCCTGGTCTT 
CATGAAAATG GAATTTCGGA CATCGATGAA GAGTTCATCT TGAAACAGTT TGACATTGAC 
TATGAGACCA AACCAAGCCA TGATGCGCTC CACACGATGA AGCTAAATCA GGTTCCTCTG 
GAGCTAAAGC GTAGTGTGGG GCTCAGTAAA CTGCAGGAGA CAGAGTTCTT CCAGAAACTA 
GGCTATGAGA GGAAACTCCA GAAACCACAG AATCCTTATA AGCCAAAGTG GGTGAAGATG 
AGGTATGGAG CATGGTATTT GAACCCCAAG TTGTGGAAAA AGCAAAGAGT AGACGAGCCT 
CTGGTTGACC CTGAGGTCTC ACATAAGGCT CAAGAGGAGA ATTTTAAAAA GGAGCTGCAG 
GAACAGGAGG AGTTACTTGC AGACCTTCAC GGAACAGTTG CCTTTAAGGA TTTCATTCTA 
AGCAGGGGCT ACAGGACGCC ACGTTTCCTT GAGAATATGT ATATCGGGAA GGAATGTAAA 
CGTGCATGTA ATAAGACTCC TATAAAACGA ACTCAAGCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM47E ( NM_001242936.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001229865.1 Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu07263
Clone ID Related Accession (Same CDS sequence)	NM_001242936.1
Accession Version	NM_001242936.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-24
Organism	Homo sapiens(human)
Product	protein FAM47E isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK124936.1, BM713546.1 and N55430.1. Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AK124936.1, SRR1803613.124968.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968189 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGATGT CTGTGCCGTG CGTCTTGTCC AGCCTGCAGA ACCATGAGCC AAATAAACCT 
CTTTTCACTA CCCAATCTCA GCTCTTATCA AAGGTGCTGG AAGTGCTTGA TCCTGACCGG 
AAGCTGGAGG ACACATGGGC TTATTGTCAG GACACCAGGA AAGGAATGAA GGAACCCACG 
AAGCTTTTAA AAAAACATTC TACCCAAGTC TACCTGGGAC CTTCCAAGAA GACGTCTGTG 
TCAAACGCAG GCCAATGGCT TTATGAAGAA AAGCCACATA AAATGGATTT GCTCCATGAA 
AATGGTCCTC GTCCTGGTCT TCATGAAAAT GTATGCAAAG CAGTTAGTGA CTTCTGCAAG 
TGGGTTACTA CTTTTGGAAT TTCGGACATC GATGAAGAGT TCATCTTGAA ACAGTTTGAC 
ATTGACTATG AGACCAAACC AAGCCATGAT GCGCTCCACA CGATGAAGCT AAATCAGGTT 
CCTCTGGAGC TAAAGCGTAG TGTGGGGCTC AGTAAACTGC AGGAGACAGA GTTCTTCCAG 
AAACTAGGCT ATGAGAGGAA ACTCCAGAAA CCACAGAATC CTTATAAGCC AAAGTGGGTG 
AAGATGAGGT ATGGAGCATG GTATTTGAAC CCCAAGTTGT GGAAAAAGCA AAGAGTAGAC 
GAGCCTCTGG TTGACCCTGA GGTCTCACAT AAGGCTCAAG AGGAGAATTT TAAAAAGGAG 
CTGCAGGAAC AGGAGGAGTT ACTTGCAGAC CTTCACGGAA CAGTTGCCTT TAAGGATTTC 
ATTCTAAGCA GGGGCTACAG GACGCCACGT TTCCTTGAGA ATATGTATAT CGGGAAGGAA 
TGTAAACGTG CATGTAATAA GACTCCTATA AAACGAACTC AAGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001229865.1
CDS	415..1302
Translation	MQMSVPCVLSSLQNHEPNKPLFTTQSQLLSKVLEVLDPDRKLEDTWAYCQDTRKGMKEPTKLLKKHSTQVYLGPSKKTSVSNAGQWLYEEKPHKMDLLHENGPRPGLHENVCKAVSDFCKWVTTFGISDIDEEFILKQFDIDYETKPSHDALHTMKLNQVPLELKRSVGLSKLQETEFFQKLGYERKLQKPQNPYKPKWVKMRYGAWYLNPKLWKKQRVDEPLVDPEVSHKAQEENFKKELQEQEELLADLHGTVAFKDFILSRGYRTPRFLENMYIGKECKRACNKTPIKRTQA

Target ORF information:

RefSeq Version	NM_001242936.1
Organism	Homo sapiens(human)
Definition	Homo sapiens family with sequence similarity 47 member E (FAM47E), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001242936.1

ORF Insert Sequence:

ATGCAGATGT CTGTGCCGTG CGTCTTGTCC AGCCTGCAGA ACCATGAGCC AAATAAACCT 
CTTTTCACTA CCCAATCTCA GCTCTTATCA AAGGTGCTGG AAGTGCTTGA TCCTGACCGG 
AAGCTGGAGG ACACATGGGC TTATTGTCAG GACACCAGGA AAGGAATGAA GGAACCCACG 
AAGCTTTTAA AAAAACATTC TACCCAAGTC TACCTGGGAC CTTCCAAGAA GACGTCTGTG 
TCAAACGCAG GCCAATGGCT TTATGAAGAA AAGCCACATA AAATGGATTT GCTCCATGAA 
AATGGTCCTC GTCCTGGTCT TCATGAAAAT GTATGCAAAG CAGTTAGTGA CTTCTGCAAG 
TGGGTTACTA CTTTTGGAAT TTCGGACATC GATGAAGAGT TCATCTTGAA ACAGTTTGAC 
ATTGACTATG AGACCAAACC AAGCCATGAT GCGCTCCACA CGATGAAGCT AAATCAGGTT 
CCTCTGGAGC TAAAGCGTAG TGTGGGGCTC AGTAAACTGC AGGAGACAGA GTTCTTCCAG 
AAACTAGGCT ATGAGAGGAA ACTCCAGAAA CCACAGAATC CTTATAAGCC AAAGTGGGTG 
AAGATGAGGT ATGGAGCATG GTATTTGAAC CCCAAGTTGT GGAAAAAGCA AAGAGTAGAC 
GAGCCTCTGG TTGACCCTGA GGTCTCACAT AAGGCTCAAG AGGAGAATTT TAAAAAGGAG 
CTGCAGGAAC AGGAGGAGTT ACTTGCAGAC CTTCACGGAA CAGTTGCCTT TAAGGATTTC 
ATTCTAAGCA GGGGCTACAG GACGCCACGT TTCCTTGAGA ATATGTATAT CGGGAAGGAA 
TGTAAACGTG CATGTAATAA GACTCCTATA AAACGAACTC AAGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson's disease in a Chinese Han population.
Journal of neural transmission (Vienna, Austria : 1996)122(11)1547-52(2015 Nov)
Chen Y,Yuan X,Cao B,Wei Q,Ou R,Yang J,Chen X,Zhao B,Song W,Wu Y,Shang H

Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD.
Journal of the American Society of Nephrology : JASN26(3)692-714(2015 Mar)
Ledo N,Ko YA,Park AS,Kang HM,Han SY,Choi P,Susztak K

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
Nature genetics46(9)989-93(2014 Sep)
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Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
PLoS genetics7(6)e1002141(2011 Jun)
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Genome-wide association study reveals genetic risk underlying Parkinson's disease.
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