NR2E3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NR2E3
Entrez Gene ID	10002
Full Name	nuclear receptor subfamily 2 group E member 3
Synonyms	ESCS,PNR,RNR,RP37,rd7
General protein information	Preferred Names nuclear receptor subfamily 2 group E member 3 Names photoreceptor-specific nuclear receptor retina-specific nuclear receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q23
Summary	This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	604485
Disorder Html:	Enhanced S-cone syndrome, 268100 (3); Retinitis pigmentosa 37, 611131 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014249.4	NP_055064.1	photoreceptor-specific nuclear receptor isoform b
NM_014249.3	NP_055064.1	photoreceptor-specific nuclear receptor isoform b
NM_016346.3	NP_057430.1	photoreceptor-specific nuclear receptor isoform a
NM_016346.4	NP_057430.1	photoreceptor-specific nuclear receptor isoform a

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	LOC100365683	XP_003750575.2
Gallus gallus (chicken)	NR2E3	NP_989925.1
Drosophila melanogaster (fruit fly)	Hr51	NP_611032.2
Xenopus tropicalis (tropical clawed frog)	nr2e3	NP_001090633.1
Homo sapiens (human)	NR2E3	NP_055064.1
	NR2E3	XP_001089693.1
Pan troglodytes (chimpanzee)	NR2E3	XP_001175025.1
Bos taurus (cattle)	NR2E3	NP_001161372.1
Mus musculus (house mouse)	Nr2e3	NP_038736.1
Danio rerio (zebrafish)	nr2e3	NP_001007369.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel NR2E3 gene mutation in autosomal recessive retinitis pigmentosa with cystic maculopathy.
Mahajan D, Votruba M
Acta ophthalmologica(2017 Nov)

Generation of an induced pluripotent stem cell (iPSC) line from a patient with autosomal dominant retinitis pigmentosa due to a mutation in the NR2E3 gene.
Terray A, Slembrouck A, Nanteau C, Chondroyer C, Zeitz C, Sahel JA, Audo I, Reichman S, Goureau O
Stem cell research241-4(2017 Oct)

Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer.
Khanal T, Choi K, Leung YK, Wang J, Kim D, Janakiram V, Cho SG, Puga A, Ho SM, Kim K
Scientific reports7(1)10662(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group.
Title: Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-? (PPAR?) are disrupted by retinal disease-associated mutations.

The frameshift mutation found in patient 1, p.I307LfsX33, is a new causative mutation for ESCS; it is located in exon 6. This mutation truncates the 410 amino acids in the normal NR2E3 protein into 306 amino acids and causes the synthesis of a protein lacking more than half of the ligand-binding domain.
Title: New truncation mutation of the NR2E3 gene in a Japanese patient with enhanced S-cone syndrome.

Autosomal dominant retinitis pigmentosa due to p.Gly56Arg mutation in the NR2E3 gene
Title: Dominant Retinitis Pigmentosa, p.Gly56Arg Mutation in NR2E3: Phenotype in a Large Cohort of 24 Cases.

NR2E3 is a novel epigenetic regulator that helps to maintain a normal epigenetic status in response to benzo(a)pyrene mediated toxic injury. NR2E3 may be a potential target for cancer prevention.
Title: Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter.

Direct sequencing of NR2E3 identified 3 previously described mutations and 4 novel mutations in Enhanced S-cone syndrome (ESCS) forms
Title: Clinical and molecular characterization of enhanced S-cone syndrome in children.

The following NR2E3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR2E3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20514	NM_014249.4 Latest version!	Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$174.50-$244.30 $349.00
OHu21890	NM_016346.4 Latest version!	Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu20514	NM_014249.3	Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$174.50-$244.30 $349.00
OHu21890	NM_016346.3	Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NR2E3 ( NM_014249.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055064.1 Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20514
Clone ID Related Accession (Same CDS sequence)	NM_014249.4 , NM_014249.3
Accession Version	NM_014249.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	photoreceptor-specific nuclear receptor isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF121129.1, AL711747.1, BU732726.1 and AW080977.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_014249.3. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) contains a longer C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF121129.1, AB307710.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000617575.5/ ENSP00000482504.1 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGAGACCA GACCAACAGC TCTGATGAGC TCCACAGTGG CTGCAGCTGC GCCTGCAGCT 
GGGGCTGCCT CCAGGAAGGA GTCTCCAGGC AGATGGGGCC TGGGGGAGGA TCCCACAGGC 
GTGAGCCCCT CGCTCCAGTG CCGCGTGTGC GGAGACAGCA GCAGCGGGAA GCACTATGGC 
ATCTATGCCT GCAACGGCTG CAGCGGCTTC TTCAAGAGGA GCGTACGGCG GAGGCTCATC 
TACAGGTGCC AGGTGGGGGC AGGGATGTGC CCCGTGGACA AGGCCCACCG CAACCAGTGC 
CAGGCCTGCC GGCTGAAGAA GTGCCTGCAG GCGGGGATGA ACCAGGACGC CGTGCAGAAC 
GAGCGCCAGC CGCGAAGCAC AGCCCAGGTC CACCTGGACA GCATGGAGTC CAACACTGAG 
TCCCGGCCGG AGTCCCTGGT GGCTCCCCCG GCCCCGGCAG GGCGCAGCCC ACGGGGCCCC 
ACACCCATGT CTGCAGCCAG AGCCCTGGGC CACCACTTCA TGGCCAGCCT TATAACAGCT 
GAAACCTGTG CTAAGCTGGA GCCAGAGGAT GCTGATGAGA ATATTGATGT CACCAGCAAT 
GACCCTGAGT TCCCCTCCTC TCCATACTCC TCTTCCTCCC CCTGCGGCCT GGACAGCATC 
CATGAGACCT CGGCTCGCCT ACTCTTCATG GCCGTCAAGT GGGCCAAGAA CCTGCCTGTG 
TTCTCCAGCC TGCCCTTCCG GGATCAGGTG ATCCTGCTGG AAGAGGCGTG GAGTGAACTC 
TTTCTCCTCG GGGCCATCCA GTGGTCTCTG CCTCTGGACA GCTGTCCTCT GCTGGCACCG 
CCCGAGGCCT CTGCTGCCGG TGGTGCCCAG GGCCGGCTCA CGCTGGCCAG CATGGAGACG 
CGTGTCCTGC AGGAAACTAT CTCTCGGTTC CGGGCATTGG CGGTGGACCC CACGGAGTTT 
GCCTGCATGA AGGCCTTGGT CCTCTTCAAG CCAGAGACGC GGGGCCTGAA GGATCCTGAG 
CACGTAGAGG CCTTGCAGGA CCAGTCCCAA GTGATGCTGA GCCAGCACAG CAAGGCCCAC 
CACCCCAGCC AGCCCGTGAG GTTTGGGAAA TTGCTCCTGC TCCTCCCGTC TTTGAGGTTT 
ATCACTGCGG AACGCATCGA GCTCCTCTTT TTCCGCAAGA CCATAGGGAA TACTCCAATG 
GAGAAGCTCC TTTGTGATAT GTTCAAAAAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055064.1
CDS	191..1423
Translation	METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN

Target ORF information:

RefSeq Version	NM_014249.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014249.4

ORF Insert Sequence:

ATGGAGACCA GACCAACAGC TCTGATGAGC TCCACAGTGG CTGCAGCTGC GCCTGCAGCT 
GGGGCTGCCT CCAGGAAGGA GTCTCCAGGC AGATGGGGCC TGGGGGAGGA TCCCACAGGC 
GTGAGCCCCT CGCTCCAGTG CCGCGTGTGC GGAGACAGCA GCAGCGGGAA GCACTATGGC 
ATCTATGCCT GCAACGGCTG CAGCGGCTTC TTCAAGAGGA GCGTACGGCG GAGGCTCATC 
TACAGGTGCC AGGTGGGGGC AGGGATGTGC CCCGTGGACA AGGCCCACCG CAACCAGTGC 
CAGGCCTGCC GGCTGAAGAA GTGCCTGCAG GCGGGGATGA ACCAGGACGC CGTGCAGAAC 
GAGCGCCAGC CGCGAAGCAC AGCCCAGGTC CACCTGGACA GCATGGAGTC CAACACTGAG 
TCCCGGCCGG AGTCCCTGGT GGCTCCCCCG GCCCCGGCAG GGCGCAGCCC ACGGGGCCCC 
ACACCCATGT CTGCAGCCAG AGCCCTGGGC CACCACTTCA TGGCCAGCCT TATAACAGCT 
GAAACCTGTG CTAAGCTGGA GCCAGAGGAT GCTGATGAGA ATATTGATGT CACCAGCAAT 
GACCCTGAGT TCCCCTCCTC TCCATACTCC TCTTCCTCCC CCTGCGGCCT GGACAGCATC 
CATGAGACCT CGGCTCGCCT ACTCTTCATG GCCGTCAAGT GGGCCAAGAA CCTGCCTGTG 
TTCTCCAGCC TGCCCTTCCG GGATCAGGTG ATCCTGCTGG AAGAGGCGTG GAGTGAACTC 
TTTCTCCTCG GGGCCATCCA GTGGTCTCTG CCTCTGGACA GCTGTCCTCT GCTGGCACCG 
CCCGAGGCCT CTGCTGCCGG TGGTGCCCAG GGCCGGCTCA CGCTGGCCAG CATGGAGACG 
CGTGTCCTGC AGGAAACTAT CTCTCGGTTC CGGGCATTGG CGGTGGACCC CACGGAGTTT 
GCCTGCATGA AGGCCTTGGT CCTCTTCAAG CCAGAGACGC GGGGCCTGAA GGATCCTGAG 
CACGTAGAGG CCTTGCAGGA CCAGTCCCAA GTGATGCTGA GCCAGCACAG CAAGGCCCAC 
CACCCCAGCC AGCCCGTGAG GTTTGGGAAA TTGCTCCTGC TCCTCCCGTC TTTGAGGTTT 
ATCACTGCGG AACGCATCGA GCTCCTCTTT TTCCGCAAGA CCATAGGGAA TACTCCAATG 
GAGAAGCTCC TTTGTGATAT GTTCAAAAAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR2E3 ( NM_014249.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055064.1 Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20514
Clone ID Related Accession (Same CDS sequence)	NM_014249.4 , NM_014249.3
Accession Version	NM_014249.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	photoreceptor-specific nuclear receptor isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL711747.1, AF121129.1, BU732726.1 and AW080977.1. This sequence is a reference standard in the RefSeqGene project. On Jul 26, 2013 this sequence version replaced NM_014249.2. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) contains a longer C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF121129.1, AB307710.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

ATGGAGACCA GACCAACAGC TCTGATGAGC TCCACAGTGG CTGCAGCTGC GCCTGCAGCT 
GGGGCTGCCT CCAGGAAGGA GTCTCCAGGC AGATGGGGCC TGGGGGAGGA TCCCACAGGC 
GTGAGCCCCT CGCTCCAGTG CCGCGTGTGC GGAGACAGCA GCAGCGGGAA GCACTATGGC 
ATCTATGCCT GCAACGGCTG CAGCGGCTTC TTCAAGAGGA GCGTACGGCG GAGGCTCATC 
TACAGGTGCC AGGTGGGGGC AGGGATGTGC CCCGTGGACA AGGCCCACCG CAACCAGTGC 
CAGGCCTGCC GGCTGAAGAA GTGCCTGCAG GCGGGGATGA ACCAGGACGC CGTGCAGAAC 
GAGCGCCAGC CGCGAAGCAC AGCCCAGGTC CACCTGGACA GCATGGAGTC CAACACTGAG 
TCCCGGCCGG AGTCCCTGGT GGCTCCCCCG GCCCCGGCAG GGCGCAGCCC ACGGGGCCCC 
ACACCCATGT CTGCAGCCAG AGCCCTGGGC CACCACTTCA TGGCCAGCCT TATAACAGCT 
GAAACCTGTG CTAAGCTGGA GCCAGAGGAT GCTGATGAGA ATATTGATGT CACCAGCAAT 
GACCCTGAGT TCCCCTCCTC TCCATACTCC TCTTCCTCCC CCTGCGGCCT GGACAGCATC 
CATGAGACCT CGGCTCGCCT ACTCTTCATG GCCGTCAAGT GGGCCAAGAA CCTGCCTGTG 
TTCTCCAGCC TGCCCTTCCG GGATCAGGTG ATCCTGCTGG AAGAGGCGTG GAGTGAACTC 
TTTCTCCTCG GGGCCATCCA GTGGTCTCTG CCTCTGGACA GCTGTCCTCT GCTGGCACCG 
CCCGAGGCCT CTGCTGCCGG TGGTGCCCAG GGCCGGCTCA CGCTGGCCAG CATGGAGACG 
CGTGTCCTGC AGGAAACTAT CTCTCGGTTC CGGGCATTGG CGGTGGACCC CACGGAGTTT 
GCCTGCATGA AGGCCTTGGT CCTCTTCAAG CCAGAGACGC GGGGCCTGAA GGATCCTGAG 
CACGTAGAGG CCTTGCAGGA CCAGTCCCAA GTGATGCTGA GCCAGCACAG CAAGGCCCAC 
CACCCCAGCC AGCCCGTGAG GTTTGGGAAA TTGCTCCTGC TCCTCCCGTC TTTGAGGTTT 
ATCACTGCGG AACGCATCGA GCTCCTCTTT TTCCGCAAGA CCATAGGGAA TACTCCAATG 
GAGAAGCTCC TTTGTGATAT GTTCAAAAAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055064.1
CDS	197..1429
Translation	METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN

Target ORF information:

RefSeq Version	NM_014249.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014249.3

ORF Insert Sequence:

ATGGAGACCA GACCAACAGC TCTGATGAGC TCCACAGTGG CTGCAGCTGC GCCTGCAGCT 
GGGGCTGCCT CCAGGAAGGA GTCTCCAGGC AGATGGGGCC TGGGGGAGGA TCCCACAGGC 
GTGAGCCCCT CGCTCCAGTG CCGCGTGTGC GGAGACAGCA GCAGCGGGAA GCACTATGGC 
ATCTATGCCT GCAACGGCTG CAGCGGCTTC TTCAAGAGGA GCGTACGGCG GAGGCTCATC 
TACAGGTGCC AGGTGGGGGC AGGGATGTGC CCCGTGGACA AGGCCCACCG CAACCAGTGC 
CAGGCCTGCC GGCTGAAGAA GTGCCTGCAG GCGGGGATGA ACCAGGACGC CGTGCAGAAC 
GAGCGCCAGC CGCGAAGCAC AGCCCAGGTC CACCTGGACA GCATGGAGTC CAACACTGAG 
TCCCGGCCGG AGTCCCTGGT GGCTCCCCCG GCCCCGGCAG GGCGCAGCCC ACGGGGCCCC 
ACACCCATGT CTGCAGCCAG AGCCCTGGGC CACCACTTCA TGGCCAGCCT TATAACAGCT 
GAAACCTGTG CTAAGCTGGA GCCAGAGGAT GCTGATGAGA ATATTGATGT CACCAGCAAT 
GACCCTGAGT TCCCCTCCTC TCCATACTCC TCTTCCTCCC CCTGCGGCCT GGACAGCATC 
CATGAGACCT CGGCTCGCCT ACTCTTCATG GCCGTCAAGT GGGCCAAGAA CCTGCCTGTG 
TTCTCCAGCC TGCCCTTCCG GGATCAGGTG ATCCTGCTGG AAGAGGCGTG GAGTGAACTC 
TTTCTCCTCG GGGCCATCCA GTGGTCTCTG CCTCTGGACA GCTGTCCTCT GCTGGCACCG 
CCCGAGGCCT CTGCTGCCGG TGGTGCCCAG GGCCGGCTCA CGCTGGCCAG CATGGAGACG 
CGTGTCCTGC AGGAAACTAT CTCTCGGTTC CGGGCATTGG CGGTGGACCC CACGGAGTTT 
GCCTGCATGA AGGCCTTGGT CCTCTTCAAG CCAGAGACGC GGGGCCTGAA GGATCCTGAG 
CACGTAGAGG CCTTGCAGGA CCAGTCCCAA GTGATGCTGA GCCAGCACAG CAAGGCCCAC 
CACCCCAGCC AGCCCGTGAG GTTTGGGAAA TTGCTCCTGC TCCTCCCGTC TTTGAGGTTT 
ATCACTGCGG AACGCATCGA GCTCCTCTTT TTCCGCAAGA CCATAGGGAA TACTCCAATG 
GAGAAGCTCC TTTGTGATAT GTTCAAAAAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR2E3 ( NM_016346.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057430.1 Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21890
Clone ID Related Accession (Same CDS sequence)	NM_016346.3 , NM_016346.4
Accession Version	NM_016346.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	photoreceptor-specific nuclear receptor isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104938.7, AF148128.1 and KF495720.1. This sequence is a reference standard in the RefSeqGene project. On Jul 26, 2013 this sequence version replaced NM_016346.2. Transcript Variant: This variant (1) represents the longer transcript and encodes isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF148128.1, HQ692847.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

ATGGAGACCA GACCAACAGC TCTGATGAGC TCCACAGTGG CTGCAGCTGC GCCTGCAGCT 
GGGGCTGCCT CCAGGAAGGA GTCTCCAGGC AGATGGGGCC TGGGGGAGGA TCCCACAGGC 
GTGAGCCCCT CGCTCCAGTG CCGCGTGTGC GGAGACAGCA GCAGCGGGAA GCACTATGGC 
ATCTATGCCT GCAACGGCTG CAGCGGCTTC TTCAAGAGGA GCGTACGGCG GAGGCTCATC 
TACAGGTGCC AGGTGGGGGC AGGGATGTGC CCCGTGGACA AGGCCCACCG CAACCAGTGC 
CAGGCCTGCC GGCTGAAGAA GTGCCTGCAG GCGGGGATGA ACCAGGACGC CGTGCAGAAC 
GAGCGCCAGC CGCGAAGCAC AGCCCAGGTC CACCTGGACA GCATGGAGTC CAACACTGAG 
TCCCGGCCGG AGTCCCTGGT GGCTCCCCCG GCCCCGGCAG GGCGCAGCCC ACGGGGCCCC 
ACACCCATGT CTGCAGCCAG AGCCCTGGGC CACCACTTCA TGGCCAGCCT TATAACAGCT 
GAAACCTGTG CTAAGCTGGA GCCAGAGGAT GCTGATGAGA ATATTGATGT CACCAGCAAT 
GACCCTGAGT TCCCCTCCTC TCCATACTCC TCTTCCTCCC CCTGCGGCCT GGACAGCATC 
CATGAGACCT CGGCTCGCCT ACTCTTCATG GCCGTCAAGT GGGCCAAGAA CCTGCCTGTG 
TTCTCCAGCC TGCCCTTCCG GGATCAGGTG ATCCTGCTGG AAGAGGCGTG GAGTGAACTC 
TTTCTCCTCG GGGCCATCCA GTGGTCTCTG CCTCTGGACA GCTGTCCTCT GCTGGCACCG 
CCCGAGGCCT CTGCTGCCGG TGGTGCCCAG GGCCGGCTCA CGCTGGCCAG CATGGAGACG 
CGTGTCCTGC AGGAAACTAT CTCTCGGTTC CGGGCATTGG CGGTGGACCC CACGGAGTTT 
GCCTGCATGA AGGCCTTGGT CCTCTTCAAG CCAGAGACGC GGGGCCTGAA GGATCCTGAG 
CACGTAGAGG CCTTGCAGGA CCAGTCCCAA GTGATGCTGA GCCAGCACAG CAAGGCCCAC 
CACCCCAGCC AGCCCGTGAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057430.1
CDS	197..1300
Translation	METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVR

Target ORF information:

RefSeq Version	NM_016346.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016346.3

ORF Insert Sequence:

ATGGAGACCA GACCAACAGC TCTGATGAGC TCCACAGTGG CTGCAGCTGC GCCTGCAGCT 
GGGGCTGCCT CCAGGAAGGA GTCTCCAGGC AGATGGGGCC TGGGGGAGGA TCCCACAGGC 
GTGAGCCCCT CGCTCCAGTG CCGCGTGTGC GGAGACAGCA GCAGCGGGAA GCACTATGGC 
ATCTATGCCT GCAACGGCTG CAGCGGCTTC TTCAAGAGGA GCGTACGGCG GAGGCTCATC 
TACAGGTGCC AGGTGGGGGC AGGGATGTGC CCCGTGGACA AGGCCCACCG CAACCAGTGC 
CAGGCCTGCC GGCTGAAGAA GTGCCTGCAG GCGGGGATGA ACCAGGACGC CGTGCAGAAC 
GAGCGCCAGC CGCGAAGCAC AGCCCAGGTC CACCTGGACA GCATGGAGTC CAACACTGAG 
TCCCGGCCGG AGTCCCTGGT GGCTCCCCCG GCCCCGGCAG GGCGCAGCCC ACGGGGCCCC 
ACACCCATGT CTGCAGCCAG AGCCCTGGGC CACCACTTCA TGGCCAGCCT TATAACAGCT 
GAAACCTGTG CTAAGCTGGA GCCAGAGGAT GCTGATGAGA ATATTGATGT CACCAGCAAT 
GACCCTGAGT TCCCCTCCTC TCCATACTCC TCTTCCTCCC CCTGCGGCCT GGACAGCATC 
CATGAGACCT CGGCTCGCCT ACTCTTCATG GCCGTCAAGT GGGCCAAGAA CCTGCCTGTG 
TTCTCCAGCC TGCCCTTCCG GGATCAGGTG ATCCTGCTGG AAGAGGCGTG GAGTGAACTC 
TTTCTCCTCG GGGCCATCCA GTGGTCTCTG CCTCTGGACA GCTGTCCTCT GCTGGCACCG 
CCCGAGGCCT CTGCTGCCGG TGGTGCCCAG GGCCGGCTCA CGCTGGCCAG CATGGAGACG 
CGTGTCCTGC AGGAAACTAT CTCTCGGTTC CGGGCATTGG CGGTGGACCC CACGGAGTTT 
GCCTGCATGA AGGCCTTGGT CCTCTTCAAG CCAGAGACGC GGGGCCTGAA GGATCCTGAG 
CACGTAGAGG CCTTGCAGGA CCAGTCCCAA GTGATGCTGA GCCAGCACAG CAAGGCCCAC 
CACCCCAGCC AGCCCGTGAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NR2E3 ( NM_016346.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057430.1 Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 1, mRNA.

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CloneID	OHu21890
Clone ID Related Accession (Same CDS sequence)	NM_016346.3 , NM_016346.4
Accession Version	NM_016346.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	photoreceptor-specific nuclear receptor isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104938.7, AF148128.1 and KF495720.1. This sequence is a reference standard in the RefSeqGene project. On Jun 1, 2019 this sequence version replaced NM_016346.3. Transcript Variant: This variant (1) represents the longer transcript and encodes isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF148128.1, HQ692847.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

ATGGAGACCA GACCAACAGC TCTGATGAGC TCCACAGTGG CTGCAGCTGC GCCTGCAGCT 
GGGGCTGCCT CCAGGAAGGA GTCTCCAGGC AGATGGGGCC TGGGGGAGGA TCCCACAGGC 
GTGAGCCCCT CGCTCCAGTG CCGCGTGTGC GGAGACAGCA GCAGCGGGAA GCACTATGGC 
ATCTATGCCT GCAACGGCTG CAGCGGCTTC TTCAAGAGGA GCGTACGGCG GAGGCTCATC 
TACAGGTGCC AGGTGGGGGC AGGGATGTGC CCCGTGGACA AGGCCCACCG CAACCAGTGC 
CAGGCCTGCC GGCTGAAGAA GTGCCTGCAG GCGGGGATGA ACCAGGACGC CGTGCAGAAC 
GAGCGCCAGC CGCGAAGCAC AGCCCAGGTC CACCTGGACA GCATGGAGTC CAACACTGAG 
TCCCGGCCGG AGTCCCTGGT GGCTCCCCCG GCCCCGGCAG GGCGCAGCCC ACGGGGCCCC 
ACACCCATGT CTGCAGCCAG AGCCCTGGGC CACCACTTCA TGGCCAGCCT TATAACAGCT 
GAAACCTGTG CTAAGCTGGA GCCAGAGGAT GCTGATGAGA ATATTGATGT CACCAGCAAT 
GACCCTGAGT TCCCCTCCTC TCCATACTCC TCTTCCTCCC CCTGCGGCCT GGACAGCATC 
CATGAGACCT CGGCTCGCCT ACTCTTCATG GCCGTCAAGT GGGCCAAGAA CCTGCCTGTG 
TTCTCCAGCC TGCCCTTCCG GGATCAGGTG ATCCTGCTGG AAGAGGCGTG GAGTGAACTC 
TTTCTCCTCG GGGCCATCCA GTGGTCTCTG CCTCTGGACA GCTGTCCTCT GCTGGCACCG 
CCCGAGGCCT CTGCTGCCGG TGGTGCCCAG GGCCGGCTCA CGCTGGCCAG CATGGAGACG 
CGTGTCCTGC AGGAAACTAT CTCTCGGTTC CGGGCATTGG CGGTGGACCC CACGGAGTTT 
GCCTGCATGA AGGCCTTGGT CCTCTTCAAG CCAGAGACGC GGGGCCTGAA GGATCCTGAG 
CACGTAGAGG CCTTGCAGGA CCAGTCCCAA GTGATGCTGA GCCAGCACAG CAAGGCCCAC 
CACCCCAGCC AGCCCGTGAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057430.1
CDS	191..1294
Translation	METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVR

Target ORF information:

RefSeq Version	NM_016346.4
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor subfamily 2 group E member 3 (NR2E3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016346.4

ORF Insert Sequence:

ATGGAGACCA GACCAACAGC TCTGATGAGC TCCACAGTGG CTGCAGCTGC GCCTGCAGCT 
GGGGCTGCCT CCAGGAAGGA GTCTCCAGGC AGATGGGGCC TGGGGGAGGA TCCCACAGGC 
GTGAGCCCCT CGCTCCAGTG CCGCGTGTGC GGAGACAGCA GCAGCGGGAA GCACTATGGC 
ATCTATGCCT GCAACGGCTG CAGCGGCTTC TTCAAGAGGA GCGTACGGCG GAGGCTCATC 
TACAGGTGCC AGGTGGGGGC AGGGATGTGC CCCGTGGACA AGGCCCACCG CAACCAGTGC 
CAGGCCTGCC GGCTGAAGAA GTGCCTGCAG GCGGGGATGA ACCAGGACGC CGTGCAGAAC 
GAGCGCCAGC CGCGAAGCAC AGCCCAGGTC CACCTGGACA GCATGGAGTC CAACACTGAG 
TCCCGGCCGG AGTCCCTGGT GGCTCCCCCG GCCCCGGCAG GGCGCAGCCC ACGGGGCCCC 
ACACCCATGT CTGCAGCCAG AGCCCTGGGC CACCACTTCA TGGCCAGCCT TATAACAGCT 
GAAACCTGTG CTAAGCTGGA GCCAGAGGAT GCTGATGAGA ATATTGATGT CACCAGCAAT 
GACCCTGAGT TCCCCTCCTC TCCATACTCC TCTTCCTCCC CCTGCGGCCT GGACAGCATC 
CATGAGACCT CGGCTCGCCT ACTCTTCATG GCCGTCAAGT GGGCCAAGAA CCTGCCTGTG 
TTCTCCAGCC TGCCCTTCCG GGATCAGGTG ATCCTGCTGG AAGAGGCGTG GAGTGAACTC 
TTTCTCCTCG GGGCCATCCA GTGGTCTCTG CCTCTGGACA GCTGTCCTCT GCTGGCACCG 
CCCGAGGCCT CTGCTGCCGG TGGTGCCCAG GGCCGGCTCA CGCTGGCCAG CATGGAGACG 
CGTGTCCTGC AGGAAACTAT CTCTCGGTTC CGGGCATTGG CGGTGGACCC CACGGAGTTT 
GCCTGCATGA AGGCCTTGGT CCTCTTCAAG CCAGAGACGC GGGGCCTGAA GGATCCTGAG 
CACGTAGAGG CCTTGCAGGA CCAGTCCCAA GTGATGCTGA GCCAGCACAG CAAGGCCCAC 
CACCCCAGCC AGCCCGTGAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel NR2E3 gene mutation in autosomal recessive retinitis pigmentosa with cystic maculopathy.
Acta ophthalmologica(2017 Nov)
Mahajan D,Votruba M

Generation of an induced pluripotent stem cell (iPSC) line from a patient with autosomal dominant retinitis pigmentosa due to a mutation in the NR2E3 gene.
Stem cell research241-4(2017 Oct)
Terray A,Slembrouck A,Nanteau C,Chondroyer C,Zeitz C,Sahel JA,Audo I,Reichman S,Goureau O

Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer.
Scientific reports7(1)10662(2017 Sep)
Khanal T,Choi K,Leung YK,Wang J,Kim D,Janakiram V,Cho SG,Puga A,Ho SM,Kim K

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NR2E3 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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