SELENOT cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOT
Entrez Gene ID	425041
Full Name	selenoprotein T
General protein information	Preferred Names selenoprotein T Names thioredoxin reductase-like selenoprotein T SELT thioredoxin reductase-like enzyme
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001006557.4	NP_001006557.3	thioredoxin reductase-like selenoprotein T precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SELT	NP_001096573.2
Mus musculus (house mouse)	Selt	NP_001035486.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009202	XP_319979.4
Canis lupus familiaris (dog)	SELT	NP_001157959.1
Homo sapiens (human)	SELT	NP_057359.2
Danio rerio (zebrafish)	selt1a	NP_840075.2
Rattus norvegicus (Norway rat)	Selt	NP_001014275.2
Gallus gallus (chicken)	SELT	NP_001006557.3
Xenopus tropicalis (tropical clawed frog)	selt	NP_988868.2
	SELT	NP_001152886.1
Drosophila melanogaster (fruit fly)	CG3887	NP_608897.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Prediction of selenoprotein T structure and its response to selenium deficiency in chicken immune organs.
You L, Liu C, Yang ZJ, Li M, Li S
Biological trace element research160(2)222-31(2014 Aug)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Gene expression profiling of chicken primordial germ cell ESTs.
Han JY, Park TS, Kim JN, Kim MA, Lim D, Lim JM, Kim H
BMC genomics7220(2006 Aug)

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Carre W, Wang X, Porter TE, Nys Y, Tang J, Bernberg E, Morgan R, Burnside J, Aggrey SE, Simon J, Cogburn LA
Physiological genomics25(3)514-24(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that a selenium -deficient diet led to a decrease in selenoprotein T (SelT), oxidative stress in the chicken immune organs.
Title: Prediction of selenoprotein T structure and its response to selenium deficiency in chicken immune organs.

The following SELENOT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa28080	NM_001006557.4 Latest version!	Gallus gallus selenoprotein T (SELENOT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$104.30 $149.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOT ( NM_001006557.4 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001006557.3 Gallus gallus selenoprotein T (SELENOT), mRNA.

Price & Availability↑

CloneID	OGa28080
Clone ID Related Accession (Same CDS sequence)	NM_001006557.4
Accession Version	NM_001006557.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Gallus gallus(chicken)
Product	thioredoxin reductase-like selenoprotein T precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ450766.1, DR419695.1, AJ720396.1 and CV862139.1. On Apr 19, 2017 this sequence version replaced NM_001006557.3. ##Evidence-Data-START## Transcript exon combination :: AJ450766.1, AJ720396.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGGCGG CCGGGCTGGG GCTGGGGATC GGGCTGCTGC TGCTGGCGGC GCTGGCGGGG 
CCGGGCGGCT CGGCGGAGCA GGGCGGCGTG CCGGCCAAGA AGCTGCGCAT GGCGTACGCC 
ACCGGGCCGC TGCTCAAGTT CCAGATCTGC GTCTCCTGAG GTTACCGGCG GGTGTTCGAG 
GAGTACATGC GGGTCATCAG CCAGCGGTAC CCCGACATCC GCATCGAGGG GGAGAACTAC 
CTGCCCCAGC CCATCTATAG GCACATAGCA TCCTTCCTGT CTGTCTTCAA ACTAGTATTA 
ATAGGCTTAA TAATTGTCGG CAAGGATCCA TTTGCTTTCT TTGGCATGCA AGCTCCAAGC 
ATCTGGCAGT GGGGCCAAGA AAACAAGGTT TATGCTTGTA TGATGGTTTT CTTCTTGAGC 
AACATGATTG AGAACCAGTG TATGTCAACG GGTGCATTTG AAATAACTTT GAATGATGTT 
CCAGTGTGGT CTAAGCTAGA GTCTGGCCAC CTTCCTTCCA TGCAGCAGCT TGTACAAATT 
CTTGATAATG AAATGAAGCT CAATGTGCAC ATGGAGTCAA TGCCTCACCA TCGATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001006557.3
CDS	74..673
Translation	MRAAGLGLGIGLLLLAALAGPGGSAEQGGVPAKKLRMAYATGPLLKFQICVS*GYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMESMPHHRS

Target ORF information:

RefSeq Version	NM_001006557.4
Organism	Gallus gallus(chicken)
Definition	Gallus gallus selenoprotein T (SELENOT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001006557.4

ORF Insert Sequence:

ATGCGGGCGG CCGGGCTGGG GCTGGGGATC GGGCTGCTGC TGCTGGCGGC GCTGGCGGGG 
CCGGGCGGCT CGGCGGAGCA GGGCGGCGTG CCGGCCAAGA AGCTGCGCAT GGCGTACGCC 
ACCGGGCCGC TGCTCAAGTT CCAGATCTGC GTCTCCTGAG GTTACCGGCG GGTGTTCGAG 
GAGTACATGC GGGTCATCAG CCAGCGGTAC CCCGACATCC GCATCGAGGG GGAGAACTAC 
CTGCCCCAGC CCATCTATAG GCACATAGCA TCCTTCCTGT CTGTCTTCAA ACTAGTATTA 
ATAGGCTTAA TAATTGTCGG CAAGGATCCA TTTGCTTTCT TTGGCATGCA AGCTCCAAGC 
ATCTGGCAGT GGGGCCAAGA AAACAAGGTT TATGCTTGTA TGATGGTTTT CTTCTTGAGC 
AACATGATTG AGAACCAGTG TATGTCAACG GGTGCATTTG AAATAACTTT GAATGATGTT 
CCAGTGTGGT CTAAGCTAGA GTCTGGCCAC CTTCCTTCCA TGCAGCAGCT TGTACAAATT 
CTTGATAATG AAATGAAGCT CAATGTGCAC ATGGAGTCAA TGCCTCACCA TCGATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Prediction of selenoprotein T structure and its response to selenium deficiency in chicken immune organs.
Biological trace element research160(2)222-31(2014 Aug)
You L,Liu C,Yang ZJ,Li M,Li S

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Gene expression profiling of chicken primordial germ cell ESTs.
BMC genomics7220(2006 Aug)
Han JY,Park TS,Kim JN,Kim MA,Lim D,Lim JM,Kim H

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Physiological genomics25(3)514-24(2006 May)
Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

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SELENOT cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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