LSS cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	LSS
Entrez Gene ID	424037
Full Name	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
General protein information	Preferred Names lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) Names lanosterol synthase
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001006514.2	NP_001006514.2	lanosterol synthase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LSS	XP_531506.3
Mus musculus (house mouse)	Lss	NP_666118.1
Kluyveromyces lactis	KLLA0B10175g	XP_451982.1
Eremothecium gossypii	AGOS_AGR351W	NP_987017.2
Schizosaccharomyces pombe (fission yeast)	erg7	NP_593702.2
Magnaporthe oryzae (rice blast fungus)	MGG_11702	XP_003710102.1
Homo sapiens (human)	LSS	NP_001001438.1
	LSS	XP_001098607.1
Danio rerio (zebrafish)	lss	NP_001077036.1
Saccharomyces cerevisiae (baker's yeast)	ERG7	NP_011939.2
Arabidopsis thaliana (thale cress)	CAS1	NP_178722.1
Canis lupus familiaris (dog)	LSS	XP_548733.4
Xenopus tropicalis (tropical clawed frog)	lss	NP_001073038.1
Rattus norvegicus (Norway rat)	Lss	NP_112311.1
Gallus gallus (chicken)	LSS	NP_001006514.2
Oryza sativa (rice)	Os02g0139700	NP_001045848.1
Bos taurus (cattle)	LSS	NP_001040029.1
Neurospora crassa	NCU01119	XP_961026.1

Gene Ontology
Bibliography

Related articles in PubMed

Cholesterol synthesis-related enzyme oxidosqualene cyclase is required to maintain self-renewal in primary erythroid progenitors.
Mejia-Pous C, Damiola F, Gandrillon O
Cell proliferation44(5)441-52(2011 Oct)

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Carre W, Wang X, Porter TE, Nys Y, Tang J, Bernberg E, Morgan R, Burnside J, Aggrey SE, Simon J, Cogburn LA
Physiological genomics25(3)514-24(2006 May)

Expressed sequence tag analysis of Eimeria-stimulated intestinal intraepithelial lymphocytes in chickens.
Min W, Lillehoj HS, Ashwell CM, van Tassell CP, Dalloul RA, Matukumalli LK, Han JY, Lillehoj EP
Molecular biotechnology30(2)143-50(2005 Jun)

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM
Genome biology6(1)R6(2005)

A comprehensive collection of chicken cDNAs.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ
Current biology : CB12(22)1965-9(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

oxidosqualene cyclase expression and activity are required to maintain erythroid progenitor cell self-renewal and may be involved in the self-renewal versus differentiation/apoptosis decision making, by keeping cells in a self-renewal state
Title: Cholesterol synthesis-related enzyme oxidosqualene cyclase is required to maintain self-renewal in primary erythroid progenitors.

The following LSS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LSS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa24708	NM_001006514.2 Latest version!	Gallus gallus lanosterol synthase (LSS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LSS ( NM_001006514.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001006514.2 Gallus gallus lanosterol synthase (LSS), mRNA.

Price & Availability↑

CloneID	OGa24708
Clone ID Related Accession (Same CDS sequence)	NM_001006514.2
Accession Version	NM_001006514.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2274bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-17
Organism	Gallus gallus(chicken)
Product	lanosterol synthase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ453276.1, AJ724535.1, BM491984.1, AJ724528.1, BU264667.1, CD734354.1, BU240685.1 and AL586203.1. On Oct 5, 2012 this sequence version replaced NM_001006514.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. COMPLETENESS: complete on the 3' end.

ATGGCGGCGG ACGGGGTGGT GCGGCGGCGC GGCGGTCCGT GGCGCACGGC GGCAGCCACG 
GCGCTGCCCT CCTGGCGGCT GCGCTGCGAG GGCGGCCGGC AGCGCTGGTG CTACCTGGAT 
GACGGCGTCG AGGACGAGGA GGCGGCCGGA GGGCGACGGG CGCAGACGGC GCTGGAGGCG 
CACAGCGTCG GCCTGGACAC GGACGCGCTC CTGCGGACGC TGCCGGCCGC CGGAACGGCG 
CGGGAGGCCG CCCGCAACGG CATGCGTTTC TACGCCACGC TGCAGGCCGA GGACGGTCAC 
TGGGCAGGCG ATTACGGCGG GCCGCTCTTC CTGCTGCCAG GGCTGCTCAT CGTCTGTCAC 
ACCGCCCGCA TCCCGCTGCC CGACGGCTTC CGCAGGGAGA TGGTGCGCTA CCTGCGCTCC 
GTGCAGCTCC CGGACGGCGG CTGGGGCCTG CACGTGGAAG ACAAATCGAC GGTGTTTGGC 
ACGGCGCTCA ACTATGTTGC CCTGAGGATC CTGGGGCTTG GCCCAGATGA CCCCGACATC 
GTGCGGGCCC GCGTCAACCT GCACAGCAAA GGAGGTGCTG TGGGGATCCC CTCTTGGGGG 
AAGTTTTGGC TGGCTGTCCT CAACGTCTAC AGCTGGGAGG GGATGAACAC GCTGCTCCCG 
GAGATGTGGC TGCTCCCTAC GTGGTTCCCA GCCCATCCAT CCAGGCTCTG GTGCCACTGC 
CGCCAGGTCT ACCTCCCCAT GAGCTACTGT TATGCCAAGC GTCTGTCAGC AGAAGAGGAT 
GAACTCATCC GGAGCTTACA GCAGGAGCTG TACGTGCAAG ACTATGCCAG CATCGACTGG 
CCAGCCCAGA GGAACAACGT GGCTGCCTGT GATGTCTACA CCCCACACAG CTGGCTACTG 
GGAATCGCCT ATGCCATCAT GAATGTGTAT GAAGCCCACC ACAGCACCTA CCTACGTCAG 
CGAGCCATCA CGGAGCTGTA TGACCACATC AAAGCTGATG ACAGATTCAC CAAGTGTATC 
AGCATTGGTC CGATTTCCAA GACCATCAAC ATGTTGGTTC GCTGGTTTGT GGATGGGGAG 
AATTCACCAG CTTTTCAGGA GCATGTTTCC AGGATCCCTG ACTATCTCTG GCTGGGCCTT 
GATGGCATGA AGATGCAGGG TACGAATGGA TCCCAGCTCT GGGACACTGC CTTTGCCGTC 
CAGGCATTCT TGGAGGCAGA AGCCCAGAAG ATACCTGAAT TCATGTCCTG CCTTCAGAAC 
GCCCATGAGT TTCTTAGGTT CACCCAGATC CCAGAGAATC CACCTGACTA CCAGAAATAT 
TACCGCCATA TGAACAAGGG TGGCTTTCCC TTTAGCACAC GGGACTGTGG CTGGATTGTG 
GCAGACTGCA CAGCAGAGGG ACTGAAGTCA ATTATGCTGC TGCAGGAGAA GTGTCCCTTC 
ATAGCCAACC CTGTCCCAGC TGAGCGCCTC TTTGATGCTG TGAATGTGTT ACTGAGCATG 
AAGAACTCAG ATGGAGGCTT TGCCACATAT GAAACCAAGA GAGGAGGCCA CTTGCTGGAG 
CTGCTGAACC CCTCGGAAGT GTTTGGTGAC ATCATGATTG ACTACACCTA TGTTGAATGC 
ACATCAGCTG TCATGCAGGC ACTGAGACAC TTCCAAGATG TGTATCCTGA GCACAGAGCC 
CCAGAAATCA GAGAGACTCT GCAGAAGGGC CTGGACTTCT GCCGCAAGAA GCAACAAGCT 
GATGGATCAT GGGAAGGGAG CTGGGGAGTT TGCTTCACGT ATGGAACCTG GTTTGGTCTG 
GAGGCATTTG CCAGTATGCA GCATGTGTAC CGTGACGGGG TGGCATGCAG AGAAGTGGCC 
CGAGCCTGCC AGTTCCTGCT CTCCAAGCAG ATGACAGATG GCGGATGGGG AGAGGACTTT 
GAATCATGTG AGCAACGCAC GTATGTGCAG AGTTCCACAT CACAGATCCA CAACACGTGT 
TGGGCCCTGC TGGGGCTCAT GGCTGTCAGG TACCCTGACA CTGGTGTGCT GGAAAGGGGC 
ATCAAACTGT TGATTGATAA GCAGCTGCCC AATGGTGACT GGCCTCAGGA GAACGTTGCT 
GGGGTGTTCA ACAAATCATG TGCCATCAGT TACACTGCCT ACCGCAATGT CTTCCCCATC 
TGGACACTTG GACGTTTCTC TCGGCTGCAT CCCAACAGCC CTCTTGCTGA GCACCTGCAA 
TCCAGACCCT TGGCTGGGGT GGGGAAGACC CCAAAGACAG CATTGTCTGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001006514.2
CDS	27..2300
Translation	MAADGVVRRRGGPWRTAAATALPSWRLRCEGGRQRWCYLDDGVEDEEAAGGRRAQTALEAHSVGLDTDALLRTLPAAGTAREAARNGMRFYATLQAEDGHWAGDYGGPLFLLPGLLIVCHTARIPLPDGFRREMVRYLRSVQLPDGGWGLHVEDKSTVFGTALNYVALRILGLGPDDPDIVRARVNLHSKGGAVGIPSWGKFWLAVLNVYSWEGMNTLLPEMWLLPTWFPAHPSRLWCHCRQVYLPMSYCYAKRLSAEEDELIRSLQQELYVQDYASIDWPAQRNNVAACDVYTPHSWLLGIAYAIMNVYEAHHSTYLRQRAITELYDHIKADDRFTKCISIGPISKTINMLVRWFVDGENSPAFQEHVSRIPDYLWLGLDGMKMQGTNGSQLWDTAFAVQAFLEAEAQKIPEFMSCLQNAHEFLRFTQIPENPPDYQKYYRHMNKGGFPFSTRDCGWIVADCTAEGLKSIMLLQEKCPFIANPVPAERLFDAVNVLLSMKNSDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFQDVYPEHRAPEIRETLQKGLDFCRKKQQADGSWEGSWGVCFTYGTWFGLEAFASMQHVYRDGVACREVARACQFLLSKQMTDGGWGEDFESCEQRTYVQSSTSQIHNTCWALLGLMAVRYPDTGVLERGIKLLIDKQLPNGDWPQENVAGVFNKSCAISYTAYRNVFPIWTLGRFSRLHPNSPLAEHLQSRPLAGVGKTPKTALSD

Target ORF information:

RefSeq Version	NM_001006514.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus lanosterol synthase (LSS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001006514.2

ORF Insert Sequence:

ATGGCGGCGG ACGGGGTGGT GCGGCGGCGC GGCGGTCCGT GGCGCACGGC GGCAGCCACG 
GCGCTGCCCT CCTGGCGGCT GCGCTGCGAG GGCGGCCGGC AGCGCTGGTG CTACCTGGAT 
GACGGCGTCG AGGACGAGGA GGCGGCCGGA GGGCGACGGG CGCAGACGGC GCTGGAGGCG 
CACAGCGTCG GCCTGGACAC GGACGCGCTC CTGCGGACGC TGCCGGCCGC CGGAACGGCG 
CGGGAGGCCG CCCGCAACGG CATGCGTTTC TACGCCACGC TGCAGGCCGA GGACGGTCAC 
TGGGCAGGCG ATTACGGCGG GCCGCTCTTC CTGCTGCCAG GGCTGCTCAT CGTCTGTCAC 
ACCGCCCGCA TCCCGCTGCC CGACGGCTTC CGCAGGGAGA TGGTGCGCTA CCTGCGCTCC 
GTGCAGCTCC CGGACGGCGG CTGGGGCCTG CACGTGGAAG ACAAATCGAC GGTGTTTGGC 
ACGGCGCTCA ACTATGTTGC CCTGAGGATC CTGGGGCTTG GCCCAGATGA CCCCGACATC 
GTGCGGGCCC GCGTCAACCT GCACAGCAAA GGAGGTGCTG TGGGGATCCC CTCTTGGGGG 
AAGTTTTGGC TGGCTGTCCT CAACGTCTAC AGCTGGGAGG GGATGAACAC GCTGCTCCCG 
GAGATGTGGC TGCTCCCTAC GTGGTTCCCA GCCCATCCAT CCAGGCTCTG GTGCCACTGC 
CGCCAGGTCT ACCTCCCCAT GAGCTACTGT TATGCCAAGC GTCTGTCAGC AGAAGAGGAT 
GAACTCATCC GGAGCTTACA GCAGGAGCTG TACGTGCAAG ACTATGCCAG CATCGACTGG 
CCAGCCCAGA GGAACAACGT GGCTGCCTGT GATGTCTACA CCCCACACAG CTGGCTACTG 
GGAATCGCCT ATGCCATCAT GAATGTGTAT GAAGCCCACC ACAGCACCTA CCTACGTCAG 
CGAGCCATCA CGGAGCTGTA TGACCACATC AAAGCTGATG ACAGATTCAC CAAGTGTATC 
AGCATTGGTC CGATTTCCAA GACCATCAAC ATGTTGGTTC GCTGGTTTGT GGATGGGGAG 
AATTCACCAG CTTTTCAGGA GCATGTTTCC AGGATCCCTG ACTATCTCTG GCTGGGCCTT 
GATGGCATGA AGATGCAGGG TACGAATGGA TCCCAGCTCT GGGACACTGC CTTTGCCGTC 
CAGGCATTCT TGGAGGCAGA AGCCCAGAAG ATACCTGAAT TCATGTCCTG CCTTCAGAAC 
GCCCATGAGT TTCTTAGGTT CACCCAGATC CCAGAGAATC CACCTGACTA CCAGAAATAT 
TACCGCCATA TGAACAAGGG TGGCTTTCCC TTTAGCACAC GGGACTGTGG CTGGATTGTG 
GCAGACTGCA CAGCAGAGGG ACTGAAGTCA ATTATGCTGC TGCAGGAGAA GTGTCCCTTC 
ATAGCCAACC CTGTCCCAGC TGAGCGCCTC TTTGATGCTG TGAATGTGTT ACTGAGCATG 
AAGAACTCAG ATGGAGGCTT TGCCACATAT GAAACCAAGA GAGGAGGCCA CTTGCTGGAG 
CTGCTGAACC CCTCGGAAGT GTTTGGTGAC ATCATGATTG ACTACACCTA TGTTGAATGC 
ACATCAGCTG TCATGCAGGC ACTGAGACAC TTCCAAGATG TGTATCCTGA GCACAGAGCC 
CCAGAAATCA GAGAGACTCT GCAGAAGGGC CTGGACTTCT GCCGCAAGAA GCAACAAGCT 
GATGGATCAT GGGAAGGGAG CTGGGGAGTT TGCTTCACGT ATGGAACCTG GTTTGGTCTG 
GAGGCATTTG CCAGTATGCA GCATGTGTAC CGTGACGGGG TGGCATGCAG AGAAGTGGCC 
CGAGCCTGCC AGTTCCTGCT CTCCAAGCAG ATGACAGATG GCGGATGGGG AGAGGACTTT 
GAATCATGTG AGCAACGCAC GTATGTGCAG AGTTCCACAT CACAGATCCA CAACACGTGT 
TGGGCCCTGC TGGGGCTCAT GGCTGTCAGG TACCCTGACA CTGGTGTGCT GGAAAGGGGC 
ATCAAACTGT TGATTGATAA GCAGCTGCCC AATGGTGACT GGCCTCAGGA GAACGTTGCT 
GGGGTGTTCA ACAAATCATG TGCCATCAGT TACACTGCCT ACCGCAATGT CTTCCCCATC 
TGGACACTTG GACGTTTCTC TCGGCTGCAT CCCAACAGCC CTCTTGCTGA GCACCTGCAA 
TCCAGACCCT TGGCTGGGGT GGGGAAGACC CCAAAGACAG CATTGTCTGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cholesterol synthesis-related enzyme oxidosqualene cyclase is required to maintain self-renewal in primary erythroid progenitors.
Cell proliferation44(5)441-52(2011 Oct)
Mejia-Pous C,Damiola F,Gandrillon O

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Physiological genomics25(3)514-24(2006 May)
Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

Expressed sequence tag analysis of Eimeria-stimulated intestinal intraepithelial lymphocytes in chickens.
Molecular biotechnology30(2)143-50(2005 Jun)
Min W,Lillehoj HS,Ashwell CM,van Tassell CP,Dalloul RA,Matukumalli LK,Han JY,Lillehoj EP

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Genome biology6(1)R6(2005)
Caldwell RB,Kierzek AM,Arakawa H,Bezzubov Y,Zaim J,Fiedler P,Kutter S,Blagodatski A,Kostovska D,Koter M,Plachy J,Carninci P,Hayashizaki Y,Buerstedde JM

A comprehensive collection of chicken cDNAs.
Current biology : CB12(22)1965-9(2002 Nov)
Boardman PE,Sanz-Ezquerro J,Overton IM,Burt DW,Bosch E,Fong WT,Tickle C,Brown WR,Wilson SA,Hubbard SJ

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LSS cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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