ADAM17 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADAM17
Entrez Gene ID	421931
Full Name	ADAM metallopeptidase domain 17
Synonyms	TACE
General protein information	Preferred Names ADAM metallopeptidase domain 17 Names disintegrin and metalloproteinase domain-containing protein 17 ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) tumor necrosis factor alpha converting enzyme
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008682.1	NP_001008682.1	disintegrin and metalloproteinase domain-containing protein 17 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ADAM17	NP_001008682.1
Pan troglodytes (chimpanzee)	ADAM17	XP_515293.2
	ADAM17	XP_002799185.1
Bos taurus (cattle)	ADAM17	XP_002691532.1
Mus musculus (house mouse)	Adam17	NP_033745.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002381	XP_312572.5
Homo sapiens (human)	ADAM17	NP_003174.3
Rattus norvegicus (Norway rat)	Adam17	NP_064702.1
Danio rerio (zebrafish)	adam17a	NP_955967.1
Caenorhabditis elegans (roundworm)	adm-4	NP_509318.1
Xenopus tropicalis (tropical clawed frog)	adam17	NP_001182159.1
Canis lupus familiaris (dog)	ADAM17	XP_005630166.1
Drosophila melanogaster (fruit fly)	Tace	NP_733334.1
Danio rerio (zebrafish)	adam17b	XP_689147.3

Gene Ontology
Bibliography

Related articles in PubMed

Differential regional expression of multiple ADAMs during feather bud formation.
Lin J, Luo J, Redies C
Developmental dynamics : an official publication of the American Association of Anatomists240(9)2142-52(2011 Sep)

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development.
Markus A, Yan X, Rolfs A, Luo J
Cellular & molecular biology letters16(3)431-51(2011 Sep)

ADAM17 overexpression promotes angiogenesis by increasing blood vessel sprouting and pericyte number during brain microvessel development.
Lin J, Lemke C, Redies C, Yan X, Mix E, Rolfs A, Luo J
The International journal of developmental biology55(10-12)961-8(2011)

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM
Genome biology6(1)R6(2005)

The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing.
Carrodeguas JA, Rodolosse A, Garza MV, Sanz-Clemente A, P?rez-P? R, Lacosta AM, Dom?nguez L, Monle?n I, S?nchez-D?az R, Sorribas V, Sarasa M
Neuroscience134(4)1285-300(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ADAM9, ADAM10, and ADAM17 are expressed in the epidermis of the feather bud.
Title: Differential regional expression of multiple ADAMs during feather bud formation.

overexpression of ADAM17 in the developing tectum promotes angiogenesis by increasing the number of pericytes and capillary sprouting in the radial vessels
Title: ADAM17 overexpression promotes angiogenesis by increasing blood vessel sprouting and pericyte number during brain microvessel development.

The following ADAM17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAM17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa24836	NM_001008682.1 Latest version!	Gallus gallus ADAM metallopeptidase domain 17 (ADAM17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADAM17 ( NM_001008682.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001008682.1 Gallus gallus ADAM metallopeptidase domain 17 (ADAM17), mRNA.

Price & Availability↑

CloneID	OGa24836
Clone ID Related Accession (Same CDS sequence)	NM_001008682.1
Accession Version	NM_001008682.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2490bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	disintegrin and metalloproteinase domain-containing protein 17 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719841.1. On Dec 20, 2004 this sequence version replaced XM_419944.1. ##Evidence-Data-START## Transcript exon combination :: AJ719841.1, AY486557.1 [ECO:0000332] ##Evidence-Data-END##

ATGAGACTCC GGCTGTGGCT GGTCTCTGCC CTGGCGCTGC TCTGGGCGCC GGGCGGGCTG 
CAGGCGCTGG GGCGGCTGCC GCGCGAGCAG CGCTACGATG CAGTTGAATC CATGCTCTCA 
AACTATGACA TCCTTTCTCA GTCCAGTATC CAGCAGCACT CACTGAAGAA GAGGGACCTC 
CAGCCTGAGA CTCATGTAGA GAGGCTTTTA AGTTTCTCAG CCCTGCAAAG GCACTTTAAA 
TTATACTTAA CTGCAACTGC TGAACACTTT TCAGAAAGAT TTCAAGCATT AATTGTGGAT 
GGTGAAGGGA AGGAAAAGGA GTATCGTGTT CAATGGCAAG ACTTTTTCAC GGGACATGTT 
GTTGGGGAGC ATAATTCCAA AGTTGTGGCA CACATCGGGG ATGAAGACTT TACTGTAAGA 
ATCAATACTG ATGGAGAAGA ATACAATATA GAGCCCCTGT GGAGATTTAT AGATAATGTT 
CAAGATGAAA GATTGCTGGT CTACAGATCT GAAGATATCA AAGATTTCTC ACGTCTGCAA 
TCCCCTAAAG TATGTGGTTA TTTAAAGCTG AACGAAGATG AACTTTTACC TAAAGGACTG 
GAAGAGAGTA AACAAAATGA AGCAAGCATC CACCGGGAGA AAAGAGCCAT TCCAGAGAGC 
TCCAAAGATA CCTGCAAGAT GTTGGTAGTG GCAGATCATC GGTTTTTCAA GTACATGGGC 
CGAGGGGAAG AGAGTACTAC TATAAACTAT TTGATTGAAT TGATAGACAG AGTGGATGAC 
ATCTACCGAA ATACTCCCTG GGACAATGAG GCCTTCAAAG GTTACGGCAT ACAAATAGAG 
CAGATTATCA TCCACAGTGA GCCAGAACGT GTAGCACCTG GAGGAAAGCA TTACAATATG 
GCAAAAAGTT ATCCAGATGA CAAGAAGGAT GCCTGGGATG TGAAAATGCT GCTAGAGCAA 
TTTAGCTTTG ATATTGCTGA GAAAGCAGCT CATGTGTGCC TTGCTCATCT CTTCACATAC 
CAAGATTTTG ATATGGGAAC ACTTGGACTG GCTTACGTTG GTTCTCCCAG ACCTAACAGC 
CATGGTGGCA TTTGTCCTAA AGCTTATCAC AGTCCGATTG TAAAGAAGGA CATCTATCTG 
AACAGTGGCT TAACCAGCAC CAAGAACTAT GGGAAAACCA TCCTCACAAA GGAGGCCGAC 
TTGGTTACAA CGCACGAACT TGGCCATAAC TTTGGAGCAG AGCATGACCC TGACAGTCTG 
CCAGAATGTG CCCCCACGGA AGACCAGGGA GGAAAATACG TTATGTATCC AATTGCTGTC 
AGTGGAGATC ATGAAAACAA TAAGATGTTC TCAAGCTGCA GCAAAAAATC CATCCATAGG 
ACCATAGAGG TCAAGGCCCA GGAGTGCTTC AAAGAGCGCA ACAACAAAGT GTGTGGGAAC 
TCCAGGGTGG ACGAAGGGGA GGAATGCGAT CCCGGCCTCT TGTACCAACG AGTTGATCCC 
TGCTGCTCTG CAGACTGCAA ACTGAAAGAT GGTGCCAAAT GCAGTGATCG GAACAGCCCC 
TGCTGTAAAG GCTGCCAGTT TGAAAGTGCC CAGAAAAAAT GCCAAGAAGC CATAAATGCC 
ACTTGTAAAG GAGAGTCTTT TTGCACGGGG AACAGCAGCG AGTGCCCTCC TCCTGGCAAT 
GCTCCAGACG ACACAATCTG TGTGGACATG GGGAAGTGCA AGGATGGCGA GTGCATCCCT 
TTCTGCGAGA GGGAGAAGAA CCTCCGCTCG TGTGCCTGCA ATGAAACGGA TAACTCCTGC 
AAGGTGTGCT GCCGGGACGA GCAGGATCGG TGCACGCCCT ACGTTGACGC CAACAACCAG 
TTCCTGTTTC TGCGCAAGGG GAAGCCTTGT ACCGTGGGCT TCTGTGACTC AAATGGCAAA 
TGTGAGAAGC AAGTACAGGA CGTGATTGAA CGATTTTGGG ATTTCATAGA CCAACTTAGC 
ATCAACACCT TTGGGAAGTT CCTGGCAGAT AACATAGTGG GCTCTGTGCT CGTCTTCTCC 
TTGCTGTTTT GGATTCCTCT CAGCATCCTT GTGCACTGTG TGGACAAGAA ATTGGACAAG 
CAATATGAGG AGAACAACAA GTCTCTGTTC TGCGCCAGTA ACGCGGAGGT GCCCAGCAGC 
CTGGACTCGG CCTCTGTGCG CATCATCAAG CCCTTCCCCG CGGCGCAGCC CACCAGTCGG 
CACCAACCCC TGCAGCCCAT CGTGGCTGCG CCCGCGGCCG CCACGGCTCC CAAGCAGGAC 
CACCAAAGAA TGGACACAAT TCAGGAGGAC CCCAGCACCG ACTCTCATAT TGACGAGGAC 
GGGTTTGAGA AGGACCCTTT CCCAAACAGC AGCTCAGCTG CCAAATCTTT TGAGGACCTG 
ACGGAGCACC CCGTCACCAG GAGTGAGAAA GCGTCGTCTT TTAAGCTACA ACGCCAGAAC 
CGAGTGGACA GCAAGGAGAC GGAGTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008682.1
CDS	164..2653
Translation	MRLRLWLVSALALLWAPGGLQALGRLPREQRYDAVESMLSNYDILSQSSIQQHSLKKRDLQPETHVERLLSFSALQRHFKLYLTATAEHFSERFQALIVDGEGKEKEYRVQWQDFFTGHVVGEHNSKVVAHIGDEDFTVRINTDGEEYNIEPLWRFIDNVQDERLLVYRSEDIKDFSRLQSPKVCGYLKLNEDELLPKGLEESKQNEASIHREKRAIPESSKDTCKMLVVADHRFFKYMGRGEESTTINYLIELIDRVDDIYRNTPWDNEAFKGYGIQIEQIIIHSEPERVAPGGKHYNMAKSYPDDKKDAWDVKMLLEQFSFDIAEKAAHVCLAHLFTYQDFDMGTLGLAYVGSPRPNSHGGICPKAYHSPIVKKDIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDSLPECAPTEDQGGKYVMYPIAVSGDHENNKMFSSCSKKSIHRTIEVKAQECFKERNNKVCGNSRVDEGEECDPGLLYQRVDPCCSADCKLKDGAKCSDRNSPCCKGCQFESAQKKCQEAINATCKGESFCTGNSSECPPPGNAPDDTICVDMGKCKDGECIPFCEREKNLRSCACNETDNSCKVCCRDEQDRCTPYVDANNQFLFLRKGKPCTVGFCDSNGKCEKQVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLLFWIPLSILVHCVDKKLDKQYEENNKSLFCASNAEVPSSLDSASVRIIKPFPAAQPTSRHQPLQPIVAAPAAATAPKQDHQRMDTIQEDPSTDSHIDEDGFEKDPFPNSSSAAKSFEDLTEHPVTRSEKASSFKLQRQNRVDSKETEC

Target ORF information:

RefSeq Version	NM_001008682.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus ADAM metallopeptidase domain 17 (ADAM17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008682.1

ORF Insert Sequence:

ATGAGACTCC GGCTGTGGCT GGTCTCTGCC CTGGCGCTGC TCTGGGCGCC GGGCGGGCTG 
CAGGCGCTGG GGCGGCTGCC GCGCGAGCAG CGCTACGATG CAGTTGAATC CATGCTCTCA 
AACTATGACA TCCTTTCTCA GTCCAGTATC CAGCAGCACT CACTGAAGAA GAGGGACCTC 
CAGCCTGAGA CTCATGTAGA GAGGCTTTTA AGTTTCTCAG CCCTGCAAAG GCACTTTAAA 
TTATACTTAA CTGCAACTGC TGAACACTTT TCAGAAAGAT TTCAAGCATT AATTGTGGAT 
GGTGAAGGGA AGGAAAAGGA GTATCGTGTT CAATGGCAAG ACTTTTTCAC GGGACATGTT 
GTTGGGGAGC ATAATTCCAA AGTTGTGGCA CACATCGGGG ATGAAGACTT TACTGTAAGA 
ATCAATACTG ATGGAGAAGA ATACAATATA GAGCCCCTGT GGAGATTTAT AGATAATGTT 
CAAGATGAAA GATTGCTGGT CTACAGATCT GAAGATATCA AAGATTTCTC ACGTCTGCAA 
TCCCCTAAAG TATGTGGTTA TTTAAAGCTG AACGAAGATG AACTTTTACC TAAAGGACTG 
GAAGAGAGTA AACAAAATGA AGCAAGCATC CACCGGGAGA AAAGAGCCAT TCCAGAGAGC 
TCCAAAGATA CCTGCAAGAT GTTGGTAGTG GCAGATCATC GGTTTTTCAA GTACATGGGC 
CGAGGGGAAG AGAGTACTAC TATAAACTAT TTGATTGAAT TGATAGACAG AGTGGATGAC 
ATCTACCGAA ATACTCCCTG GGACAATGAG GCCTTCAAAG GTTACGGCAT ACAAATAGAG 
CAGATTATCA TCCACAGTGA GCCAGAACGT GTAGCACCTG GAGGAAAGCA TTACAATATG 
GCAAAAAGTT ATCCAGATGA CAAGAAGGAT GCCTGGGATG TGAAAATGCT GCTAGAGCAA 
TTTAGCTTTG ATATTGCTGA GAAAGCAGCT CATGTGTGCC TTGCTCATCT CTTCACATAC 
CAAGATTTTG ATATGGGAAC ACTTGGACTG GCTTACGTTG GTTCTCCCAG ACCTAACAGC 
CATGGTGGCA TTTGTCCTAA AGCTTATCAC AGTCCGATTG TAAAGAAGGA CATCTATCTG 
AACAGTGGCT TAACCAGCAC CAAGAACTAT GGGAAAACCA TCCTCACAAA GGAGGCCGAC 
TTGGTTACAA CGCACGAACT TGGCCATAAC TTTGGAGCAG AGCATGACCC TGACAGTCTG 
CCAGAATGTG CCCCCACGGA AGACCAGGGA GGAAAATACG TTATGTATCC AATTGCTGTC 
AGTGGAGATC ATGAAAACAA TAAGATGTTC TCAAGCTGCA GCAAAAAATC CATCCATAGG 
ACCATAGAGG TCAAGGCCCA GGAGTGCTTC AAAGAGCGCA ACAACAAAGT GTGTGGGAAC 
TCCAGGGTGG ACGAAGGGGA GGAATGCGAT CCCGGCCTCT TGTACCAACG AGTTGATCCC 
TGCTGCTCTG CAGACTGCAA ACTGAAAGAT GGTGCCAAAT GCAGTGATCG GAACAGCCCC 
TGCTGTAAAG GCTGCCAGTT TGAAAGTGCC CAGAAAAAAT GCCAAGAAGC CATAAATGCC 
ACTTGTAAAG GAGAGTCTTT TTGCACGGGG AACAGCAGCG AGTGCCCTCC TCCTGGCAAT 
GCTCCAGACG ACACAATCTG TGTGGACATG GGGAAGTGCA AGGATGGCGA GTGCATCCCT 
TTCTGCGAGA GGGAGAAGAA CCTCCGCTCG TGTGCCTGCA ATGAAACGGA TAACTCCTGC 
AAGGTGTGCT GCCGGGACGA GCAGGATCGG TGCACGCCCT ACGTTGACGC CAACAACCAG 
TTCCTGTTTC TGCGCAAGGG GAAGCCTTGT ACCGTGGGCT TCTGTGACTC AAATGGCAAA 
TGTGAGAAGC AAGTACAGGA CGTGATTGAA CGATTTTGGG ATTTCATAGA CCAACTTAGC 
ATCAACACCT TTGGGAAGTT CCTGGCAGAT AACATAGTGG GCTCTGTGCT CGTCTTCTCC 
TTGCTGTTTT GGATTCCTCT CAGCATCCTT GTGCACTGTG TGGACAAGAA ATTGGACAAG 
CAATATGAGG AGAACAACAA GTCTCTGTTC TGCGCCAGTA ACGCGGAGGT GCCCAGCAGC 
CTGGACTCGG CCTCTGTGCG CATCATCAAG CCCTTCCCCG CGGCGCAGCC CACCAGTCGG 
CACCAACCCC TGCAGCCCAT CGTGGCTGCG CCCGCGGCCG CCACGGCTCC CAAGCAGGAC 
CACCAAAGAA TGGACACAAT TCAGGAGGAC CCCAGCACCG ACTCTCATAT TGACGAGGAC 
GGGTTTGAGA AGGACCCTTT CCCAAACAGC AGCTCAGCTG CCAAATCTTT TGAGGACCTG 
ACGGAGCACC CCGTCACCAG GAGTGAGAAA GCGTCGTCTT TTAAGCTACA ACGCCAGAAC 
CGAGTGGACA GCAAGGAGAC GGAGTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential regional expression of multiple ADAMs during feather bud formation.
Developmental dynamics : an official publication of the American Association of Anatomists240(9)2142-52(2011 Sep)
Lin J,Luo J,Redies C

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development.
Cellular & molecular biology letters16(3)431-51(2011 Sep)
Markus A,Yan X,Rolfs A,Luo J

ADAM17 overexpression promotes angiogenesis by increasing blood vessel sprouting and pericyte number during brain microvessel development.
The International journal of developmental biology55(10-12)961-8(2011)
Lin J,Lemke C,Redies C,Yan X,Mix E,Rolfs A,Luo J

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Genome biology6(1)R6(2005)
Caldwell RB,Kierzek AM,Arakawa H,Bezzubov Y,Zaim J,Fiedler P,Kutter S,Blagodatski A,Kostovska D,Koter M,Plachy J,Carninci P,Hayashizaki Y,Buerstedde JM

The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing.
Neuroscience134(4)1285-300(2005)
Carrodeguas JA,Rodolosse A,Garza MV,Sanz-Clemente A,P?rez-P? R,Lacosta AM,Dom?nguez L,Monle?n I,S?nchez-D?az R,Sorribas V,Sarasa M

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ADAM17 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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