SELENOK cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOK
Entrez Gene ID	415995
Full Name	selenoprotein K
Synonyms	SELK
General protein information	Preferred Names selenoprotein K Names selenoprotein K
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025441.2	NP_001020612.1	selenoprotein K

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Selk	NP_064363.2
Rattus norvegicus (Norway rat)	Selk	NP_997472.2
Gallus gallus (chicken)	SELK	NP_001020612.1
Canis lupus familiaris (dog)	SELK	NP_001108350.1
Bos taurus (cattle)	SELK	NP_001032566.2
	SELK	NP_001152853.1
Homo sapiens (human)	SELK	NP_067060.2
Pan troglodytes (chimpanzee)	SELK	NP_001108349.1
Danio rerio (zebrafish)	selk	NP_001004681.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Silencing of Selenoprotein K Induces Inflammatory Response and Activates Heat Shock Proteins Expression in Chicken Myoblasts.
Fan R, Yao H, Cao C, Zhao X, Khalid A, Zhao J, Zhang Z, Xu S
Biological trace element research180(1)135-145(2017 Nov)

Glutathione Peroxidase 1, Selenoprotein K, and Selenoprotein H May Play Important Roles in Chicken Testes in Response to Selenium Deficiency.
Gao Y, Zhang J, Huang X, Zhang G
Biological trace element research179(2)271-276(2017 Oct)

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM
Genome biology6(1)R6(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SELENOK gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOK cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa26509	NM_001025441.2 Latest version!	Gallus gallus selenoprotein K (SELENOK), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOK ( NM_001025441.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001020612.1 Gallus gallus selenoprotein K (SELENOK), mRNA.

Price & Availability↑

CloneID	OGa26509
Clone ID Related Accession (Same CDS sequence)	NM_001025441.2
Accession Version	NM_001025441.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-04
Organism	Gallus gallus(chicken)
Product	selenoprotein K
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU486117.1 and AJ728086.1. On May 19, 2006 this sequence version replaced NM_001025441.1. ##Evidence-Data-START## Transcript exon combination :: CR352597.1, BU338572.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGTACA TATCTAATGG ACAAGTTTTG GATAACCGGA GCCGGGCTCC TTGGAGCTTG 
TCAGCCATAA CAGATTTCTT CTGGTCAATA GCAGACTTTG TAGTTATGTT CTTCCAGAGC 
ATTATTCAAC CAGACCTGAG GAGAAGAGGC TACACATCTT CCTCCTACTT AGGACAAAGT 
GATGGAAGAG GGCCTCCAGG AAATCCTCGC CGTAGAATGG GCAGAATAAA TCACTGGGGT 
GGAGGCCCTA GTCCACCACC AATGGCTGGA GGTGGATGAG GAAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020612.1
CDS	68..355
Translation	MVYISNGQVLDNRSRAPWSLSAITDFFWSIADFVVMFFQSIIQPDLRRRGYTSSSYLGQSDGRGPPGNPRRRMGRINHWGGGPSPPPMAGGG*GR

Target ORF information:

RefSeq Version	NM_001025441.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus selenoprotein K (SELENOK), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025441.2

ORF Insert Sequence:

ATGGTGTACA TATCTAATGG ACAAGTTTTG GATAACCGGA GCCGGGCTCC TTGGAGCTTG 
TCAGCCATAA CAGATTTCTT CTGGTCAATA GCAGACTTTG TAGTTATGTT CTTCCAGAGC 
ATTATTCAAC CAGACCTGAG GAGAAGAGGC TACACATCTT CCTCCTACTT AGGACAAAGT 
GATGGAAGAG GGCCTCCAGG AAATCCTCGC CGTAGAATGG GCAGAATAAA TCACTGGGGT 
GGAGGCCCTA GTCCACCACC AATGGCTGGA GGTGGATGAG GAAGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Silencing of Selenoprotein K Induces Inflammatory Response and Activates Heat Shock Proteins Expression in Chicken Myoblasts.
Biological trace element research180(1)135-145(2017 Nov)
Fan R,Yao H,Cao C,Zhao X,Khalid A,Zhao J,Zhang Z,Xu S

Glutathione Peroxidase 1, Selenoprotein K, and Selenoprotein H May Play Important Roles in Chicken Testes in Response to Selenium Deficiency.
Biological trace element research179(2)271-276(2017 Oct)
Gao Y,Zhang J,Huang X,Zhang G

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Genome biology6(1)R6(2005)
Caldwell RB,Kierzek AM,Arakawa H,Bezzubov Y,Zaim J,Fiedler P,Kutter S,Blagodatski A,Kostovska D,Koter M,Plachy J,Carninci P,Hayashizaki Y,Buerstedde JM

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SELENOK cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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