CDH6 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDH6
Entrez Gene ID	414842
Full Name	cadherin 6
Synonyms	c-cad6B,cadherin-6,cadherin-6B
General protein information	Preferred Names cadherin 6 Names cadherin-6 cadherin 6, type 2, K-cadherin (fetal kidney) cadherin 6B
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001758.2	NP_001001758.1	cadherin-6 precursor
XM_025147082.1	XP_025002850.1	cadherin-6 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDH6	NP_004923.1
Pan troglodytes (chimpanzee)	CDH6	XP_001158019.3
Rattus norvegicus (Norway rat)	Cdh6	NP_037059.1
Gallus gallus (chicken)	CDH6	NP_001001758.1
Mus musculus (house mouse)	Cdh6	NP_031692.2
Danio rerio (zebrafish)	cdh6	NP_001013538.1
Xenopus tropicalis (tropical clawed frog)	cdh6	XP_002935627.1
	CDH6	XP_001084546.2
Bos taurus (cattle)	CDH6	NP_001029812.1

Gene Ontology
Bibliography

Related articles in PubMed

Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation.
Schiffmacher AT, Xie V, Taneyhill LA
The Journal of cell biology215(5)735-747(2016 Dec)

Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT.
Padmanabhan R, Taneyhill LA
Journal of cell science128(9)1773-86(2015 May)

Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons.
Park KS, Gumbiner BM
Biochemical and biophysical research communications459(3)504-8(2015 Apr)

Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest.
Schiffmacher AT, Padmanabhan R, Jhingory S, Taneyhill LA
Molecular biology of the cell25(1)41-54(2014 Jan)

Tetraspanin18 is a FoxD3-responsive antagonist of cranial neural crest epithelial-to-mesenchymal transition that maintains cadherin-6B protein.
Fairchild CL, Gammill LS
Journal of cell science126(Pt 6)1464-76(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cad6B C-terminal fragments possesses a novel pro-epithelial-to-mesenchymal transition (EMT) role by up-regulating EMT effector genes in vivo.
Title: Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation.

Cad6B is removed from premigratory neural crest cells through cell surface internalization events that include clathrin-mediated endocytosis and macropinocytosis.
Title: Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT.

Knockdown or loss of function of Cadherin-6B suppressed the generation of Islet-1-expressing cells in the dorsal neural tube, but not the Lim-1/2 positive dorsal cell population.
Title: Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons.

A dual mechanism for Cad6B proteolysis involving two ADAMs, along with gamma-secretase, during cranial neural crest cell epithelial-to-mesenchymal transitions.
Title: Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest.

these data reveal post-translational regulation of Cad6B protein levels by Tspan18 that must be relieved by a FoxD3-dependent mechanism in order for cranial neural crest cells to migrate.
Title: Tetraspanin18 is a FoxD3-responsive antagonist of cranial neural crest epithelial-to-mesenchymal transition that maintains cadherin-6B protein.

The following CDH6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDH6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00325	NM_001001758.2 Latest version!	Gallus gallus cadherin 6 (CDH6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00
OGa145774	XM_025147082.1 Latest version!	Gallus gallus cadherin 6 (CDH6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDH6 ( NM_001001758.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001001758.1 Gallus gallus cadherin 6 (CDH6), mRNA.

Price & Availability↑

CloneID	OGa00325
Clone ID Related Accession (Same CDS sequence)	NM_001001758.2
Accession Version	NM_001001758.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2373bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Gallus gallus(chicken)
Product	cadherin-6 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D42149.1. On Dec 24, 2015 this sequence version replaced NM_001001758.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D42149.1 [ECO:0000332] ##Evidence-Data-END##

ATGAGAACTT ACCATTGCTT CTGGTTGCTG TTTTGGGCTG GCCAGCCCCA CCAAAGTTTT 
TTAACTTTGC TGTCCAAAAG GACTAGTGGC TTTCCAGAGA AGGAAAAGGT TTTGGTATTG 
TCTGGAAACA GCAGGAGAGA CCTCAGTCGT TCCAAAAGGA GTTGGATGTG GAATCAGTTC 
TTTTTACTGG AAGAATATAC AGGAACTGAC TATCAGTATG TTGGCAAGCT GCATTCAGAC 
CAGGATAAAG GAGATGGATC ACTTAAGTAC ATCCTTTCTG GAGATGGAGC AGGAGACCTC 
TTCATTATCA ATGAAAACAC TGGTGACATC CAAGCCACAA AGAGACTAGA CAGAGAAGAA 
AAGCCTGTGT ACATACTTCG TGCCCAGGCT ATAAACCGAA GAACTGGAAG ACCAGTGGAA 
CCAGAATCTG AGTTCATCAT CAAGATCCAT GATATCAACG ACAATGAGCC AATGTTTACA 
AAGGACGTTT ACAATGCCAG CATTCCAGAA ATGTCAGATG TTGGTACCTT TGTTGTGCAA 
GTCACTGCAA CTGATGCCGA TGATCCTACA TATGGGAACA GCGCTAAAGT TGTCTACAGC 
ATTCTCCAGG GACAACCATA TTTCTCTGTA GAATCTGAGA CAGGTATTAT TAAAACTGCT 
TTGCTAAACA TGGACCGTGA AAACAGGGAG CAATATCAAG TGGTCATCCA AGCTAAGGAC 
ATGGGAGGCC AGATGGGCGG ATTATCAGGA ACCACCACTG TGAACATCAC ACTGACCGAC 
GTAAATGACA ATCCTCCTCG GTTCCCCCAG AGCACCTACC AATTCAGAGC TCCTGAGTCT 
ACGCCACCTG ACTCACCAAT TGGCAGGATT AAAGCTAATG ATGCAGATGT GGATGAAAAT 
GCAGAGATTG AATACAGCAT CACTGAGGGG GATGGATATG ACATGTTTGG AATTACCACA 
GACAAGGACA CACAGGAAGG AATTATAACT GTCAAAAAGG CACTGGATTT TGAAAATAAA 
AACTTGTATA TTCTGAAGGT GGAAGCCACC AATACTCACG TGGACCCTCG ATTCCTCTAC 
TTGGGGCCAT TCAAGGATTC AGCCACAATC AGAATTCAAG TGGAAGATGT AGATGAACCC 
CCTGTGTTCA GCAGACCAGC ATATATAATT GAAGTGAAAG AAGATGTTCC AATAAACAGT 
GTAATAGGAA CAGTAACAGC ACAGGATCCA GATGCTGCCA AGAACCCTGT CAAGTATTCT 
GTAGATCGAC ACACTGATAT GGACAGAGTA TTCAACATCA ACTCAGGAAA TGGTTCGATA 
TTTACGTCAA AAACTCTTGA CCGGGAAACA TTGCTATGGC ACAACATTAC AGTAATAGCA 
GCAGAGATCA ACAACCCAAA ACAAAGCAGC CGTGTCCCAG TGTTCATTAA GGTTTTGGAT 
GTAAACGACA ATGCTCCAGA GTTTGCCATG TTTTATGAGA CCTTTGTCTG TGAAAATGCA 
AAGGCAGAAC AGCTGATACA AACATTGAGT GCTGTTGATA AAGATGACTC TTACAGTGGA 
CACCAGTTTT CATTCAGCAT AGCTCCAGAG GCAGCCAGCA GCTCAAACTT TACACTCCAG 
GACAACAGAG ACAACACAGC GGGGATTTTC ACCCGAAAAA TCAGATATAA CCGGCATGAA 
ATGAGTACCT ACCTTTTGCC AGTGGTAATA TCAGACAATG ACTACCCTAT CCAGAGCAGC 
ACTGAAACAG TGACTATTCG TGTATGTGCT TGTGACCATC GAGGAAAGAT GCTGTCCTGT 
AATGCGGAAG CCTTGATTCA TCCTACTGGT CTTAGCACTG GGGCTCTTAT TGCCATTCTT 
CTCTGTATCA TTATATTACT TGTTACAGTG GTGTTGTTTG CAGCACTGAG ACGGCAAAGG 
AAAAAAGAGC CTTTGATTAT TTCCAAAGAA GACATCAGAG ACAACATTGT CAGTTATAAT 
GATGAAGGTG GTGGAGAGGA AGACACCCAG GCATTTGATA TCGGCACGCT GAGGAATCCC 
GAAGCCATAG ATGATAATAA ATTACGCAGA GACATTGTGC CAGAAACGCT TTTTATGCCA 
CGGCGGACTG CAACAGCCCG AGATAACACG GATGTCAGAG ATTTCATTAA CCAAAGGTTA 
AAGGAGAATG ATACAGACCC AGCAGCCCCC CCGTATGACT CGTTAGCGAC CTACGCATAC 
GAAGGTAATG GTTCTGTGGC AGAGTCCCTC AGCTCTCTGG AGTCGGTGAC TACAGACGGA 
GACCAGGACT ATGATTACCT CAGTGACTGG GGGCCGCGGT TTAAAAAGTT GGCAGATATG 
TATGGCTCAA TGGACAGTGA CAAAGACTCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001758.1
CDS	293..2665
Translation	MRTYHCFWLLFWAGQPHQSFLTLLSKRTSGFPEKEKVLVLSGNSRRDLSRSKRSWMWNQFFLLEEYTGTDYQYVGKLHSDQDKGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPMFTKDVYNASIPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFRAPESTPPDSPIGRIKANDADVDENAEIEYSITEGDGYDMFGITTDKDTQEGIITVKKALDFENKNLYILKVEATNTHVDPRFLYLGPFKDSATIRIQVEDVDEPPVFSRPAYIIEVKEDVPINSVIGTVTAQDPDAAKNPVKYSVDRHTDMDRVFNINSGNGSIFTSKTLDRETLLWHNITVIAAEINNPKQSSRVPVFIKVLDVNDNAPEFAMFYETFVCENAKAEQLIQTLSAVDKDDSYSGHQFSFSIAPEAASSSNFTLQDNRDNTAGIFTRKIRYNRHEMSTYLLPVVISDNDYPIQSSTETVTIRVCACDHRGKMLSCNAEALIHPTGLSTGALIAILLCIIILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIDDNKLRRDIVPETLFMPRRTATARDNTDVRDFINQRLKENDTDPAAPPYDSLATYAYEGNGSVAESLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGSMDSDKDS

Target ORF information:

RefSeq Version	NM_001001758.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus cadherin 6 (CDH6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001758.2

ORF Insert Sequence:

ATGAGAACTT ACCATTGCTT CTGGTTGCTG TTTTGGGCTG GCCAGCCCCA CCAAAGTTTT 
TTAACTTTGC TGTCCAAAAG GACTAGTGGC TTTCCAGAGA AGGAAAAGGT TTTGGTATTG 
TCTGGAAACA GCAGGAGAGA CCTCAGTCGT TCCAAAAGGA GTTGGATGTG GAATCAGTTC 
TTTTTACTGG AAGAATATAC AGGAACTGAC TATCAGTATG TTGGCAAGCT GCATTCAGAC 
CAGGATAAAG GAGATGGATC ACTTAAGTAC ATCCTTTCTG GAGATGGAGC AGGAGACCTC 
TTCATTATCA ATGAAAACAC TGGTGACATC CAAGCCACAA AGAGACTAGA CAGAGAAGAA 
AAGCCTGTGT ACATACTTCG TGCCCAGGCT ATAAACCGAA GAACTGGAAG ACCAGTGGAA 
CCAGAATCTG AGTTCATCAT CAAGATCCAT GATATCAACG ACAATGAGCC AATGTTTACA 
AAGGACGTTT ACAATGCCAG CATTCCAGAA ATGTCAGATG TTGGTACCTT TGTTGTGCAA 
GTCACTGCAA CTGATGCCGA TGATCCTACA TATGGGAACA GCGCTAAAGT TGTCTACAGC 
ATTCTCCAGG GACAACCATA TTTCTCTGTA GAATCTGAGA CAGGTATTAT TAAAACTGCT 
TTGCTAAACA TGGACCGTGA AAACAGGGAG CAATATCAAG TGGTCATCCA AGCTAAGGAC 
ATGGGAGGCC AGATGGGCGG ATTATCAGGA ACCACCACTG TGAACATCAC ACTGACCGAC 
GTAAATGACA ATCCTCCTCG GTTCCCCCAG AGCACCTACC AATTCAGAGC TCCTGAGTCT 
ACGCCACCTG ACTCACCAAT TGGCAGGATT AAAGCTAATG ATGCAGATGT GGATGAAAAT 
GCAGAGATTG AATACAGCAT CACTGAGGGG GATGGATATG ACATGTTTGG AATTACCACA 
GACAAGGACA CACAGGAAGG AATTATAACT GTCAAAAAGG CACTGGATTT TGAAAATAAA 
AACTTGTATA TTCTGAAGGT GGAAGCCACC AATACTCACG TGGACCCTCG ATTCCTCTAC 
TTGGGGCCAT TCAAGGATTC AGCCACAATC AGAATTCAAG TGGAAGATGT AGATGAACCC 
CCTGTGTTCA GCAGACCAGC ATATATAATT GAAGTGAAAG AAGATGTTCC AATAAACAGT 
GTAATAGGAA CAGTAACAGC ACAGGATCCA GATGCTGCCA AGAACCCTGT CAAGTATTCT 
GTAGATCGAC ACACTGATAT GGACAGAGTA TTCAACATCA ACTCAGGAAA TGGTTCGATA 
TTTACGTCAA AAACTCTTGA CCGGGAAACA TTGCTATGGC ACAACATTAC AGTAATAGCA 
GCAGAGATCA ACAACCCAAA ACAAAGCAGC CGTGTCCCAG TGTTCATTAA GGTTTTGGAT 
GTAAACGACA ATGCTCCAGA GTTTGCCATG TTTTATGAGA CCTTTGTCTG TGAAAATGCA 
AAGGCAGAAC AGCTGATACA AACATTGAGT GCTGTTGATA AAGATGACTC TTACAGTGGA 
CACCAGTTTT CATTCAGCAT AGCTCCAGAG GCAGCCAGCA GCTCAAACTT TACACTCCAG 
GACAACAGAG ACAACACAGC GGGGATTTTC ACCCGAAAAA TCAGATATAA CCGGCATGAA 
ATGAGTACCT ACCTTTTGCC AGTGGTAATA TCAGACAATG ACTACCCTAT CCAGAGCAGC 
ACTGAAACAG TGACTATTCG TGTATGTGCT TGTGACCATC GAGGAAAGAT GCTGTCCTGT 
AATGCGGAAG CCTTGATTCA TCCTACTGGT CTTAGCACTG GGGCTCTTAT TGCCATTCTT 
CTCTGTATCA TTATATTACT TGTTACAGTG GTGTTGTTTG CAGCACTGAG ACGGCAAAGG 
AAAAAAGAGC CTTTGATTAT TTCCAAAGAA GACATCAGAG ACAACATTGT CAGTTATAAT 
GATGAAGGTG GTGGAGAGGA AGACACCCAG GCATTTGATA TCGGCACGCT GAGGAATCCC 
GAAGCCATAG ATGATAATAA ATTACGCAGA GACATTGTGC CAGAAACGCT TTTTATGCCA 
CGGCGGACTG CAACAGCCCG AGATAACACG GATGTCAGAG ATTTCATTAA CCAAAGGTTA 
AAGGAGAATG ATACAGACCC AGCAGCCCCC CCGTATGACT CGTTAGCGAC CTACGCATAC 
GAAGGTAATG GTTCTGTGGC AGAGTCCCTC AGCTCTCTGG AGTCGGTGAC TACAGACGGA 
GACCAGGACT ATGATTACCT CAGTGACTGG GGGCCGCGGT TTAAAAAGTT GGCAGATATG 
TATGGCTCAA TGGACAGTGA CAAAGACTCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDH6 ( XM_025147082.1 ) cDNA ORF clone, Gallus gallus(chicken) -> XP_025002850.1 Gallus gallus cadherin 6 (CDH6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OGa145774
Clone ID Related Accession (Same CDS sequence)	XM_025147082.1
Accession Version	XM_025147082.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2373bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-16
Organism	Gallus gallus(chicken)
Product	cadherin-6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006089.5) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAACTT ACCATTGCTT CTGGTTGCTG TTTTGGGCTG GCCAGCCCCA CCAAAGTTTT 
TTAACTTTGC TGTCCAAAAG GACTAGTGGC TTTCCAGAGA AGGAAAAGGT TTTGGTATTG 
TCTGGAAACA GCAGGAGAGA CCTCAGTCGT TCCAAAAGGA GTTGGATGTG GAATCAGTTC 
TTTTTACTGG AAGAATATAC AGGAACTGAC TATCAGTATG TTGGCAAGCT GCATTCAGAC 
CAGGATAAAG GAGATGGATC ACTTAAGTAC ATCCTTTCTG GAGATGGAGC AGGAGACCTC 
TTCATTATCA ATGAAAACAC TGGTGACATC CAAGCCACAA AGAGACTAGA CAGAGAAGAA 
AAGCCTGTGT ACATACTTCG TGCCCAGGCT ATAAACCGAA GAACTGGAAG ACCAGTGGAA 
CCAGAATCTG AGTTCATCAT CAAGATCCAT GATATCAACG ACAATGAGCC AATGTTTACA 
AAGGACGTTT ACAACGCCAG CATTCCAGAA ATGTCAGATG TTGGTACCTT TGTTGTGCAA 
GTCACTGCAA CTGATGCCGA TGATCCTACA TATGGGAACA GCGCTAAAGT TGTCTACAGC 
ATTCTCCAGG GACAACCATA TTTCTCTGTA GAATCTGAGA CAGGTATTAT TAAAACTGCT 
TTGCTAAACA TGGACCGTGA AAACAGGGAG CAATATCAAG TGGTCATCCA AGCTAAGGAC 
ATGGGAGGCC AGATGGGCGG ATTATCAGGA ACCACCACTG TGAACATCAC ACTGACCGAC 
GTAAATGACA ATCCTCCTCG GTTCCCCCAG AGCACCTACC AATTCAGAGC TCCTGAGTCT 
ACGCCACCTG ACTCACCAAT TGGCAGGATT AAAGCTAATG ATGCAGATGT GGATGAAAAT 
GCAGAGATTG AATACAGCAT CACTGAGGGG GATGGATATG ACATGTTTGG AATTACCACA 
GACAAGGACA CACAGGAAGG AATTATAACT GTCAAAAAGG CACTGGATTT TGAAAATAAA 
AACTTGTATA TTCTGAAGGT GGAAGCCACC AATACTCACG TGGACCCTCG ATTCCTCTAC 
TTGGGGCCAT TCAAGGATTC AGCCACAATC AGAATTCAAG TGGAAGATGT AGATGAACCC 
CCTGTGTTCA GCAGACCAGC ATATATAATT GAAGTGAAAG AAGATGTTCC AATAAACAGT 
GTAATAGGAA CAGTAACAGC ACAGGATCCA GATGCTGCCA AGAACCCTGT CAAGTATTCT 
GTAGATCGAC ACACTGATAT GGACAGAGTA TTCAACATCA ACTCAGGAAA TGGTTCGATA 
TTTACGTCAA AAACTCTTGA CCGGGAAACA TTGCTATGGC ACAACATTAC AGTAATAGCA 
GCAGAGATCA ACAACCCAAA ACAAAGCAGC CGTGTCCCAG TGTTCATTAA GGTTTTGGAT 
GTAAACGACA ATGCTCCAGA GTTTGCCATG TTTTATGAGA CCTTTGTCTG TGAAAATGCA 
AAGGCAGAAC AGCTGATACA AACATTGAGT GCTGTTGATA AAGATGACTC TTACAGTGGA 
CACCAGTTTT CATTCAGCAT AGCTCCAGAG GCAGCCAGCA GCTCAAACTT TACACTCCAG 
GACAACAGAG ACAACACAGC GGGGATTTTC ACCCGAAAAA TCAGATATAA CCGGCATGAA 
ATGAGTACCT ACCTTTTGCC AGTGGTAATA TCAGACAATG ACTACCCTAT CCAGAGCAGC 
ACTGAAACAG TGACTATTCG TGTATGTGCT TGTGACCATC GAGGAAAGAT GCTGTCCTGT 
AATGCGGAAG CCTTGATTCA TCCTACTGGT CTTAGCACTG GGGCTCTTAT TGCCATTCTT 
CTCTGTATCA TTATATTACT TGTTACAGTG GTGTTGTTTG CAGCACTGAG ACGGCAAAGG 
AAAAAAGAGC CTTTGATTAT TTCCAAAGAA GACATCAGAG ACAACATTGT CAGTTATAAT 
GATGAAGGTG GTGGAGAGGA AGACACCCAG GCATTTGATA TCGGCACGCT GAGGAATCCC 
GAAGCCATAG ATGATAATAA ATTACGCAGA GACATTGTGC CAGAAACGCT TTTTATGCCA 
CGGCGGACTG CAACAGCCCG AGATAACACG GATGTCAGAG ATTTCATTAA CCAAAGGTTA 
AAGGAGAATG ATACAGACCC AGCAGCCCCC CCGTATGACT CGTTAGCGAC CTACGCATAC 
GAAGGTAATG GTTCTGTGGC AGAGTCCCTC AGCTCTCTGG AGTCGGTGAC TACAGACGGA 
GACCAGGACT ATGATTACCT CAGTGACTGG GGGCCGCGGT TTAAAAAGTT GGCAGATATG 
TATGGCTCAA TGGACAGTGA CAAAGACTCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_025002850.1
CDS	675..3047
Translation	MRTYHCFWLLFWAGQPHQSFLTLLSKRTSGFPEKEKVLVLSGNSRRDLSRSKRSWMWNQFFLLEEYTGTDYQYVGKLHSDQDKGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPMFTKDVYNASIPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFRAPESTPPDSPIGRIKANDADVDENAEIEYSITEGDGYDMFGITTDKDTQEGIITVKKALDFENKNLYILKVEATNTHVDPRFLYLGPFKDSATIRIQVEDVDEPPVFSRPAYIIEVKEDVPINSVIGTVTAQDPDAAKNPVKYSVDRHTDMDRVFNINSGNGSIFTSKTLDRETLLWHNITVIAAEINNPKQSSRVPVFIKVLDVNDNAPEFAMFYETFVCENAKAEQLIQTLSAVDKDDSYSGHQFSFSIAPEAASSSNFTLQDNRDNTAGIFTRKIRYNRHEMSTYLLPVVISDNDYPIQSSTETVTIRVCACDHRGKMLSCNAEALIHPTGLSTGALIAILLCIIILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIDDNKLRRDIVPETLFMPRRTATARDNTDVRDFINQRLKENDTDPAAPPYDSLATYAYEGNGSVAESLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGSMDSDKDS

Target ORF information:

RefSeq Version	XM_025147082.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus cadherin 6 (CDH6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_025147082.1

ORF Insert Sequence:

ATGAGAACTT ACCATTGCTT CTGGTTGCTG TTTTGGGCTG GCCAGCCCCA CCAAAGTTTT 
TTAACTTTGC TGTCCAAAAG GACTAGTGGC TTTCCAGAGA AGGAAAAGGT TTTGGTATTG 
TCTGGAAACA GCAGGAGAGA CCTCAGTCGT TCCAAAAGGA GTTGGATGTG GAATCAGTTC 
TTTTTACTGG AAGAATATAC AGGAACTGAC TATCAGTATG TTGGCAAGCT GCATTCAGAC 
CAGGATAAAG GAGATGGATC ACTTAAGTAC ATCCTTTCTG GAGATGGAGC AGGAGACCTC 
TTCATTATCA ATGAAAACAC TGGTGACATC CAAGCCACAA AGAGACTAGA CAGAGAAGAA 
AAGCCTGTGT ACATACTTCG TGCCCAGGCT ATAAACCGAA GAACTGGAAG ACCAGTGGAA 
CCAGAATCTG AGTTCATCAT CAAGATCCAT GATATCAACG ACAATGAGCC AATGTTTACA 
AAGGACGTTT ACAACGCCAG CATTCCAGAA ATGTCAGATG TTGGTACCTT TGTTGTGCAA 
GTCACTGCAA CTGATGCCGA TGATCCTACA TATGGGAACA GCGCTAAAGT TGTCTACAGC 
ATTCTCCAGG GACAACCATA TTTCTCTGTA GAATCTGAGA CAGGTATTAT TAAAACTGCT 
TTGCTAAACA TGGACCGTGA AAACAGGGAG CAATATCAAG TGGTCATCCA AGCTAAGGAC 
ATGGGAGGCC AGATGGGCGG ATTATCAGGA ACCACCACTG TGAACATCAC ACTGACCGAC 
GTAAATGACA ATCCTCCTCG GTTCCCCCAG AGCACCTACC AATTCAGAGC TCCTGAGTCT 
ACGCCACCTG ACTCACCAAT TGGCAGGATT AAAGCTAATG ATGCAGATGT GGATGAAAAT 
GCAGAGATTG AATACAGCAT CACTGAGGGG GATGGATATG ACATGTTTGG AATTACCACA 
GACAAGGACA CACAGGAAGG AATTATAACT GTCAAAAAGG CACTGGATTT TGAAAATAAA 
AACTTGTATA TTCTGAAGGT GGAAGCCACC AATACTCACG TGGACCCTCG ATTCCTCTAC 
TTGGGGCCAT TCAAGGATTC AGCCACAATC AGAATTCAAG TGGAAGATGT AGATGAACCC 
CCTGTGTTCA GCAGACCAGC ATATATAATT GAAGTGAAAG AAGATGTTCC AATAAACAGT 
GTAATAGGAA CAGTAACAGC ACAGGATCCA GATGCTGCCA AGAACCCTGT CAAGTATTCT 
GTAGATCGAC ACACTGATAT GGACAGAGTA TTCAACATCA ACTCAGGAAA TGGTTCGATA 
TTTACGTCAA AAACTCTTGA CCGGGAAACA TTGCTATGGC ACAACATTAC AGTAATAGCA 
GCAGAGATCA ACAACCCAAA ACAAAGCAGC CGTGTCCCAG TGTTCATTAA GGTTTTGGAT 
GTAAACGACA ATGCTCCAGA GTTTGCCATG TTTTATGAGA CCTTTGTCTG TGAAAATGCA 
AAGGCAGAAC AGCTGATACA AACATTGAGT GCTGTTGATA AAGATGACTC TTACAGTGGA 
CACCAGTTTT CATTCAGCAT AGCTCCAGAG GCAGCCAGCA GCTCAAACTT TACACTCCAG 
GACAACAGAG ACAACACAGC GGGGATTTTC ACCCGAAAAA TCAGATATAA CCGGCATGAA 
ATGAGTACCT ACCTTTTGCC AGTGGTAATA TCAGACAATG ACTACCCTAT CCAGAGCAGC 
ACTGAAACAG TGACTATTCG TGTATGTGCT TGTGACCATC GAGGAAAGAT GCTGTCCTGT 
AATGCGGAAG CCTTGATTCA TCCTACTGGT CTTAGCACTG GGGCTCTTAT TGCCATTCTT 
CTCTGTATCA TTATATTACT TGTTACAGTG GTGTTGTTTG CAGCACTGAG ACGGCAAAGG 
AAAAAAGAGC CTTTGATTAT TTCCAAAGAA GACATCAGAG ACAACATTGT CAGTTATAAT 
GATGAAGGTG GTGGAGAGGA AGACACCCAG GCATTTGATA TCGGCACGCT GAGGAATCCC 
GAAGCCATAG ATGATAATAA ATTACGCAGA GACATTGTGC CAGAAACGCT TTTTATGCCA 
CGGCGGACTG CAACAGCCCG AGATAACACG GATGTCAGAG ATTTCATTAA CCAAAGGTTA 
AAGGAGAATG ATACAGACCC AGCAGCCCCC CCGTATGACT CGTTAGCGAC CTACGCATAC 
GAAGGTAATG GTTCTGTGGC AGAGTCCCTC AGCTCTCTGG AGTCGGTGAC TACAGACGGA 
GACCAGGACT ATGATTACCT CAGTGACTGG GGGCCGCGGT TTAAAAAGTT GGCAGATATG 
TATGGCTCAA TGGACAGTGA CAAAGACTCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation.
The Journal of cell biology215(5)735-747(2016 Dec)
Schiffmacher AT,Xie V,Taneyhill LA

Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT.
Journal of cell science128(9)1773-86(2015 May)
Padmanabhan R,Taneyhill LA

Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons.
Biochemical and biophysical research communications459(3)504-8(2015 Apr)
Park KS,Gumbiner BM

Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest.
Molecular biology of the cell25(1)41-54(2014 Jan)
Schiffmacher AT,Padmanabhan R,Jhingory S,Taneyhill LA

Tetraspanin18 is a FoxD3-responsive antagonist of cranial neural crest epithelial-to-mesenchymal transition that maintains cadherin-6B protein.
Journal of cell science126(Pt 6)1464-76(2013 Mar)
Fairchild CL,Gammill LS

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CDH6 cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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