VKORC1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	VKORC1
Entrez Gene ID	404205
Full Name	vitamin K epoxide reductase complex, subunit 1
General protein information	Preferred Names vitamin K epoxide reductase complex, subunit 1 Names vitamin K epoxide reductase complex, subunit 1 phylloquinone epoxide reductase vitamin K1 epoxide reductase (warfarin-sensitive)
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_206807.1	NP_996530.1	vitamin K epoxide reductase complex, subunit 1 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Carre W, Wang X, Porter TE, Nys Y, Tang J, Bernberg E, Morgan R, Burnside J, Aggrey SE, Simon J, Cogburn LA
Physiological genomics25(3)514-24(2006 May)

Genes encoding vitamin-K epoxide reductase are present in Drosophila and trypanosomatid protists.
Robertson HM
Genetics168(2)1077-80(2004 Oct)

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Rost S, Fregin A, Ivaskevicius V, Conzelmann E, H?rtnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, M?ller CR, Strom TM, Oldenburg J
Nature427(6974)537-41(2004 Feb)

Identification of the gene for vitamin K epoxide reductase.
Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW
Nature427(6974)541-4(2004 Feb)

A comprehensive collection of chicken cDNAs.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ
Current biology : CB12(22)1965-9(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following VKORC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VKORC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa01172	NM_206807.1 Latest version!	Gallus gallus vitamin K epoxide reductase complex, subunit 1 (VKORC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VKORC1 ( NM_206807.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_996530.1 Gallus gallus vitamin K epoxide reductase complex, subunit 1 (VKORC1), mRNA.

Price & Availability↑

CloneID	OGa01172
Clone ID Related Accession (Same CDS sequence)	NM_206807.1
Accession Version	NM_206807.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2013-05-14
Organism	Gallus gallus(chicken)
Product	vitamin K epoxide reductase complex, subunit 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Hugh Robertson. The reference sequence was derived from AW355622.1 and BU114821.1. Sequence Note: The two accessions are overlapping ESTs that provide the coding region but there is a frameshift that is corrected by trace ti 250234451. This gene is otherwise not in the current chicken genome assembly.

ATGGCGGCGC GCGCGGCGTT GTGCGCGGTG GGGTTGGCGC TGGCGGGGTA CGCGCTGCAC 
GTGGAGCGCG CGCACGAGAG GGACCCCACG TACCGCGCGA GCTGCGACCT CGGGCCCAGC 
GTGTCGTGCA CGCGCGTCTT CGCCTCCAGG TGGGGCCGCG GTTTGGGGCT GCTGGAGGCG 
TTTGTGGGTC GGGACAGCGC CATCAACGTC CCCAACAGCG TCATTGGGAT CGCCTTCTAC 
AGCCTGCAGC ACTGCTCGGC GCAGTGCCGG GCAAGAGCCT CCTCCGCGGC GCTGCTGGTG 
ACGTCGGTGA CGTCGGTGCT GGCGTCGCTG TACCTGGCGC TGGTGTTAGC CTTCGGCCTC 
CACGACCTCT GCCTCGTCTG CCTCAGCACC TACGTCGTCA ACGCCGCCCT CCTCTTCCTC 
AACTGGAGGC GCTGGCGGCG CTGCGGACAA ACCGCCGTCC GGAAACGCGA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996530.1
CDS	7..480
Translation	MAARAALCAVGLALAGYALHVERAHERDPTYRASCDLGPSVSCTRVFASRWGRGLGLLEAFVGRDSAINVPNSVIGIAFYSLQHCSAQCRARASSAALLVTSVTSVLASLYLALVLAFGLHDLCLVCLSTYVVNAALLFLNWRRWRRCGQTAVRKRE

Target ORF information:

RefSeq Version	NM_206807.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus vitamin K epoxide reductase complex, subunit 1 (VKORC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_206807.1

ORF Insert Sequence:

ATGGCGGCGC GCGCGGCGTT GTGCGCGGTG GGGTTGGCGC TGGCGGGGTA CGCGCTGCAC 
GTGGAGCGCG CGCACGAGAG GGACCCCACG TACCGCGCGA GCTGCGACCT CGGGCCCAGC 
GTGTCGTGCA CGCGCGTCTT CGCCTCCAGG TGGGGCCGCG GTTTGGGGCT GCTGGAGGCG 
TTTGTGGGTC GGGACAGCGC CATCAACGTC CCCAACAGCG TCATTGGGAT CGCCTTCTAC 
AGCCTGCAGC ACTGCTCGGC GCAGTGCCGG GCAAGAGCCT CCTCCGCGGC GCTGCTGGTG 
ACGTCGGTGA CGTCGGTGCT GGCGTCGCTG TACCTGGCGC TGGTGTTAGC CTTCGGCCTC 
CACGACCTCT GCCTCGTCTG CCTCAGCACC TACGTCGTCA ACGCCGCCCT CCTCTTCCTC 
AACTGGAGGC GCTGGCGGCG CTGCGGACAA ACCGCCGTCC GGAAACGCGA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.
Physiological genomics25(3)514-24(2006 May)
Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

Genes encoding vitamin-K epoxide reductase are present in Drosophila and trypanosomatid protists.
Genetics168(2)1077-80(2004 Oct)
Robertson HM

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Nature427(6974)537-41(2004 Feb)
Rost S,Fregin A,Ivaskevicius V,Conzelmann E,H?rtnagel K,Pelz HJ,Lappegard K,Seifried E,Scharrer I,Tuddenham EG,M?ller CR,Strom TM,Oldenburg J

Identification of the gene for vitamin K epoxide reductase.
Nature427(6974)541-4(2004 Feb)
Li T,Chang CY,Jin DY,Lin PJ,Khvorova A,Stafford DW

A comprehensive collection of chicken cDNAs.
Current biology : CB12(22)1965-9(2002 Nov)
Boardman PE,Sanz-Ezquerro J,Overton IM,Burt DW,Bosch E,Fong WT,Tickle C,Brown WR,Wilson SA,Hubbard SJ

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VKORC1 cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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