BCL2 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	BCL2
Entrez Gene ID	396282
Full Name	BCL2, apoptosis regulator
Synonyms	BCL-2,PCKBCL2
General protein information	Preferred Names BCL2, apoptosis regulator Names apoptosis regulator Bcl-2 B-cell CLL/lymphoma 2
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_205339.2	NP_990670.2	apoptosis regulator Bcl-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	BCL2	NP_000624.2
Pan troglodytes (chimpanzee)	BCL2	XP_001145537.1
Canis lupus familiaris (dog)	BCL2	NP_001002949.1
Xenopus tropicalis (tropical clawed frog)	bcl2	XP_002934442.1
Bos taurus (cattle)	BCL2	NP_001159958.1
Rattus norvegicus (Norway rat)	Bcl2	NP_058689.1
Gallus gallus (chicken)	BCL2	NP_990670.1
Mus musculus (house mouse)	Bcl2	NP_033871.2

Gene Ontology
Bibliography

Related articles in PubMed

miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities.
Jia X, Ouyang H, Abdalla BA, Xu H, Nie Q, Zhang X
Biochimica et biophysica acta1860(6)674-684(2017 06)

The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers.
Huang J, Cui H, Peng X, Fang J, Zuo Z, Deng J, Wu B
International journal of environmental research and public health10(12)7310-26(2013 Dec)

Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers.
Liu J, Cui H, Peng X, Fang J, Zuo Z, Wang H, Wu B, Deng Y, Wang K
Biological trace element research152(1)25-30(2013 Apr)

Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation.
Pucci B, Adams CS, Fertala J, Snyder BC, Mansfield KD, Tafani M, Freeman T, Shapiro IM
Journal of cellular physiology210(3)609-15(2007 Mar)

The role of mitochondria, cytochrome c and caspase-9 in embryonic lens fibre cell denucleation.
Sanders EJ, Parker E
Journal of anatomy201(2)121-35(2002 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings have provided a novel mechanism whereby miR-16 represses Bcl2 and FOXO1 expression to maintain myoblast growth and skeletal muscle mass.
Title: miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities.

mRNA expression was higher in Bax and Caspase-3, and lower in Bcl-2 of the 300, 600 and 900 mg/kg groups. SOD, CAT and GSH-Px activities, ability to inhibit hydroxyl radical, and GSH contents were decreased, and MDA contents were increased in all groups.
Title: The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers.

Data suggest that lymphocyte apoptosis in the cecal tonsil of broilers was mediated by direct effects of fluoride on the expression of Bcl-2, Bax, and caspase-3: [bax]
Title: Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers.

The level of mitochondrial Bcl-2 was decreased during maturation.
Title: Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation.

The following BCL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa28418	NM_205339.2 Latest version!	Gallus gallus BCL2, apoptosis regulator (BCL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BCL2 ( NM_205339.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990670.2 Gallus gallus BCL2, apoptosis regulator (BCL2), mRNA.

Price & Availability↑

CloneID	OGa28418
Clone ID Related Accession (Same CDS sequence)	NM_205339.2
Accession Version	NM_205339.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Gallus gallus(chicken)
Product	apoptosis regulator Bcl-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159826.1 and AADN05000024.1. On Feb 20, 2015 this sequence version replaced NM_205339.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: Z11961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2201357, SAMEA2201358 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCTCACC CCGGGAGAAG AGGCTACGAC AACCGCGAGA TAGTGCTGAA GTACATCCAC 
TATAAACTCT CGCAGCGGGG CTACGACTGG GCCGCCGGCG AGGACAGGCC GCCCGTGCCC 
CCGGCCCCGG CTCCCGCTGC TGCTCCCGCT GCGGTGGCTG CTGCTGGAGC CTCCTCCCAC 
CACCGCCCCG AGCCCCCCGG CTCGGCTGCT GCTAGTGAGG TGCCCCCGGC TGAGGGGCTG 
CGCCCCGCGC CTCCCGGCGT CCACCTCGCC CTGCGCCAGG CCGGGGACGA GTTCTCGCGC 
CGCTACCAGA GGGACTTCGC CCAGATGTCG GGCCAGCTGC ACCTGACGCC CTTCACGGCC 
CACGGCCGCT TCGTGGCCGT GGTGGAGGAG CTCTTCCGTG ATGGGGTCAA CTGGGGCCGG 
ATCGTCGCCT TCTTCGAGTT CGGCGGCGTG ATGTGCGTCG AGAGCGTCAA CCGGGAGATG 
TCGCCGCTGG TGGACAACAT TGCCACCTGG ATGACCGAGT ACCTGAACCG GCACCTGCAC 
AACTGGATCC AGGACAACGG AGGATGGGAT GCCTTTGTGG AATTGTACGG CAACAGTATG 
AGGCCTTTGT TCGATTTCTC CTGGATCTCT CTGAAGACCA TCCTGAGCCT GGTTCTGGTG 
GGAGCTTGCA TCACTCTTGG CGCTTATCTT GGACATAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990670.2
CDS	170..871
Translation	MAHPGRRGYDNREIVLKYIHYKLSQRGYDWAAGEDRPPVPPAPAPAAAPAAVAAAGASSHHRPEPPGSAAASEVPPAEGLRPAPPGVHLALRQAGDEFSRRYQRDFAQMSGQLHLTPFTAHGRFVAVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIATWMTEYLNRHLHNWIQDNGGWDAFVELYGNSMRPLFDFSWISLKTILSLVLVGACITLGAYLGHK

Target ORF information:

RefSeq Version	NM_205339.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus BCL2, apoptosis regulator (BCL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205339.2

ORF Insert Sequence:

ATGGCTCACC CCGGGAGAAG AGGCTACGAC AACCGCGAGA TAGTGCTGAA GTACATCCAC 
TATAAACTCT CGCAGCGGGG CTACGACTGG GCCGCCGGCG AGGACAGGCC GCCCGTGCCC 
CCGGCCCCGG CTCCCGCTGC TGCTCCCGCT GCGGTGGCTG CTGCTGGAGC CTCCTCCCAC 
CACCGCCCCG AGCCCCCCGG CTCGGCTGCT GCTAGTGAGG TGCCCCCGGC TGAGGGGCTG 
CGCCCCGCGC CTCCCGGCGT CCACCTCGCC CTGCGCCAGG CCGGGGACGA GTTCTCGCGC 
CGCTACCAGA GGGACTTCGC CCAGATGTCG GGCCAGCTGC ACCTGACGCC CTTCACGGCC 
CACGGCCGCT TCGTGGCCGT GGTGGAGGAG CTCTTCCGTG ATGGGGTCAA CTGGGGCCGG 
ATCGTCGCCT TCTTCGAGTT CGGCGGCGTG ATGTGCGTCG AGAGCGTCAA CCGGGAGATG 
TCGCCGCTGG TGGACAACAT TGCCACCTGG ATGACCGAGT ACCTGAACCG GCACCTGCAC 
AACTGGATCC AGGACAACGG AGGATGGGAT GCCTTTGTGG AATTGTACGG CAACAGTATG 
AGGCCTTTGT TCGATTTCTC CTGGATCTCT CTGAAGACCA TCCTGAGCCT GGTTCTGGTG 
GGAGCTTGCA TCACTCTTGG CGCTTATCTT GGACATAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-16 controls myoblast proliferation and apoptosis through directly suppressing Bcl2 and FOXO1 activities.
Biochimica et biophysica acta1860(6)674-684(2017 06)
Jia X,Ouyang H,Abdalla BA,Xu H,Nie Q,Zhang X

The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers.
International journal of environmental research and public health10(12)7310-26(2013 Dec)
Huang J,Cui H,Peng X,Fang J,Zuo Z,Deng J,Wu B

Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers.
Biological trace element research152(1)25-30(2013 Apr)
Liu J,Cui H,Peng X,Fang J,Zuo Z,Wang H,Wu B,Deng Y,Wang K

Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation.
Journal of cellular physiology210(3)609-15(2007 Mar)
Pucci B,Adams CS,Fertala J,Snyder BC,Mansfield KD,Tafani M,Freeman T,Shapiro IM

The role of mitochondria, cytochrome c and caspase-9 in embryonic lens fibre cell denucleation.
Journal of anatomy201(2)121-35(2002 Aug)
Sanders EJ,Parker E

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BCL2 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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