IHH cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	IHH
Entrez Gene ID	395801
Full Name	indian hedgehog
General protein information	Preferred Names indian hedgehog Names indian hedgehog protein
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204957.2	NP_990288.1	indian hedgehog protein precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IHH	NP_001070338.2
Danio rerio (zebrafish)	ihhb	NP_571163.1
Pan troglodytes (chimpanzee)	IHH	XP_526034.2
Rattus norvegicus (Norway rat)	Ihh	NP_445836.1
Xenopus tropicalis (tropical clawed frog)	ihh	XP_004917692.1
Homo sapiens (human)	IHH	NP_002172.2
	IHH	XP_001092385.2
Canis lupus familiaris (dog)	IHH	XP_545653.3
Mus musculus (house mouse)	Ihh	NP_034674.1
Gallus gallus (chicken)	IHH	NP_990288.1
Danio rerio (zebrafish)	ihha	NP_001030165.2

Gene Ontology
Bibliography

Related articles in PubMed

The Ihh signal is essential for regulating proliferation and hypertrophy of cultured chicken chondrocytes.
Ma RS, Zhou ZL, Luo JW, Zhang H, Hou JF
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology166(2)117-22(2013 Oct)

Growth of limb muscle is dependent on skeletal-derived Indian hedgehog.
Bren-Mattison Y, Hausburg M, Olwin BB
Developmental biology356(2)486-95(2011 Aug)

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range.
Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KS, Chan D
Nature458(7242)1196-200(2009 Apr)

IHH and FGF8 coregulate elongation of digit primordia.
Zhou J, Meng J, Guo S, Gao B, Ma G, Zhu X, Hu J, Xiao Y, Lin C, Wang H, Ding L, Feng G, Guo X, He L
Biochemical and biophysical research communications363(3)513-8(2007 Nov)

Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis.
Shimo T, Gentili C, Iwamoto M, Wu C, Koyama E, Pacifici M
Developmental dynamics : an official publication of the American Association of Anatomists229(3)607-17(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Based on these results, the Ihh signal is essential for balancing chicken chondrocyte proliferation and hypertrophy, and the regulatory function of PTHrP acts in an Ihh-dependent manner.
Title: The Ihh signal is essential for regulating proliferation and hypertrophy of cultured chicken chondrocytes.

Reduction of Ihh in chicken embryo hindlimbs reduced skeletal muscle mass similar to that seen in Ihh(-/-) mouse embryos
Title: Growth of limb muscle is dependent on skeletal-derived Indian hedgehog.

IHH and FGF8 maybe play different roles and act synergistically to promote chondrogenesis during digit primordia elongation.
Title: IHH and FGF8 coregulate elongation of digit primordia.

Indian hedgehog and syndecan-3 have roles in chondrocyte proliferation and limb skeletogenesis
Title: Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis.

BMPs are integrated into the Ihh/PTHrP signaling loop, and a fine balance of BMP signaling is essential for normal chondrocyte maturation and skeletal development.
Title: ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.

The following IHH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IHH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00315	NM_204957.2 Latest version!	Gallus gallus indian hedgehog (IHH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	Quote Price

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IHH ( NM_204957.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990288.1 Gallus gallus indian hedgehog (IHH), mRNA.

Price & Availability↑

CloneID	OGa00315
Clone ID Related Accession (Same CDS sequence)	NM_204957.2
Accession Version	NM_204957.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Gallus gallus(chicken)
Product	indian hedgehog protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U58511.1. On Mar 21, 2015 this sequence version replaced NM_204957.1. ##Evidence-Data-START## Transcript exon combination :: U58511.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAGCCGG CGCGGCTGCT GCTGCTGCTG AGCGGGTGCG CGCTGCTGCT GGCGCCGGCC 
GTGCGCTGCT GCGGGCCGGG CAGGGTTGTG GGCAGCCGCC GCCGGCCGCC CCGCAAGCTC 
ATCCCGCTCG CCTACAAGCA GTTCAGCCCC AACGTGCCCG AGAAGACGCT GGGGGCCAGC 
GGGCGCTACG AGGGCAAGAT CGCGCGGAAC TCGGAGCGCT TCAAGGAGCT CACGCCCAAC 
TACAACCCCG ACATCATCTT CAAGGACGAG GAGAACACCG GCGCCGACCG GCTCATGACC 
CAGCGCTGCA AGGACCGCCT GAACTCCCTG GCCATCTCCG TCATGAACCA GTGGCCGGGG 
GTGAAGCTGC GGGTGACGGA GGGCTGGGAT GAGGACGGCC ACCACTCGGA GGAGTCGCTG 
CATTACGAGG GCCGAGCCGT GGACATCACG ACGTCAGACA GGGACCGCAA CAAGTACGGC 
ATGCTTGCCC GCCTGGCTGT GGAGGCCGGC TTTGACTGGG TCTACTACGA GTCCAAGGCG 
CACATCCACT GCTCCGTCAA GTCAGAGCAC TCGGCTGCCG CGAAGACGGG CGGCTGCTTC 
CCCGGGCGGG CGCTGGCGAC GCTGGAGAAC GGTGCCCGGA CGCCACTGTG GGCACTGCGG 
CCGGGCCAGC GGGTGCTGGC GATGGACGGG GCGGGCCGGC CCACCTACAG CGACTTCCTG 
GCCTTCCTGG ACAAGGAGCC GCGCGCCCTC ACTGCCTTCC ACGTCATCGA GACGCGGCAG 
CCGCCCCGGC GCCTGGCCCT GACGCCCACC CACCTGCTCT TCGTGGCCGA CAACGCCTCG 
GCGCCCGCCG CCCAATTCCG CCCCACCTTC GCCAGCCACG TGCAGCCCGG ACACTTCGTG 
CTGGTGGCGG TGGGCTCGGG GGGGCTGCAG CCCGCCGAAG TGGTGGGGGT GAGGGGCCGG 
ACGGACGTGG GGGCTTACGC CCCGCTGACG CGACACGGGA CGCTGGTGGT GGACGACGTG 
GTGGCCTCGT GCTTCGCCCT GGTGCGGGAG CAGCAGCTGG CGCAGATGGC CTTCTGGCCG 
CTGCGGCTGT ACCACAGCCT GCTGGGGGGG CCGGGGGTGC AGGGCGACGG TGTGCACTGG 
TACTCGGGGC TGCTCTACCG CCTGGGCAGG ATGCTGCTGC CCCCCGACAG CTTCCACCCG 
CTGGGGGCGC CCCGGGCCGA GAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990288.1
CDS	303..1529
Translation	MKPARLLLLLSGCALLLAPAVRCCGPGRVVGSRRRPPRKLIPLAYKQFSPNVPEKTLGASGRYEGKIARNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGMLARLAVEAGFDWVYYESKAHIHCSVKSEHSAAAKTGGCFPGRALATLENGARTPLWALRPGQRVLAMDGAGRPTYSDFLAFLDKEPRALTAFHVIETRQPPRRLALTPTHLLFVADNASAPAAQFRPTFASHVQPGHFVLVAVGSGGLQPAEVVGVRGRTDVGAYAPLTRHGTLVVDDVVASCFALVREQQLAQMAFWPLRLYHSLLGGPGVQGDGVHWYSGLLYRLGRMLLPPDSFHPLGAPRAES

Target ORF information:

RefSeq Version	NM_204957.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus indian hedgehog (IHH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204957.2

ORF Insert Sequence:

ATGAAGCCGG CGCGGCTGCT GCTGCTGCTG AGCGGGTGCG CGCTGCTGCT GGCGCCGGCC 
GTGCGCTGCT GCGGGCCGGG CAGGGTTGTG GGCAGCCGCC GCCGGCCGCC CCGCAAGCTC 
ATCCCGCTCG CCTACAAGCA GTTCAGCCCC AACGTGCCCG AGAAGACGCT GGGGGCCAGC 
GGGCGCTACG AGGGCAAGAT CGCGCGGAAC TCGGAGCGCT TCAAGGAGCT CACGCCCAAC 
TACAACCCCG ACATCATCTT CAAGGACGAG GAGAACACCG GCGCCGACCG GCTCATGACC 
CAGCGCTGCA AGGACCGCCT GAACTCCCTG GCCATCTCCG TCATGAACCA GTGGCCGGGG 
GTGAAGCTGC GGGTGACGGA GGGCTGGGAT GAGGACGGCC ACCACTCGGA GGAGTCGCTG 
CATTACGAGG GCCGAGCCGT GGACATCACG ACGTCAGACA GGGACCGCAA CAAGTACGGC 
ATGCTTGCCC GCCTGGCTGT GGAGGCCGGC TTTGACTGGG TCTACTACGA GTCCAAGGCG 
CACATCCACT GCTCCGTCAA GTCAGAGCAC TCGGCTGCCG CGAAGACGGG CGGCTGCTTC 
CCCGGGCGGG CGCTGGCGAC GCTGGAGAAC GGTGCCCGGA CGCCACTGTG GGCACTGCGG 
CCGGGCCAGC GGGTGCTGGC GATGGACGGG GCGGGCCGGC CCACCTACAG CGACTTCCTG 
GCCTTCCTGG ACAAGGAGCC GCGCGCCCTC ACTGCCTTCC ACGTCATCGA GACGCGGCAG 
CCGCCCCGGC GCCTGGCCCT GACGCCCACC CACCTGCTCT TCGTGGCCGA CAACGCCTCG 
GCGCCCGCCG CCCAATTCCG CCCCACCTTC GCCAGCCACG TGCAGCCCGG ACACTTCGTG 
CTGGTGGCGG TGGGCTCGGG GGGGCTGCAG CCCGCCGAAG TGGTGGGGGT GAGGGGCCGG 
ACGGACGTGG GGGCTTACGC CCCGCTGACG CGACACGGGA CGCTGGTGGT GGACGACGTG 
GTGGCCTCGT GCTTCGCCCT GGTGCGGGAG CAGCAGCTGG CGCAGATGGC CTTCTGGCCG 
CTGCGGCTGT ACCACAGCCT GCTGGGGGGG CCGGGGGTGC AGGGCGACGG TGTGCACTGG 
TACTCGGGGC TGCTCTACCG CCTGGGCAGG ATGCTGCTGC CCCCCGACAG CTTCCACCCG 
CTGGGGGCGC CCCGGGCCGA GAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Ihh signal is essential for regulating proliferation and hypertrophy of cultured chicken chondrocytes.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology166(2)117-22(2013 Oct)
Ma RS,Zhou ZL,Luo JW,Zhang H,Hou JF

Growth of limb muscle is dependent on skeletal-derived Indian hedgehog.
Developmental biology356(2)486-95(2011 Aug)
Bren-Mattison Y,Hausburg M,Olwin BB

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range.
Nature458(7242)1196-200(2009 Apr)
Gao B,Hu J,Stricker S,Cheung M,Ma G,Law KF,Witte F,Briscoe J,Mundlos S,He L,Cheah KS,Chan D

IHH and FGF8 coregulate elongation of digit primordia.
Biochemical and biophysical research communications363(3)513-8(2007 Nov)
Zhou J,Meng J,Guo S,Gao B,Ma G,Zhu X,Hu J,Xiao Y,Lin C,Wang H,Ding L,Feng G,Guo X,He L

Indian hedgehog and syndecans-3 coregulate chondrocyte proliferation and function during chick limb skeletogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists229(3)607-17(2004 Mar)
Shimo T,Gentili C,Iwamoto M,Wu C,Koyama E,Pacifici M

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IHH cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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