TRPV4 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRPV4
Entrez Gene ID	395427
Full Name	transient receptor potential cation channel subfamily V member 4
Synonyms	VR-OAC
General protein information	Preferred Names transient receptor potential cation channel subfamily V member 4 Names transient receptor potential cation channel subfamily V member 4 vanilloid receptor-related osmotically activated channel protein
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204692.1	NP_990023.1	transient receptor potential cation channel subfamily V member 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	TRPV4	NP_067638.3
Canis lupus familiaris (dog)	TRPV4	NP_001120787.1
Bos taurus (cattle)	TRPV4	NP_001179314.1
Mus musculus (house mouse)	Trpv4	NP_071300.2
Xenopus tropicalis (tropical clawed frog)	trpv4	XP_002932129.1
Gallus gallus (chicken)	TRPV4	NP_990023.1
Pan troglodytes (chimpanzee)	TRPV4	XP_003314024.1
Rattus norvegicus (Norway rat)	Trpv4	NP_076460.1
Danio rerio (zebrafish)	trpv4	NP_001036195.1

Gene Ontology
Bibliography

Related articles in PubMed

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P?.
Takahashi N, Hamada-Nakahara S, Itoh Y, Takemura K, Shimada A, Ueda Y, Kitamata M, Matsuoka R, Hanawa-Suetsugu K, Senju Y, Mori MX, Kiyonaka S, Kohda D, Kitao A, Mori Y, Suetsugu S
Nature communications54994(2014 Sep)

Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.
Phelps CB, Wang RR, Choo SS, Gaudet R
The Journal of biological chemistry285(1)731-40(2010 Jan)

PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.
Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S
The Journal of biological chemistry281(27)18753-62(2006 Jul)

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.
Liedtke W, Choe Y, Mart?-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S
Cell103(3)525-35(2000 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRPV4 ankyrin domain is a lipid-binding domain in which interactions with PI(4,5)P2.
Title: TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P?.

A multiligand binding site for ATP and calmodulin previously identified in the TRPV1 ankyrin repeat domain is conserved in TRPV3 and TRPV4, but not TRPV2.
Title: Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.

PACSIN 3 specifically affects the endocytosis of TRPV4, thereby modulating its subcellular localization
Title: PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.

The following TRPV4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRPV4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa24752	NM_204692.1 Latest version!	Gallus gallus transient receptor potential cation channel subfamily V member 4 (TRPV4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRPV4 ( NM_204692.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_990023.1 Gallus gallus transient receptor potential cation channel subfamily V member 4 (TRPV4), mRNA.

Price & Availability↑

CloneID	OGa24752
Clone ID Related Accession (Same CDS sequence)	NM_204692.1
Accession Version	NM_204692.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2559bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Gallus gallus(chicken)
Product	transient receptor potential cation channel subfamily V member 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF261883.1. ##Evidence-Data-START## Transcript exon combination :: AF261883.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCAGACC CCGAAGACCC CCGTGATGCT GGGGACGTGC TGGGGGATGA CTCCTTCCCG 
CTCTCCTCGC TGGCCAACCT GTTTGAGGTG GAGGACACCC CGTCTCCTGC TGAGCCATCC 
CGGGGTCCCC CCGGCGCTGG GGATGGAAAG CAAAACCTCC GGATGAAATT CCACGGGGCG 
TTCCGGAAAG GCCCCCCAAA ACCCATGGAG CTGCTGGAGT CCACCATCTA CGAGTCGTCA 
GTGGTCCCTG CACCCAAAAA GGCCCCCATG GATTCCCTCT TCGACTACGG CACCTACAGG 
CAGCACCCCA GCGAGAACAA ACGCTGGCGC AGGAGGGTCG TGGAGAAGCC GGTGGCTGGC 
ACCAAGGGGC CGGCACCCAA CCCGCCGCCC GTCCTCAAGG TGTTCAACAG ACCCATCCTC 
TTCGACATCG TCTCCCGGGG GTCCCCAGAT GGCCTGGAGG GTCTCCTCTC CTTCCTGCTC 
ACCCACAAGA AGCGTCTGAC GGATGAGGAG TTCCGAGAGC CCTCAACAGG GAAGACGTGC 
CTGCCCAAAG CGCTGCTCAA CCTGAGTGCT GGCCGGAATG ACACCATCCC CATCCTCCTC 
GACATCGCCG AGAAGACGGG AAACATGCGG GAGTTCATCA ACTCACCCTT CCGTGATGTC 
TACTACAGAG GTCAGACAGC GCTGCACATC GCCATTGAGC GCCGCTGCAA GCACTACGTG 
GAGCTGCTGG TGGAGAAGGG TGCCGACGTG CACGCCCAGG CCCGTGGTCG CTTCTTCCAG 
CCCAAGGATG AGGGCGGCTA CTTCTATTTC GGAGAGCTGC CCCTCTCACT GGCCGCCTGC 
ACCAACCAGC CCCACATCGT GCACTATCTG ACGGAGAATG GGCACAAGCA GGCAGACCTG 
CGGCGCCAGG ACTCGCGCGG CAACACCGTG CTGCATGCTC TGGTTGCCAT CGCTGACAAC 
ACCCGTGAGA ACACCAAGTT TGTCACCAAG ATGTACGACC TGCTCCTCAT CAAGTGCGCC 
AAGCTCTTCC CCGACACCAA CCTCGAGGCC CTGCTCAACA ACGATGGCCT CTCTCCACTC 
ATGATGGCTG CCAAGACTGG CAAGATCGGG ATCTTCCAGC ACATCATCCG CCGGGAGATC 
GCAGATGAGG ACGTCCGGCA CCTCTCGCGC AAGTTCAAGG ATTGGGCATA CGGCCCCGTC 
TACTCCTCAC TCTACGATCT CTCCTCACTG GATACCTGCG GGGAGGAGGT GTCCGTGTTG 
GAGATCCTCG TTTACAACAG CAAGATTGAG AACCGCCATG AGATGTTGGC CGTGGAGCCC 
ATCAACGAAC TGCTGCGCGA CAAGTGGCGC AAGTTCGGTG CTGTCTCCTT CTACATCAGC 
GTGGTCTCCT ACCTCTGTGC CATGATCATC TTCACCCTCA TCGCCTATTA CCGCCCCATG 
GAAGGCCCCC CACCGTACCC CTACACTACA ACCATCGACT ACCTGCGGCT GGCCGGGGAG 
ATCATCACCC TCCTCACCGG CATCCTCTTC TTCTTCTCCA ATATCAAAGA TCTCTTCATG 
AAGAAGTGCC CAGGTGTGAA CTCGTTCTTC ATCGATGGCT CATTTCAGCT GCTCTACTTC 
ATCTACTCGG TGCTGGTGAT CGTCACGGCA GGGCTGTACC TGGGTGGTGT CGAGGCTTAC 
CTGGCTGTCA TGGTCTTTGC TTTGGTCCTG GGCTGGATGA ATGCGCTCTA CTTCACGCGA 
GGGCTCAAGC TGACGGGGAC CTACAGCATC ATGATCCAGA AGATCCTCTT CAAAGACCTG 
TTCCGCTTCC TCCTGGTCTA TCTGCTATTC ATGATTGGCT ACGCCTCAGC ACTGGTGTCC 
CTCCTGAACC CGTGTCCCAG CAGCGAGTCC TGCAGTGAGG ATCACTCCAA CTGCACGCTG 
CCCACCTACC CCTCATGCCG GGACAGTCAG ACCTTCAGCA CCTTCCTGCT TGACCTCTTC 
AAGCTCACCA TTGGCATGGG TGACCTGGAG ATGCTGGAGA GTGCCAAGTA CCCTGGTGTC 
TTCATCATCC TGCTTGTCAC CTACATCATC CTCACCTTCG TGCTGCTCCT CAACATGCTC 
ATCGCCCTCA TGGGTGAGAC AGTGGGCCAG GTGTCCAAGG AGAGCAAACA CATCTGGAAG 
TTGCAGTGGG CCACCACCAT CCTGGACATC GAGCGCTCCT TCCCTCTCTT CCTGCGGAGA 
GCATTTCGCT CTGGGGAGAT GGTGACCGTG GGGAAGGGCA CTGATGGGAC CCCTGACCGC 
CGCTGGTGCT TCAGGGTGGA TGAGGTGAAC TGGTCCCACT GGAACCAGAA CCTGGGCATC 
ATCAGCGAGG ACCCGGGCAA GAGCGACACT TACCAGTACT ACGGCTTCTC CCATACCGTG 
GGGCGGCTGC GGAGAGATCG ATGGTCAACG GTGGTGCCAC GCGTGGTGGA GCTCAACAAG 
AGCTGCCCAA CGGAGGATGT GGTTGTGCCA TTGGGGACCA TGGGCACGGC AGAGGCGCGG 
GAGCGACGAC ACGGGCAGAC CCCCAGCTCC CCACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_990023.1
CDS	129..2687
Translation	MADPEDPRDAGDVLGDDSFPLSSLANLFEVEDTPSPAEPSRGPPGAGDGKQNLRMKFHGAFRKGPPKPMELLESTIYESSVVPAPKKAPMDSLFDYGTYRQHPSENKRWRRRVVEKPVAGTKGPAPNPPPVLKVFNRPILFDIVSRGSPDGLEGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSAGRNDTIPILLDIAEKTGNMREFINSPFRDVYYRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAKLFPDTNLEALLNNDGLSPLMMAAKTGKIGIFQHIIRREIADEDVRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYISVVSYLCAMIIFTLIAYYRPMEGPPPYPYTTTIDYLRLAGEIITLLTGILFFFSNIKDLFMKKCPGVNSFFIDGSFQLLYFIYSVLVIVTAGLYLGGVEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCPSSESCSEDHSNCTLPTYPSCRDSQTFSTFLLDLFKLTIGMGDLEMLESAKYPGVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPLFLRRAFRSGEMVTVGKGTDGTPDRRWCFRVDEVNWSHWNQNLGIISEDPGKSDTYQYYGFSHTVGRLRRDRWSTVVPRVVELNKSCPTEDVVVPLGTMGTAEARERRHGQTPSSPL

Target ORF information:

RefSeq Version	NM_204692.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus transient receptor potential cation channel subfamily V member 4 (TRPV4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204692.1

ORF Insert Sequence:

ATGGCAGACC CCGAAGACCC CCGTGATGCT GGGGACGTGC TGGGGGATGA CTCCTTCCCG 
CTCTCCTCGC TGGCCAACCT GTTTGAGGTG GAGGACACCC CGTCTCCTGC TGAGCCATCC 
CGGGGTCCCC CCGGCGCTGG GGATGGAAAG CAAAACCTCC GGATGAAATT CCACGGGGCG 
TTCCGGAAAG GCCCCCCAAA ACCCATGGAG CTGCTGGAGT CCACCATCTA CGAGTCGTCA 
GTGGTCCCTG CACCCAAAAA GGCCCCCATG GATTCCCTCT TCGACTACGG CACCTACAGG 
CAGCACCCCA GCGAGAACAA ACGCTGGCGC AGGAGGGTCG TGGAGAAGCC GGTGGCTGGC 
ACCAAGGGGC CGGCACCCAA CCCGCCGCCC GTCCTCAAGG TGTTCAACAG ACCCATCCTC 
TTCGACATCG TCTCCCGGGG GTCCCCAGAT GGCCTGGAGG GTCTCCTCTC CTTCCTGCTC 
ACCCACAAGA AGCGTCTGAC GGATGAGGAG TTCCGAGAGC CCTCAACAGG GAAGACGTGC 
CTGCCCAAAG CGCTGCTCAA CCTGAGTGCT GGCCGGAATG ACACCATCCC CATCCTCCTC 
GACATCGCCG AGAAGACGGG AAACATGCGG GAGTTCATCA ACTCACCCTT CCGTGATGTC 
TACTACAGAG GTCAGACAGC GCTGCACATC GCCATTGAGC GCCGCTGCAA GCACTACGTG 
GAGCTGCTGG TGGAGAAGGG TGCCGACGTG CACGCCCAGG CCCGTGGTCG CTTCTTCCAG 
CCCAAGGATG AGGGCGGCTA CTTCTATTTC GGAGAGCTGC CCCTCTCACT GGCCGCCTGC 
ACCAACCAGC CCCACATCGT GCACTATCTG ACGGAGAATG GGCACAAGCA GGCAGACCTG 
CGGCGCCAGG ACTCGCGCGG CAACACCGTG CTGCATGCTC TGGTTGCCAT CGCTGACAAC 
ACCCGTGAGA ACACCAAGTT TGTCACCAAG ATGTACGACC TGCTCCTCAT CAAGTGCGCC 
AAGCTCTTCC CCGACACCAA CCTCGAGGCC CTGCTCAACA ACGATGGCCT CTCTCCACTC 
ATGATGGCTG CCAAGACTGG CAAGATCGGG ATCTTCCAGC ACATCATCCG CCGGGAGATC 
GCAGATGAGG ACGTCCGGCA CCTCTCGCGC AAGTTCAAGG ATTGGGCATA CGGCCCCGTC 
TACTCCTCAC TCTACGATCT CTCCTCACTG GATACCTGCG GGGAGGAGGT GTCCGTGTTG 
GAGATCCTCG TTTACAACAG CAAGATTGAG AACCGCCATG AGATGTTGGC CGTGGAGCCC 
ATCAACGAAC TGCTGCGCGA CAAGTGGCGC AAGTTCGGTG CTGTCTCCTT CTACATCAGC 
GTGGTCTCCT ACCTCTGTGC CATGATCATC TTCACCCTCA TCGCCTATTA CCGCCCCATG 
GAAGGCCCCC CACCGTACCC CTACACTACA ACCATCGACT ACCTGCGGCT GGCCGGGGAG 
ATCATCACCC TCCTCACCGG CATCCTCTTC TTCTTCTCCA ATATCAAAGA TCTCTTCATG 
AAGAAGTGCC CAGGTGTGAA CTCGTTCTTC ATCGATGGCT CATTTCAGCT GCTCTACTTC 
ATCTACTCGG TGCTGGTGAT CGTCACGGCA GGGCTGTACC TGGGTGGTGT CGAGGCTTAC 
CTGGCTGTCA TGGTCTTTGC TTTGGTCCTG GGCTGGATGA ATGCGCTCTA CTTCACGCGA 
GGGCTCAAGC TGACGGGGAC CTACAGCATC ATGATCCAGA AGATCCTCTT CAAAGACCTG 
TTCCGCTTCC TCCTGGTCTA TCTGCTATTC ATGATTGGCT ACGCCTCAGC ACTGGTGTCC 
CTCCTGAACC CGTGTCCCAG CAGCGAGTCC TGCAGTGAGG ATCACTCCAA CTGCACGCTG 
CCCACCTACC CCTCATGCCG GGACAGTCAG ACCTTCAGCA CCTTCCTGCT TGACCTCTTC 
AAGCTCACCA TTGGCATGGG TGACCTGGAG ATGCTGGAGA GTGCCAAGTA CCCTGGTGTC 
TTCATCATCC TGCTTGTCAC CTACATCATC CTCACCTTCG TGCTGCTCCT CAACATGCTC 
ATCGCCCTCA TGGGTGAGAC AGTGGGCCAG GTGTCCAAGG AGAGCAAACA CATCTGGAAG 
TTGCAGTGGG CCACCACCAT CCTGGACATC GAGCGCTCCT TCCCTCTCTT CCTGCGGAGA 
GCATTTCGCT CTGGGGAGAT GGTGACCGTG GGGAAGGGCA CTGATGGGAC CCCTGACCGC 
CGCTGGTGCT TCAGGGTGGA TGAGGTGAAC TGGTCCCACT GGAACCAGAA CCTGGGCATC 
ATCAGCGAGG ACCCGGGCAA GAGCGACACT TACCAGTACT ACGGCTTCTC CCATACCGTG 
GGGCGGCTGC GGAGAGATCG ATGGTCAACG GTGGTGCCAC GCGTGGTGGA GCTCAACAAG 
AGCTGCCCAA CGGAGGATGT GGTTGTGCCA TTGGGGACCA TGGGCACGGC AGAGGCGCGG 
GAGCGACGAC ACGGGCAGAC CCCCAGCTCC CCACTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P?.
Nature communications54994(2014 Sep)
Takahashi N,Hamada-Nakahara S,Itoh Y,Takemura K,Shimada A,Ueda Y,Kitamata M,Matsuoka R,Hanawa-Suetsugu K,Senju Y,Mori MX,Kiyonaka S,Kohda D,Kitao A,Mori Y,Suetsugu S

Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.
The Journal of biological chemistry285(1)731-40(2010 Jan)
Phelps CB,Wang RR,Choo SS,Gaudet R

PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.
The Journal of biological chemistry281(27)18753-62(2006 Jul)
Cuajungco MP,Grimm C,Oshima K,D'hoedt D,Nilius B,Mensenkamp AR,Bindels RJ,Plomann M,Heller S

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.
Cell103(3)525-35(2000 Oct)
Liedtke W,Choe Y,Mart?-Renom MA,Bell AM,Denis CS,Sali A,Hudspeth AJ,Friedman JM,Heller S

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TRPV4 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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