CXCR4 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCR4
Entrez Gene ID	395324
Full Name	C-X-C motif chemokine receptor 4
General protein information	Preferred Names C-X-C motif chemokine receptor 4 Names C-X-C chemokine receptor type 4 chemokine (C-X-C motif) receptor 4 chemokine receptor CXCR4
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204617.2	NP_989948.2	C-X-C chemokine receptor type 4

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CXCR4	NP_989948.2
Danio rerio (zebrafish)	cxcr4a	NP_571957.2
Danio rerio (zebrafish)	cxcr4b	NP_571909.1
Pan troglodytes (chimpanzee)	CXCR4	NP_001009047.1
Mus musculus (house mouse)	Cxcr4	NP_034041.2
Rattus norvegicus (Norway rat)	Cxcr4	NP_071541.2
Xenopus tropicalis (tropical clawed frog)	cxcr4	NP_001090831.1
Homo sapiens (human)	CXCR4	NP_003458.1
	CXCR4	NP_001036110.1
Canis lupus familiaris (dog)	CXCR4	NP_001041491.1
Bos taurus (cattle)	CXCR4	NP_776726.1

Gene Ontology
Bibliography

Related articles in PubMed

C-X-C chemokine receptor type 4 (CXCR4) is a key receptor for chicken primordial germ cell migration.
Lee JH, Park JW, Kim SW, Park J, Park TS
The Journal of reproduction and development63(6)555-562(2017 Dec)

Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations.
Escot S, Blavet C, Faure E, Zaffran S, Duband JL, Fournier-Thibault C
Development (Cambridge, England)143(4)582-8(2016 Feb)

Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling.
Masyuk M, Abduelmula A, Morosan-Puopolo G, ?demis V, Rehimi R, Khalida N, Yusuf F, Engele J, Tamamura H, Theiss C, Brand-Saberi B
Histochemistry and cell biology142(5)473-88(2014 Nov)

Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects.
Escot S, Blavet C, H?rtle S, Duband JL, Fournier-Thibault C
Circulation research113(5)505-16(2013 Aug)

Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate.
Katsumoto K, Kume S
Development (Cambridge, England)138(10)1947-55(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the possibility of a pivotal role for the SDF1/CXCR4 axis in DiGeorge syndrome etiology.
Title: Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations.

demonstration of the importance of the CXCR4/SDF-1 axis for the pectoral girdle muscle formation in avians and mammals
Title: Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling.

Cxcr4 loss-of-function causes delayed migration and enhanced death of cardiac neural crest cells.
Title: Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects.

Gut endoderm and angioblasts attract each other through reciprocal CXCL12 and CXCR4 signaling. This has a pivotal role in the fate establishment of the pancreatic progenitor cells.
Title: Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate.

CXCR4-expressing subset of sympathetic ganglia (SG) cells comprises the neuronal core of the SGs, while later migrating SG-destined neural crest cells that do not express CXCR4 colonize the non-neuronal perimeter.
Title: CXCR4 controls ventral migration of sympathetic precursor cells.

The following CXCR4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCR4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00775	NM_204617.2 Latest version!	Gallus gallus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCR4 ( NM_204617.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989948.2 Gallus gallus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.

Price & Availability↑

CloneID	OGa00775
Clone ID Related Accession (Same CDS sequence)	NM_204617.2
Accession Version	NM_204617.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-08-18
Organism	Gallus gallus(chicken)
Product	C-X-C chemokine receptor type 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AADN05000350.1 and AF294794.1. On Sep 27, 2011 this sequence version replaced NM_204617.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. ##Evidence-Data-START## Transcript exon combination :: AJ454503.1, HAEK01023487.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2201377, SAMEA2201381 [ECO:0000348] ##Evidence-Data-END##

ATGGACGGCA GCATGGACGG TTTGGATCTG TCCTCTGGCA TACTCATTGA ATTTGCTGAC 
AATGGCTCGG AGGAGATTGG CTCAGCTGAC TATGGAGACT ATGGAGAGCC ATGCTTTCAG 
CATGAAAACG CTGATTTCAA CCGGATCTTC TTGCCAACCA TCTACTCCAT CATCTTCCTA 
ACAGGAATAA TCGGGAATGG ATTGGTTATC ATTGTTATGG GCTACCAGAA GAAGCAAAGA 
AGCATGACTG ATAAATACAG GCTGCACCTC TCTGTGGCTG ACCTCCTCTT TGTCATCACC 
TTGCCATTCT GGTCTGTGGA TGCAGCCATA AGCTGGTACT TCGGAAATGT CCTGTGTAAG 
GCAGTTCATG TCATTTACAC AGTCAACCTC TATAGCAGTG TCTTGATTTT GGCTTTCATA 
AGTTTAGATC GTTACCTGGC AATAGTCCAT GCCACCAACA GCCAGCGACC CCGAAAGCTG 
TTGGCTGAGA AGATTGTGTA TGTGGGTGTC TGGCTGCCAG CTGTGCTTCT CACAGTGCCT 
GATATAATTT TTGCCAGTAC GAGTGAAGTA GAAGGACGGT ATCTCTGTGA TCGCATGTAC 
CCTCATGACA ACTGGCTGAT TTCTTTCAGA TTCCAGCATA TCTTGGTAGG ACTTGTCTTG 
CCTGGTCTAA TAATCCTGAC TTGCTATTGT ATTATCATAT CTAAGCTGTC ACATTCAAAA 
GGCCACCAGA AGCGCAAAGC CTTGAAGACA ACAGTTATCC TCATTCTTAC CTTCTTTGCC 
TGTTGGCTGC CGTATTACAT TGGCATCAGC ATAGACACGT TCATCTTGCT TGGAGTCATC 
AGACATCGCT GCAGCTTGGA CACAATCGTG CACAAATGGA TCTCTATCAC AGAAGCCCTT 
GCGTTCTTCC ATTGCTGCCT CAATCCAATT CTTTACGCCT TCCTGGGTGC CAAGTTCAAA 
ACATCAGCAC AAAATGCCTT GACATCTGTT AGCAGAGGAT CAAGCCTCAA GATTCTTTCA 
AAAAGCAAAC GTGGGGGACA TTCTTCTGTT TCTACAGAGT CAGAGTCTTC AAGTTTCCAT 
TCCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989948.2
CDS	70..1158
Translation	MDGSMDGLDLSSGILIEFADNGSEEIGSADYGDYGEPCFQHENADFNRIFLPTIYSIIFLTGIIGNGLVIIVMGYQKKQRSMTDKYRLHLSVADLLFVITLPFWSVDAAISWYFGNVLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKIVYVGVWLPAVLLTVPDIIFASTSEVEGRYLCDRMYPHDNWLISFRFQHILVGLVLPGLIILTCYCIIISKLSHSKGHQKRKALKTTVILILTFFACWLPYYIGISIDTFILLGVIRHRCSLDTIVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQNALTSVSRGSSLKILSKSKRGGHSSVSTESESSSFHSS

Target ORF information:

RefSeq Version	NM_204617.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204617.2

ORF Insert Sequence:

ATGGACGGCA GCATGGACGG TTTGGATCTG TCCTCTGGCA TACTCATTGA ATTTGCTGAC 
AATGGCTCGG AGGAGATTGG CTCAGCTGAC TATGGAGACT ATGGAGAGCC ATGCTTTCAG 
CATGAAAACG CTGATTTCAA CCGGATCTTC TTGCCAACCA TCTACTCCAT CATCTTCCTA 
ACAGGAATAA TCGGGAATGG ATTGGTTATC ATTGTTATGG GCTACCAGAA GAAGCAAAGA 
AGCATGACTG ATAAATACAG GCTGCACCTC TCTGTGGCTG ACCTCCTCTT TGTCATCACC 
TTGCCATTCT GGTCTGTGGA TGCAGCCATA AGCTGGTACT TCGGAAATGT CCTGTGTAAG 
GCAGTTCATG TCATTTACAC AGTCAACCTC TATAGCAGTG TCTTGATTTT GGCTTTCATA 
AGTTTAGATC GTTACCTGGC AATAGTCCAT GCCACCAACA GCCAGCGACC CCGAAAGCTG 
TTGGCTGAGA AGATTGTGTA TGTGGGTGTC TGGCTGCCAG CTGTGCTTCT CACAGTGCCT 
GATATAATTT TTGCCAGTAC GAGTGAAGTA GAAGGACGGT ATCTCTGTGA TCGCATGTAC 
CCTCATGACA ACTGGCTGAT TTCTTTCAGA TTCCAGCATA TCTTGGTAGG ACTTGTCTTG 
CCTGGTCTAA TAATCCTGAC TTGCTATTGT ATTATCATAT CTAAGCTGTC ACATTCAAAA 
GGCCACCAGA AGCGCAAAGC CTTGAAGACA ACAGTTATCC TCATTCTTAC CTTCTTTGCC 
TGTTGGCTGC CGTATTACAT TGGCATCAGC ATAGACACGT TCATCTTGCT TGGAGTCATC 
AGACATCGCT GCAGCTTGGA CACAATCGTG CACAAATGGA TCTCTATCAC AGAAGCCCTT 
GCGTTCTTCC ATTGCTGCCT CAATCCAATT CTTTACGCCT TCCTGGGTGC CAAGTTCAAA 
ACATCAGCAC AAAATGCCTT GACATCTGTT AGCAGAGGAT CAAGCCTCAA GATTCTTTCA 
AAAAGCAAAC GTGGGGGACA TTCTTCTGTT TCTACAGAGT CAGAGTCTTC AAGTTTCCAT 
TCCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

C-X-C chemokine receptor type 4 (CXCR4) is a key receptor for chicken primordial germ cell migration.
The Journal of reproduction and development63(6)555-562(2017 Dec)
Lee JH,Park JW,Kim SW,Park J,Park TS

Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations.
Development (Cambridge, England)143(4)582-8(2016 Feb)
Escot S,Blavet C,Faure E,Zaffran S,Duband JL,Fournier-Thibault C

Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling.
Histochemistry and cell biology142(5)473-88(2014 Nov)
Masyuk M,Abduelmula A,Morosan-Puopolo G,?demis V,Rehimi R,Khalida N,Yusuf F,Engele J,Tamamura H,Theiss C,Brand-Saberi B

Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects.
Circulation research113(5)505-16(2013 Aug)
Escot S,Blavet C,H?rtle S,Duband JL,Fournier-Thibault C

Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate.
Development (Cambridge, England)138(10)1947-55(2011 May)
Katsumoto K,Kume S

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CXCR4 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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