GH cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	GH
Entrez Gene ID	378781
Full Name	growth hormone
Synonyms	GH1,cGH
General protein information	Preferred Names growth hormone Names somatotropin growth hormone 1 neural retina growth hormone
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204359.2	NP_989690.1	somatotropin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CSHL1	NP_072101.1
	CSH4	NP_001040620.1
Rattus norvegicus (Norway rat)	Gh1	NP_001030020.2
Pan troglodytes (chimpanzee)	PL-B	NP_001008999.1
	CSH3	NP_001040618.1
Canis lupus familiaris (dog)	GH1	NP_001003168.1
Bos taurus (cattle)	GH1	NP_851339.1
Danio rerio (zebrafish)	gh1	NP_001018328.2
Xenopus tropicalis (tropical clawed frog)	LOC100492540	XP_002933088.2
Mus musculus (house mouse)	Gh	NP_032143.1
Gallus gallus (chicken)	GH	NP_989690.1
Xenopus tropicalis (tropical clawed frog)	LOC100490878	XP_002934109.2

Gene Ontology
Bibliography

Related articles in PubMed

Negative Glucocorticoid Response-Like Element from the First Intron of the Chicken Growth Hormone Gene Represses Gene Expression in the Rat Pituitary Tumor Cell Line.
Ma JE, Lang QQ, Qiu FF, Zhang L, Li XG, Luo W, Wang J, Wang X, Lin XR, Liu WS, Nie QH, Zhang XQ
International journal of molecular sciences17(11)(2016 Nov)

Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH.
El-Magd MA, Saleh AA, Abdel-Hamid TM, Saleh RM, Afifi MA
General and comparative endocrinology237131-139(2016 Oct)

[MspI-POLYMORPHISM IN FOURTH INTRON OF THE GROWTH HORMONE GENE IN CHICKEN POPULATIONS OF DIFFERENT BREEDS. ANALYSIS OF THE CAUSES OF ADDITIONAL RESTRICTION PATTERN ORIGIN].
Kulibaba RA, Yurko PS, Liashenkon YV
TSitologiia i genetika49(6)30-7(2015 Nov-Dec)

Mechanisms involved in glucocorticoid induction of pituitary GH expression during embryonic development.
Ellestad LE, Puckett SA, Porter TE
Endocrinology156(3)1066-79(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

There is a negative glucocorticoid response-like element located in the +591/+609 region within the first intron of chicken growth hormone (cGH), which is essential for the down-regulation of cGH expression.
Title: Negative Glucocorticoid Response-Like Element from the First Intron of the Chicken Growth Hormone Gene Represses Gene Expression in the Rat Pituitary Tumor Cell Line.

This is the first study to demonstrate that single nucleotide polymorphisms in GHSR can increase appetite, growth traits, expression and level of GHRL, suggesting a hunger signal role for endogenous GHRL.
Title: Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH.

It is shown that in all examined chicken populations the growth hormone gene is polymorphic.
Title: [MspI-POLYMORPHISM IN FOURTH INTRON OF THE GROWTH HORMONE GENE IN CHICKEN POPULATIONS OF DIFFERENT BREEDS. ANALYSIS OF THE CAUSES OF ADDITIONAL RESTRICTION PATTERN ORIGIN].

The molecular mechanisms underlying glucocorticoid recruitment of somatotrophs during embryogenesis were studied; these provide insight into glucocorticoid-induced developmental changes in other tissues and cell types.
Title: Mechanisms involved in glucocorticoid induction of pituitary GH expression during embryonic development.

T185G growth hormone polymorphism was significantly associated with the egg production traits in chickens.
Title: Association of chicken growth hormone polymorphisms with egg production.

The following GH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00085	NM_204359.2 Latest version!	Gallus gallus growth hormone (GH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GH ( NM_204359.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989690.1 Gallus gallus growth hormone (GH), mRNA.

Price & Availability↑

CloneID	OGa00085
Clone ID Related Accession (Same CDS sequence)	NM_204359.2
Accession Version	NM_204359.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Gallus gallus(chicken)
Product	somatotropin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X17618.1. On Aug 30, 2012 this sequence version replaced NM_204359.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X17618.1, M35609.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCTCCAG GCTCGTGGTT TTCTCCTCTC CTCATCGCTG TGGTCACGCT GGGACTGCCG 
CAGGAAGCTG CTGCCACCTT CCCTGCCATG CCCCTCTCCA ACCTGTTTGC CAACGCTGTG 
CTGAGGGCTC AGCACCTCCA CCTCCTGGCT GCCGAGACAT ATAAAGAGTT CGAACGCACC 
TATATTCCGG AGGACCAGAG GTACACCAAC AAAAACTCCC AGGCTGCGTT TTGTTACTCA 
GAAACCATCC CAGCTCCCAC GGGGAAGGAT GACGCCCAGC AGAAGTCAGA CATGGAGCTG 
CTTCGGTTTT CACTGGTTCT CATCCAGTCC TGGCTGACCC CCGTGCAATA CCTAAGCAAG 
GTGTTCACGA ACAACTTGGT TTTTGGCACC TCAGACAGAG TGTTTGAGAA ACTAAAGGAC 
CTGGAAGAAG GGATCCAAGC CCTGATGAGG GAGCTGGAGG ACCGATCACC GCGGGGCCCG 
CAGCTCCTCA GACCCACCTA CGATAAGTTC GACATCCACC TGCGCAACGA GGACGCCCTG 
CTGAAGAACT ACGGCCTGCT GTCCTGCTTC AAGAAGGATC TGCACAAGGT GGAGACCTAC 
CTGAAGGTGA TGAAGTGCCG GCGCTTCGGA GAGAGCAACT GCACCATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989690.1
CDS	34..684
Translation	MAPGSWFSPLLIAVVTLGLPQEAAATFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMELLRFSLVLIQSWLTPVQYLSKVFTNNLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI

Target ORF information:

RefSeq Version	NM_204359.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus growth hormone (GH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204359.2

ORF Insert Sequence:

ATGGCTCCAG GCTCGTGGTT TTCTCCTCTC CTCATCGCTG TGGTCACGCT GGGACTGCCG 
CAGGAAGCTG CTGCCACCTT CCCTGCCATG CCCCTCTCCA ACCTGTTTGC CAACGCTGTG 
CTGAGGGCTC AGCACCTCCA CCTCCTGGCT GCCGAGACAT ATAAAGAGTT CGAACGCACC 
TATATTCCGG AGGACCAGAG GTACACCAAC AAAAACTCCC AGGCTGCGTT TTGTTACTCA 
GAAACCATCC CAGCTCCCAC GGGGAAGGAT GACGCCCAGC AGAAGTCAGA CATGGAGCTG 
CTTCGGTTTT CACTGGTTCT CATCCAGTCC TGGCTGACCC CCGTGCAATA CCTAAGCAAG 
GTGTTCACGA ACAACTTGGT TTTTGGCACC TCAGACAGAG TGTTTGAGAA ACTAAAGGAC 
CTGGAAGAAG GGATCCAAGC CCTGATGAGG GAGCTGGAGG ACCGATCACC GCGGGGCCCG 
CAGCTCCTCA GACCCACCTA CGATAAGTTC GACATCCACC TGCGCAACGA GGACGCCCTG 
CTGAAGAACT ACGGCCTGCT GTCCTGCTTC AAGAAGGATC TGCACAAGGT GGAGACCTAC 
CTGAAGGTGA TGAAGTGCCG GCGCTTCGGA GAGAGCAACT GCACCATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Negative Glucocorticoid Response-Like Element from the First Intron of the Chicken Growth Hormone Gene Represses Gene Expression in the Rat Pituitary Tumor Cell Line.
International journal of molecular sciences17(11)(2016 Nov)
Ma JE,Lang QQ,Qiu FF,Zhang L,Li XG,Luo W,Wang J,Wang X,Lin XR,Liu WS,Nie QH,Zhang XQ

Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH.
General and comparative endocrinology237131-139(2016 Oct)
El-Magd MA,Saleh AA,Abdel-Hamid TM,Saleh RM,Afifi MA

[MspI-POLYMORPHISM IN FOURTH INTRON OF THE GROWTH HORMONE GENE IN CHICKEN POPULATIONS OF DIFFERENT BREEDS. ANALYSIS OF THE CAUSES OF ADDITIONAL RESTRICTION PATTERN ORIGIN].
TSitologiia i genetika49(6)30-7(2015 Nov-Dec)
Kulibaba RA,Yurko PS,Liashenkon YV

Mechanisms involved in glucocorticoid induction of pituitary GH expression during embryonic development.
Endocrinology156(3)1066-79(2015 Mar)
Ellestad LE,Puckett SA,Porter TE

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GH cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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