ADAM10 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADAM10
Entrez Gene ID	374113
Full Name	ADAM metallopeptidase domain 10
General protein information	Preferred Names ADAM metallopeptidase domain 10 Names disintegrin and metalloproteinase domain-containing protein 10 a disintegrin and metalloproteinase domain 10
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204261.2	NP_989592.2	disintegrin and metalloproteinase domain-containing protein 10 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ADAM10	NP_776921.1
Danio rerio (zebrafish)	adam10a	NP_001152786.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003070	XP_312756.5
Xenopus tropicalis (tropical clawed frog)	adam10	NP_001037869.1
Pan troglodytes (chimpanzee)	ADAM10	XP_001172405.1
Mus musculus (house mouse)	Adam10	NP_031425.2
Rattus norvegicus (Norway rat)	Adam10	NP_062127.1
	ADAM10	XP_001097016.1
Homo sapiens (human)	ADAM10	NP_001101.1
Canis lupus familiaris (dog)	ADAM10	XP_005638749.1
Gallus gallus (chicken)	ADAM10	NP_989592.2

Gene Ontology
Bibliography

Related articles in PubMed

ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina.
Paudel S, Kim YH, Huh MI, Kim SJ, Chang Y, Park YJ, Lee KW, Jung JC
Journal of cellular biochemistry114(4)942-54(2013 Apr)

Differential regional expression of multiple ADAMs during feather bud formation.
Lin J, Luo J, Redies C
Developmental dynamics : an official publication of the American Association of Anatomists240(9)2142-52(2011 Sep)

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development.
Markus A, Yan X, Rolfs A, Luo J
Cellular & molecular biology letters16(3)431-51(2011 Sep)

Suppression of ADAM 10-induced Delta-1 shedding inhibits cell proliferation during the chondro-inhibitory action of TGF-beta3.
Jin EJ, Choi YA, Sonn JK, Kang SS
Molecules and cells24(1)139-47(2007 Aug)

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM
Genome biology6(1)R6(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ADAM10 kockdown suppresses the ganglion cell differentiation.
Title: ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina.

ADAM9, ADAM10, and ADAM17 are expressed in the epidermis of the feather bud.
Title: Differential regional expression of multiple ADAMs during feather bud formation.

in cultured chick leg bud mesenchyme cells, TGF-beta 3 downregulates ADAM 10 & inhibits cell proliferation & subsequent precartilage condensation by inhibiting the ectodomain shedding of delta-1, & that this results in the activation of Notch signaling.
Title: Suppression of ADAM 10-induced Delta-1 shedding inhibits cell proliferation during the chondro-inhibitory action of TGF-beta3.

The following ADAM10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAM10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa26652	NM_204261.2 Latest version!	Gallus gallus ADAM metallopeptidase domain 10 (ADAM10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADAM10 ( NM_204261.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989592.2 Gallus gallus ADAM metallopeptidase domain 10 (ADAM10), mRNA.

Price & Availability↑

CloneID	OGa26652
Clone ID Related Accession (Same CDS sequence)	NM_204261.2
Accession Version	NM_204261.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2250bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-20
Organism	Gallus gallus(chicken)
Product	disintegrin and metalloproteinase domain-containing protein 10 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ851442.1, AJ851616.1, AJ723612.1, BU244890.1, AY077631.1, BU140408.1, BU385649.1, BU237332.1 and BU467048.1. On Jul 27, 2012 this sequence version replaced NM_204261.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. COMPLETENESS: complete on the 3' end.

ATGGATCTAG CGAGGACGAT AATCCTGCTG TGCTCCTGGG CGGCGGGCGC CGGAGGCCAA 
TATGGAAATC CTCTAAATAA ATACATTAGA CATTATGAAG GATTATCTTA TGATGTGGAT 
TTGTTACACC AAAAACACCA GCGTGCCAAA AGAGCAGTAT CGCATGAAGA TCAGTTCTTG 
CGCCTCGACT TTCATGCTCA TGGAAGACAA TTCAACCTTC GAATGAAGAG AGATACATCT 
CTTTTTAGTG AGGACTTTAA ATTAGAAACA TCAAACCAAG TAATTGATTA TGATACCTCC 
CATATTTACA CTGGACACAT TTATGGTGAG CAGGGAAGTT TTAGCCATGG GTCTGTTATT 
GATGGAAGAT TTGAAGGATT CATCCAAACT CACAGTGGGA CCTTTTATGT TGAGCCAGCA 
GAGAGATATA TTAAGGACAG AACTCTACCG TTCCACTCTG TCATCTATCA TGAAGATGAT 
ATCAAATATC CTCATAAATA TGGACCACAA GGAGGTTGTG CAGATCATTC AGTGTTTGAA 
AGAATGCAGA AGTACCAGAT GACTGGTATA GAAGAACCAA CAACAGAGAA GCCTTCTGAA 
GAGTCTGACA GCGACGGTCC TCAGCTTTTA AGAAAAAAAC GTGCCACTCA AGCTGAAAAA 
AACACTTGTC AGCTGTATAT TCAGACTGAT CATCTGTTCT ATAAACACTA TGGAACAAGG 
GAAGCTGTAA TTGCACAGAT ATCCAGCCAT GTTAAAGCAA TTGACACAAT TTACCGCTCA 
ACAGATTTCT CAGGAATCCG TAACATCAGC TTTATGGTGA AGCGAATAAG AATTAACACA 
ACTGTAGATG AGAAGGACCC TTCAAATCCC TTCAGGTTTC CTAACATTGG TGTGGAAAAG 
TTTCTGGAAC TGAACTCAGA ACAGAATCAT GATGATTATT GTTTGGCCTA TGTATTTACG 
GACCGTGATT TTGATGATGG AGTCCTTGGT CTAGCTTGGG TTGGAGCCCC TTCAGGAAGC 
TCTGGTGGGA TATGTGAAAA GAGCAAACTG TATTCTGATG GTAAGAAGAA GTCTTTGAAC 
ACTGGAATCA TCACTGTTCA GAACTATGGC TCTCATGTTC CTCCCAAGGT TTCGCATATC 
ACTTTTGCTC ATGAGGTTGG ACATAACTTT GGCTCACCTC ATGATTCTGG AATGGAATGC 
ACTCCAGGGG AGTCCAAGAA CTTGGGACAG AAAGAAAATG GGAATTATAT CATGTATGCA 
AGAGCTACAT CTGGGGACAA ACTTAATAAC AACAAGTTCT CACTCTGTAG TATTCGAAAT 
ATCAGCCAAG TTCTTGAGAA AAAGAGAAAT AACTGCTTTG TTGAGTCTGG TCAACCTATC 
TGTGGTAATG GACTGGTAGA AGAAGGAGAG CAGTGTGATT GTGGATACAG TGATCAGTGT 
AAAGATGAAT GCTGTTACGA TGCAAACCAA TCAGATGATA AAAAATGCAA GTTAAAACCA 
GGCAAATCCT GCAGCCCTAG CCAAGGCCCT TGCTGTACTG CGCAATGTAA TTTCAAACTG 
AAGACTGATA AGTGCCGAAA TGATTCGGAC TGTGCGAGGG AGGGAATGTG TAATGGTTAC 
AGTGCTCTCT GTCCTGCCTC TCAGCCTAAA CAGAACTTCA CAGAATGCAA CAGGCGTACA 
CAAGTTTGCA TAAAAGGGCA ATGTACTGGC TCTATCTGTG AGAAGTACGA CTTGGAGGAA 
TGCACATGCG CTAGTTCAGA TGGCAAGGAT GACAGAGAAC TGTGTCATGT CTGCTGCATG 
AGAAAAATGG ACCCGGATAC TTGTGCAAGC ACGGGCTCCA GCCGCTGGGA GAAACACTTT 
GCTCGTAAAA CTATTACGTT GCAACCAGGA TCTCCTTGTA ATGATTTCAG AGGCTACTGT 
GATGTGTTTA TGAGATGTCG GCTGGTAGAT GCTGATGGCC CTCTAGCTCG GTTAAAGAAA 
GCAATTTTTA ATCCTGAGCT GTATGAAAAT ATTGCAGAAT GGATCGTGGC TCATTGGTGG 
GCAGTATTGC TTATGGGAAT TGCCCTGATC ATGTTAATGG CTGGTTTCAT TAAGATATGC 
AGTGTTCATA CTCCAAGCAG TAATCCAAAG TTGCCTCCTC ATAAACCACT TCCAGGCACT 
TTAAAAAGGA GGAGACCGCC ACAAACTGCT CAGCCACCAC AGCGACAAAG GCCCCGAGAG 
AGCTATCAGA TGGGACATAT GAGACATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989592.2
CDS	230..2479
Translation	MDLARTIILLCSWAAGAGGQYGNPLNKYIRHYEGLSYDVDLLHQKHQRAKRAVSHEDQFLRLDFHAHGRQFNLRMKRDTSLFSEDFKLETSNQVIDYDTSHIYTGHIYGEQGSFSHGSVIDGRFEGFIQTHSGTFYVEPAERYIKDRTLPFHSVIYHEDDIKYPHKYGPQGGCADHSVFERMQKYQMTGIEEPTTEKPSEESDSDGPQLLRKKRATQAEKNTCQLYIQTDHLFYKHYGTREAVIAQISSHVKAIDTIYRSTDFSGIRNISFMVKRIRINTTVDEKDPSNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGMECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGLVEEGEQCDCGYSDQCKDECCYDANQSDDKKCKLKPGKSCSPSQGPCCTAQCNFKLKTDKCRNDSDCAREGMCNGYSALCPASQPKQNFTECNRRTQVCIKGQCTGSICEKYDLEECTCASSDGKDDRELCHVCCMRKMDPDTCASTGSSRWEKHFARKTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFNPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPHKPLPGTLKRRRPPQTAQPPQRQRPRESYQMGHMRH

Target ORF information:

RefSeq Version	NM_204261.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus ADAM metallopeptidase domain 10 (ADAM10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204261.2

ORF Insert Sequence:

ATGGATCTAG CGAGGACGAT AATCCTGCTG TGCTCCTGGG CGGCGGGCGC CGGAGGCCAA 
TATGGAAATC CTCTAAATAA ATACATTAGA CATTATGAAG GATTATCTTA TGATGTGGAT 
TTGTTACACC AAAAACACCA GCGTGCCAAA AGAGCAGTAT CGCATGAAGA TCAGTTCTTG 
CGCCTCGACT TTCATGCTCA TGGAAGACAA TTCAACCTTC GAATGAAGAG AGATACATCT 
CTTTTTAGTG AGGACTTTAA ATTAGAAACA TCAAACCAAG TAATTGATTA TGATACCTCC 
CATATTTACA CTGGACACAT TTATGGTGAG CAGGGAAGTT TTAGCCATGG GTCTGTTATT 
GATGGAAGAT TTGAAGGATT CATCCAAACT CACAGTGGGA CCTTTTATGT TGAGCCAGCA 
GAGAGATATA TTAAGGACAG AACTCTACCG TTCCACTCTG TCATCTATCA TGAAGATGAT 
ATCAAATATC CTCATAAATA TGGACCACAA GGAGGTTGTG CAGATCATTC AGTGTTTGAA 
AGAATGCAGA AGTACCAGAT GACTGGTATA GAAGAACCAA CAACAGAGAA GCCTTCTGAA 
GAGTCTGACA GCGACGGTCC TCAGCTTTTA AGAAAAAAAC GTGCCACTCA AGCTGAAAAA 
AACACTTGTC AGCTGTATAT TCAGACTGAT CATCTGTTCT ATAAACACTA TGGAACAAGG 
GAAGCTGTAA TTGCACAGAT ATCCAGCCAT GTTAAAGCAA TTGACACAAT TTACCGCTCA 
ACAGATTTCT CAGGAATCCG TAACATCAGC TTTATGGTGA AGCGAATAAG AATTAACACA 
ACTGTAGATG AGAAGGACCC TTCAAATCCC TTCAGGTTTC CTAACATTGG TGTGGAAAAG 
TTTCTGGAAC TGAACTCAGA ACAGAATCAT GATGATTATT GTTTGGCCTA TGTATTTACG 
GACCGTGATT TTGATGATGG AGTCCTTGGT CTAGCTTGGG TTGGAGCCCC TTCAGGAAGC 
TCTGGTGGGA TATGTGAAAA GAGCAAACTG TATTCTGATG GTAAGAAGAA GTCTTTGAAC 
ACTGGAATCA TCACTGTTCA GAACTATGGC TCTCATGTTC CTCCCAAGGT TTCGCATATC 
ACTTTTGCTC ATGAGGTTGG ACATAACTTT GGCTCACCTC ATGATTCTGG AATGGAATGC 
ACTCCAGGGG AGTCCAAGAA CTTGGGACAG AAAGAAAATG GGAATTATAT CATGTATGCA 
AGAGCTACAT CTGGGGACAA ACTTAATAAC AACAAGTTCT CACTCTGTAG TATTCGAAAT 
ATCAGCCAAG TTCTTGAGAA AAAGAGAAAT AACTGCTTTG TTGAGTCTGG TCAACCTATC 
TGTGGTAATG GACTGGTAGA AGAAGGAGAG CAGTGTGATT GTGGATACAG TGATCAGTGT 
AAAGATGAAT GCTGTTACGA TGCAAACCAA TCAGATGATA AAAAATGCAA GTTAAAACCA 
GGCAAATCCT GCAGCCCTAG CCAAGGCCCT TGCTGTACTG CGCAATGTAA TTTCAAACTG 
AAGACTGATA AGTGCCGAAA TGATTCGGAC TGTGCGAGGG AGGGAATGTG TAATGGTTAC 
AGTGCTCTCT GTCCTGCCTC TCAGCCTAAA CAGAACTTCA CAGAATGCAA CAGGCGTACA 
CAAGTTTGCA TAAAAGGGCA ATGTACTGGC TCTATCTGTG AGAAGTACGA CTTGGAGGAA 
TGCACATGCG CTAGTTCAGA TGGCAAGGAT GACAGAGAAC TGTGTCATGT CTGCTGCATG 
AGAAAAATGG ACCCGGATAC TTGTGCAAGC ACGGGCTCCA GCCGCTGGGA GAAACACTTT 
GCTCGTAAAA CTATTACGTT GCAACCAGGA TCTCCTTGTA ATGATTTCAG AGGCTACTGT 
GATGTGTTTA TGAGATGTCG GCTGGTAGAT GCTGATGGCC CTCTAGCTCG GTTAAAGAAA 
GCAATTTTTA ATCCTGAGCT GTATGAAAAT ATTGCAGAAT GGATCGTGGC TCATTGGTGG 
GCAGTATTGC TTATGGGAAT TGCCCTGATC ATGTTAATGG CTGGTTTCAT TAAGATATGC 
AGTGTTCATA CTCCAAGCAG TAATCCAAAG TTGCCTCCTC ATAAACCACT TCCAGGCACT 
TTAAAAAGGA GGAGACCGCC ACAAACTGCT CAGCCACCAC AGCGACAAAG GCCCCGAGAG 
AGCTATCAGA TGGGACATAT GAGACATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ADAM10 mediates N-cadherin ectodomain shedding during retinal ganglion cell differentiation in primary cultured retinal cells from the developing chick retina.
Journal of cellular biochemistry114(4)942-54(2013 Apr)
Paudel S,Kim YH,Huh MI,Kim SJ,Chang Y,Park YJ,Lee KW,Jung JC

Differential regional expression of multiple ADAMs during feather bud formation.
Developmental dynamics : an official publication of the American Association of Anatomists240(9)2142-52(2011 Sep)
Lin J,Luo J,Redies C

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development.
Cellular & molecular biology letters16(3)431-51(2011 Sep)
Markus A,Yan X,Rolfs A,Luo J

Suppression of ADAM 10-induced Delta-1 shedding inhibits cell proliferation during the chondro-inhibitory action of TGF-beta3.
Molecules and cells24(1)139-47(2007 Aug)
Jin EJ,Choi YA,Sonn JK,Kang SS

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Genome biology6(1)R6(2005)
Caldwell RB,Kierzek AM,Arakawa H,Bezzubov Y,Zaim J,Fiedler P,Kutter S,Blagodatski A,Kostovska D,Koter M,Plachy J,Carninci P,Hayashizaki Y,Buerstedde JM

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ADAM10 cDNA ORF clone, Gallus gallus(chicken)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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