CRY1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRY1
Entrez Gene ID	374093
Full Name	cryptochrome circadian clock 1
General protein information	Preferred Names cryptochrome circadian clock 1 Names cryptochrome-1 cryptochrome 1 (photolyase-like)
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_204245.1	NP_989576.1	cryptochrome-1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CRY1	NP_001098885.1
Mus musculus (house mouse)	Cry1	NP_031797.1
Gallus gallus (chicken)	CRY1	NP_989576.1
Xenopus tropicalis (tropical clawed frog)	cry1	NP_001017311.2
Danio rerio (zebrafish)	cry1a	NP_001070765.2
	CRY1	XP_001100653.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004261	XP_313179.4
Rattus norvegicus (Norway rat)	Cry1	NP_942045.2
Homo sapiens (human)	CRY1	NP_004066.1
Pan troglodytes (chimpanzee)	CRY1	XP_509339.2
Canis lupus familiaris (dog)	CRY1	XP_005625994.1
Danio rerio (zebrafish)	cry1b	NP_571865.4

Gene Ontology
Bibliography

Related articles in PubMed

Magnetoreception: activated cryptochrome 1a concurs with magnetic orientation in birds.
Nie?ner C, Denzau S, Stapput K, Ahmad M, Peichl L, Wiltschko W, Wiltschko R
Journal of the Royal Society, Interface10(88)20130638(2013 Nov)

Avian ultraviolet/violet cones identified as probable magnetoreceptors.
Niessner C, Denzau S, Gross JC, Peichl L, Bischof HJ, Fleissner G, Wiltschko W, Wiltschko R
PloS one6(5)e20091(2011)

Cry1 expression in the chicken pineal gland: effects of changes in the light/dark conditions.
Nagy AD, Csernus VJ
General and comparative endocrinology152(2-3)144-7(2007 Jun-Jul)

Chicken pineal Cry genes: light-dependent up-regulation of cCry1 and cCry2 transcripts.
Yamamoto K, Okano T, Fukada Y
Neuroscience letters313(1-2)13-6(2001 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Activated Cry1a is thus found at all those wavelengths at which birds can orient using their magnetic inclination compass, supporting the role of Cry1a as receptor molecule.
Title: Magnetoreception: activated cryptochrome 1a concurs with magnetic orientation in birds.

environmental illumination activates a complex regulatory cascade that includes both up- and down-regulation of the Cry1 gene which inverses the 24h pattern of Cry1 mRNA expression within one period
Title: Cry1 expression in the chicken pineal gland: effects of changes in the light/dark conditions.

data characterize a non-opsin photoreception mechanism in the chick iris and suggest a conserved photoreceptive role for cryptochromes in vertebrates
Title: Nonvisual photoreception in the chick iris.

The following CRY1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRY1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa00301	NM_204245.1 Latest version!	Gallus gallus cryptochrome circadian regulator 1 (CRY1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRY1 ( NM_204245.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989576.1 Gallus gallus cryptochrome circadian regulator 1 (CRY1), mRNA.

Price & Availability↑

CloneID	OGa00301
Clone ID Related Accession (Same CDS sequence)	NM_204245.1
Accession Version	NM_204245.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1866bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Gallus gallus(chicken)
Product	cryptochrome-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY034432.1. ##Evidence-Data-START## Transcript exon combination :: AY034432.1 [ECO:0000332] ##Evidence-Data-END##

ATGGGGGTGA ACGCCGTGCA CTGGTTCCGC AAGGGGCTGC GGCTCCACGA CAACCCGGCG 
CTGCGGGAGT GCATCCGGGG CGCCGACACC GTGCGCTGCG TCTACATCCT GGACCCCTGG 
TTCGCCGGCT CCTCCAACGT GGGCATCAAC CGCTGGCGGT TTCTGCTTCA GTGTCTTGAG 
GATCTTGATG CCAATCTACG GAAACTGAAT TCACGTTTGT TTGTTATTCG TGGACAGCCA 
GCAGATGTTT TCCCCAGGCT TTTTAAGGAA TGGAGCATTG CAAAACTCTC TATTGAATAT 
GATTCTGAAC CGTTTGGGAA GGAGAGAGAT GCAGCAATTA AGAAGCTGGC TAGTGAAGCT 
GGAGTGGAGG TCATCGTTCG AATTTCTCAC ACATTATATG ACCTAGACAA AATAATAGAA 
TTAAATGGAG GACAGCCACC TCTTACTTAC AAGCGATTCC AGACTCTAAT TAGTAGGATG 
GAACCACTGG AGATGCCAGT GGAGACTATA ACCCCAGAGG TAATGCAGAA ATGTACCACT 
CCTGTCTCTG ATGACCATGA TGAGAAATAC GGTGTCCCGT CGCTTGAAGA GCTAGGTTTT 
GACACAGATG GTCTGCCTTC TGCAGTATGG CCTGGGGGAG AAACAGAAGC TCTCACACGA 
CTGGAAAGGC ATCTAGAACG AAAGGCTTGG GTAGCAAACT TTGAAAGACC ACGAATGAAC 
GCCAATTCCC TTCTGGCAAG CCCTACAGGG CTTAGTCCCT ACCTCCGCTT TGGCTGTTTG 
TCCTGTCGAC TCTTTTATTT CAAGTTAACG GACCTGTACA AAAAGGTAAA AAAGAACAGC 
TCCCCTCCCC TCTCCCTCTA TGGCCAGCTG TTATGGCGTG AATTTTTCTA CACAGCAGCA 
ACTAACAATC CACGGTTTGA TAAAATGGAG GGGAATCCTA TCTGTGTTCA AATTCCATGG 
GATAAGAATC CTGAGGCTTT GGCCAAATGG GCAGAAGGCA GGACAGGTTT TCCTTGGATT 
GATGCAATTA TGACGCAGCT TCGTCAAGAA GGCTGGATTC ACCACTTAGC TCGGCATGCT 
GTGGCATGCT TTTTGACTCG AGGTGACCTC TGGATTAGCT GGGAAGAAGG AATGAAGGTC 
TTTGAAGAGC TCTTACTTGA TGCAGATTGG AGTGTGAATG CTGGAAGCTG GATGTGGCTA 
TCCTGTAGTT CCTTCTTTCA GCAGTTTTTT CACTGCTACT GTCCAGTGGG TTTTGGCAGA 
AGAACTGACC CAAATGGAGA TTACATCAGA CGTTACTTGC CTGTACTTAG AGGTTTCCCT 
GCAAAATACA TCTATGATCC TTGGAATGCC CCAGAGAGTG TCCAGAAGGC TGCAAAATGT 
GTTATAGGAG TTAACTATCC CAAACCAATG GTAAACCATG CGGAAGCAAG CCGTCTGAAT 
ATTGAGAGGA TGAAACAAAT CTACCAGCAG CTTTCACGAT ACAGAGGACT GGGTCTTCTT 
GCAACAGTGC CTTCTAATCC AAATGGAAAT GGAAATGGTG GCCTAATGAG CTTTTCACCA 
GGAGAAAGCA TTTCTGGTTG CAGCAGTGCA GGAGGAGCTC AGCTGGGAAC TGGTGATGGT 
CAGACAGTTG GCGTTCAGAC ATGTGCCCTG GGAGACTCTC ATACAGGAGG AAGTGGAGTT 
CAGCAGCAAG GTTACTGTCA AGCAAGTAGT ATCTTACGCT ACGCTCATGG AGACAATCAG 
CAATCACACT TAATGCAACC AGGAAGAGCA TCTCTTGGTA CTGGCATTAG CGCCGGGAAA 
CGCCCAAATC CAGAAGAAGA AACTCAAAGT GTTGGGCCGA AAGTCCAGCG GCAGAGCACA 
AATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989576.1
CDS	96..1961
Translation	MGVNAVHWFRKGLRLHDNPALRECIRGADTVRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFKEWSIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDKIIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMQKCTTPVSDDHDEKYGVPSLEELGFDTDGLPSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPESVQKAAKCVIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLATVPSNPNGNGNGGLMSFSPGESISGCSSAGGAQLGTGDGQTVGVQTCALGDSHTGGSGVQQQGYCQASSILRYAHGDNQQSHLMQPGRASLGTGISAGKRPNPEEETQSVGPKVQRQSTN

Target ORF information:

RefSeq Version	NM_204245.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus cryptochrome circadian regulator 1 (CRY1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204245.1

ORF Insert Sequence:

ATGGGGGTGA ACGCCGTGCA CTGGTTCCGC AAGGGGCTGC GGCTCCACGA CAACCCGGCG 
CTGCGGGAGT GCATCCGGGG CGCCGACACC GTGCGCTGCG TCTACATCCT GGACCCCTGG 
TTCGCCGGCT CCTCCAACGT GGGCATCAAC CGCTGGCGGT TTCTGCTTCA GTGTCTTGAG 
GATCTTGATG CCAATCTACG GAAACTGAAT TCACGTTTGT TTGTTATTCG TGGACAGCCA 
GCAGATGTTT TCCCCAGGCT TTTTAAGGAA TGGAGCATTG CAAAACTCTC TATTGAATAT 
GATTCTGAAC CGTTTGGGAA GGAGAGAGAT GCAGCAATTA AGAAGCTGGC TAGTGAAGCT 
GGAGTGGAGG TCATCGTTCG AATTTCTCAC ACATTATATG ACCTAGACAA AATAATAGAA 
TTAAATGGAG GACAGCCACC TCTTACTTAC AAGCGATTCC AGACTCTAAT TAGTAGGATG 
GAACCACTGG AGATGCCAGT GGAGACTATA ACCCCAGAGG TAATGCAGAA ATGTACCACT 
CCTGTCTCTG ATGACCATGA TGAGAAATAC GGTGTCCCGT CGCTTGAAGA GCTAGGTTTT 
GACACAGATG GTCTGCCTTC TGCAGTATGG CCTGGGGGAG AAACAGAAGC TCTCACACGA 
CTGGAAAGGC ATCTAGAACG AAAGGCTTGG GTAGCAAACT TTGAAAGACC ACGAATGAAC 
GCCAATTCCC TTCTGGCAAG CCCTACAGGG CTTAGTCCCT ACCTCCGCTT TGGCTGTTTG 
TCCTGTCGAC TCTTTTATTT CAAGTTAACG GACCTGTACA AAAAGGTAAA AAAGAACAGC 
TCCCCTCCCC TCTCCCTCTA TGGCCAGCTG TTATGGCGTG AATTTTTCTA CACAGCAGCA 
ACTAACAATC CACGGTTTGA TAAAATGGAG GGGAATCCTA TCTGTGTTCA AATTCCATGG 
GATAAGAATC CTGAGGCTTT GGCCAAATGG GCAGAAGGCA GGACAGGTTT TCCTTGGATT 
GATGCAATTA TGACGCAGCT TCGTCAAGAA GGCTGGATTC ACCACTTAGC TCGGCATGCT 
GTGGCATGCT TTTTGACTCG AGGTGACCTC TGGATTAGCT GGGAAGAAGG AATGAAGGTC 
TTTGAAGAGC TCTTACTTGA TGCAGATTGG AGTGTGAATG CTGGAAGCTG GATGTGGCTA 
TCCTGTAGTT CCTTCTTTCA GCAGTTTTTT CACTGCTACT GTCCAGTGGG TTTTGGCAGA 
AGAACTGACC CAAATGGAGA TTACATCAGA CGTTACTTGC CTGTACTTAG AGGTTTCCCT 
GCAAAATACA TCTATGATCC TTGGAATGCC CCAGAGAGTG TCCAGAAGGC TGCAAAATGT 
GTTATAGGAG TTAACTATCC CAAACCAATG GTAAACCATG CGGAAGCAAG CCGTCTGAAT 
ATTGAGAGGA TGAAACAAAT CTACCAGCAG CTTTCACGAT ACAGAGGACT GGGTCTTCTT 
GCAACAGTGC CTTCTAATCC AAATGGAAAT GGAAATGGTG GCCTAATGAG CTTTTCACCA 
GGAGAAAGCA TTTCTGGTTG CAGCAGTGCA GGAGGAGCTC AGCTGGGAAC TGGTGATGGT 
CAGACAGTTG GCGTTCAGAC ATGTGCCCTG GGAGACTCTC ATACAGGAGG AAGTGGAGTT 
CAGCAGCAAG GTTACTGTCA AGCAAGTAGT ATCTTACGCT ACGCTCATGG AGACAATCAG 
CAATCACACT TAATGCAACC AGGAAGAGCA TCTCTTGGTA CTGGCATTAG CGCCGGGAAA 
CGCCCAAATC CAGAAGAAGA AACTCAAAGT GTTGGGCCGA AAGTCCAGCG GCAGAGCACA 
AATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Magnetoreception: activated cryptochrome 1a concurs with magnetic orientation in birds.
Journal of the Royal Society, Interface10(88)20130638(2013 Nov)
Nie?ner C,Denzau S,Stapput K,Ahmad M,Peichl L,Wiltschko W,Wiltschko R

Avian ultraviolet/violet cones identified as probable magnetoreceptors.
PloS one6(5)e20091(2011)
Niessner C,Denzau S,Gross JC,Peichl L,Bischof HJ,Fleissner G,Wiltschko W,Wiltschko R

Cry1 expression in the chicken pineal gland: effects of changes in the light/dark conditions.
General and comparative endocrinology152(2-3)144-7(2007 Jun-Jul)
Nagy AD,Csernus VJ

Chicken pineal Cry genes: light-dependent up-regulation of cCry1 and cCry2 transcripts.
Neuroscience letters313(1-2)13-6(2001 Nov)
Yamamoto K,Okano T,Fukada Y

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CRY1 cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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