CALD1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	CALD1
Entrez Gene ID	373965
Full Name	caldesmon 1
General protein information	Preferred Names caldesmon 1 Names caldesmon CDM
Gene Type	protein-coding
Organism	Gallus gallus(chicken)

mRNA and Protein(s)

mRNA	Protein	Name
NM_204158.1	NP_989489.1	caldesmon

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cald1	NP_663550.1
Rattus norvegicus (Norway rat)	Cald1	NP_037278.1
Pan troglodytes (chimpanzee)	CALD1	XP_001142755.2
	CALD1	XP_001104210.2
Gallus gallus (chicken)	CALD1	NP_989489.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinity.
Hamden SS, Schroeter MM, Chalovich JM
Biophysical journal99(6)1861-8(2010 Sep)

Modulation of actin mechanics by caldesmon and tropomyosin.
Greenberg MJ, Wang CL, Lehman W, Moore JR
Cell motility and the cytoskeleton65(2)156-64(2008 Feb)

The mechanism of smooth muscle caldesmon-tropomyosin inhibition of the elementary steps of the actomyosin ATPase.
Alahyan M, Webb MR, Marston SB, El-Mezgueldi M
The Journal of biological chemistry281(28)19433-48(2006 Jul)

Modes of caldesmon binding to actin: sites of caldesmon contact and modulation of interactions by phosphorylation.
Foster DB, Huang R, Hatch V, Craig R, Graceffa P, Lehman W, Wang CL
The Journal of biological chemistry279(51)53387-94(2004 Dec)

Natively unfolded C-terminal domain of caldesmon remains substantially unstructured after the effective binding to calmodulin.
Permyakov SE, Millett IS, Doniach S, Permyakov EA, Uversky VN
Proteins53(4)855-62(2003 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the region between residues 627 and 642 may contribute to the overall regulation of caldesmon's activity
Title: Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinity.

interstrand crosslinking by the C-terminal actin-binding fragment of caldesmon, H32K, increases persistence length by 1.6-fold for actin filament
Title: Modulation of actin mechanics by caldesmon and tropomyosin.

steady state actomyosin ATPase by caldesmon and tropomyosin
Title: The mechanism of smooth muscle caldesmon-tropomyosin inhibition of the elementary steps of the actomyosin ATPase.

unphosphorylated, but not ERK-phosphorylated, caldesmon could stabilize actin filaments and resist F-actin severing or depolymerization in both smooth muscle and nonmuscle cells
Title: Modes of caldesmon binding to actin: sites of caldesmon contact and modulation of interactions by phosphorylation.

The following CALD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CALD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa28096	NM_204158.1 Latest version!	Gallus gallus caldesmon 1 (CALD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CALD1 ( NM_204158.1 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_989489.1 Gallus gallus caldesmon 1 (CALD1), mRNA.

Price & Availability↑

CloneID	OGa28096
Clone ID Related Accession (Same CDS sequence)	NM_204158.1
Accession Version	NM_204158.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2271bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Gallus gallus(chicken)
Product	caldesmon
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J04968.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J04968.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATGACT TTGAACGCCG TAGAGAACTC AGGAGGCAAA AGCGTGAGGA AATGCGCCTT 
GAAGCAGAGA GACTGTCCTA CCAGAGAAAT GATGATGATG AGGAAGAAGC TGCCAGAGAA 
CGTCGTCGAC GAGCTCGACA GGAAAGGCTG CGGCAAAAGG AAGAAGGAGA TGTATCAGGG 
GAAGTAACAG AGAAATCAGA AGTTAATGCC CAGAACAGTG TGGCAGAAGA AGAAACGAAA 
CGTAGTACAG ATGATGAAGC TGCATTGTTG GAGAGACTGG CAAGACGGGA AGAGAGACGC 
CAAAAACGTC TACAGGAAGC CCTGGAACGT CAAAAGGAAT TTGACCCAAC GATCACAGAT 
GGGAGCTTGT CAGTGCCCAG CAGGAGAGAA GTAAACAATG TGGAAGAAAA TGAGATCACA 
GGGAAAGAGG AAAAGGTTGA AACACGCCAA GGACGCTGTG AGATTGAGGA AACAGAAACA 
GTTACCAAAT CGTACCAAAG GAACAATTGG AGGCAAGATG GAGAAGAAGA GGGAAAAAAA 
GAAGAAAAAG ACTCAGAAGA GGAGAAACCA AAGGAGGTAC CCACAGAGGA AAATCAGGTA 
GATGTGGCAG TAGAAAAGTC CACAGATAAA GAAGAGGTGG TAGAAACAAA AACTCTAGCT 
GTAAATGCAG AGAATGATAC AAATGCTATG CTGGAAGGGG AGCAGAGTAT AACTGATGCT 
GCAGATAAAG AGAAGGAAGA GGCTGAGAAA GAAAGGGAGA AACTTGAGGC AGAAGAAAAG 
GAGAGGTTAA AAGCAGAAGA AGAAAAGAAG GCAGCTGAAG AAAAACAGAA AGCAGAGGAG 
GAAAAGAAGG CAGCTGAGGA AAGAGAGCGG GCTAAAGCAG AAGAGGAGAA GAGAGCAGCT 
GAGGAAAGAG AGAGGGCTAA GGCAGAAGAG GAGAGGAAAG CAGCTGAGGA GAGGGCTAAG 
GCAGAAGAGG AAAGGAAAGC AGCTGAGGAG AGGGCTAAGG CAGAAGAGGA AAGGAAAGCA 
GCTGAGGAGA GGGCTAAGGC AGAAAAGGAG AGGAAAGCAG CTGAGGAGAG AGAGAGGGCT 
AAGGCAGAAG AGGAAAAGAG GGCAGCTGAA GAAAAGGCTA GGTTAGAGGC AGAAAAATTA 
AAGGAAAAGA AAAAGATGGA AGAGAAGAAA GCCCAAGAGG AAAAAGCTCA AGCAAATTTG 
CTAAGAAAAC AGGAGGAAGA CAAAGAGGCT AAAGTGGAAG CTAAAAAGGA AAGCTTACCA 
GAGAAGCTTC AACCTACCTC CAAAAAAGAT CAGGTAAAAG ACAACAAGGA TAAAGAAAAA 
GCACCCAAGG AGGAAATGAA GAGTGTCTGG GATCGTAAAA GGGGAGTTCC AGAACAAAAG 
GCACAGAATG GAGAACGTGA ACTCACTACC CCCAAACTTA AATCTACTGA AAATGCTTTT 
GGACGCTCCA ACTTGAAAGG AGCTGCAAAT GCTGAGGCTG GCTCCGAGAA GCTGAAGGAG 
AAACAGCAGG AGGCAGCTGT GGAGCTGGAT GAGCTGAAGA AAAGGCGGGA GGAGCGCCGG 
AAAATCCTGG AGGAAGAGGA GCAGAAGAAG AAACAGGAGG AGGCTGAGAG AAAAATCAGA 
GAGGAGGAGG AAAAGAAGAG GATGAAGGAA GAAATTGAAA GGAGAAGAGC TGAAGCTGCT 
GAGAAACGTC AGAAAGTGCC AGAAGATGGC GTATCTGAAG AAAAGAAGCC ATTTAAATGT 
TTCAGTCCTA AAGGTTCATC TCTCAAGATA GAAGAACGAG CAGAATTTTT GAACAAATCC 
GCTCAGAAGA GTGGTATGAA ACCTGCCCAC ACGACAGCAG TTGTCTCAAA GATTGACAGT 
AGACTTGAGC AATATACTAG TGCAGTTGTG GGCAACAAGG CTGCAAAACC CGCCAAACCA 
GCAGCCTCTG ACCTTCCTGT TCCAGCTGAG GGTGTCCGTA ATATCAAGAG CATGTGGGAG 
AAAGGGAATG TTTTTTCATC ACCTGGGGGA ACAGGAACAC CAAATAAGGA AACTGCTGGA 
CTGAAAGTTG GTGTCTCCAG TCGTATCAAC GAATGGCTAA CCAAGACCCC AGAGGGTAAC 
AAATCGCCTG CTCCAAAACC TTCTGATTTA AGACCAGGAG ATGTATCCGG CAAACGTAAT 
CTCTGGGAGA AGCAGTCAGT TGAAAAGCCA GCTGCTTCTT CTTCAAAGGT AACAGCTACG 
GGGAAAAAAT CAGAGACTAA TGGTTTGAGA CAATTTGAGA AAGAACCGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_989489.1
CDS	235..2505
Translation	MDDFERRRELRRQKREEMRLEAERLSYQRNDDDEEEAARERRRRARQERLRQKEEGDVSGEVTEKSEVNAQNSVAEEETKRSTDDEAALLERLARREERRQKRLQEALERQKEFDPTITDGSLSVPSRREVNNVEENEITGKEEKVETRQGRCEIEETETVTKSYQRNNWRQDGEEEGKKEEKDSEEEKPKEVPTEENQVDVAVEKSTDKEEVVETKTLAVNAENDTNAMLEGEQSITDAADKEKEEAEKEREKLEAEEKERLKAEEEKKAAEEKQKAEEEKKAAEERERAKAEEEKRAAEERERAKAEEERKAAEERAKAEEERKAAEERAKAEEERKAAEERAKAEKERKAAEERERAKAEEEKRAAEEKARLEAEKLKEKKKMEEKKAQEEKAQANLLRKQEEDKEAKVEAKKESLPEKLQPTSKKDQVKDNKDKEKAPKEEMKSVWDRKRGVPEQKAQNGERELTTPKLKSTENAFGRSNLKGAANAEAGSEKLKEKQQEAAVELDELKKRREERRKILEEEEQKKKQEEAERKIREEEEKKRMKEEIERRRAEAAEKRQKVPEDGVSEEKKPFKCFSPKGSSLKIEERAEFLNKSAQKSGMKPAHTTAVVSKIDSRLEQYTSAVVGNKAAKPAKPAASDLPVPAEGVRNIKSMWEKGNVFSSPGGTGTPNKETAGLKVGVSSRINEWLTKTPEGNKSPAPKPSDLRPGDVSGKRNLWEKQSVEKPAASSSKVTATGKKSETNGLRQFEKEP

Target ORF information:

RefSeq Version	NM_204158.1
Organism	Gallus gallus(chicken)
Definition	Gallus gallus caldesmon 1 (CALD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_204158.1

ORF Insert Sequence:

ATGGATGACT TTGAACGCCG TAGAGAACTC AGGAGGCAAA AGCGTGAGGA AATGCGCCTT 
GAAGCAGAGA GACTGTCCTA CCAGAGAAAT GATGATGATG AGGAAGAAGC TGCCAGAGAA 
CGTCGTCGAC GAGCTCGACA GGAAAGGCTG CGGCAAAAGG AAGAAGGAGA TGTATCAGGG 
GAAGTAACAG AGAAATCAGA AGTTAATGCC CAGAACAGTG TGGCAGAAGA AGAAACGAAA 
CGTAGTACAG ATGATGAAGC TGCATTGTTG GAGAGACTGG CAAGACGGGA AGAGAGACGC 
CAAAAACGTC TACAGGAAGC CCTGGAACGT CAAAAGGAAT TTGACCCAAC GATCACAGAT 
GGGAGCTTGT CAGTGCCCAG CAGGAGAGAA GTAAACAATG TGGAAGAAAA TGAGATCACA 
GGGAAAGAGG AAAAGGTTGA AACACGCCAA GGACGCTGTG AGATTGAGGA AACAGAAACA 
GTTACCAAAT CGTACCAAAG GAACAATTGG AGGCAAGATG GAGAAGAAGA GGGAAAAAAA 
GAAGAAAAAG ACTCAGAAGA GGAGAAACCA AAGGAGGTAC CCACAGAGGA AAATCAGGTA 
GATGTGGCAG TAGAAAAGTC CACAGATAAA GAAGAGGTGG TAGAAACAAA AACTCTAGCT 
GTAAATGCAG AGAATGATAC AAATGCTATG CTGGAAGGGG AGCAGAGTAT AACTGATGCT 
GCAGATAAAG AGAAGGAAGA GGCTGAGAAA GAAAGGGAGA AACTTGAGGC AGAAGAAAAG 
GAGAGGTTAA AAGCAGAAGA AGAAAAGAAG GCAGCTGAAG AAAAACAGAA AGCAGAGGAG 
GAAAAGAAGG CAGCTGAGGA AAGAGAGCGG GCTAAAGCAG AAGAGGAGAA GAGAGCAGCT 
GAGGAAAGAG AGAGGGCTAA GGCAGAAGAG GAGAGGAAAG CAGCTGAGGA GAGGGCTAAG 
GCAGAAGAGG AAAGGAAAGC AGCTGAGGAG AGGGCTAAGG CAGAAGAGGA AAGGAAAGCA 
GCTGAGGAGA GGGCTAAGGC AGAAAAGGAG AGGAAAGCAG CTGAGGAGAG AGAGAGGGCT 
AAGGCAGAAG AGGAAAAGAG GGCAGCTGAA GAAAAGGCTA GGTTAGAGGC AGAAAAATTA 
AAGGAAAAGA AAAAGATGGA AGAGAAGAAA GCCCAAGAGG AAAAAGCTCA AGCAAATTTG 
CTAAGAAAAC AGGAGGAAGA CAAAGAGGCT AAAGTGGAAG CTAAAAAGGA AAGCTTACCA 
GAGAAGCTTC AACCTACCTC CAAAAAAGAT CAGGTAAAAG ACAACAAGGA TAAAGAAAAA 
GCACCCAAGG AGGAAATGAA GAGTGTCTGG GATCGTAAAA GGGGAGTTCC AGAACAAAAG 
GCACAGAATG GAGAACGTGA ACTCACTACC CCCAAACTTA AATCTACTGA AAATGCTTTT 
GGACGCTCCA ACTTGAAAGG AGCTGCAAAT GCTGAGGCTG GCTCCGAGAA GCTGAAGGAG 
AAACAGCAGG AGGCAGCTGT GGAGCTGGAT GAGCTGAAGA AAAGGCGGGA GGAGCGCCGG 
AAAATCCTGG AGGAAGAGGA GCAGAAGAAG AAACAGGAGG AGGCTGAGAG AAAAATCAGA 
GAGGAGGAGG AAAAGAAGAG GATGAAGGAA GAAATTGAAA GGAGAAGAGC TGAAGCTGCT 
GAGAAACGTC AGAAAGTGCC AGAAGATGGC GTATCTGAAG AAAAGAAGCC ATTTAAATGT 
TTCAGTCCTA AAGGTTCATC TCTCAAGATA GAAGAACGAG CAGAATTTTT GAACAAATCC 
GCTCAGAAGA GTGGTATGAA ACCTGCCCAC ACGACAGCAG TTGTCTCAAA GATTGACAGT 
AGACTTGAGC AATATACTAG TGCAGTTGTG GGCAACAAGG CTGCAAAACC CGCCAAACCA 
GCAGCCTCTG ACCTTCCTGT TCCAGCTGAG GGTGTCCGTA ATATCAAGAG CATGTGGGAG 
AAAGGGAATG TTTTTTCATC ACCTGGGGGA ACAGGAACAC CAAATAAGGA AACTGCTGGA 
CTGAAAGTTG GTGTCTCCAG TCGTATCAAC GAATGGCTAA CCAAGACCCC AGAGGGTAAC 
AAATCGCCTG CTCCAAAACC TTCTGATTTA AGACCAGGAG ATGTATCCGG CAAACGTAAT 
CTCTGGGAGA AGCAGTCAGT TGAAAAGCCA GCTGCTTCTT CTTCAAAGGT AACAGCTACG 
GGGAAAAAAT CAGAGACTAA TGGTTTGAGA CAATTTGAGA AAGAACCGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinity.
Biophysical journal99(6)1861-8(2010 Sep)
Hamden SS,Schroeter MM,Chalovich JM

Modulation of actin mechanics by caldesmon and tropomyosin.
Cell motility and the cytoskeleton65(2)156-64(2008 Feb)
Greenberg MJ,Wang CL,Lehman W,Moore JR

The mechanism of smooth muscle caldesmon-tropomyosin inhibition of the elementary steps of the actomyosin ATPase.
The Journal of biological chemistry281(28)19433-48(2006 Jul)
Alahyan M,Webb MR,Marston SB,El-Mezgueldi M

Modes of caldesmon binding to actin: sites of caldesmon contact and modulation of interactions by phosphorylation.
The Journal of biological chemistry279(51)53387-94(2004 Dec)
Foster DB,Huang R,Hatch V,Craig R,Graceffa P,Lehman W,Wang CL

Natively unfolded C-terminal domain of caldesmon remains substantially unstructured after the effective binding to calmodulin.
Proteins53(4)855-62(2003 Dec)
Permyakov SE,Millett IS,Doniach S,Permyakov EA,Uversky VN

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CALD1 cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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