TNFRSF4 cDNA ORF clone, Felis catus(domestic cat)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNFRSF4
Entrez Gene ID	493665
Full Name	TNF receptor superfamily member 4
Synonyms	CD134,OX40
Gene Type	protein-coding
Organism	Felis catus(domestic cat)

mRNA and Protein(s)

mRNA	Protein	Name
XM_023257814.1	XP_023113582.1	tumor necrosis factor receptor superfamily member 4 isoform X1
NM_001009200.1	NP_001009200.1	tumor necrosis factor receptor superfamily member 4 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.
Hong Y, Fink E, Hu QY, Kiosses WB, Elder JH
Journal of virology84(14)7225-32(2010 Jul)

Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134.
Grant CK, Fink EA, Sundstrom M, Torbett BE, Elder JH
Proceedings of the National Academy of Sciences of the United States of America106(47)19980-5(2009 Nov)

CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells.
Reggeti F, Ackerley C, Bienzle D
The Journal of general virology89(Pt 1)277-87(2008 Jan)

Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope.
de Parseval A, Grant CK, Sastry KJ, Elder JH
Journal of virology80(6)3088-91(2006 Mar)

Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor.
de Parseval A, Chatterji U, Sun P, Elder JH
Proceedings of the National Academy of Sciences of the United States of America101(35)13044-9(2004 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that OrfA acts to markedly reduce cell surface expression of the FIV primary binding receptor, CD134.
Title: OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.

Data show that the presence of antibodies to CD134 correlated with lower virus loads and a better overall health status in FIV(+) cats.
Title: Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134.

Expression of CD134 and CXCR4 on feline T and B and dendritic cells (and macrophages was examined and the kinetics of feline immunodeficiency virus replication were assessed.
Title: CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells.

These findings provide direct evidence for a sequential interaction of FIV Env with CD134 and CXCR4.
Title: Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope.

The following TNFRSF4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFb24666	NM_001009200.1 Latest version!	Felis catus TNF receptor superfamily member 4 (TNFRSF4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFb79056	XM_023257814.1 Latest version!	Felis catus TNF receptor superfamily member 4 (TNFRSF4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNFRSF4 ( NM_001009200.1 ) cDNA ORF clone, Felis catus(domestic cat) -> NP_001009200.1 Felis catus TNF receptor superfamily member 4 (TNFRSF4), mRNA.

Price & Availability↑

CloneID	OFb24666
Clone ID Related Accession (Same CDS sequence)	NM_001009200.1
Accession Version	NM_001009200.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Felis catus(domestic cat)
Product	tumor necrosis factor receptor superfamily member 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY738589.1. ##Evidence-Data-START## Transcript exon combination :: AY738589.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN04498525, SAMN04498534 [ECO:0000350] ##Evidence-Data-END##

ATGAGGGTGG TTGTGGGGGC TCAGCGGCCC AGGGCGCCTC ACTCAGCTGT CCAGCTCCTG 
GGGCTTGTGC TGGGCACCGC GGCCGCGCTC CACTGTGTCG GGAACACCTA CCCCAAAGAC 
GGCAAGTGCT GTAGCGAGTG CCCACCAGGT TATGGGATGG AGAGTCGCTG CAGCGGTGAC 
CAGGACACCA AGTGCCTCCA GTGCGCGTCC GGCTTCTACA ACGAGGCCGT GAACTACGAG 
CCTTGCAAGC CCTGCACACA GTGCAACCAG AGAAGTGGGA GCGAGCCCAA GCAGAGATGC 
ACACCCACGC AGGACACCGT CTGCCGCTGC AGGCCAGGCA CTGAGCCCCA GGACGGTTAC 
GATCGTGGAG TCGACTGTGC CCCGTGCCCA CCGGGACATT TCTCCCCAGG TGATGACCAG 
GCTTGCAAGC CCTGGACCAA CTGCACCTTG GCGGGAAAGC GCACGCTGAG GCCGGCCAGC 
CAAGGCTCAG ATGCCGTGTG TGAGGACAGG AGCCCCCCAG CCACCACGCC TTGGGAGACC 
CAGGGCCCCC CAGTCCGGCC CCCTACCACC CAGCCCACCA CAGCCTGGCC TAGGACCTCA 
CAGGAGCCCT TCACACCCCC TGCAGAGCCC CCCAGGGGTC CCCAGCTGGC CGCGGTCCTG 
GGCCTGGGCC TGGGCCTGCT TGCCCCGGTG GCGGCCGCAC TGGCCCTGCT CCTGCACCAC 
AGAGCCTGGC GGCTACCCCC CGGTGGAAAT AGCTTCCGGA CCCCCATCCA AGAGGAGCAT 
GCCGATGCCA ACTCCACCCT GGCCAAGATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009200.1
CDS	10..822
Translation	MRVVVGAQRPRAPHSAVQLLGLVLGTAAALHCVGNTYPKDGKCCSECPPGYGMESRCSGDQDTKCLQCASGFYNEAVNYEPCKPCTQCNQRSGSEPKQRCTPTQDTVCRCRPGTEPQDGYDRGVDCAPCPPGHFSPGDDQACKPWTNCTLAGKRTLRPASQGSDAVCEDRSPPATTPWETQGPPVRPPTTQPTTAWPRTSQEPFTPPAEPPRGPQLAAVLGLGLGLLAPVAAALALLLHHRAWRLPPGGNSFRTPIQEEHADANSTLAKI

Target ORF information:

RefSeq Version	NM_001009200.1
Organism	Felis catus(domestic cat)
Definition	Felis catus TNF receptor superfamily member 4 (TNFRSF4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009200.1

ORF Insert Sequence:

ATGAGGGTGG TTGTGGGGGC TCAGCGGCCC AGGGCGCCTC ACTCAGCTGT CCAGCTCCTG 
GGGCTTGTGC TGGGCACCGC GGCCGCGCTC CACTGTGTCG GGAACACCTA CCCCAAAGAC 
GGCAAGTGCT GTAGCGAGTG CCCACCAGGT TATGGGATGG AGAGTCGCTG CAGCGGTGAC 
CAGGACACCA AGTGCCTCCA GTGCGCGTCC GGCTTCTACA ACGAGGCCGT GAACTACGAG 
CCTTGCAAGC CCTGCACACA GTGCAACCAG AGAAGTGGGA GCGAGCCCAA GCAGAGATGC 
ACACCCACGC AGGACACCGT CTGCCGCTGC AGGCCAGGCA CTGAGCCCCA GGACGGTTAC 
GATCGTGGAG TCGACTGTGC CCCGTGCCCA CCGGGACATT TCTCCCCAGG TGATGACCAG 
GCTTGCAAGC CCTGGACCAA CTGCACCTTG GCGGGAAAGC GCACGCTGAG GCCGGCCAGC 
CAAGGCTCAG ATGCCGTGTG TGAGGACAGG AGCCCCCCAG CCACCACGCC TTGGGAGACC 
CAGGGCCCCC CAGTCCGGCC CCCTACCACC CAGCCCACCA CAGCCTGGCC TAGGACCTCA 
CAGGAGCCCT TCACACCCCC TGCAGAGCCC CCCAGGGGTC CCCAGCTGGC CGCGGTCCTG 
GGCCTGGGCC TGGGCCTGCT TGCCCCGGTG GCGGCCGCAC TGGCCCTGCT CCTGCACCAC 
AGAGCCTGGC GGCTACCCCC CGGTGGAAAT AGCTTCCGGA CCCCCATCCA AGAGGAGCAT 
GCCGATGCCA ACTCCACCCT GGCCAAGATC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNFRSF4 ( XM_023257814.1 ) cDNA ORF clone, Felis catus(domestic cat) -> XP_023113582.1 Felis catus TNF receptor superfamily member 4 (TNFRSF4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OFb79056
Clone ID Related Accession (Same CDS sequence)	XM_023257814.1
Accession Version	XM_023257814.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 777bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-11
Organism	Felis catus(domestic cat)
Product	tumor necrosis factor receptor superfamily member 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_018730.3) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Felis catus Annotation Release 104 Annotation Version :: 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 13% of CDS bases ##RefSeq-Attributes-END##

ATGGCGGTGG GTCGAGCGGG CGTGGCGAAG GCTGACCCTG AGTGGCCCCC TGCCCGCTGG 
GAGAGCCGCC TCTGCCTCCG CCCCAGCCGC TTCCACCCTC CTCGTCCTGC AGGTTATGGG 
ATGGAGAGTC GCTGCAGCGG TGACCAGGAC ACCAAGTGCC TCCAGTGCGC GTCCGGCTTC 
TACAACGAGG CCGTGAACTA CGAGCCTTGC AAGCCCTGCA CACAGTGCAA CCAGAGAAGT 
GGGAGCGAGC CCAAGCAGAG ATGCACACCC ACGCAGGACA CCGTCTGCCG CTGCAGGCCA 
GGCACTGAGC CCCAGGACGG TTACGATCGT GGAGTCGACT GTGCCCCGTG CCCACCGGGA 
CATTTCTCCC CAGGTGATGA CCAGGCTTGC AAGCCCTGGA CCAACTGCAC CTTGGCGGGA 
AAGCGCACGC TGAGGCCGGC CAGCCAAGGC TCAGATGCCG TGTGTGAGGA CAGGAGCCCC 
CCAGCCACCA CGCCTTGGGA GACCCAGGGC CCCCCAGTCC GGCCCCCTAC CACCCAGCCC 
ACCACAGCCT GGCCTAGGAC CTCACAGGAG CCCTTCACAC CCCCTGCAGA GCCCCCCAGG 
GGTCCCCAGC TGGCCGCGGT CCTGGGCCTG GGCCTGGGCC TGCTTGCCCC GGTGGCGGCC 
GCACTGGCCC TGCTCCTGCA CCACAGAGCC TGGCGGCTAC CCCCCGGTGG AAATAGCTTC 
CGGACCCCCA TCCAAGAGGA GCATGCCGAT GCCAACTCCA CCCTGGCCAA GATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_023113582.1
CDS	1..777
Translation	MAVGRAGVAKADPEWPPARWESRLCLRPSRFHPPRPAGYGMESRCSGDQDTKCLQCASGFYNEAVNYEPCKPCTQCNQRSGSEPKQRCTPTQDTVCRCRPGTEPQDGYDRGVDCAPCPPGHFSPGDDQACKPWTNCTLAGKRTLRPASQGSDAVCEDRSPPATTPWETQGPPVRPPTTQPTTAWPRTSQEPFTPPAEPPRGPQLAAVLGLGLGLLAPVAAALALLLHHRAWRLPPGGNSFRTPIQEEHADANSTLAKI

Target ORF information:

RefSeq Version	XM_023257814.1
Organism	Felis catus(domestic cat)
Definition	Felis catus TNF receptor superfamily member 4 (TNFRSF4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_023257814.1

ORF Insert Sequence:

ATGGCGGTGG GTCGAGCGGG CGTGGCGAAG GCTGACCCTG AGTGGCCCCC TGCCCGCTGG 
GAGAGCCGCC TCTGCCTCCG CCCCAGCCGC TTCCACCCTC CTCGTCCTGC AGGTTATGGG 
ATGGAGAGTC GCTGCAGCGG TGACCAGGAC ACCAAGTGCC TCCAGTGCGC GTCCGGCTTC 
TACAACGAGG CCGTGAACTA CGAGCCTTGC AAGCCCTGCA CACAGTGCAA CCAGAGAAGT 
GGGAGCGAGC CCAAGCAGAG ATGCACACCC ACGCAGGACA CCGTCTGCCG CTGCAGGCCA 
GGCACTGAGC CCCAGGACGG TTACGATCGT GGAGTCGACT GTGCCCCGTG CCCACCGGGA 
CATTTCTCCC CAGGTGATGA CCAGGCTTGC AAGCCCTGGA CCAACTGCAC CTTGGCGGGA 
AAGCGCACGC TGAGGCCGGC CAGCCAAGGC TCAGATGCCG TGTGTGAGGA CAGGAGCCCC 
CCAGCCACCA CGCCTTGGGA GACCCAGGGC CCCCCAGTCC GGCCCCCTAC CACCCAGCCC 
ACCACAGCCT GGCCTAGGAC CTCACAGGAG CCCTTCACAC CCCCTGCAGA GCCCCCCAGG 
GGTCCCCAGC TGGCCGCGGT CCTGGGCCTG GGCCTGGGCC TGCTTGCCCC GGTGGCGGCC 
GCACTGGCCC TGCTCCTGCA CCACAGAGCC TGGCGGCTAC CCCCCGGTGG AAATAGCTTC 
CGGACCCCCA TCCAAGAGGA GCATGCCGAT GCCAACTCCA CCCTGGCCAA GATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection.
Journal of virology84(14)7225-32(2010 Jul)
Hong Y,Fink E,Hu QY,Kiosses WB,Elder JH

Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134.
Proceedings of the National Academy of Sciences of the United States of America106(47)19980-5(2009 Nov)
Grant CK,Fink EA,Sundstrom M,Torbett BE,Elder JH

CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells.
The Journal of general virology89(Pt 1)277-87(2008 Jan)
Reggeti F,Ackerley C,Bienzle D

Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope.
Journal of virology80(6)3088-91(2006 Mar)
de Parseval A,Grant CK,Sastry KJ,Elder JH

Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor.
Proceedings of the National Academy of Sciences of the United States of America101(35)13044-9(2004 Aug)
de Parseval A,Chatterji U,Sun P,Elder JH