Catsup cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Catsup
Entrez Gene ID	48805
Full Name	Catecholamines up
Synonyms	Bc,CG10449,Dmel\CG10449,catsup,cg10449,dCATSUP,dZipCATSUP,dZipCatsup,fs(2)ltoQT50,l(2)37Bc,l(2)E13,l(2)k05402,l(2)k05424
General protein information	Preferred Names Catecholamines up Names CG10449 gene product from transcript CG10449-RA CG10449-PA Catsup-PA catecholamines up catsup
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 37B11-37B11\|2-53.9 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_080192.3	NP_524931.1	catecholamines up

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Catsup	NP_524931.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008034	XP_317427.4
Caenorhabditis elegans (roundworm)	hke-4.1	NP_503070.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of Catsup function causes Notch to accumulate abnormally in the endoplasmic reticulum (ER) and Golgi compartments, resulting in impaired Notch signaling. In addition, Catsup mutant cells exhibit elevated ER stress, suggesting that impaired zinc homeostasis causes increased levels of misfolded proteins within the secretory compartment.
Title: Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup.

The results of this study concluded that Catsup regulates and links the dopamine synthesis and transport networks.
Title: Catecholamines up integrates dopamine synthesis and synaptic trafficking.

Molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep.
Title: Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep.

Catsup is a pleiotropic quantitative trait gene, but individual quantitative trait nucleotides do not have pleiotropic effects. Molecular population genetic analyses are consistent with balancing selection maintaining multiple functional polymorphisms.
Title: Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila.

The following Catsup gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Catsup cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa15273	NM_080192.3 Latest version!	Drosophila melanogaster catecholamines up (Catsup), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Catsup ( NM_080192.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524931.1 Drosophila melanogaster catecholamines up (Catsup), mRNA.

Price & Availability↑

CloneID	OFa15273
Clone ID Related Accession (Same CDS sequence)	NM_080192.3
Accession Version	NM_080192.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1350bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	catecholamines up
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jan 16, 2013 this sequence version replaced NM_080192.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCCAAAC AAGTGGCTGA TTACCAGTGC AGTAAGCTCC AGTTGTACCA AAAGCTGGCA 
CTGGTCGTAA TCCTGGGAGC AGTGCTTTTC TCGCTCCCGG CGTTGTGCGC CGGCCAGGGC 
AATCCCAGTT TCAAATACTC GCGGGAAGCC AACGAAAACT TCGATCCGCA GAAGGCTCCA 
CGGGCGGAGC ACCATCATCA TCATGATCAT GACCACGATC ATGGACACCA CCACCACGGG 
CACGATCATG ATCATGACCA CGACCACGGG CATGATCATG GACACCATCA TCACGGGCAC 
GATCATGATC ATGACCACGA CCACGGACAC CATCATCACG GGCACGATGA AAGGCACACC 
AAGGCAAAGC CGGATTTGGA TATGAGCACC ATTTGGTTGC ACTCGATCGG CTCAACTCTT 
CTTATCAGTG CCGCTCCCTT CGTGCTGCTG TATATCATTC CCCTAGACAA CAGTGAGGCG 
ATGAAGCCGC GTCTCAAAGT GCTTCTGGCC TTTGCTTCTG GCGGTTTGTT GGGTGATGCC 
TTTCTGCACT TGATTCCTCA TGCCACGCAT CCACACAGTC ATGGAGAACA CGGCCACGAT 
CACGGCCATG ATCACCATCA TCATCATGAT GGCGAGGAGC ATGAACATGG TCACAGCCAC 
GATATGAGCA TTGGTCTGTG GGTCCTTGGA GGAATCATTG CCTTCCTTTC AGTGGAGAAA 
CTGGTACGCA TTCTAAAGGG CGGTCATGGA GGACACGGCC ACAGCCATGG AGCACCAAAG 
CCAAAACCAG TGCCTGCTAA GAAAAAGTCC TCTGACAAAG AAGACAGCGG AGATGGAGAC 
AAACCGGCAA AGCCAGCCAA GATCAAGTCC AAGAAACCAG AAGCGGAGCC AGAAGGCGAA 
GTGGAGATTT CCGGCTACTT GAATTTGGCG GCGGACTTTG CTCACAACTT CACCGATGGC 
CTGGCCATCG GCGCCTCCTA TTTGGCGGGC AACAGCATTG GCATTGTGAC CACTATCACT 
ATTCTGCTGC ACGAAGTGCC CCATGAGATT GGTGACTTTG CCATTCTTAT AAAGTCTGGC 
TGTTCCAGGC GAAAGGCAAT GCTTCTGCAG CTCGTCACAG CGCTCGGAGC TTTGGCGGGC 
ACAGCGCTAG CTCTTCTGGG AGCTGGAGGC GGGGACGGAT CGGCCCCATG GGTCTTGCCC 
TTCACAGCCG GCGGTTTTAT TTACATCGCA ACAGTGAGTG TCCTGCCGGA GCTGCTTGAG 
GAGTCTACGA AACTGAAACA GTCGCTGAAG GAAATCTTTG CGCTGCTAAC CGGCGTAGCC 
CTAATGATCG TTATCGCCAA GTTCGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524931.1
CDS	85..1434
Translation	MAKQVADYQCSKLQLYQKLALVVILGAVLFSLPALCAGQGNPSFKYSREANENFDPQKAPRAEHHHHHDHDHDHGHHHHGHDHDHDHDHGHDHGHHHHGHDHDHDHDHGHHHHGHDERHTKAKPDLDMSTIWLHSIGSTLLISAAPFVLLYIIPLDNSEAMKPRLKVLLAFASGGLLGDAFLHLIPHATHPHSHGEHGHDHGHDHHHHHDGEEHEHGHSHDMSIGLWVLGGIIAFLSVEKLVRILKGGHGGHGHSHGAPKPKPVPAKKKSSDKEDSGDGDKPAKPAKIKSKKPEAEPEGEVEISGYLNLAADFAHNFTDGLAIGASYLAGNSIGIVTTITILLHEVPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGGGDGSAPWVLPFTAGGFIYIATVSVLPELLEESTKLKQSLKEIFALLTGVALMIVIAKFE

Target ORF information:

RefSeq Version	NM_080192.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster catecholamines up (Catsup), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080192.3

ORF Insert Sequence:

ATGGCCAAAC AAGTGGCTGA TTACCAGTGC AGTAAGCTCC AGTTGTACCA AAAGCTGGCA 
CTGGTCGTAA TCCTGGGAGC AGTGCTTTTC TCGCTCCCGG CGTTGTGCGC CGGCCAGGGC 
AATCCCAGTT TCAAATACTC GCGGGAAGCC AACGAAAACT TCGATCCGCA GAAGGCTCCA 
CGGGCGGAGC ACCATCATCA TCATGATCAT GACCACGATC ATGGACACCA CCACCACGGG 
CACGATCATG ATCATGACCA CGACCACGGG CATGATCATG GACACCATCA TCACGGGCAC 
GATCATGATC ATGACCACGA CCACGGACAC CATCATCACG GGCACGATGA AAGGCACACC 
AAGGCAAAGC CGGATTTGGA TATGAGCACC ATTTGGTTGC ACTCGATCGG CTCAACTCTT 
CTTATCAGTG CCGCTCCCTT CGTGCTGCTG TATATCATTC CCCTAGACAA CAGTGAGGCG 
ATGAAGCCGC GTCTCAAAGT GCTTCTGGCC TTTGCTTCTG GCGGTTTGTT GGGTGATGCC 
TTTCTGCACT TGATTCCTCA TGCCACGCAT CCACACAGTC ATGGAGAACA CGGCCACGAT 
CACGGCCATG ATCACCATCA TCATCATGAT GGCGAGGAGC ATGAACATGG TCACAGCCAC 
GATATGAGCA TTGGTCTGTG GGTCCTTGGA GGAATCATTG CCTTCCTTTC AGTGGAGAAA 
CTGGTACGCA TTCTAAAGGG CGGTCATGGA GGACACGGCC ACAGCCATGG AGCACCAAAG 
CCAAAACCAG TGCCTGCTAA GAAAAAGTCC TCTGACAAAG AAGACAGCGG AGATGGAGAC 
AAACCGGCAA AGCCAGCCAA GATCAAGTCC AAGAAACCAG AAGCGGAGCC AGAAGGCGAA 
GTGGAGATTT CCGGCTACTT GAATTTGGCG GCGGACTTTG CTCACAACTT CACCGATGGC 
CTGGCCATCG GCGCCTCCTA TTTGGCGGGC AACAGCATTG GCATTGTGAC CACTATCACT 
ATTCTGCTGC ACGAAGTGCC CCATGAGATT GGTGACTTTG CCATTCTTAT AAAGTCTGGC 
TGTTCCAGGC GAAAGGCAAT GCTTCTGCAG CTCGTCACAG CGCTCGGAGC TTTGGCGGGC 
ACAGCGCTAG CTCTTCTGGG AGCTGGAGGC GGGGACGGAT CGGCCCCATG GGTCTTGCCC 
TTCACAGCCG GCGGTTTTAT TTACATCGCA ACAGTGAGTG TCCTGCCGGA GCTGCTTGAG 
GAGTCTACGA AACTGAAACA GTCGCTGAAG GAAATCTTTG CGCTGCTAAC CGGCGTAGCC 
CTAATGATCG TTATCGCCAA GTTCGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Catsup cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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