l(2)dtl cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	l(2)dtl
Entrez Gene ID	46326
Full Name	lethal-(2)-denticleless
Synonyms	CG11295,Cdt2,DTL83,Dmel\CG11295,L2DTL,cdt2
General protein information	Preferred Names lethal-(2)-denticleless Names CG11295 gene product from transcript CG11295-RA CG11295-PA l(2)dtl-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 59F6-59F6

mRNA and Protein(s)

mRNA	Protein	Name
NM_080132.3	NP_524871.1	lethal-(2)-denticleless

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	l(2)dtl	NP_524871.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007166	XP_308602.4

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

L(2)dtl is essential for Drosophila development.
Title: Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility.

L2DTL and PCNA interact with CUL4/DDB1 complexes and are involved in CDT1 degradation after DNA damage.
Title: L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.

The following l(2)dtl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the l(2)dtl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa12743	NM_080132.3 Latest version!	Drosophila melanogaster lethal-(2)-denticleless (l(2)dtl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

l(2)dtl ( NM_080132.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524871.1 Drosophila melanogaster lethal-(2)-denticleless (l(2)dtl), mRNA.

Price & Availability↑

CloneID	OFa12743
Clone ID Related Accession (Same CDS sequence)	NM_080132.3
Accession Version	NM_080132.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2310bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	lethal-(2)-denticleless
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_080132.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGAACATTT ACAACAAGTT GCGGGCCAGG GAGCATGGCT ACGGCAATGA GAGGACCTAC 
GACTTCGCCC TGCGCCGCCT TTCCGTGGCC AAGGAGGACA GCTGGCGGGG CATCGCGCCG 
GCCAACTACT GCCCAGACTT CAATCCGGAA CCGCCGATCT TCTCCGCCAA GTTCGCCAAC 
TGCGATGGCT ATCGGCACAT CCTGGCGATC GCCAACGAGG ACGGCAAGAT CACGCTGCAG 
GACACCACCC AGCGCAACCA CCAGCCGGAG GAGCAGTCCC TGGTGGGCCC GCAGTGCCAC 
TTCAACGCCG TTTTCGATCT GGAATGGGCA CCCGGCCAGA TGCGCTTCGT CTCCGCCTCG 
GGCGATCACA CTGCCAGACT GTGGGAGGTG GCGGGCTCCG GCATACGCGG CCTGAACTCC 
TATGTGGGTC ACACAAGGTC CGTCAAGTCG GCGGCCTTTA AGCGCACCGA TCCCGCTGTC 
TTCGCCACCG GCGGCCGTGA TGGCGCCATT CTCATCTGGG ACATCAGGGC CAATCTCAAT 
ATGGACCTCA CGTCACGCGT GGACAACTGC ATCTACAGCG GTCACACGGG CGGACCGGGC 
ACGCCAGTCT CACAGCGCAA GCAGCGCACA CGCACTCCCA AGATGGCCGG AGGAACCACC 
TCGAGCAGCA TCACTGGCTT GGCCTTCCAG GACAACGATA CGTTGATCTC CTGTGGTGCC 
GGTGACGGAG TCATCAAGGT GTGGGACCTG CGGCGCAACT ACACAGCCTA CAAAAAGGAG 
CCACTGCCCA GGCACAAGCT GCCATATGCC GGCAGCTCCA CCTTCCGTGG ATTCACCAAC 
CTCATTGTGG ACGCGTCAGG CACGAGGCTG TATGCCAACT GCATGGACAA CACCATCTAT 
TGCTACAATC TGGCCTCCTA CTCGCAGCGC CCGCTGGCGT GCTACAAGGG ACTCCTTAAC 
TCCACGTTCT ACATCAAATC CTGCCTCAGC CCGGACGGCA AGTATCTGCT GAGCGGAAGC 
AGCGACGAGC GGGCTTACAT CTGGAACCTG GACCACGCCG AGGAGCCGCT CGTTGCACTG 
GCCGGACACA CGGTGGAGGT AACCTGCGTG GCCTGGGGCT CCAGCCACGA TTGCCCCATT 
GTCACGTGCA GCGATGATGC GCGTCACAAA ATCTGGCGGA TTGGACCCGA CCTGGATGGC 
CTCAGCGAGG CGGAGCGGGC GGAAAAGTAC CGAGGAACTG CCTCCTACGT CAGGGAGTTC 
GGCAAGAAGG CATTTGGTCC GTCTAGTGGA AATCACAAGT ACAATCTTCG AGATCTGGAG 
TCCACGCCAA GATCTCTGAA GCGCCTTATG GATCAAAATG AAAGGACGCC AGGTTCCGTG 
GAAAAGACGA CGACCAAGCG TTCGTTCCTG GAAATGCTGG GCGTAGCTGG CCAGGAGACG 
GAAGCCACAG AACAGCCCCA GAAACGGGCG AAGCCACTGG AGTCACGTGG AAGGCGGCTC 
TTTGGACCTT CTAGCCAGGA AACTGCTTGC AGGCACATAC AACTTCAGTC CATAAACGAG 
GAAGATGCCT CGCCGAGCAA GAGACAAAAG GAGAACTCTG CCGCGGAGGA TGTCTCACCA 
CTGCACAAGC TTCTCAGCAC ACCAAGTCAT TCCCCTTTGA GTGAGAATGT CAACCATGTG 
TACACCTCCC CGCCAACCAC GTCAGCGGCA GCAGCAGCGG TGGCTGCAGA CGCGCTTAAT 
CCGCCGCCGA TCTCCGCTGC CATCTACTCG CCCACCTCCA ACCTGCCCAA TTACGTGCTG 
GATGGCGAGG CACCGCACCT GGGCATCATG TCGCCCAAGC GGAAGGCGAA GGAGAAGGTG 
GACTGGCTGA CGAATATCCG CAAACAGAAG CTGATGAGTG GCAGGGCCCA TGTGACGCTC 
AGCGAAAAGA TCAGCGAGGA GCAGCAGGCC GATGTGCTGG CATCCCCGCG CCTCCAGAGT 
CTGCGGCAGT CAGAGTGCAG TCCCAGGATA CACGCCTCGC CCCGCAGACG CATCTCCCAT 
ACGGACGGAG GCGGTGGCAC GCCGGCTGGC AGCTCCTCGC ACTCCCATTC CCAATCCCAG 
CCAAAAACGC CCACTTCCAG TAGGCGAAAC AGCGAGACGA CGCTCCTGCG ATTCTTTAGC 
ATTCAGAGAA GTAGCAGTGT GCCGGCGGAG GAAACAACGA CAACGAATGC GGCTCCCTCC 
TCTTCTGATC CCCATCCCCC GGCAGTGACT GCGCCCGCAG CCACGCCCCT CAGCATGCGC 
ACGCCCACGA CGGCGGTGGG CAGCGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524871.1
CDS	159..2468
Translation	MNIYNKLRAREHGYGNERTYDFALRRLSVAKEDSWRGIAPANYCPDFNPEPPIFSAKFANCDGYRHILAIANEDGKITLQDTTQRNHQPEEQSLVGPQCHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAGSGIRGLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILIWDIRANLNMDLTSRVDNCIYSGHTGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYKKEPLPRHKLPYAGSSTFRGFTNLIVDASGTRLYANCMDNTIYCYNLASYSQRPLACYKGLLNSTFYIKSCLSPDGKYLLSGSSDERAYIWNLDHAEEPLVALAGHTVEVTCVAWGSSHDCPIVTCSDDARHKIWRIGPDLDGLSEAERAEKYRGTASYVREFGKKAFGPSSGNHKYNLRDLESTPRSLKRLMDQNERTPGSVEKTTTKRSFLEMLGVAGQETEATEQPQKRAKPLESRGRRLFGPSSQETACRHIQLQSINEEDASPSKRQKENSAAEDVSPLHKLLSTPSHSPLSENVNHVYTSPPTTSAAAAAVAADALNPPPISAAIYSPTSNLPNYVLDGEAPHLGIMSPKRKAKEKVDWLTNIRKQKLMSGRAHVTLSEKISEEQQADVLASPRLQSLRQSECSPRIHASPRRRISHTDGGGGTPAGSSSHSHSQSQPKTPTSSRRNSETTLLRFFSIQRSSSVPAEETTTTNAAPSSSDPHPPAVTAPAATPLSMRTPTTAVGSD

Target ORF information:

RefSeq Version	NM_080132.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster lethal-(2)-denticleless (l(2)dtl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080132.3

ORF Insert Sequence:

ATGAACATTT ACAACAAGTT GCGGGCCAGG GAGCATGGCT ACGGCAATGA GAGGACCTAC 
GACTTCGCCC TGCGCCGCCT TTCCGTGGCC AAGGAGGACA GCTGGCGGGG CATCGCGCCG 
GCCAACTACT GCCCAGACTT CAATCCGGAA CCGCCGATCT TCTCCGCCAA GTTCGCCAAC 
TGCGATGGCT ATCGGCACAT CCTGGCGATC GCCAACGAGG ACGGCAAGAT CACGCTGCAG 
GACACCACCC AGCGCAACCA CCAGCCGGAG GAGCAGTCCC TGGTGGGCCC GCAGTGCCAC 
TTCAACGCCG TTTTCGATCT GGAATGGGCA CCCGGCCAGA TGCGCTTCGT CTCCGCCTCG 
GGCGATCACA CTGCCAGACT GTGGGAGGTG GCGGGCTCCG GCATACGCGG CCTGAACTCC 
TATGTGGGTC ACACAAGGTC CGTCAAGTCG GCGGCCTTTA AGCGCACCGA TCCCGCTGTC 
TTCGCCACCG GCGGCCGTGA TGGCGCCATT CTCATCTGGG ACATCAGGGC CAATCTCAAT 
ATGGACCTCA CGTCACGCGT GGACAACTGC ATCTACAGCG GTCACACGGG CGGACCGGGC 
ACGCCAGTCT CACAGCGCAA GCAGCGCACA CGCACTCCCA AGATGGCCGG AGGAACCACC 
TCGAGCAGCA TCACTGGCTT GGCCTTCCAG GACAACGATA CGTTGATCTC CTGTGGTGCC 
GGTGACGGAG TCATCAAGGT GTGGGACCTG CGGCGCAACT ACACAGCCTA CAAAAAGGAG 
CCACTGCCCA GGCACAAGCT GCCATATGCC GGCAGCTCCA CCTTCCGTGG ATTCACCAAC 
CTCATTGTGG ACGCGTCAGG CACGAGGCTG TATGCCAACT GCATGGACAA CACCATCTAT 
TGCTACAATC TGGCCTCCTA CTCGCAGCGC CCGCTGGCGT GCTACAAGGG ACTCCTTAAC 
TCCACGTTCT ACATCAAATC CTGCCTCAGC CCGGACGGCA AGTATCTGCT GAGCGGAAGC 
AGCGACGAGC GGGCTTACAT CTGGAACCTG GACCACGCCG AGGAGCCGCT CGTTGCACTG 
GCCGGACACA CGGTGGAGGT AACCTGCGTG GCCTGGGGCT CCAGCCACGA TTGCCCCATT 
GTCACGTGCA GCGATGATGC GCGTCACAAA ATCTGGCGGA TTGGACCCGA CCTGGATGGC 
CTCAGCGAGG CGGAGCGGGC GGAAAAGTAC CGAGGAACTG CCTCCTACGT CAGGGAGTTC 
GGCAAGAAGG CATTTGGTCC GTCTAGTGGA AATCACAAGT ACAATCTTCG AGATCTGGAG 
TCCACGCCAA GATCTCTGAA GCGCCTTATG GATCAAAATG AAAGGACGCC AGGTTCCGTG 
GAAAAGACGA CGACCAAGCG TTCGTTCCTG GAAATGCTGG GCGTAGCTGG CCAGGAGACG 
GAAGCCACAG AACAGCCCCA GAAACGGGCG AAGCCACTGG AGTCACGTGG AAGGCGGCTC 
TTTGGACCTT CTAGCCAGGA AACTGCTTGC AGGCACATAC AACTTCAGTC CATAAACGAG 
GAAGATGCCT CGCCGAGCAA GAGACAAAAG GAGAACTCTG CCGCGGAGGA TGTCTCACCA 
CTGCACAAGC TTCTCAGCAC ACCAAGTCAT TCCCCTTTGA GTGAGAATGT CAACCATGTG 
TACACCTCCC CGCCAACCAC GTCAGCGGCA GCAGCAGCGG TGGCTGCAGA CGCGCTTAAT 
CCGCCGCCGA TCTCCGCTGC CATCTACTCG CCCACCTCCA ACCTGCCCAA TTACGTGCTG 
GATGGCGAGG CACCGCACCT GGGCATCATG TCGCCCAAGC GGAAGGCGAA GGAGAAGGTG 
GACTGGCTGA CGAATATCCG CAAACAGAAG CTGATGAGTG GCAGGGCCCA TGTGACGCTC 
AGCGAAAAGA TCAGCGAGGA GCAGCAGGCC GATGTGCTGG CATCCCCGCG CCTCCAGAGT 
CTGCGGCAGT CAGAGTGCAG TCCCAGGATA CACGCCTCGC CCCGCAGACG CATCTCCCAT 
ACGGACGGAG GCGGTGGCAC GCCGGCTGGC AGCTCCTCGC ACTCCCATTC CCAATCCCAG 
CCAAAAACGC CCACTTCCAG TAGGCGAAAC AGCGAGACGA CGCTCCTGCG ATTCTTTAGC 
ATTCAGAGAA GTAGCAGTGT GCCGGCGGAG GAAACAACGA CAACGAATGC GGCTCCCTCC 
TCTTCTGATC CCCATCCCCC GGCAGTGACT GCGCCCGCAG CCACGCCCCT CAGCATGCGC 
ACGCCCACGA CGGCGGTGGG CAGCGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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l(2)dtl cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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