Lk6 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lk6
Entrez Gene ID	44672
Full Name	Lk6 kinase
Synonyms	CG17342,CG6929,Dmel\CG17342,LK6,MESR8,MNK/LK6,anon-WO0172774.84,lk6
General protein information	Preferred Names Lk6 kinase Names CG17342 gene product from transcript CG17342-RA CG17342-PA CG17342-PB Lk6-PA Lk6-PB
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 86E17-86E18

mRNA and Protein(s)

mRNA	Protein	Name
NM_169423.3	NP_731624.1	Lk6 kinase, isoform B
NM_143729.3	NP_651986.2	Lk6 kinase, isoform A

Pathways from BioSystems

Homologies

Homo sapiens (human)	MKNK1	NP_003675.2
	MKNK1	XP_001098645.1
Gallus gallus (chicken)	MKNK1	XP_004936825.1
Bos taurus (cattle)	MKNK1	NP_001030435.1
Danio rerio (zebrafish)	mknk1	NP_001108211.2
Drosophila melanogaster (fruit fly)	Lk6	NP_651986.2
Pan troglodytes (chimpanzee)	MKNK1	XP_001162430.1
Rattus norvegicus (Norway rat)	Mknk1	NP_001037732.1
Xenopus tropicalis (tropical clawed frog)	mknk1	NP_001008051.1
Canis lupus familiaris (dog)	MKNK1	XP_005629088.1
Mus musculus (house mouse)	Mknk1	NP_001272416.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that it is via Lk6, regulators of the translation factor eIF4E, FOXO and TOR also converge to regulate protein synthesis.
Title: Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

results show that LK6 binds to ERK and is activated by ERK signalling and it is responsible for phosphorylating eIF4E in Drosophila
Title: The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo.

Lk6 exerts a tight control on Eukaryotic initiation factor 4E phosphorylation and is necessary for normal growth and development.
Title: Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development.

Lk6 function is dispensable under a high protein diet, whereas loss of Lk6 function causes a significant growth reduction when the amino acid content in the diet is reduced.
Title: Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E.

The following Lk6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lk6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa06860	NM_143729.3 Latest version!	Drosophila melanogaster Lk6 kinase (Lk6), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$629.30 $899.00
OFa06861	NM_169423.3 Latest version!	Drosophila melanogaster Lk6 kinase (Lk6), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$629.30 $899.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lk6 ( NM_143729.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_651986.2 Drosophila melanogaster Lk6 kinase (Lk6), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa06860
Clone ID Related Accession (Same CDS sequence)	NM_143729.3
Accession Version	NM_143729.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Lk6 kinase, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_143729.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTGGAGC CCAAGTCCGG GACAGCTGCT TCTGCCGCTG CTGCGAAAGC AAGCAACAAC 
AATAACAACA ACCACCCCCG TGGATCTGGG GACAGCGGCA TCCGGAGTGG CAGCGGCATT 
TCCTGCAGCA ACACGGACAA CAGCTGCAGC CAGAGTCAGT CAGACGGACA GAATGAGCTG 
ACGCGCTACA GCAGCGAGGA TGTGTCGGGC AACGAGTCCA GCGAGGCGCC CAACATGACC 
GAGGTGGAAC GCCAGGCGGA GCTTAACAGG CACAAGGAGG AGATGCAGAA GAAGCGGCGC 
AAGAAACGCA TCAGCTCCTC CCTTCATTCC TCAACCTTTC AGGAGCTGTA CAAGCTGACT 
GGCGAGATTC TTGGCGAGGG AGCCTACGCA TCGGTGCAAA CTTGCGTTAA CATCTACACC 
GATCTGGAGT ATGCCGTGAA GGTGATCGAT AAGATACCGG GGCATGCGCG TGCACGTGTC 
TTTCGCGAAG TGGAGACATT CCATCACTGC CAGGGCCATT TGGGCATCTT GCAACTGATT 
GAATTCTTTG AGGATGACGA GAAGTTCTAC CTGGTATTCG AGAAGATCAA CGGTGGTCCA 
TTGCTATCGC GCATACAGGA GCACATTTGC TTCTCCGAGC ATGAGGCCTC GCAGATAATC 
AAGGAGATCG CCTCCGGACT TGATTTTCTG CACAAGAAGG GCATTGCCCA TCGTGATCTC 
AAGCCGGAGA ATATTCTGTG TGTCAAGACG GATTCGCTGT GCCCAATCAA GATTTGCGAC 
TTTGATTTGG GTTCGGGGAT TAAGTTCACT ACGGACATCT CGTCGCCAGC AGCCACTCCT 
CAGTTATTGA CACCAGTTGG CAGTGCCGAG TTTATGGCTC CGGAAGTGGT CGATTTGTTT 
GTGGGTGAGG CACACTATTA CGATAAGAGG TGCGATTTGT GGTCCCTGGG AGTCATTGCT 
TACATCCTGC TCTGCGGTTA TCCGCCATTT TCGGGCAACT GTGGTGAGGA TTGCGGCTGG 
AATCGCGGTG AAAACTGCCG CACGTGCCAG GAACTGCTTT TCGAGTCCAT TCAAGAAGGA 
CACTTTTCTT TCCCGGAGGC CGAGTGGCAC GATGTCAGCG ATGAGGCCAA GGACCTAATT 
TCTAATCTGC TTGTCAAGAA GGCATCGAAC CGCCTCAGTG CCGAGGCAGT GTTGAATCAC 
CCATGGATTC GTATGTGCGA GCAGGAGCCA CCGGCAAGCA AGCATGGCAG GCGCCACAAG 
GCTTTGCAAA CGCCCAGTAA CATCCGACGC AATCACCAGT CGGCAAGGGA AATCTCGCAG 
TTTGCCGAAT CTGCTATGGC CGTCAAGCGT GTGGTCCTAC AGCATTTCTC GATGCGCTAC 
GATTACATGA AAGAGCGTCC CAACATCTAC CAGCCATCGC AGGCCTACAT GGATGCCTAT 
AGCGATGAAA ACTACAATCC CAAGCCGCCG GGTCATTACA CTCGCAATCG CTCGCAGCGC 
AATCCCGCTT CCTCCTTGTG CGGCTACGGA GGGCGTATGT CCTCGATGCA CGGCCAGCGG 
GCCAATAGCC GTCGGTCTTC CCGAAATGCG TCTCGCAATG CATCTGCAAT TTATCCGAAT 
AGCGGGGGCT TCAAGACATT GAACGTCCAC GAGGAAGATG ACGACGATGA AGGTCTGGAG 
GCTTTTGGCC ACATCGATGA TGATGATGAG TGGAGCAGGT CTAGGAGGGA ATATCAGCAG 
CAGTGTGAGA CGCTGGGCGA GGATCGCTTT AGGCGTCAGA GCGGAAGCGA AGGCGACGAA 
GTGGAAGATG ATGAGGATGG AGAGAATGAG GACTATCAGC ACTATAAGCA TTACTGGCGC 
GAATTAGACG AGGAAGAGGG CGACGACTAT CTGTATGAGC AGCAGCAGCG CGTCGATGAT 
AAATTCGGGG AAGAGGAGTT CGAGGACGAA CCAAAGGAGG AAACTCAAGC TGACAATCTA 
AAGCTATCGA AAGCTTACGT GGAGCAAGTT GGCGAGACCA ATGTGGAGAA ATCGAAGCCA 
CAGGACGATA ACGGTGGGTA TATAAGGGAG GACCTTATTA TGGATAATAT GGATATGAAG 
AAAAACACTC AGCAAAGCGA ATTTGCTAAG CTCACCATAA TGCGCAACGA TGCGCAGACG 
GAGGAGAATA AGATAATGCA GCAGCAGGAT GAGGAGAAGA AAGAGGAAAA ACAGCAGGAT 
GATGTTGATG GGGCTAAGAA GCAAGGACCA TCAAGTGATA TTAGTGCTAC TACCATCACC 
GATAATAACA AGCTGCAAAC ACCAGTTATG ACTACAACAC ACATTAACAA CTGGCAAACT 
GGCGATGCAA TTGAAGATGA TGATGTTAAA CTATTGGATA GTATTAGTGA TTTAAATGAA 
AAGCTACCTG AAATTTATGA GACTGCAAAT ATTGTTGTCA ACTCAGCGGC AGTGCCAGCA 
GCATCGACAC CAGCAGCATC AGCAACACGC CCACCAACCG ATAACCCAGA GGAAGATGAT 
TCGAACGTGA CCAAACCGAC GACTACTGCT GAGGGGACAA CAATGCAAAC GACTTTTGGC 
ATGTCAGCGG AAGAGGAGAA GCCTGTAGCC CTATCCCACA CCGCGGGTCA CCACAGCAAG 
ACCGGCCGCA CTGTTAACTT TGCCCCCGAT GCATATCAGA ACGACGAGGA TGCCGATATC 
GACGAGGACG ACGACTACGA TGACGAGGAG AATCTGCATG AGCACAGCAA GCAACAGCTG 
CCGTCCAATG CCTACACTCG TAAGCAGCGA CAGCAGCACC AGCGGTACAT TGTGCCACGC 
TACCAGCTTG CGGATCAAGT TCCTCAGAGG CAGCACACCG AAAACTGGCG TTATCGCACC 
CATCACTCGC AGGAACAGCA GCCGACAGCG GACTATCGCA AGTATCGCCC GCCGTTTAGC 
ACCGGAGGCG GCGGTGGCCA CCATGGCAAC CAGCAGCGCA ATTACCTGGG GAGCTTCTCG 
CACAGCGGCG GTGCCGCTGG TTACAAGATT GCTCCAATGC CGCCACCAAT GCAGCCGCCT 
CCGCGGCACA ACAGCGCCGG AAGCAGTGGC AGTGGTAGCG GCAGCGGCGG ATCTCCGCCA 
TCTGACGAGC AGTCGGCCAT ACGCAACTGG CGTCAGGATT GTGTTTACGC CCGCAGTTGC 
GGGATGAACC AGGGACCGGA ACAGCAGCGG CACAACCGTT CGTCGGGTCA GCGTGTCCAG 
CAGCAGCCGC GGATTGGCAG TGGACGCTTC GCCCACCTGC AGGCGGCCCA ATTGATGGAC 
GAGTTGCCTG ATATGAGGAT CGGCCTTTCG CCGCCCAGCG AGAGTGTACT GCTCCAAAGG 
CGCCTGCGCC AGCAGCAGCG GGCCAACGAT CTGTCTGAGT ACTGCGAGCC GGCCACCGCC 
AGTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_651986.2
CDS	812..4240
Translation	MVEPKSGTAASAAAAKASNNNNNNHPRGSGDSGIRSGSGISCSNTDNSCSQSQSDGQNELTRYSSEDVSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGGFKTLNVHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCETLGEDRFRRQSGSEGDEVEDDEDGENEDYQHYKHYWRELDEEEGDDYLYEQQQRVDDKFGEEEFEDEPKEETQADNLKLSKAYVEQVGETNVEKSKPQDDNGGYIREDLIMDNMDMKKNTQQSEFAKLTIMRNDAQTEENKIMQQQDEEKKEEKQQDDVDGAKKQGPSSDISATTITDNNKLQTPVMTTTHINNWQTGDAIEDDDVKLLDSISDLNEKLPEIYETANIVVNSAAVPAASTPAASATRPPTDNPEEDDSNVTKPTTTAEGTTMQTTFGMSAEEEKPVALSHTAGHHSKTGRTVNFAPDAYQNDEDADIDEDDDYDDEENLHEHSKQQLPSNAYTRKQRQQHQRYIVPRYQLADQVPQRQHTENWRYRTHHSQEQQPTADYRKYRPPFSTGGGGGHHGNQQRNYLGSFSHSGGAAGYKIAPMPPPMQPPPRHNSAGSSGSGSGSGGSPPSDEQSAIRNWRQDCVYARSCGMNQGPEQQRHNRSSGQRVQQQPRIGSGRFAHLQAAQLMDELPDMRIGLSPPSESVLLQRRLRQQQRANDLSEYCEPATASG

Target ORF information:

RefSeq Version	NM_143729.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Lk6 kinase (Lk6), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_143729.3

ORF Insert Sequence:

ATGGTGGAGC CCAAGTCCGG GACAGCTGCT TCTGCCGCTG CTGCGAAAGC AAGCAACAAC 
AATAACAACA ACCACCCCCG TGGATCTGGG GACAGCGGCA TCCGGAGTGG CAGCGGCATT 
TCCTGCAGCA ACACGGACAA CAGCTGCAGC CAGAGTCAGT CAGACGGACA GAATGAGCTG 
ACGCGCTACA GCAGCGAGGA TGTGTCGGGC AACGAGTCCA GCGAGGCGCC CAACATGACC 
GAGGTGGAAC GCCAGGCGGA GCTTAACAGG CACAAGGAGG AGATGCAGAA GAAGCGGCGC 
AAGAAACGCA TCAGCTCCTC CCTTCATTCC TCAACCTTTC AGGAGCTGTA CAAGCTGACT 
GGCGAGATTC TTGGCGAGGG AGCCTACGCA TCGGTGCAAA CTTGCGTTAA CATCTACACC 
GATCTGGAGT ATGCCGTGAA GGTGATCGAT AAGATACCGG GGCATGCGCG TGCACGTGTC 
TTTCGCGAAG TGGAGACATT CCATCACTGC CAGGGCCATT TGGGCATCTT GCAACTGATT 
GAATTCTTTG AGGATGACGA GAAGTTCTAC CTGGTATTCG AGAAGATCAA CGGTGGTCCA 
TTGCTATCGC GCATACAGGA GCACATTTGC TTCTCCGAGC ATGAGGCCTC GCAGATAATC 
AAGGAGATCG CCTCCGGACT TGATTTTCTG CACAAGAAGG GCATTGCCCA TCGTGATCTC 
AAGCCGGAGA ATATTCTGTG TGTCAAGACG GATTCGCTGT GCCCAATCAA GATTTGCGAC 
TTTGATTTGG GTTCGGGGAT TAAGTTCACT ACGGACATCT CGTCGCCAGC AGCCACTCCT 
CAGTTATTGA CACCAGTTGG CAGTGCCGAG TTTATGGCTC CGGAAGTGGT CGATTTGTTT 
GTGGGTGAGG CACACTATTA CGATAAGAGG TGCGATTTGT GGTCCCTGGG AGTCATTGCT 
TACATCCTGC TCTGCGGTTA TCCGCCATTT TCGGGCAACT GTGGTGAGGA TTGCGGCTGG 
AATCGCGGTG AAAACTGCCG CACGTGCCAG GAACTGCTTT TCGAGTCCAT TCAAGAAGGA 
CACTTTTCTT TCCCGGAGGC CGAGTGGCAC GATGTCAGCG ATGAGGCCAA GGACCTAATT 
TCTAATCTGC TTGTCAAGAA GGCATCGAAC CGCCTCAGTG CCGAGGCAGT GTTGAATCAC 
CCATGGATTC GTATGTGCGA GCAGGAGCCA CCGGCAAGCA AGCATGGCAG GCGCCACAAG 
GCTTTGCAAA CGCCCAGTAA CATCCGACGC AATCACCAGT CGGCAAGGGA AATCTCGCAG 
TTTGCCGAAT CTGCTATGGC CGTCAAGCGT GTGGTCCTAC AGCATTTCTC GATGCGCTAC 
GATTACATGA AAGAGCGTCC CAACATCTAC CAGCCATCGC AGGCCTACAT GGATGCCTAT 
AGCGATGAAA ACTACAATCC CAAGCCGCCG GGTCATTACA CTCGCAATCG CTCGCAGCGC 
AATCCCGCTT CCTCCTTGTG CGGCTACGGA GGGCGTATGT CCTCGATGCA CGGCCAGCGG 
GCCAATAGCC GTCGGTCTTC CCGAAATGCG TCTCGCAATG CATCTGCAAT TTATCCGAAT 
AGCGGGGGCT TCAAGACATT GAACGTCCAC GAGGAAGATG ACGACGATGA AGGTCTGGAG 
GCTTTTGGCC ACATCGATGA TGATGATGAG TGGAGCAGGT CTAGGAGGGA ATATCAGCAG 
CAGTGTGAGA CGCTGGGCGA GGATCGCTTT AGGCGTCAGA GCGGAAGCGA AGGCGACGAA 
GTGGAAGATG ATGAGGATGG AGAGAATGAG GACTATCAGC ACTATAAGCA TTACTGGCGC 
GAATTAGACG AGGAAGAGGG CGACGACTAT CTGTATGAGC AGCAGCAGCG CGTCGATGAT 
AAATTCGGGG AAGAGGAGTT CGAGGACGAA CCAAAGGAGG AAACTCAAGC TGACAATCTA 
AAGCTATCGA AAGCTTACGT GGAGCAAGTT GGCGAGACCA ATGTGGAGAA ATCGAAGCCA 
CAGGACGATA ACGGTGGGTA TATAAGGGAG GACCTTATTA TGGATAATAT GGATATGAAG 
AAAAACACTC AGCAAAGCGA ATTTGCTAAG CTCACCATAA TGCGCAACGA TGCGCAGACG 
GAGGAGAATA AGATAATGCA GCAGCAGGAT GAGGAGAAGA AAGAGGAAAA ACAGCAGGAT 
GATGTTGATG GGGCTAAGAA GCAAGGACCA TCAAGTGATA TTAGTGCTAC TACCATCACC 
GATAATAACA AGCTGCAAAC ACCAGTTATG ACTACAACAC ACATTAACAA CTGGCAAACT 
GGCGATGCAA TTGAAGATGA TGATGTTAAA CTATTGGATA GTATTAGTGA TTTAAATGAA 
AAGCTACCTG AAATTTATGA GACTGCAAAT ATTGTTGTCA ACTCAGCGGC AGTGCCAGCA 
GCATCGACAC CAGCAGCATC AGCAACACGC CCACCAACCG ATAACCCAGA GGAAGATGAT 
TCGAACGTGA CCAAACCGAC GACTACTGCT GAGGGGACAA CAATGCAAAC GACTTTTGGC 
ATGTCAGCGG AAGAGGAGAA GCCTGTAGCC CTATCCCACA CCGCGGGTCA CCACAGCAAG 
ACCGGCCGCA CTGTTAACTT TGCCCCCGAT GCATATCAGA ACGACGAGGA TGCCGATATC 
GACGAGGACG ACGACTACGA TGACGAGGAG AATCTGCATG AGCACAGCAA GCAACAGCTG 
CCGTCCAATG CCTACACTCG TAAGCAGCGA CAGCAGCACC AGCGGTACAT TGTGCCACGC 
TACCAGCTTG CGGATCAAGT TCCTCAGAGG CAGCACACCG AAAACTGGCG TTATCGCACC 
CATCACTCGC AGGAACAGCA GCCGACAGCG GACTATCGCA AGTATCGCCC GCCGTTTAGC 
ACCGGAGGCG GCGGTGGCCA CCATGGCAAC CAGCAGCGCA ATTACCTGGG GAGCTTCTCG 
CACAGCGGCG GTGCCGCTGG TTACAAGATT GCTCCAATGC CGCCACCAAT GCAGCCGCCT 
CCGCGGCACA ACAGCGCCGG AAGCAGTGGC AGTGGTAGCG GCAGCGGCGG ATCTCCGCCA 
TCTGACGAGC AGTCGGCCAT ACGCAACTGG CGTCAGGATT GTGTTTACGC CCGCAGTTGC 
GGGATGAACC AGGGACCGGA ACAGCAGCGG CACAACCGTT CGTCGGGTCA GCGTGTCCAG 
CAGCAGCCGC GGATTGGCAG TGGACGCTTC GCCCACCTGC AGGCGGCCCA ATTGATGGAC 
GAGTTGCCTG ATATGAGGAT CGGCCTTTCG CCGCCCAGCG AGAGTGTACT GCTCCAAAGG 
CGCCTGCGCC AGCAGCAGCG GGCCAACGAT CTGTCTGAGT ACTGCGAGCC GGCCACCGCC 
AGTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lk6 ( NM_169423.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_731624.1 Drosophila melanogaster Lk6 kinase (Lk6), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa06861
Clone ID Related Accession (Same CDS sequence)	NM_169423.3
Accession Version	NM_169423.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3273bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Lk6 kinase, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_169423.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTTAGACG GACAGAATGA GCTGACGCGC TACAGCAGCG AGGATGTGTC GGGCAACGAG 
TCCAGCGAGG CGCCCAACAT GACCGAGGTG GAACGCCAGG CGGAGCTTAA CAGGCACAAG 
GAGGAGATGC AGAAGAAGCG GCGCAAGAAA CGCATCAGCT CCTCCCTTCA TTCCTCAACC 
TTTCAGGAGC TGTACAAGCT GACTGGCGAG ATTCTTGGCG AGGGAGCCTA CGCATCGGTG 
CAAACTTGCG TTAACATCTA CACCGATCTG GAGTATGCCG TGAAGGTGAT CGATAAGATA 
CCGGGGCATG CGCGTGCACG TGTCTTTCGC GAAGTGGAGA CATTCCATCA CTGCCAGGGC 
CATTTGGGCA TCTTGCAACT GATTGAATTC TTTGAGGATG ACGAGAAGTT CTACCTGGTA 
TTCGAGAAGA TCAACGGTGG TCCATTGCTA TCGCGCATAC AGGAGCACAT TTGCTTCTCC 
GAGCATGAGG CCTCGCAGAT AATCAAGGAG ATCGCCTCCG GACTTGATTT TCTGCACAAG 
AAGGGCATTG CCCATCGTGA TCTCAAGCCG GAGAATATTC TGTGTGTCAA GACGGATTCG 
CTGTGCCCAA TCAAGATTTG CGACTTTGAT TTGGGTTCGG GGATTAAGTT CACTACGGAC 
ATCTCGTCGC CAGCAGCCAC TCCTCAGTTA TTGACACCAG TTGGCAGTGC CGAGTTTATG 
GCTCCGGAAG TGGTCGATTT GTTTGTGGGT GAGGCACACT ATTACGATAA GAGGTGCGAT 
TTGTGGTCCC TGGGAGTCAT TGCTTACATC CTGCTCTGCG GTTATCCGCC ATTTTCGGGC 
AACTGTGGTG AGGATTGCGG CTGGAATCGC GGTGAAAACT GCCGCACGTG CCAGGAACTG 
CTTTTCGAGT CCATTCAAGA AGGACACTTT TCTTTCCCGG AGGCCGAGTG GCACGATGTC 
AGCGATGAGG CCAAGGACCT AATTTCTAAT CTGCTTGTCA AGAAGGCATC GAACCGCCTC 
AGTGCCGAGG CAGTGTTGAA TCACCCATGG ATTCGTATGT GCGAGCAGGA GCCACCGGCA 
AGCAAGCATG GCAGGCGCCA CAAGGCTTTG CAAACGCCCA GTAACATCCG ACGCAATCAC 
CAGTCGGCAA GGGAAATCTC GCAGTTTGCC GAATCTGCTA TGGCCGTCAA GCGTGTGGTC 
CTACAGCATT TCTCGATGCG CTACGATTAC ATGAAAGAGC GTCCCAACAT CTACCAGCCA 
TCGCAGGCCT ACATGGATGC CTATAGCGAT GAAAACTACA ATCCCAAGCC GCCGGGTCAT 
TACACTCGCA ATCGCTCGCA GCGCAATCCC GCTTCCTCCT TGTGCGGCTA CGGAGGGCGT 
ATGTCCTCGA TGCACGGCCA GCGGGCCAAT AGCCGTCGGT CTTCCCGAAA TGCGTCTCGC 
AATGCATCTG CAATTTATCC GAATAGCGGG GGCTTCAAGA CATTGAACGT CCACGAGGAA 
GATGACGACG ATGAAGGTCT GGAGGCTTTT GGCCACATCG ATGATGATGA TGAGTGGAGC 
AGGTCTAGGA GGGAATATCA GCAGCAGTGT GAGACGCTGG GCGAGGATCG CTTTAGGCGT 
CAGAGCGGAA GCGAAGGCGA CGAAGTGGAA GATGATGAGG ATGGAGAGAA TGAGGACTAT 
CAGCACTATA AGCATTACTG GCGCGAATTA GACGAGGAAG AGGGCGACGA CTATCTGTAT 
GAGCAGCAGC AGCGCGTCGA TGATAAATTC GGGGAAGAGG AGTTCGAGGA CGAACCAAAG 
GAGGAAACTC AAGCTGACAA TCTAAAGCTA TCGAAAGCTT ACGTGGAGCA AGTTGGCGAG 
ACCAATGTGG AGAAATCGAA GCCACAGGAC GATAACGGTG GGTATATAAG GGAGGACCTT 
ATTATGGATA ATATGGATAT GAAGAAAAAC ACTCAGCAAA GCGAATTTGC TAAGCTCACC 
ATAATGCGCA ACGATGCGCA GACGGAGGAG AATAAGATAA TGCAGCAGCA GGATGAGGAG 
AAGAAAGAGG AAAAACAGCA GGATGATGTT GATGGGGCTA AGAAGCAAGG ACCATCAAGT 
GATATTAGTG CTACTACCAT CACCGATAAT AACAAGCTGC AAACACCAGT TATGACTACA 
ACACACATTA ACAACTGGCA AACTGGCGAT GCAATTGAAG ATGATGATGT TAAACTATTG 
GATAGTATTA GTGATTTAAA TGAAAAGCTA CCTGAAATTT ATGAGACTGC AAATATTGTT 
GTCAACTCAG CGGCAGTGCC AGCAGCATCG ACACCAGCAG CATCAGCAAC ACGCCCACCA 
ACCGATAACC CAGAGGAAGA TGATTCGAAC GTGACCAAAC CGACGACTAC TGCTGAGGGG 
ACAACAATGC AAACGACTTT TGGCATGTCA GCGGAAGAGG AGAAGCCTGT AGCCCTATCC 
CACACCGCGG GTCACCACAG CAAGACCGGC CGCACTGTTA ACTTTGCCCC CGATGCATAT 
CAGAACGACG AGGATGCCGA TATCGACGAG GACGACGACT ACGATGACGA GGAGAATCTG 
CATGAGCACA GCAAGCAACA GCTGCCGTCC AATGCCTACA CTCGTAAGCA GCGACAGCAG 
CACCAGCGGT ACATTGTGCC ACGCTACCAG CTTGCGGATC AAGTTCCTCA GAGGCAGCAC 
ACCGAAAACT GGCGTTATCG CACCCATCAC TCGCAGGAAC AGCAGCCGAC AGCGGACTAT 
CGCAAGTATC GCCCGCCGTT TAGCACCGGA GGCGGCGGTG GCCACCATGG CAACCAGCAG 
CGCAATTACC TGGGGAGCTT CTCGCACAGC GGCGGTGCCG CTGGTTACAA GATTGCTCCA 
ATGCCGCCAC CAATGCAGCC GCCTCCGCGG CACAACAGCG CCGGAAGCAG TGGCAGTGGT 
AGCGGCAGCG GCGGATCTCC GCCATCTGAC GAGCAGTCGG CCATACGCAA CTGGCGTCAG 
GATTGTGTTT ACGCCCGCAG TTGCGGGATG AACCAGGGAC CGGAACAGCA GCGGCACAAC 
CGTTCGTCGG GTCAGCGTGT CCAGCAGCAG CCGCGGATTG GCAGTGGACG CTTCGCCCAC 
CTGCAGGCGG CCCAATTGAT GGACGAGTTG CCTGATATGA GGATCGGCCT TTCGCCGCCC 
AGCGAGAGTG TACTGCTCCA AAGGCGCCTG CGCCAGCAGC AGCGGGCCAA CGATCTGTCT 
GAGTACTGCG AGCCGGCCAC CGCCAGTGGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_731624.1
CDS	520..3792
Translation	MLDGQNELTRYSSEDVSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGGFKTLNVHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCETLGEDRFRRQSGSEGDEVEDDEDGENEDYQHYKHYWRELDEEEGDDYLYEQQQRVDDKFGEEEFEDEPKEETQADNLKLSKAYVEQVGETNVEKSKPQDDNGGYIREDLIMDNMDMKKNTQQSEFAKLTIMRNDAQTEENKIMQQQDEEKKEEKQQDDVDGAKKQGPSSDISATTITDNNKLQTPVMTTTHINNWQTGDAIEDDDVKLLDSISDLNEKLPEIYETANIVVNSAAVPAASTPAASATRPPTDNPEEDDSNVTKPTTTAEGTTMQTTFGMSAEEEKPVALSHTAGHHSKTGRTVNFAPDAYQNDEDADIDEDDDYDDEENLHEHSKQQLPSNAYTRKQRQQHQRYIVPRYQLADQVPQRQHTENWRYRTHHSQEQQPTADYRKYRPPFSTGGGGGHHGNQQRNYLGSFSHSGGAAGYKIAPMPPPMQPPPRHNSAGSSGSGSGSGGSPPSDEQSAIRNWRQDCVYARSCGMNQGPEQQRHNRSSGQRVQQQPRIGSGRFAHLQAAQLMDELPDMRIGLSPPSESVLLQRRLRQQQRANDLSEYCEPATASG

Target ORF information:

RefSeq Version	NM_169423.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Lk6 kinase (Lk6), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_169423.3

ORF Insert Sequence:

ATGTTAGACG GACAGAATGA GCTGACGCGC TACAGCAGCG AGGATGTGTC GGGCAACGAG 
TCCAGCGAGG CGCCCAACAT GACCGAGGTG GAACGCCAGG CGGAGCTTAA CAGGCACAAG 
GAGGAGATGC AGAAGAAGCG GCGCAAGAAA CGCATCAGCT CCTCCCTTCA TTCCTCAACC 
TTTCAGGAGC TGTACAAGCT GACTGGCGAG ATTCTTGGCG AGGGAGCCTA CGCATCGGTG 
CAAACTTGCG TTAACATCTA CACCGATCTG GAGTATGCCG TGAAGGTGAT CGATAAGATA 
CCGGGGCATG CGCGTGCACG TGTCTTTCGC GAAGTGGAGA CATTCCATCA CTGCCAGGGC 
CATTTGGGCA TCTTGCAACT GATTGAATTC TTTGAGGATG ACGAGAAGTT CTACCTGGTA 
TTCGAGAAGA TCAACGGTGG TCCATTGCTA TCGCGCATAC AGGAGCACAT TTGCTTCTCC 
GAGCATGAGG CCTCGCAGAT AATCAAGGAG ATCGCCTCCG GACTTGATTT TCTGCACAAG 
AAGGGCATTG CCCATCGTGA TCTCAAGCCG GAGAATATTC TGTGTGTCAA GACGGATTCG 
CTGTGCCCAA TCAAGATTTG CGACTTTGAT TTGGGTTCGG GGATTAAGTT CACTACGGAC 
ATCTCGTCGC CAGCAGCCAC TCCTCAGTTA TTGACACCAG TTGGCAGTGC CGAGTTTATG 
GCTCCGGAAG TGGTCGATTT GTTTGTGGGT GAGGCACACT ATTACGATAA GAGGTGCGAT 
TTGTGGTCCC TGGGAGTCAT TGCTTACATC CTGCTCTGCG GTTATCCGCC ATTTTCGGGC 
AACTGTGGTG AGGATTGCGG CTGGAATCGC GGTGAAAACT GCCGCACGTG CCAGGAACTG 
CTTTTCGAGT CCATTCAAGA AGGACACTTT TCTTTCCCGG AGGCCGAGTG GCACGATGTC 
AGCGATGAGG CCAAGGACCT AATTTCTAAT CTGCTTGTCA AGAAGGCATC GAACCGCCTC 
AGTGCCGAGG CAGTGTTGAA TCACCCATGG ATTCGTATGT GCGAGCAGGA GCCACCGGCA 
AGCAAGCATG GCAGGCGCCA CAAGGCTTTG CAAACGCCCA GTAACATCCG ACGCAATCAC 
CAGTCGGCAA GGGAAATCTC GCAGTTTGCC GAATCTGCTA TGGCCGTCAA GCGTGTGGTC 
CTACAGCATT TCTCGATGCG CTACGATTAC ATGAAAGAGC GTCCCAACAT CTACCAGCCA 
TCGCAGGCCT ACATGGATGC CTATAGCGAT GAAAACTACA ATCCCAAGCC GCCGGGTCAT 
TACACTCGCA ATCGCTCGCA GCGCAATCCC GCTTCCTCCT TGTGCGGCTA CGGAGGGCGT 
ATGTCCTCGA TGCACGGCCA GCGGGCCAAT AGCCGTCGGT CTTCCCGAAA TGCGTCTCGC 
AATGCATCTG CAATTTATCC GAATAGCGGG GGCTTCAAGA CATTGAACGT CCACGAGGAA 
GATGACGACG ATGAAGGTCT GGAGGCTTTT GGCCACATCG ATGATGATGA TGAGTGGAGC 
AGGTCTAGGA GGGAATATCA GCAGCAGTGT GAGACGCTGG GCGAGGATCG CTTTAGGCGT 
CAGAGCGGAA GCGAAGGCGA CGAAGTGGAA GATGATGAGG ATGGAGAGAA TGAGGACTAT 
CAGCACTATA AGCATTACTG GCGCGAATTA GACGAGGAAG AGGGCGACGA CTATCTGTAT 
GAGCAGCAGC AGCGCGTCGA TGATAAATTC GGGGAAGAGG AGTTCGAGGA CGAACCAAAG 
GAGGAAACTC AAGCTGACAA TCTAAAGCTA TCGAAAGCTT ACGTGGAGCA AGTTGGCGAG 
ACCAATGTGG AGAAATCGAA GCCACAGGAC GATAACGGTG GGTATATAAG GGAGGACCTT 
ATTATGGATA ATATGGATAT GAAGAAAAAC ACTCAGCAAA GCGAATTTGC TAAGCTCACC 
ATAATGCGCA ACGATGCGCA GACGGAGGAG AATAAGATAA TGCAGCAGCA GGATGAGGAG 
AAGAAAGAGG AAAAACAGCA GGATGATGTT GATGGGGCTA AGAAGCAAGG ACCATCAAGT 
GATATTAGTG CTACTACCAT CACCGATAAT AACAAGCTGC AAACACCAGT TATGACTACA 
ACACACATTA ACAACTGGCA AACTGGCGAT GCAATTGAAG ATGATGATGT TAAACTATTG 
GATAGTATTA GTGATTTAAA TGAAAAGCTA CCTGAAATTT ATGAGACTGC AAATATTGTT 
GTCAACTCAG CGGCAGTGCC AGCAGCATCG ACACCAGCAG CATCAGCAAC ACGCCCACCA 
ACCGATAACC CAGAGGAAGA TGATTCGAAC GTGACCAAAC CGACGACTAC TGCTGAGGGG 
ACAACAATGC AAACGACTTT TGGCATGTCA GCGGAAGAGG AGAAGCCTGT AGCCCTATCC 
CACACCGCGG GTCACCACAG CAAGACCGGC CGCACTGTTA ACTTTGCCCC CGATGCATAT 
CAGAACGACG AGGATGCCGA TATCGACGAG GACGACGACT ACGATGACGA GGAGAATCTG 
CATGAGCACA GCAAGCAACA GCTGCCGTCC AATGCCTACA CTCGTAAGCA GCGACAGCAG 
CACCAGCGGT ACATTGTGCC ACGCTACCAG CTTGCGGATC AAGTTCCTCA GAGGCAGCAC 
ACCGAAAACT GGCGTTATCG CACCCATCAC TCGCAGGAAC AGCAGCCGAC AGCGGACTAT 
CGCAAGTATC GCCCGCCGTT TAGCACCGGA GGCGGCGGTG GCCACCATGG CAACCAGCAG 
CGCAATTACC TGGGGAGCTT CTCGCACAGC GGCGGTGCCG CTGGTTACAA GATTGCTCCA 
ATGCCGCCAC CAATGCAGCC GCCTCCGCGG CACAACAGCG CCGGAAGCAG TGGCAGTGGT 
AGCGGCAGCG GCGGATCTCC GCCATCTGAC GAGCAGTCGG CCATACGCAA CTGGCGTCAG 
GATTGTGTTT ACGCCCGCAG TTGCGGGATG AACCAGGGAC CGGAACAGCA GCGGCACAAC 
CGTTCGTCGG GTCAGCGTGT CCAGCAGCAG CCGCGGATTG GCAGTGGACG CTTCGCCCAC 
CTGCAGGCGG CCCAATTGAT GGACGAGTTG CCTGATATGA GGATCGGCCT TTCGCCGCCC 
AGCGAGAGTG TACTGCTCCA AAGGCGCCTG CGCCAGCAGC AGCGGGCCAA CGATCTGTCT 
GAGTACTGCG AGCCGGCCAC CGCCAGTGGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Lk6 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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