tll cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	tll
Entrez Gene ID	43656
Full Name	tailless
Synonyms	CG1378,Dmel\CG1378,NR2E2,TLL,Tll,dm-tll
General protein information	Preferred Names tailless Names CG1378 gene product from transcript CG1378-RA CG1378-PA tailles tll-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 100A6-100A6\|3-102 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_079857.4	NP_524596.1	tailless

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	tll	NP_524596.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000819	XP_316782.3

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We then show that Rx controls proliferation within the MBNB clones independently of Tailless (Tll) and Prospero (Pros), and does not regulate the expression of other key regulators of MB development, Eyeless (Ey) and Dachshund (Dac). Our data support that the role of Rx in forebrain development is conserved between vertebrates and fly.
Title: Retinal homeobox promotes cell growth, proliferation and survival of mushroom body neuroblasts in the Drosophila brain.

tll regulates the precise timing of the transition from neuroepithelial cells to medulla neuroblasts; tll has a crucial role for the specification of lamina precursor cells
Title: Characterization of tailless functions during Drosophila optic lobe formation.

Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both proteins physically interact in the PI. tll knockdown-induced aggression is fully suppressed by blocking neuropeptide processing or release from the PI
Title: Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis.

Both position and timing of posterior segmentation gene expression domains vary strongly from embryo-to-embryo in tll mutants.
Title: Lack of tailless leads to an increase in expression variability in Drosophila embryos.

drm is activated under the control of tll and triggers development of the small intestine cell-non-autonomously through some extracellular signaling
Title: The drumstick gene acts cell-non-autonomously and triggers specification of the small intestine in the Drosophila hindgut.

The following tll gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the tll cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa06705	NM_079857.4 Latest version!	Drosophila melanogaster tailless (tll), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

tll ( NM_079857.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524596.1 Drosophila melanogaster tailless (tll), mRNA.

Price & Availability↑

CloneID	OFa06705
Clone ID Related Accession (Same CDS sequence)	NM_079857.4
Accession Version	NM_079857.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	tailless
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_079857.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCAGTCGT CGGAGGGTTC ACCAGACATG ATGGATCAGA AATACAACAG CGTGCGTCTT 
TCGCCAGCGG CATCGAGTCG CATTCTATAC CATGTGCCCT GCAAAGTCTG CAGAGATCAC 
AGCTCCGGCA AGCATTACGG CATCTACGCC TGTGATGGCT GCGCCGGATT CTTCAAGAGG 
AGCATTCGGA GATCCCGGCA GTATGTGTGC AAGTCGCAGA AGCAGGGACT CTGTGTGGTG 
GACAAGACGC ACAGGAACCA ATGTAGGGCT TGCCGACTGA GGAAGTGCTT TGAGGTCGGA 
ATGAACAAGG ATGCAGTGCA GCACGAGCGG GGACCGCGGA ACTCCACTCT GCGTCGCCAC 
ATGGCCATGT ACAAGGATGC CATGATGGGC GCCGGCGAGA TGCCACAAAT ACCCGCCGAA 
ATTCTGATGA ACACGGCTGC CTTGACCGGC TTTCCTGGAG TACCGATGCC CATGCCTGGC 
CTGCCCCAGA GGGCTGGTCA TCATCCTGCT CACATGGCTG CCTTCCAGCC GCCACCATCG 
GCTGCCGCTG TCTTGGACTT ATCCGTGCCA CGAGTGCCCC ATCACCCGGT GCACCAAGGA 
CACCACGGTT TCTTCTCGCC CACCGCCGCC TACATGAATG CCCTGGCCAC TCGGGCCCTG 
CCCCCCACTC CTCCGCTGAT GGCAGCTGAG CACATCAAGG AAACCGCGGC GGAACACCTA 
TTCAAGAACG TCAACTGGAT CAAGAGCGTA CGGGCCTTCA CCGAACTGCC CATGCCGGAT 
CAGCTGCTCC TGCTGGAGGA GTCCTGGAAG GAGTTCTTCA TCCTGGCCAT GGCCCAGTAC 
CTAATGCCCA TGAATTTCGC CCAGCTGCTG TTCGTCTACG AGTCCGAGAA TGCCAACCGG 
GAGATCATGG GCATGGTGAC CCGCGAGGTG CACGCCTTCC AGGAGGTGCT GAACCAACTG 
TGCCATCTGA ACATTGACAG CACCGAGTAC GAGTGTCTGA GGGCTATTTC GCTCTTCCGT 
AAGTCACCAC CGTCGGCAAG TTCTACCGAG GATTTAGCCA ACAGCTCAAT CCTGACAGGA 
AGCGGCAGCC CGAACTCCTC GGCCTCTGCT GAATCCAGGG GTCTTCTGGA GTCGGGAAAA 
GTGGCGGCCA TGCACAACGA TGCCCGGAGT GCGCTGCACA ACTACATCCA GAGGACCCAT 
CCCTCGCAGC CCATGCGATT CCAGACGCTC TTGGGCGTGG TGCAGCTGAT GCACAAGGTC 
TCAAGCTTCA CCATCGAGGA GCTGTTCTTC CGAAAGACCA TCGGCGACAT CACCATTGTG 
CGCCTCATCT CCGACATGTA CAGTCAGCGC AAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524596.1
CDS	233..1591
Translation	MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI

Target ORF information:

RefSeq Version	NM_079857.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster tailless (tll), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079857.4

ORF Insert Sequence:

ATGCAGTCGT CGGAGGGTTC ACCAGACATG ATGGATCAGA AATACAACAG CGTGCGTCTT 
TCGCCAGCGG CATCGAGTCG CATTCTATAC CATGTGCCCT GCAAAGTCTG CAGAGATCAC 
AGCTCCGGCA AGCATTACGG CATCTACGCC TGTGATGGCT GCGCCGGATT CTTCAAGAGG 
AGCATTCGGA GATCCCGGCA GTATGTGTGC AAGTCGCAGA AGCAGGGACT CTGTGTGGTG 
GACAAGACGC ACAGGAACCA ATGTAGGGCT TGCCGACTGA GGAAGTGCTT TGAGGTCGGA 
ATGAACAAGG ATGCAGTGCA GCACGAGCGG GGACCGCGGA ACTCCACTCT GCGTCGCCAC 
ATGGCCATGT ACAAGGATGC CATGATGGGC GCCGGCGAGA TGCCACAAAT ACCCGCCGAA 
ATTCTGATGA ACACGGCTGC CTTGACCGGC TTTCCTGGAG TACCGATGCC CATGCCTGGC 
CTGCCCCAGA GGGCTGGTCA TCATCCTGCT CACATGGCTG CCTTCCAGCC GCCACCATCG 
GCTGCCGCTG TCTTGGACTT ATCCGTGCCA CGAGTGCCCC ATCACCCGGT GCACCAAGGA 
CACCACGGTT TCTTCTCGCC CACCGCCGCC TACATGAATG CCCTGGCCAC TCGGGCCCTG 
CCCCCCACTC CTCCGCTGAT GGCAGCTGAG CACATCAAGG AAACCGCGGC GGAACACCTA 
TTCAAGAACG TCAACTGGAT CAAGAGCGTA CGGGCCTTCA CCGAACTGCC CATGCCGGAT 
CAGCTGCTCC TGCTGGAGGA GTCCTGGAAG GAGTTCTTCA TCCTGGCCAT GGCCCAGTAC 
CTAATGCCCA TGAATTTCGC CCAGCTGCTG TTCGTCTACG AGTCCGAGAA TGCCAACCGG 
GAGATCATGG GCATGGTGAC CCGCGAGGTG CACGCCTTCC AGGAGGTGCT GAACCAACTG 
TGCCATCTGA ACATTGACAG CACCGAGTAC GAGTGTCTGA GGGCTATTTC GCTCTTCCGT 
AAGTCACCAC CGTCGGCAAG TTCTACCGAG GATTTAGCCA ACAGCTCAAT CCTGACAGGA 
AGCGGCAGCC CGAACTCCTC GGCCTCTGCT GAATCCAGGG GTCTTCTGGA GTCGGGAAAA 
GTGGCGGCCA TGCACAACGA TGCCCGGAGT GCGCTGCACA ACTACATCCA GAGGACCCAT 
CCCTCGCAGC CCATGCGATT CCAGACGCTC TTGGGCGTGG TGCAGCTGAT GCACAAGGTC 
TCAAGCTTCA CCATCGAGGA GCTGTTCTTC CGAAAGACCA TCGGCGACAT CACCATTGTG 
CGCCTCATCT CCGACATGTA CAGTCAGCGC AAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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tll cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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