Drice cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Drice
Entrez Gene ID	43514
Full Name	Death related ICE-like caspase
Synonyms	CG7788,DRICE,Dmel\CG7788,DrICE,DrIce,Drive,ICE,Ice,caspase 3,crice,drICE,drIce,drice,ice
General protein information	Preferred Names Death related ICE-like caspase Names CG7788 gene product from transcript CG7788-RA CG7788-PA Drice-PA Ice caspase-3 death related ICE-like caspase interleukin-1beta-converting enzyme
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 99C1-99C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_079827.3	NP_524551.2	death related ICE-like caspase

Pathways from BioSystems

Homologies

Homo sapiens (human)	CASP7	NP_203124.1
Rattus norvegicus (Norway rat)	Casp7	NP_071596.1
Canis lupus familiaris (dog)	CASP7	XP_005637795.1
Bos taurus (cattle)	CASP7	XP_002698555.1
Gallus gallus (chicken)	CASP7	XP_421764.3
Drosophila melanogaster (fruit fly)	Ice	NP_524551.2
Drosophila melanogaster (fruit fly)	Dcp-1	NP_476974.1
Pan troglodytes (chimpanzee)	CASP7	XP_508043.2
	CASP7	XP_001090833.1
Danio rerio (zebrafish)	casp7	NP_001018443.1
Mus musculus (house mouse)	Casp7	NP_031637.1
Anopheles gambiae (African malaria mosquito)	CASPS7	XP_316795.2
Xenopus tropicalis (tropical clawed frog)	casp7	NP_001016299.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.
Title: Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.

drICE plays an important role in activating corpse clearance in dying cells, and that an additional function of effector caspases is required for the activation of corpse clearance as well as that for carrying out cell death.
Title: The role of the effector caspases drICE and dcp-1 for cell death and corpse clearance in the developing optic lobe in Drosophila.

Both autophagy and caspase activity are induced by 20-hydroxyecdysone during the larval-prepupal transition.
Title: Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition.

The cleaved DIAP1 binds drICE, inhibits its protease activity, and also targets drICE for ubiquitylation.
Title: Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE.

Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1, and ice
Title: Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis.

The following Drice gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Drice cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa06543	NM_079827.3 Latest version!	Drosophila melanogaster death related ICE-like caspase (Drice), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Drice ( NM_079827.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524551.2 Drosophila melanogaster death related ICE-like caspase (Drice), mRNA.

Price & Availability↑

CloneID	OFa06543
Clone ID Related Accession (Same CDS sequence)	NM_079827.3
Accession Version	NM_079827.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	death related ICE-like caspase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_079827.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGACGCCA CTAACAATGG AGAATCCGCC GACCAGGTGG GCATCAGGGT GGGCAATCCG 
GAGCAGCCCA ACGATCACAC AGATGCCCTG GGCTCCGTGG GATCCGGAGG AGCGGGTAGC 
AGCGGCCTGG TCGCAGGATC CTCGCATCCT TACGGCAGCG GAGCCATTGG GCAGCTGGCC 
AACGGGTACA GCTCACCCTC GTCCAGCTAC CGTAAGAATG TAGCCAAAAT GGTCACCGAC 
CGCCATGCAG CCGAGTACAA CATGCGCCAC AAGAACCGCG GAATGGCACT GATCTTCAAC 
CATGAGCACT TCGAGGTGCC CACCTTGAAG TCTCGCGCGG GAACCAATGT GGACTGCGAG 
AATCTGACTC GGGTGCTCAA GCAGCTGGAC TTCGAAGTGA CCGTGTACAA GGACTGCCGC 
TACAAGGACA TTTTGAGGAC AATCGAGTAT GCAGCGTCGC AGAATCACAG CGATAGTGAT 
TGCATCCTGG TCGCCATCCT GTCGCACGGC GAGATGGGCT ACATCTACGC CAAGGACACA 
CAGTACAAGC TGGATAACAT CTGGAGCTTC TTCACGGCCA ATCACTGCCC CTCGCTAGCC 
GGCAAACCCA AGTTGTTCTT CATACAGGCC TGCCAGGGCG ACAGATTGGA TGGCGGAGTG 
ACCATGCAGC GTTCTCAGAC GGAAACCGAT GGCGACTCCT CGATGAGCTA CAAGATTCCA 
GTGCACGCCG ACTTTCTGAT CGCCTACTCG ACGGTTCCTG GATTCTATTC GTGGCGCAAC 
ACCACCCGCG GCAGCTGGTT CATGCAGAGC CTGTGCGCCG AACTGGCGGC CAATGGCAAG 
CGGCTGGACA TCCTGACCCT GCTCACATTC GTGTGCCAGC GGGTGGCCGT GGACTTTGAG 
TCCTGCACCC CGGACACTCC GGAGATGCAC CAGCAGAAGC AGATACCCTG CATAACCACC 
ATGCTGACGC GCATTCTGCG TTTCAGCGAC AAGCAGTTGG CACCAGCCGG ACGGGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524551.2
CDS	241..1260
Translation	MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPYGSGAIGQLANGYSSPSSSYRKNVAKMVTDRHAAEYNMRHKNRGMALIFNHEHFEVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAASQNHSDSDCILVAILSHGEMGYIYAKDTQYKLDNIWSFFTANHCPSLAGKPKLFFIQACQGDRLDGGVTMQRSQTETDGDSSMSYKIPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAVDFESCTPDTPEMHQQKQIPCITTMLTRILRFSDKQLAPAGRV

Target ORF information:

RefSeq Version	NM_079827.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster death related ICE-like caspase (Drice), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079827.3

ORF Insert Sequence:

ATGGACGCCA CTAACAATGG AGAATCCGCC GACCAGGTGG GCATCAGGGT GGGCAATCCG 
GAGCAGCCCA ACGATCACAC AGATGCCCTG GGCTCCGTGG GATCCGGAGG AGCGGGTAGC 
AGCGGCCTGG TCGCAGGATC CTCGCATCCT TACGGCAGCG GAGCCATTGG GCAGCTGGCC 
AACGGGTACA GCTCACCCTC GTCCAGCTAC CGTAAGAATG TAGCCAAAAT GGTCACCGAC 
CGCCATGCAG CCGAGTACAA CATGCGCCAC AAGAACCGCG GAATGGCACT GATCTTCAAC 
CATGAGCACT TCGAGGTGCC CACCTTGAAG TCTCGCGCGG GAACCAATGT GGACTGCGAG 
AATCTGACTC GGGTGCTCAA GCAGCTGGAC TTCGAAGTGA CCGTGTACAA GGACTGCCGC 
TACAAGGACA TTTTGAGGAC AATCGAGTAT GCAGCGTCGC AGAATCACAG CGATAGTGAT 
TGCATCCTGG TCGCCATCCT GTCGCACGGC GAGATGGGCT ACATCTACGC CAAGGACACA 
CAGTACAAGC TGGATAACAT CTGGAGCTTC TTCACGGCCA ATCACTGCCC CTCGCTAGCC 
GGCAAACCCA AGTTGTTCTT CATACAGGCC TGCCAGGGCG ACAGATTGGA TGGCGGAGTG 
ACCATGCAGC GTTCTCAGAC GGAAACCGAT GGCGACTCCT CGATGAGCTA CAAGATTCCA 
GTGCACGCCG ACTTTCTGAT CGCCTACTCG ACGGTTCCTG GATTCTATTC GTGGCGCAAC 
ACCACCCGCG GCAGCTGGTT CATGCAGAGC CTGTGCGCCG AACTGGCGGC CAATGGCAAG 
CGGCTGGACA TCCTGACCCT GCTCACATTC GTGTGCCAGC GGGTGGCCGT GGACTTTGAG 
TCCTGCACCC CGGACACTCC GGAGATGCAC CAGCAGAAGC AGATACCCTG CATAACCACC 
ATGCTGACGC GCATTCTGCG TTTCAGCGAC AAGCAGTTGG CACCAGCCGG ACGGGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Drice cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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